Research
  • Name:Bin Li

  • Office Location:Room 806, West#5 Building, 280 South Chongqing Road, Shanghai, China 200025

  • Telephone:86-21-63846590

  • Email:binli@@shsmu.edu.cn


Education


2001.09-2006.07 University of Pennsylvania School of Medicine Postdoctoral Fellow



1996.09-2001.07 Peking University Ph.D.



Career

2016.09-current Shanghai Institute of Immunology     Principle Investigator
2009.02-2016.09 Institut Pasteur of Shanghai, CAS     Principle Investigator
2006.07-2009.02 University of Pennsylvania School of Medicine     Faculty Research Associate

Research Interests

Research in my laboratory mainly focuses on understanding molecular mechanisms underlying the functional stability, plasticity and balance of FOXP3+ Regulatory T cells (Treg) and RORgt+ T helper 17 cells (Th17) in inflammatory diseases, as well as their therapeutic modulation, especially by compounds from Traditional Chinese medicine. By using and developing animal models with Treg-specific depletion of enzymatic subunits of FOXP3 complex, as well as these state-of-art cutting-edge technologies in single cell sequencing and immune cell metabolism, we are revealing the functional role of peripheral tissue-specific Treg cells in vitro and in vivo in health and disease settings. We expect that our original findings will be utilised by biomedical industry and be beneficial to human health.


1. Li Y, Lu Y, Lin SH, Li N, Han Y, Huang Q, Zhao Y, Xie F, Guo Y, Deng B, Tsun A, Du J, Li D, Sun J, Shi G, Zheng F, Su X, Duan S, Zheng SG, Wang G, Tong X*, Li B*. Insulin signaling establishes a developmental trajectory of adipose regulatory T cells. Nat Immunol. 2021 Sep;22(9):1175-1185. doi: 10.1038/s41590-021-01010-3. Epub 2021 Aug 24. PMID: 34429546.

2. Lu Y, Li Y, Liu Q, Tian N, Du P, Zhu F, Han Y, Liu X, Liu X, Peng X, Wang X, Wu Y, Tong L, Li Y, Zhu Y, Wu L, Zhang P, Xu Y, Chen H, Li B*, Tong X*. MondoA-Thioredoxin-Interacting Protein Axis Maintains Regulatory T-Cell Identity and Function in Colorectal Cancer Microenvironment. Gastroenterology. 2021 Aug;161(2):575-591.e16. doi: 10.1053/j.gastro.2021.04.041. Epub 2021 Apr 24. PMID: 33901495.

3. Liu Y, Du J, Liu X, Wang L, Han Y, Huang C, Liang R, Zheng F, Shi G*, Li B*. MG149 inhibits histone acetyltransferase KAT8-mediated IL-33 acetylation to alleviate allergic airway inflammation and airway hyperresponsiveness. Signal Transduct Target Ther. 2021 Sep 8;6(1):321. doi: 10.1038/s41392-021-00667-4. PMID: 34493712; PMCID: PMC8423820.

4. Zhang W, Liu X, Zhu Y, Liu X, Gu Y, Dai X*, Li B*. Transcriptional and posttranslational regulation of Th17/Treg balance in health and disease. Eur J Immunol. 2021 Jul 28. doi: 10.1002/eji.202048794. Epub ahead of print. PMID: 34322865.

5. Zhai T, Wang C, Xu Y, Huang W, Yuan Z, Wang T, Dai S, Peng S, Pang T, Jiang W, Huang Y, Zou Y, Xu Y, Sun J, Gong X, Zhang J, Tsun A*, Li B* & Miao X*. Generation of a safe and efficacious llama single-domain antibody fragment (vHH) targeting the membrane-proximal region of 4-1BB for engineering therapeutic bispecific antibodies for cancer. J Immunother Cancer. 2021 Jun;9(6):e002131. doi: 10.1136/jitc-2020-002131. PMID: 34172514; PMCID: PMC8237747.

6. Lin Y, Zhang D, Li Y, Li Y, Li B*, Du M*. Decidual NR2F2-Expressing CD4+ T Cells Promote TH2 Transcriptional Program During Early Pregnancy. Front Immunol. 2021 May 18;12:670777. doi: 10.3389/fimmu.2021.670777. PMID: 34084171; PMCID: PMC8168462.

7. Deng B, Zhang W, Zhu Y, Li Y, Li D, Li B*. FOXP3+ regulatory T cells and age-related diseases. FEBS J. 2021 Feb 2. doi: 10.1111/febs.15743. Epub ahead of print. PMID: 33529458.

8. Hou X, Zhu F, Ni Y, Chen T, Du J, Liu X, Han Y, Liu Y, Du W, Li Y, Wang X, Li D, Liang R, Li B*, Shi G*. USP4 is pathogenic in allergic airway inflammation by inhibiting regulatory T cell response. Life Sci. 2021 Sep 15;281:119720. doi: 10.1016/j.lfs.2021.119720. Epub 2021 Jun 16. PMID: 34144056.

9. Liang CL, Lu W, Qiu F, Li D, Liu H, Zheng F, Zhang Q, Chen Y, Lu C, Li B, Dai Z. Paeoniflorin ameliorates murine lupus nephritis by increasing CD4+Foxp3+ Treg cells via enhancing mTNFα-TNFR2 pathway. Biochem Pharmacol. 2021 Mar;185:114434.

10. Li H, Yu X, Shi B, Zhang K, Yuan L, Liu X, Wang P, Lv J, Meng G, Xuan Q, Wu W, Li B, Peng X, Qin X, Liu W, Zhong L, Peng Z. Reduced pannexin 1-IL-33 axis function in donor livers increases risk of MRSA infection in liver transplant recipients. Sci Transl Med. 2021 Aug 11;13(606):eaaz6169. doi: 10.1126/scitranslmed.aaz6169. PMID: 34380770.

11. Zeng F, Chen H, Chen L, Mao J, Cai S, Xiao Y, Li J, Shi J, Li B, Xu Y, Tan Z, Gong F, Li B, Qian Y, Dong L, Zheng F. An Autocrine Circuit of IL-33 in Keratinocytes Is Involved in the Progression of Psoriasis. J Invest Dermatol. 2021 Mar;141(3):596-606.e7.

12. Yang M, Huang Q, Li C, Jiang Z, Sun J, Wang Z, Liang R, Li D*, Li B*, Zhao H*. TOX Acts as a Tumor Suppressor by Inhibiting mTOR Signaling in Colorectal Cancer. Front Immunol. 2021 Apr 9;12:647540. doi: 10.3389/fimmu.2021.647540.

13. Wang X, Cheng H, Shen Y, Li B*. Metabolic Choice Tunes Foxp3+ Regulatory T Cell Function. Adv Exp Med Biol. 2021;1278:81-94.

14. Liu X, Meng X, Peng X, Yao Q, Zhu F, Ding Z, Sun H, Liu X, Li D, Lu Y, Tang H, Li B*, Peng Z*. Impaired AGO2/miR-185-3p/NRP1 axis promotes colorectal cancer metastasis. Cell Death Dis. 2021 Apr 12;12(4):390.

15. Qian Y, Zhu Y, Li Y*, Li B*. Legend of the Sentinels: Development of Lung Resident Memory T Cells and Their Roles in Diseases. Front Immunol. 2021 Feb 2;11:624411.

16. Zhang Y, Xiong DH, Li Y, Xu G, Zhang B, Liu Y, Zhang S, Huang Q, Chen S, Zeng F, Guo J, Li B, Qin Z, Zhang Z. Schistosoma japonicum Infection in Treg-Specific USP21 Knockout Mice. J Immunol Res. 2021 Feb 9;2021:6613162. doi: 10.1155/2021/6613162. PMID: 33628844; PMCID: PMC7886505.

17. Zhu Y, Qian Y, Li Z, Li Y*, Li B*. Neoantigen-reactive T cell: An emerging role in adoptive cellular immunotherapy. MedComm (2020). 2021 Apr 23;2(2):207-220. doi: 10.1002/mco2.41. PMID: 34766142; PMCID: PMC8491202.

18. Liu X, Tian N, Huang Q, Xu Z, Cheng H, Liu X, Li D, Liang R, Li B*, Dai X*. hnRNPA1 enhances FOXP3 stability to promote the differentiation and functions of regulatory T cells. FEBS Lett. 2021 Jul;595(14):1962-1974. doi: 10.1002/1873-3468.14142. Epub 2021 Jun 22. PMID: 34080184.

19. Qian SJ, Huang QR, Chen RY, Mo JJ, Zhou LY, Zhao Y, Li B*, Lai HC*. Single-Cell RNA Sequencing Identifies New Inflammation-Promoting Cell Subsets in Asian Patients With Chronic Periodontitis. Front Immunol. 2021 Sep 8;12:711337. doi: 10.3389/fimmu.2021.711337. PMID: 34566966; PMCID: PMC8455889.

20. Luo L, Liang W, Pang J, Xu G, Chen Y, Guo X, Wang X, Zhao Y, Lai Y, Liu Y, Li B, Su B, Zhang S, Baniyash M, Shen L, Chen L, Ling Y, Wang Y, Liang Q, Lu H, Zhang Z, Wang F. Dynamics of TCR repertoire and T cell function in COVID-19 convalescent individuals. Cell Discov. 2021 Sep 28;7(1):89. doi: 10.1038/s41421-021-00321-x. PMID: 34580278; PMCID: PMC8476510.

21. Liu Y, Huang Q, Du J, Huang C, Li D, Dai X, Liang R, Li B*, Shi G*. Comparative analysis of global transcriptome, proteome and acetylome in house dust mite-induced murine allergic asthma model. Clin Transl Med. 2021 Nov;11(11):e590. doi: 10.1002/ctm2.590. PMID: 34841691; PMCID: PMC8571946.

22. Cheng H, Wang L, Yang B, Li D, Wang X, Liu X, Tian N, Huang Q, Feng R, Wang Z, Liang R, Dai SM, Lv L, Wu J*, Zang YS*, Li B*. Cutting Edge: Inhibition of Glycogen Synthase Kinase 3 Activity Induces the Generation and Enhanced Suppressive Function of Human IL-10+ FOXP3+-Induced Regulatory T Cells. J Immunol. 2020 Sep 15;205(6):1497-1502. doi: 10.4049/jimmunol.2000136. Epub 2020 Aug 19. PMID: 32817370; PMCID: PMC7477744.

23. Yang J, Wei P, Barbi J, Huang Q, Yang E, Bai Y, Nie J, Gao Y, Tao J, Lu Y, Xie C, Hou X, Ren J, Wu X, Meng J, Zhang Y, Fu J, Kou W, Gao Y, Chen Z, Liang R, Tsun A, Li D, Guo W, Zhang S, Zheng SG, Niu J, Galardy P, Tong X, Shi G, Li H*, Pan F*, Li B*. The deubiquitinase USP44 promotes Treg function during inflammation by preventing FOXP3 degradation. EMBO Rep. 2020 Sep 3;21(9):e50308. doi: 10.15252/embr.202050308. Epub 2020 Jul 9. PMID: 32644293; PMCID: PMC7507386.

24. Gu W, Ge R, Zhu F, Li D, Liang R, Ge J, Wang Y, Li B, Qiu J. PARP-1 inhibitor-AG14361 suppresses acute allograft rejection via stabilizing CD4+FoxP3+ regulatory T cells. Pathol Res Pract. 2020 Aug;216(8):153021. doi: 10.1016/j.prp.2020.153021. Epub 2020 May 21. PMID: 32703489.

25. Yang M, Wang A, Li C, Sun J, Yi G, Cheng H, Liu X, Wang Z, Zhou Y, Yao G, Wang S, Liang R, Li B*, Li D*, Zhao H*. Methylation-Induced Silencing of ALDH2 Facilitates Lung Adenocarcinoma Bone Metastasis by Activating the MAPK Pathway. Front Oncol. 2020 Jul 30;10:1141. doi: 10.3389/fonc.2020.01141. PMID: 32850324; PMCID: PMC7406638.

26. Tian N, Liu Q, Li Y, Tong L, Lu Y, Zhu Y, Zhang P, Chen H, Hu L, Meng J, Feng M, Li M, Zheng L, Li B, Xu T, Wu L, Tong X. Transketolase Deficiency in Adipose Tissues Protects Mice From Diet-Induced Obesity by Promoting Lipolysis. Diabetes. 2020 Jul;69(7):1355-1367. doi: 10.2337/db19-1087. Epub 2020 Apr 15. PMID: 32295803.

27. Wang A, Yang M, Liang R, Zhu F, Zhu F, Liu X, Han Y, Lin R, Wang X, Li D, Li H, Yuan X, Zhao H*, Li B*. Mouse Double Minute 2 Homolog-Mediated Ubiquitination Facilitates Forkhead Box P3 Stability and Positively Modulates Human Regulatory T Cell Function. Front Immunol. 2020 Jun 19;11:1087. doi: 10.3389/fimmu.2020.01087. PMID: 32636834; PMCID: PMC7318079.

28. Gang Yi, Yi Zhao, Feng Xie, Fuxiang Zhu, Ziyun Wan, Xiu Qiu, Huanming Yang, Jian Wang, Bing Su, Lei Chen, Wei Zhang, Yong Hou, Xun Xu, Yinyan He, Andy Tsun, Xiao Liu, Bin Li*. Single-cell RNA-seq unveils critical regulators of human FOXP3+ regulatory T cell stability. Science Bulletin Volume 65, Issue 13, 15 July 2020, Pages 1114-1124.

29. Bai F, Zhang P, Fu Y, Chen H, Zhang M, Huang Q, Li D*, Li B*, Wu K*. Targeting ANXA1 abrogates Treg-mediated immune suppression in triple-negative breast cancer. J Immunother Cancer. 2020 Apr;8(1):e000169. doi: 10.1136/jitc-2019-000169. PMID: 32300050; PMCID: PMC7204868.

30. Wang X, Yang Y, Ren D, Xia Y, He W, Wu Q, Zhang J, Liu M, Du Y, Ren C, Li B, Shen J, Zhang Y. JQ1, a bromodomain inhibitor, suppresses Th17 effectors by blocking p300-mediated acetylation of RORγt. Br J Pharmacol. 2020 Jul;177(13):2959-2973. doi: 10.1111/bph.15023. Epub 2020 Mar 23. PMID: 32060899; PMCID: PMC7280011.

31. Zhao J, Zhang Y, Liu XS, Zhu FM, Xie F, Jiang CY, Zhang ZY, Gao YL, Wang YC, Li B*, Xia SJ*, Han BM*. RNA-binding protein Musashi2 stabilizing androgen receptor drives prostate cancer progression. Cancer Sci. 2020 Feb;111(2):369-382. doi: 10.1111/cas.14280. Epub 2020 Jan 4. PMID: 31833612; PMCID: PMC7004550.

32. Huang Q, Liu X, Zhang Y, Huang J, Li D*, Li B*. Molecular feature and therapeutic perspectives of immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome. J Genet Genomics. 2020 Jan 20;47(1):17-26. doi: 10.1016/j.jgg.2019.11.011. Epub 2020 Jan 24. PMID: 32081609.

33. Huang J, Wang S, Jia Y, Zhang Y, Dai X*, Li B*. Targeting FOXP3 complex ensemble in drug discovery. Adv Protein Chem Struct Biol. 2020;121:143-168. doi: 10.1016/bs.apcsb.2019.11.010. Epub 2020 Jan 7. PMID: 32312420.

34. Wang A, Zhu F, Liang R, Li D, Li B*. Regulation of T cell differentiation and function by ubiquitin-specific proteases. Cell Immunol. 2019 Jun;340:103922. doi: 10.1016/j.cellimm.2019.103922. Epub 2019 May 3. PMID: 31078284.

35. Zhao Y, Li X, Zhao W, Wang J, Yu J, Wan Z, Gao K, Yi G, Wang X, Fan B, Wu Q, Chen B, Xie F, Wu J, Zhang W, Chen F, Yang H, Wang J, Xu X, Li B, Liu S, Hou Y, Liu X. Single-cell transcriptomic landscape of nucleated cells in umbilical cord blood. Gigascience. 2019 May 1;8(5):giz047. doi: 10.1093/gigascience/giz047. PMID: 31049560; PMCID: PMC6497034.

36. Ren J, Han L, Tang J, Liu Y, Deng X, Liu Q, Hao P, Feng X, Li B, Hu H, Wang H. Foxp1 is critical for the maintenance of regulatory T-cell homeostasis and suppressive function. PLoS Biol. 2019 May 24;17(5):e3000270. doi: 10.1371/journal.pbio.3000270. PMID: 31125332; PMCID: PMC6534289.

37. Nagai Y, Ji MQ, Zhu F, Xiao Y, Tanaka Y, Kambayashi T, Fujimoto S, Goldberg MM, Zhang H, Li B, Ohtani T, Greene MI. PRMT5 Associates With the FOXP3 Homomer and When Disabled Enhances Targeted p185erbB2/neu Tumor Immunotherapy. Front Immunol. 2019 Feb 8;10:174. doi: 10.3389/fimmu.2019.00174. PMID: 30800128; PMCID: PMC6375878.

38. Ni X, Kou W, Gu J, Wei P, Wu X, Peng H, Tao J, Yan W, Yang X, Lebid A, Park BV, Chen Z, Tian Y, Fu J, Newman S, Wang X, Shen H, Li B, Blazar BR, Wang X, Barbi J, Pan F, Lu L. TRAF6 directs FOXP3 localization and facilitates regulatory T-cell function through K63-linked ubiquitination. EMBO J. 2019 May 2;38(9):e99766. doi: 10.15252/embj.201899766. Epub 2019 Mar 18. PMID: 30886050; PMCID: PMC6484404.

39. Huang Y, Fang S, Li D, Zhou H*, Li B*, Fan X*. The involvement of T cell pathogenesis in thyroid-associated ophthalmopathy. Eye (Lond). 2019 Feb;33(2):176-182. doi: 10.1038/s41433-018-0279-9. Epub 2018 Dec 7. PMID: 30531993; PMCID: PMC6367411.

40. Fang S, Huang Y, Wang N, Zhang S, Zhong S, Li Y, Sun J, Liu X, Wang Y, Gu P, Li B*, Zhou H*, Fan X*. Insights Into Local Orbital Immunity: Evidence for the Involvement of the Th17 Cell Pathway in Thyroid-Associated Ophthalmopathy. J Clin Endocrinol Metab. 2019 May 1;104(5):1697-1711. doi: 10.1210/jc.2018-01626. Erratum in: J Clin Endocrinol Metab. 2020 Jan 1;105(1): PMID: 30517642.

41. Li C, Liu X, Liu Y, Liu X, Wang R, Liao J, Wu S, Fan J, Peng Z, Li B, Wang Z. Keratin 80 promotes migration and invasion of colorectal carcinoma by interacting with PRKDC via activating the AKT pathway. Cell Death Dis. 2018 Sep 27;9(10):1009. doi: 10.1038/s41419-018-1030-y. PMID: 30262880; PMCID: PMC6160410.

42. Yu X, Lao Y, Teng XL, Li S, Zhou Y, Wang F, Guo X, Deng S, Chang Y, Wu X, Liu Z, Chen L, Lu LM, Cheng J, Li B, Su B, Jiang J, Li HB, Huang C, Yi J, Zou Q. SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation. Nat Commun. 2018 Aug 8;9(1):3157. doi: 10.1038/s41467-018-05676-6. PMID: 30089837; PMCID: PMC6082899.

43. Zhu F, Yi G, Liu X, Zhu F, Zhao A, Wang A, Zhu R, Chen Z, Zhao B, Fang S, Yu X, Lin R, Liang R, Li D, Zhao W, Zhang Z, Guo W, Zhang S, Ge S, Fan X, Zhao G*, Li B*. Ring finger protein 31-mediated atypical ubiquitination stabilizes forkhead box P3 and thereby stimulates regulatory T-cell function. J Biol Chem. 2018 Dec 28;293(52):20099-20111. doi: 10.1074/jbc.RA118.005802. Epub 2018 Nov 2. PMID: 30389786; PMCID: PMC6311505.

44. Tong X*, Li B*. A role of IL-25, a sibling of IL-17, in triggering psoriatic skin inflammation. Sci China Life Sci. 2018 Nov;61(11):1437-1438. doi: 10.1007/s11427-018-9330-x. Epub 2018 Oct 16. PMID: 30334146.

45. Yi G, Guo S, Liu W, Wang H, Liu R, Tsun A, Jin G*, Li B*. Identification and functional analysis of heterogeneous FOXP3+ Treg cell subpopulations in human pancreatic ductal adenocarcinoma. Science Bulletin, 2018,63(15):972-981.

46. Fang S, Huang Y, Liu X, Zhong S, Wang N, Zhao B, Li Y, Sun J, Wang Y, Zhang S, Gu P, Zhou H*, Li B*, Fan X*. Interaction Between CCR6+ Th17 Cells and CD34+ Fibrocytes Promotes Inflammation: Implications in Graves' Orbitopathy in Chinese Population. Invest Ophthalmol Vis Sci. 2018 May 1;59(6):2604-2614. doi: 10.1167/iovs.18-24008. PMID: 29847667.

47. Ni Y, Hao J, Hou X, Du W, Yu Y, Chen T, Wei Z, Li Y, Zhu F, Wang S, Liang R, Li D, Lu Y, Liao K, Li B*, Shi G*. Dephosphorylated Polymerase I and Transcript Release Factor Prevents Allergic Asthma Exacerbations by Limiting IL-33 Release. Front Immunol. 2018 Jun 21;9:1422. doi: 10.3389/fimmu.2018.01422. PMID: 29977243; PMCID: PMC6021487.

48. Shi B, Geng J, Wang YH, Wei H, Walters B, Li W, Luo X, Stevens A, Pittman M, Li B, Thompson SR, Hu H. Foxp1 Negatively Regulates T Follicular Helper Cell Differentiation and Germinal Center Responses by Controlling Cell Migration and CTLA-4. J Immunol. 2018 Jan 15;200(2):586-594. doi: 10.4049/jimmunol.1701000. Epub 2017 Dec 6. PMID: 29212910; PMCID: PMC5891213.

49. Zhou P, Ding X, Wan X, Liu L, Yuan X, Zhang W, Hui X, Meng G, Xiao H, Li B, Zhong J, Hou F, Deng L, Zhang Y. MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation. Nat Commun. 2018 Mar 28;9(1):1243. doi: 10.1038/s41467-018-03563-8. PMID: 29593341; PMCID: PMC5871759.

50. Liu J, Huang X, Hao S, Wang Y, Liu M, Xu J, Zhang X, Yu T, Gan S, Dai D, Luo X, Lu Q, Mao C, Zhang Y, Shen N, Li B, Huang M, Zhu X, Jin J, Cheng X, Sun SC, Xiao Y. Peli1 negatively regulates noncanonical NF-κB signaling to restrain systemic lupus erythematosus. Nat Commun. 2018 Mar 19;9(1):1136. doi: 10.1038/s41467-018-03530-3. PMID: 29555915; PMCID: PMC5859150.

51. Jiang W, Zhou X, Li Z, Liu K, Wang W, Tan R, Cong X, Shan J, Zhan Y, Cui Z, Jiang L, Li Q, Shen S, Bai M, Cheng Y, Li B, Tan M, Ma DK, Liu JO, Dang Y. Prolyl 4-hydroxylase 2 promotes B-cell lymphoma progression via hydroxylation of Carabin. Blood. 2018 Mar 22;131(12):1325-1336. doi: 10.1182/blood-2017-07-794875. Epub 2018 Feb 1. PMID: 29437589; PMCID: PMC5865229.

52. Zhang L, He X, Li F, Pan H, Huang X, Wen X, Zhang H, Li B, Ge S, Xu X, Jia R, Fan X. The miR-181 family promotes cell cycle by targeting CTDSPL, a phosphatase-like tumor suppressor in uveal melanoma. J Exp Clin Cancer Res. 2018 Jan 30;37(1):15. doi: 10.1186/s13046-018-0679-5. PMID: 29382357; PMCID: PMC5791374.

53. Lu Y, Kim NM, Jiang YW, Zhang H, Zheng D, Zhu FX, Liang R, Li B*, Xu HX*. Cambogin suppresses dextran sulphate sodium-induced colitis by enhancing Treg cell stability and function. Br J Pharmacol. 2018 Apr;175(7):1085-1099. doi: 10.1111/bph.14150. Epub 2018 Feb 21. PMID: 29352742; PMCID: PMC5843713.  

54. Tong J, Cao G, Zhang T, Sefik E, Amezcua Vesely MC, Broughton JP, Zhu S, Li H, Li B, Chen L, Chang HY, Su B, Flavell RA, Li HB. m6A mRNA methylation sustains Treg suppressive functions. Cell Res. 2018 Feb;28(2):253-256. doi: 10.1038/cr.2018.7. Epub 2018 Jan 5. PMID: 29303144; PMCID: PMC5799823.

55. Shan J, Zhao B, Shan Z, Nie J, Deng R, Xiong R, Tsun A, Pan W, Zhao H, Chen L, Jin Y, Qian Z, Lui K, Liang R, Li D, Sun B, Lavillette D, Xu K*, Li B*. Histone demethylase LSD1 restricts influenza A virus infection by erasing IFITM3-K88 monomethylation. PLoS Pathog. 2017 Dec 27;13(12):e1006773. doi: 10.1371/journal.ppat.1006773. Erratum in: PLoS Pathog. 2018 Apr 30;14 (4):e1007037. Erratum in: PLoS Pathog. 2021 Feb 22;17(2):e1009359. PMID: 29281729; PMCID: PMC5760097.

56. Li P, Li Y, Zhu L, Yang Z, He J, Wang L, Shang Q, Pan H, Wang H, Ma X, Li B, Fan X, Ge S, Jia R, Zhang H. Targeting secreted cytokine BMP9 gates the attenuation of hepatic fibrosis. Biochim Biophys Acta Mol Basis Dis. 2018 Mar;1864(3):709-720. doi: 10.1016/j.bbadis.2017.12.008. Epub 2017 Dec 6. PMID: 29223735.

57. Li Y, Strick-Marchand H, Lim AI, Ren J, Masse-Ranson G, Dan Li, Jouvion G, Rogge L, Lucas S, Bin Li, Di Santo JP. Regulatory T cells control toxicity in a humanized model of IL-2 therapy. Nat Commun. 2017 Nov 24;8(1):1762. doi: 10.1038/s41467-017-01570-9. PMID: 29176694; PMCID: PMC5701141.  

58. Fang S, Huang Y, Zhong S, Li Y, Zhang Y, Li Y, Sun J, Liu X, Wang Y, Zhang S, Xu T, Sun X, Gu P, Li D, Zhou H*, Li B*, Fan X*. Regulation of Orbital Fibrosis and Adipogenesis by Pathogenic Th17 Cells in Graves Orbitopathy. J Clin Endocrinol Metab. 2017 Nov 1;102(11):4273-4283. doi: 10.1210/jc.2017-01349. PMID: 28938397.  

59. Guo Z, Xu P, Ge S, Zhang C, Zheng X, Xu J, Liu Z, Li B, Ge S. Ubiquitin specific peptidase 4 stabilizes interferon regulatory factor protein and promotes its function to facilitate interleukin-4 expression in T helper type 2 cells. Int J Mol Med. 2017 Oct;40(4):979-986. doi: 10.3892/ijmm.2017.3087. Epub 2017 Aug 3. PMID: 28791349; PMCID: PMC5593473.

60. Zhang P, Wang H, Luo X, Liu H, Lu B, Li T, Yang S, Gu Q, Li B, Wang F, Sun X. MicroRNA-155 Inhibits Polarization of Macrophages to M2-Type and Suppresses Choroidal Neovascularization. Inflammation. 2018 Feb;41(1):143-153. doi: 10.1007/s10753-017-0672-8. PMID: 28965281.

61. Luo X, Zhu F, Chen Z, Li D, Li B*. Regulation of Metabolism Across Different Subsets of T Cells in Cancer. Adv Exp Med Biol. 2017;1011:197-209. doi: 10.1007/978-94-024-1170-6_6. PMID: 28875491.

62. Zhu F, Wang A, Li Y, Liang R, Li D, Li B*. Adipose Tissue-Resident Regulatory T Cells. Adv Exp Med Biol. 2017;1011:153-162. doi: 10.1007/978-94-024-1170-6_4. PMID: 28875489.

63. Ma S, Wan X, Deng Z, Shi L, Hao C, Zhou Z, Zhou C, Fang Y, Liu J, Yang J, Chen X, Li T, Zang A, Yin S, Li B, Plumas J, Chaperot L, Zhang X, Xu G, Jiang L, Shen N, Xiong S, Gao X, Zhang Y, Xiao H. Epigenetic regulator CXXC5 recruits DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs. J Exp Med. 2017 May 1;214(5):1471-1491. doi: 10.1084/jem.20161149. Epub 2017 Apr 17. PMID: 28416650; PMCID: PMC5413332.  

64. Li H, Zhou ZQ, Yang ZR, Tong DN, Guan J, Shi BJ, Nie J, Ding XT, Li B, Zhou GW, Zhang ZY. MicroRNA-191 acts as a tumor promoter by modulating the TET1-p53 pathway in intrahepatic cholangiocarcinoma. Hepatology. 2017 Jul;66(1):136-151. doi: 10.1002/hep.29116. Epub 2017 May 18. PMID: 28194813.  

65. Wang S, Li Y, Zhu F, Lin F, Luo X, Zhao B, Zhang P, Li D, Gao Y, Liang R, Liu L, Tsun A, Yuan X*, Wu K*, Li B*. DNMT1 cooperates with MBD4 to inhibit the expression of Glucocorticoid-induced TNFR-related protein in human T cells. FEBS Lett. 2017 Jul;591(13):1929-1939. doi: 10.1002/1873-3468.12690. Epub 2017 Jun 10. PMID: 28542810.

66. Lin R, Nie J, Ren J, Liang R, Li D, Wang P, Gao C, Zhuo C, Yang C*, Li B*. USP4 interacts and positively regulates IRF8 function via K48-linked deubiquitination in regulatory T cells. FEBS Lett. 2017 Jun;591(12):1677-1686. doi: 10.1002/1873-3468.12668. Epub 2017 Jun 7. PMID: 28477415.

67. Chen Y, Wang L, Jin J, Luan Y, Chen C, Li Y, Chu H, Wang X, Liao G, Yu Y, Teng H, Wang Y, Pan W, Fang L, Liao L, Jiang Z, Ge X, Li B, Wang P. p38 inhibition provides anti-DNA virus immunity by regulation of USP21 phosphorylation and STING activation. J Exp Med. 2017 Apr 3;214(4):991-1010. doi: 10.1084/jem.20161387. Epub 2017 Mar 2. PMID: 28254948; PMCID: PMC5379979.

68. Li Y, Lu Y, Wang S, Han Z, Zhu F, Ni Y, Liang R, Zhang Y, Leng Q, Wei G, Shi G, Zhu R, Li D, Wang H, Zheng SG, Xu H, Tsun A, Li B*. USP21 prevents the generation of T-helper-1-like Treg cells. Nat Commun. 2016 Nov 18;7:13559. doi: 10.1038/ncomms13559. PMID: 27857073; PMCID: PMC5120220.

69. Wang K, Gu J, Ni X, Ding Z, Wang Q, Zhou H, Zheng S, Li B, Lu L. CD25 signaling regulates the function and stability of peripheral Foxp3+ regulatory T cells derived from the spleen and lymph nodes of mice. Mol Immunol. 2016 Aug;76:35-40. doi: 10.1016/j.molimm.2016.06.007. Epub 2016 Jun 23. PMID: 27344615.

70. Li Y, Li B*. A Translational Perspective of a Deubiquitinase Inhibitor in Antitumor Immunity. EBioMedicine. 2016 Nov;13:7-8. doi: 10.1016/j.ebiom.2016.11.008. Epub 2016 Nov 8. PMID: 27840006; PMCID: PMC5264434.

71. Jin J, Liu J, Chen C, Liu Z, Jiang C, Chu H, Pan W, Wang X, Zhang L, Li B, Jiang C, Ge X, Xie X, Wang P. The deubiquitinase USP21 maintains the stemness of mouse embryonic stem cells via stabilization of Nanog. Nat Commun. 2016 Nov 25;7:13594. doi: 10.1038/ncomms13594. PMID: 27886188; PMCID: PMC5133637.

72. Fang S, Huang Y, Wang S, Zhang Y, Luo X, Liu L, Zhong S, Liu X, Li D, Liang R, Miranda P, Gu P, Zhou H*, Fan X*, Li B*. IL-17A Exacerbates Fibrosis by Promoting the Proinflammatory and Profibrotic Function of Orbital Fibroblasts in TAO. J Clin Endocrinol Metab. 2016 Aug;101(8):2955-65. doi: 10.1210/jc.2016-1882. Epub 2016 May 25. PMID: 27224264.

73. Lu Y, Cai S, Nie J, Li Y, Shi G, Hao J, Fu W, Tan H, Chen S, Li B*, Xu H*. The natural compound nujiangexanthone A suppresses mast cell activation and allergic asthma. Biochem Pharmacol. 2016 Jan 15;100:61-72. doi: 10.1016/j.bcp.2015.11.004. Epub 2015 Nov 10. PMID: 26571438.

74. Luo X, Nie J, Wang S, Chen Z, Chen W, Li D, Hu H, Li B*. Poly(ADP-ribosyl)ation of FOXP3 protein mediated by PARP-1 regulates the function of regulatory T cells. J Biol Chem. 2016 Jan 15;291(3):1201. doi: 10.1074/jbc.A115.661611. Erratum for: J Biol Chem. 2015 Nov 27;290(48):28675-82. PMID: 26773129; PMCID: PMC4714207.  

75. Ding X, Jiang W, Zhou P, Liu L, Wan X, Yuan X, Wang X, Chen M, Chen J, Yang J, Kong C, Li B, Peng C, Wong CC, Hou F, Zhang Y. Mixed Lineage Leukemia 5 (MLL5) Protein Stability Is Cooperatively Regulated by O-GlcNac Transferase (OGT) and Ubiquitin Specific Protease 7 (USP7). PLoS One. 2015 Dec 17;10(12):e0145023. doi: 10.1371/journal.pone.0145023. PMID: 26678539; PMCID: PMC4683056.

76. Wang X, Yang J, Han L, Zhao K, Wu Q, Bao L, Li Z, Lv L*, Li B*. TRAF5-mediated Lys-63-linked Polyubiquitination Plays an Essential Role in Positive Regulation of RORγt in Promoting IL-17A Expression. J Biol Chem. 2015 Nov 27;290(48):29086-94. doi: 10.1074/jbc.M115.664573. Epub 2015 Oct 9. PMID: 26453305; PMCID: PMC4661420.  

77. Deng G, Nagai Y, Xiao Y, Li Z, Dai S, Ohtani T, Banham A, Li B, Wu SL, Hancock W, Samanta A, Zhang H, Greene MI. Pim-2 Kinase Influences Regulatory T Cell Function and Stability by Mediating Foxp3 Protein N-terminal Phosphorylation. J Biol Chem. 2015 Aug 14;290(33):20211-20. doi: 10.1074/jbc.M115.638221. Epub 2015 May 18. PMID: 25987564; PMCID: PMC4536430.

78. Wu Y, Yang L, Zhao J, Li C, Nie J, Liu F, Zhuo C, Zheng Y, Li B, Wang Z, Xu Y. Nuclear-enriched abundant transcript 1 as a diagnostic and prognostic biomarker in colorectal cancer. Mol Cancer. 2015 Nov 9;14:191. doi: 10.1186/s12943-015-0455-5. PMID: 26552600; PMCID: PMC4640217.

79. Li D*, Kong C, Tsun A, Chen C, Song H, Shi G, Pan W, Dai D, Shen N, Li B*. MiR-125a-5p Decreases the Sensitivity of Treg cells Toward IL-6-Mediated Conversion by Inhibiting IL-6R and STAT3 Expression. Sci Rep. 2015 Oct 1;5:14615. doi: 10.1038/srep14615. PMID: 26424054; PMCID: PMC4589732.

80. Lin F, Luo X, Tsun A, Li Z, Li D, Li B*. Kaempferol enhances the suppressive function of Treg cells by inhibiting FOXP3 phosphorylation. Int Immunopharmacol. 2015 Oct;28(2):859-65. doi: 10.1016/j.intimp.2015.03.044. Epub 2015 Apr 11. PMID: 25870037.

81. Song H, Tao L, Chen C, Pan L, Hao J, Ni Y, Li D, Li B*, Shi G*. USP17-mediated deubiquitination and stabilization of HDAC2 in cigarette smoke extract-induced inflammation. Int J Clin Exp Pathol. 2015 Sep 1;8(9):10707-15. PMID: 26617781; PMCID: PMC4637596.

82. Tao L, Chen C, Song H, Piccioni M, Shi G*, Li B*. Deubiquitination and stabilization of IL-33 by USP21. Int J Clin Exp Pathol. 2014 Jul 15;7(8):4930-7. PMID: 25197364; PMCID: PMC4152054.

83. Han L, Yang J, Wang X, Li D, Lv L*, Li B*. Th17 cells in autoimmune diseases. Front Med. 2015 Mar;9(1):10-9. doi: 10.1007/s11684-015-0388-9. Epub 2015 Feb 4. PMID: 25652649.

84. Nie J, Li YY, Zheng SG, Tsun A*, Li B*. FOXP3(+) Treg Cells and Gender Bias in Autoimmune Diseases. Front Immunol. 2015 Sep 28;6:493. doi: 10.3389/fimmu.2015.00493. PMID: 26441996; PMCID: PMC4585344.  

85. Wu Q, Nie J, Gao Y, Xu P, Sun Q, Yang J, Han L, Chen Z, Wang X, Lv L, Tsun A, Shen J*, Li B*. Reciprocal regulation of RORγt acetylation and function by p300 and HDAC1. Sci Rep. 2015 Nov 9;5:16355. doi: 10.1038/srep16355. PMID: 26549310; PMCID: PMC4817527.  

86. Li B*, Zheng SG*. How regulatory T cells sense and adapt to inflammation. Cell Mol Immunol. 2015 Sep;12(5):519-20. doi: 10.1038/cmi.2015.65. Epub 2015 Aug 17. PMID: 26277895; PMCID: PMC4579659.

87. Zhou X, Tang J, Cao H, Fan H*, Li B*. Tissue resident regulatory T cells: novel therapeutic targets for human disease. Cell Mol Immunol. 2015 Sep;12(5):543-52. doi: 10.1038/cmi.2015.23. Epub 2015 Apr 20. PMID: 25891216; PMCID: PMC4579654.  

88. Li Z, Li D, Tsun A, Li B*. FOXP3+ regulatory T cells and their functional regulation. Cell Mol Immunol. 2015 Sep;12(5):558-65. doi: 10.1038/cmi.2015.10. Epub 2015 Feb 16. PMID: 25683611; PMCID: PMC4579651.

89. Gao Y, Tang J, Chen W, Li Q, Nie J, Lin F, Wu Q, Chen Z, Gao Z, Fan H, Tsun A, Shen J, Chen G, Liu Z, Lou Z, Olsen NJ, Zheng SG*, Li B*. Inflammation negatively regulates FOXP3 and regulatory T-cell function via DBC1. Proc Natl Acad Sci U S A. 2015 Jun 23;112(25):E3246-54. doi: 10.1073/pnas.1421463112. Epub 2015 Jun 9. PMID: 26060310; PMCID: PMC4485127.

90. Yang J, Xu P, Han L, Guo Z, Wang X, Chen Z, Nie J, Yin S, Piccioni M, Tsun A, Lv L*, Ge S*, Li B*. Cutting edge: Ubiquitin-specific protease 4 promotes Th17 cell function under inflammation by deubiquitinating and stabilizing RORγt. J Immunol. 2015 May 1;194(9):4094-7. doi: 10.4049/jimmunol.1401451. Epub 2015 Mar 27. PMID: 25821221.  

91. Xie M, Xuan B, Shan J, Pan D, Sun Y, Shan Z, Zhang J, Yu D, Li B*, Qian Z*. Human cytomegalovirus exploits interferon-induced transmembrane proteins to facilitate morphogenesis of the virion assembly compartment. J Virol. 2015 Mar;89(6):3049-61. doi: 10.1128/JVI.03416-14. Epub 2014 Dec 31. PMID: 25552713; PMCID: PMC4337551.  

92. Zhuo C, Xu Y, Ying M, Li Q, Huang L, Li D, Cai S*, Li B*. FOXP3+ Tregs: heterogeneous phenotypes and conflicting impacts on survival outcomes in patients with colorectal cancer. Immunol Res. 2015 Mar;61(3):338-47. doi: 10.1007/s12026-014-8616-y. PMID: 25608795.  

93. Liu BC*, Zhang L, Su JS, Tsun A, Li B. Treatment of postoperative infectious complications in patients with human immunodeficiency virus infection. World J Emerg Med. 2014;5(2):103-6. doi: 10.5847/wjem.j.issn.1920-8642.2014.02.004. PMID: 25215157; PMCID: PMC4129878.

94. Piccioni M, Chen Z, Tsun A, Li B*. Regulatory T-cell differentiation and their function in immune regulation. Adv Exp Med Biol. 2014;841:67-97. doi: 10.1007/978-94-017-9487-9_4. PMID: 25261205.

95. Li Z, Lin F, Zhuo C, Deng G, Chen Z, Yin S, Gao Z, Piccioni M, Tsun A, Cai S, Zheng SG, Zhang Y, Li B*. PIM1 kinase phosphorylates the human transcription factor FOXP3 at serine 422 to negatively regulate its activity under inflammation. J Biol Chem. 2014 Sep 26;289(39):26872-26881. doi: 10.1074/jbc.M114.586651. Epub 2014 Aug 5. PMID: 25096571; PMCID: PMC4175328.

96. Pan L, Chen Z, Wang L, Chen C, Li D, Wan H, Li B*, Shi G*. Deubiquitination and stabilization of T-bet by USP10. Biochem Biophys Res Commun. 2014 Jul 4;449(3):289-94. doi: 10.1016/j.bbrc.2014.05.037. Epub 2014 May 17. PMID: 24845384.  

97. Zhuo C, Li Z, Xu Y, Wang Y, Li Q, Peng J, Zheng H, Wu P, Li B*, Cai S*. Higher FOXP3-TSDR demethylation rates in adjacent normal tissues in patients with colon cancer were associated with worse survival. Mol Cancer. 2014 Jun 18;13:153. doi: 10.1186/1476-4598-13-153. PMID: 24938080; PMCID: PMC4074420.    

98. Han L, Yang J, Wang X, Wu Q, Yin S, Li Z, Zhang J, Xing Y, Chen Z, Tsun A, Li D, Piccioni M, Zhang Y, Guo Q, Jiang L, Bao L, Lv L*, Li B*. The E3 deubiquitinase USP17 is a positive regulator of retinoic acid-related orphan nuclear receptor γt (RORγt) in Th17 cells. J Biol Chem. 2014 Sep 12;289(37):25546-55. doi: 10.1074/jbc.M114.565291. Epub 2014 Jul 28. PMID: 25070893; PMCID: PMC4162160.

99. Gao Y, Lin F, Xu P, Nie J, Chen Z, Su J, Tang J, Wu Q, Li Y, Guo Z, Gao Z, Li D, Shen J, Ge S, Tsun A*, Li B*. USP22 is a positive regulator of NFATc2 on promoting IL2 expression. FEBS Lett. 2014 Mar 18;588(6):878-83. doi: 10.1016/j.febslet.2014.02.016. Epub 2014 Feb 20. PMID: 24561192.  

100. Shan Z, Han Q, Nie J, Cao X, Chen Z, Yin S, Gao Y, Lin F, Zhou X, Xu K, Fan H, Qian Z, Sun B, Zhong J, Li B*, Tsun A*. Negative regulation of interferon-induced transmembrane protein 3 by SET7-mediated lysine monomethylation. J Biol Chem. 2013 Dec 6;288(49):35093-103. doi: 10.1074/jbc.M113.511949. Epub 2013 Oct 15. PMID: 24129573; PMCID: PMC3853261.  

101. Chen Z, Barbi J, Bu S, Yang HY, Li Z, Gao Y, Jinasena D, Fu J, Lin F, Chen C, Zhang J, Yu N, Li X, Shan Z, Nie J, Gao Z, Tian H, Li Y, Yao Z, Zheng Y, Park BV, Pan Z, Zhang J, Dang E, Li Z, Wang H, Luo W, Li L, Semenza GL, Zheng SG, Loser K, Tsun A, Greene MI, Pardoll DM, Pan F*, Li B*. The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3. Immunity. 2013 Aug 22;39(2):272-85. doi: 10.1016/j.immuni.2013.08.006. PMID: 23973223; PMCID: PMC3817295.  

102. Chen Z, Luo X, Lu Y, Zhu T, Wang J, Tsun A*, Li B*. Ubiquitination signals critical to regulatory T cell development and function. Int Immunopharmacol. 2013 Jul;16(3):348-52. doi: 10.1016/j.intimp.2013.01.023. Epub 2013 Feb 14. PMID: 23415874.  

103. Li Y, Tsun A, Gao Z, Han Z, Gao Y, Li Z, Lin F, Wang Y, Wei G, Yao Z, Li B*. 60-kDa Tat-interactive protein (TIP60) positively regulates Th-inducing POK (ThPOK)-mediated repression of eomesodermin in human CD4+ T cells. J Biol Chem. 2013 May 31;288(22):15537-46. doi: 10.1074/jbc.M112.430207. Epub 2013 Apr 22. PMID: 23609452; PMCID: PMC3668715.

104. Zhang J, Chen C, Hou X, Gao Y, Lin F, Yang J, Gao Z, Pan L, Tao L, Wen C, Yao Z, Tsun A, Shi G*, Li B*. Identification of the E3 deubiquitinase ubiquitin-specific peptidase 21 (USP21) as a positive regulator of the transcription factor GATA3. J Biol Chem. 2013 Mar 29;288(13):9373-82. doi: 10.1074/jbc.M112.374744. Epub 2013 Feb 10. PMID: 23395819; PMCID: PMC3611007.

105. Gao Z, Gao Y, Li Z, Chen Z, Lu D, Tsun A*, Li B*. Synergy between IL-6 and TGF-β signaling promotes FOXP3 degradation. Int J Clin Exp Pathol. 2012;5(7):626-33. Epub 2012 Sep 5. PMID: 22977658; PMCID: PMC3438759.

106. Song X, Li B (Co-first author), Xiao Y, Chen C, Wang Q, Liu Y, Berezov A, Xu C, Gao Y, Li Z, Wu SL, Cai Z, Zhang H, Karger BL, Hancock WW, Wells AD, Zhou Z, Greene MI. Structural and biological features of FOXP3 dimerization relevant to regulatory T cell function. Cell Rep. 2012 Jun 28;1(6):665-75. doi: 10.1016/j.celrep.2012.04.012. Epub 2012 Jun 15. PMID: 22813742; PMCID: PMC3401381.

107. Tsun A, Chen Z, Li B*. Romance of the three kingdoms: RORgammat allies with HIF1alpha against FoxP3 in regulating T cell metabolism and differentiation. Protein Cell. 2011 Oct;2(10):778-81. doi: 10.1007/s13238-011-1114-2. PMID: 22058032; PMCID: PMC4875303.

108. Tsun A, Li YY, Li B*. You, me and Foxp3: immune regulation for two. Immunotherapy. 2011 Oct;3(10):1139-42. doi: 10.2217/imt.11.118. PMID: 21995568.

109. Chen Z, Lin F, Gao Y, Li Z, Zhang J, Xing Y, Deng Z, Yao Z, Tsun A, Li B*. FOXP3 and RORγt: transcriptional regulation of Treg and Th17. Int Immunopharmacol. 2011 May;11(5):536-42. doi: 10.1016/j.intimp.2010.11.008. Epub 2010 Nov 23. PMID: 21081189.

110. Xiao Y, Li B, Zhou Z, Hancock WW, Zhang H, Greene MI. Histone acetyltransferase mediated regulation of FOXP3 acetylation and Treg function. Curr Opin Immunol. 2010 Oct;22(5):583-91. doi: 10.1016/j.coi.2010.08.013. Epub 2010 Sep 24. PMID: 20869864; PMCID: PMC2967626.

111. Saouaf SJ, Li B, Zhang G, Shen Y, Furuuchi N, Hancock WW, Greene MI. Deacetylase inhibition increases regulatory T cell function and decreases incidence and severity of collagen-induced arthritis. Exp Mol Pathol. 2009 Oct;87(2):99-104. doi: 10.1016/j.yexmp.2009.06.003. Epub 2009 Jul 3. PMID: 19577564; PMCID: PMC2753738.

112. Zhou Z, Song X, Berezov A, Li B*, Greene MI*. Structural aspects of the FOXP3 regulatory complex as an immunopharmacological target. Int Immunopharmacol. 2009 May;9(5):518-20. doi: 10.1016/j.intimp.2009.01.018. Epub 2009 Jan 29. PMID: 19539569.

113. Samanta A, Li B(Co-first author), Song X, Bembas K, Zhang G, Katsumata M, Saouaf SJ, Wang Q, Hancock WW, Shen Y, Greene MI. TGF-beta and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3. Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14023-7. doi: 10.1073/pnas.0806726105. Epub 2008 Sep 8. PMID: 18779564; PMCID: PMC2544572.

114. Zhou Z, Song X, Berezov A, Zhang G, Li Y, Zhang H, Murali R, Li B, Greene MI. Human glucocorticoid-induced TNF receptor ligand regulates its signaling activity through multiple oligomerization states. Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5465-70. doi: 10.1073/pnas.0711350105. Epub 2008 Mar 31. PMID: 18378892; PMCID: PMC2291095.

115. Li B, Greene MI. Special regulatory T-cell review: FOXP3 biochemistry in regulatory T cells--how diverse signals regulate suppression. Immunology. 2008 Jan;123(1):17-9. doi: 10.1111/j.1365-2567.2007.02774.x. PMID: 18154614; PMCID: PMC2433283.

116. Tao R, de Zoeten EF, Ozkaynak E, Chen C, Wang L, Porrett PM, Li B, Turka LA, Olson EN, Greene MI, Wells AD, Hancock WW. Deacetylase inhibition promotes the generation and function of regulatory T cells. Nat Med. 2007 Nov;13(11):1299-307. doi: 10.1038/nm1652. Epub 2007 Oct 7. PMID: 17922010.

117. Tao R, de Zoeten EF, Ozkaynak E, Wang L, Li B, Greene MI, Wells AD, Hancock WW. Histone deacetylase inhibitors and transplantation. Curr Opin Immunol. 2007 Oct;19(5):589-95. doi: 10.1016/j.coi.2007.07.015. Epub 2007 Aug 24. PMID: 17719760; PMCID: PMC2693068.

118. Li B, Saouaf SJ, Samanta A, Shen Y, Hancock WW, Greene MI. Biochemistry and therapeutic implications of mechanisms involved in FOXP3 activity in immune suppression. Curr Opin Immunol. 2007 Oct;19(5):583-8. doi: 10.1016/j.coi.2007.07.006. Epub 2007 Aug 20. PMID: 17703930.

119. Li B, Greene MI. FOXP3 actively represses transcription by recruiting the HAT/HDAC complex. Cell Cycle. 2007 Jun 15;6(12):1432-6. Epub 2007 May 10. PMID: 17592252.

120. Li B, Samanta A, Song X, Iacono KT, Brennan P, Chatila TA, Roncador G, Banham AH, Riley JL, Wang Q, Shen Y, Saouaf SJ, Greene MI. FOXP3 is a homo-oligomer and a component of a supramolecular regulatory complex disabled in the human XLAAD/IPEX autoimmune disease. Int Immunol. 2007 Jul;19(7):825-35. doi: 10.1093/intimm/dxm043. Epub 2007 Jun 22. PMID: 17586580.

121. Li B, Samanta A, Song X, Iacono KT, Bembas K, Tao R, Basu S, Riley JL, Hancock WW, Shen Y, Saouaf SJ, Greene MI. FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression. Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4571-6. doi: 10.1073/pnas.0700298104. Epub 2007 Mar 7. PMID: 17360565; PMCID: PMC1838642.

122. Li B, Samanta A, Song X, Furuuchi K, Iacono KT, Kennedy S, Katsumata M, Saouaf SJ, Greene MI. FOXP3 ensembles in T-cell regulation. Immunol Rev. 2006 Aug;212:99-113. doi: 10.1111/j.0105-2896.2006.00405.x. PMID: 16903909.

123. Brennan PJ, Saouaf SJ, Van Dyken S, Marth JD, Li B, Bhandoola A, Greene MI. Sialylation regulates peripheral tolerance in CD4+ T cells. Int Immunol. 2006 May;18(5):627-35. doi: 10.1093/intimm/dxh344. Epub 2005 Nov 15. PMID: 16291658.

124. Wang Q, Hirohashi Y, Furuuchi K, Zhao H, Liu Q, Zhang H, Murali R, Berezov A, Du X, Li B, Greene MI. The centrosome in normal and transformed cells. DNA Cell Biol. 2004 Aug;23(8):475-89. doi: 10.1089/1044549041562276. PMID: 15307950.

125. Li B, Huang X, Zhao J. Expression of hetN during heterocyst differentiation and its inhibition of hetR up-regulation in the cyanobacterium Anabaena sp. PCC 7120. FEBS Lett. 2002 Apr 24;517(1-3):87-91. doi: 10.1016/s0014-5793(02)02582-6. PMID: 12062415.

126. Li T, Huang X, Zhou R, Liu Y, Li B, Nomura C, Zhao J. Differential expression and localization of Mn and Fe superoxide dismutases in the heterocystous cyanobacterium Anabaena sp. strain PCC 7120. J Bacteriol. 2002 Sep;184(18):5096-103. doi: 10.1128/JB.184.18.5096-5103.2002. PMID: 12193626; PMCID: PMC135309.


Zhizhen Qin

2021 M.S. candidate

E-mail:qinzhizhen1108@@hotmail.com


Xue Jiang

2021 Ph.D. candidate

E-mail:jiang874136500@@163.com


Xueyu Dai,Ph.D.

Associate Professor

E-mail:daixueyu@@shsmu.edu.cn


Tianhang Zhai

2019 Ph.D. candidate

E-mail:tianhangzhai@@163.com


Zhan Xu

2019 Ph.D. candidate

E-mail:xz12114225@@163.com


Qianru Huang

2018 Ph.D. candidate

E-mail:389461221@@qq.com


11AA9

Jieqiong Chen

Postdoc

E-mail:jieqiong86@@hotmail.com


Weiqi Zhang

2019 Ph.D. Candidate

E-mail:chanvi7@@126.com


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Zeng Wang

Postdoc

E-mail:wz2573749689@@126.com


6C9DA


Guojun Qu

2021 Ph.D. Candidate

E-mail:xiaoguojun@@126.com



Ning Li

Postdoc

E-mail:lining8505@@shsmu.edu.cn


Mengdi Yang

Shanghai No.6 peoples hospital Ph.D. Candidate

E-mail:yangmengdi0325@@126.com


Yixian Guo

Renji Hospitotal 2017 M.S. Candidate

E-mail:gyx9410@163.com


Feng Xie

2019 Ph.D. Candidate

E-mail:xiefeng0504@sjtu.edu.cn


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Mingzhu Chen,B.S


E-mail:chen_mingzhu2018@163.com


Suyuan Ji

Postdoc

E-mail:jsyqingchen@163.com


Biaolong Deng

2018 Ph.D. Candidate

E-mail:472172992@@qq.com


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Xinnan Liu

2018 Ph.D.Candidate

E-mail:liu_xjll@@163.com


Dan Li,Ph.D.

Assistant Research Fellow

E-mail:danli@@shsmu.edu.cn


Yangyang Li

Postdoc

E-mail:liyangyangsibs@@163.com


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Xiaoxia Wang

Postdoc

E-mail:wangxiaoxia@@sibs.ac.cn


Hao Cheng

Postdoc

E-mail:chenghaowj@@sjtu.edu.cn



Lab Location:280 Chongqing S. Rd, Huangpu DC, Shanghai

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