• Name:Florent Ginhoux

  • Office Location:

  • Telephone:



1997-1999 University Pierre et Marie CURIE (Paris VI) Bachelor Degree, Master Degree and Certificate of Biochemistry

2000 University Pierre et Marie CURIE (Paris VI) Master of Advanced Studies in Fundamental Immunology

2004.06 University of Paris VI Ph.D. in Immunology


2004.09-2006.12 Mount Sinai School of Medicine, New York     Postdoctoral fellow
2007.01-2008.06 Mount Sinai School of Medicine, New York     Instructor
2008.07-2009.03 Mount Sinai School of Medicine, New York     Assistant Professor
2009-Present Singapore Immunology Network (SIgN), Singapore     Principal Investigator


Dendritic Cell and Macrophage Ontogeny

Dendritic cells (DCs), monocytes and macrophages play crucial and distinct roles in tissue homeostasis and immunity, but also contribute to a broad spectrum of pathologies and are thus attractive therapeutic targets. Potential intervention strategies aiming at manipulation of these cells will require in-depth insights of their origins and the mechanisms that govern their homeostasis.

The focus of the laboratory is to understand the ontogeny of DCs, monocytes and macrophages, their differentiation pathways and how their unique ontogeny dictates their immune functions. Our approach encompasses the integration of high dimensional platforms such as RNAseq, single cell transcriptome analysis using microfluidic RNA sequencing and deep immunophenotypic assessment using state of the art 18 parameters flow cytometry orCytometry by Time-Of-Flight mass spectrometry (CyTOF) (In collaboration with Dr Evan Newell, SIgN). Such high density molecular profiling at the single level and at unprecedented dimensionality and complexity will provide new insights in the biology of DC, monocyte and macrophage cell populations.Defining macrophage and DC populations on the criteria of their origin may aid our understanding of their discrete roles in tissue immunity and homeostasis, as ontogeny of DC and macrophage subsets likely underlie their functional specializations.

Amanda Shin

Research Assistant

Zhaoyuan Liu,Ph.D.


Lab Location:Room 1111, No.5 Bldg., West Area, 280 South Chongqing Rd.,Shanghai



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