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曹建平

作者:   发布时间 :2020年10月28日

个人简介

 

姓名:曹建平               

性别:                   

出生年月:196410 

学位/学历:博士            

职称:研究员、博士生导师                   

现任职务:中国疾病预防控制中心寄生虫病预防控制所(国家热带病研究中心)副所长、国家卫生健康委寄生虫病原与媒介生物学重点实验室副主任,《中国寄生虫学与寄生虫病杂志》主编,《疾病监测》副主编

电子邮件:caojpcdc@163.com   

办公地址:上海市黄浦区瑞金二路207

办公电话:021-6473525813651811278

传真:021-64376308

教育经历

19829月至19877月,南京医学院,临床医疗专业,大学本科,学士学位

19899月至19927月,南京医学院,基础医学专业,硕士研究生,硕士学位

19959月至19987月,中国预防医学科学院,病原生物学,博士研究生,博士学位

          

工作经历

19878月至199912 镇江医学院工作

20001月至今 中国疾病预防控制中心寄生虫病预防控制所(国家热带病研究中心)工作

 

社会/学术任职和活动

任中华医学科技奖第二届和第三届评审委员会委员、上海科技发展重点领域技术预见专家、上海市寄生虫学会理事长、中华医学会热带病与寄生虫学分会副主任委员、中国微生物学会人兽共患病病原学专业委员会副主任委员、上海市免疫学会理事等

 

研究方向/主要研究内容

1.寄生虫与宿主相互作用机制

2.寄生虫感染免疫及其调控机制,疫苗研制

3.新发寄生虫病分子流行病学、致病机制与跨种传播、监测与风险评估关键技术研究

 

科研/教学研究项目

作为负责人先后承担科研课题26项,其中包括国家“863”计划、国家科技重大专项、国家科技攻关计划、国家自然科学基金和国家卫生行业科研专项等国家级课题16

 

1. 日本血吸虫虫卵外泌体源microRNA-1促进肝脏纤维化的作用及其机制研究,No.819719692020-2023,国家自然科学基金面上项目

2. Vγ2γδT细胞促日本血吸虫感染小鼠肝纤维化作用机制研究,No.817722252018-2021,国家自然科学基金面上项目

3. 日本血吸虫感染晚期小鼠脾脏淋巴滤泡再形成及机制研究,No.813718412014-2017,国家自然科学基金面上项目

4. 日本血吸虫致宿主脾脏淋巴滤泡破坏相关虫源分子的研究,No.308722122009-2011,国家自然科学基金面上项目

5. 日本血吸虫免疫逃避机制相关分子的研究,No.303712622004-2006,国家自然科学基金

6. 肉源性、水源性寄生虫病监测和风险评估关键技术研究及应用,2015020212016-2018,国家卫生行业科研专项

7. 我国未来病原体战略研究(寄生虫分课题),L15220332015-2017,中国工程院与国家自然基金委中长期发展战略研究

8. 日本血吸虫病基因工程多价疫苗的研究,2006AA02Z4442006-2010,国家“863”计划

9. 日本血吸虫基因工程疫苗的研究,2001AA2151512001-20032004AA2152402004-2005,国家“863”计划

10. 日本血吸虫病基因工程多价疫苗和DNA疫苗的研究,2004AA2Z35202004-2005,国家科技重大专项

11. 隐孢子虫病快速检测方法及虫株鉴别的研究,2003BA712A03-062003-2005,国家科技攻关计划

12. 野生动物与媒介携带的病原微生物种群、分布特征及其发生规律研究(寄生虫课题),2016YFC12019002016-2019,国家重点研发计划

13. 隐孢子虫病的诊断,201316012013-2015,国家卫生行业标准

14. 自然疫源性传染病病原谱流行规律及变异研究(寄生虫子课题),2012ZX10004-201-0042012-2015,国家传染病重大专项

15. 特殊传染病诊断试剂企业研发/产品评价用参考品的研制(寄生虫子课题),2013ZX10004-8052012-2015,国家科技重大专项

16. 自然疫源性传染病病原谱流行规律及变异研究(寄生虫子课题),2009ZX10004-201-0042009-2011,国家传染病重大专项

17. 寄生虫病与病媒控制,No.GWV-10.1-XK132020-2022,上海市公共卫生体系建设三年行动计划(2020-2022)重点学科项目

18. 重点学科-热带病学,15GWZK01012016-2019,上海市公共卫生体系建设三年行动计划重点学科项目

19. 日本血吸虫病基因工程疫苗临床前研究,0643190262007-2009,上海市生物医药重点项目

20. 抗日本血吸虫雌雄虫合抱基因工程疫苗的研究,03DZ192312004-2006,上海市科技攻关重大计划

 

主要学术成果


著作

1.《临床微生物学手册》(第12版)共同主译,中华医学电子音像出版社,北京,2020

2.《曼氏热带病》(第23版),副主译,上海科学技术出版社,上海,2020

3.《腹泻症候群病原学监测与检测技术》,副主编,中山大学出版社,广州,2016

4.《现代寄生虫病学》(第2版),副主编,人民军医出版社,北京,2015

 

专利

获授权国家发明专利5件,1件已转化

1.     沈玉娟,曹建平,刘华,袁忠英,姜岩岩,尹建海,王燕娟. 多重PCR检测肠道新发原虫试剂盒及检测方法,ZL   201510093500.9   2017.2

2.     沈玉娟,陈盛霞,金红,李峰,潘雨青,孙启艳,吴亮,曹建平. 基于图像的寄生虫虫卵形状识别方法,ZL   201110022426.32012.10   已转化

3.     尹建海,曹建平,刘丛珊,张皓冰,沈玉娟. 熊果酸在制备抗包虫药物中的应用,ZL 2016 1 0517861.62019.4

4.     曹建平Ugwu Chidiebere   Emmanuel、沈玉娟、姜岩岩、段李平、袁忠英. 银杏酸在抗隐孢子虫中的应用,

ZL   201310539693.72016.3

5.     曹建平,蔡辉霞,沈玉娟,韩秀敏,胡媛,王虎,卢潍媛,徐馀信,官亚宜. 诊断细粒棘球蚴病的重组抗原蛋白、其制备方法和用途,ZL 201010284913.22012.8

 

荣誉及奖项

作为第一完成人获医学科技奖4项,获国家卫生计生有突出贡献中青年专家、国家抗震救灾医药卫生先进个人、全国血防卫士、上海市职工创新工作室等

1. 我国重要新发肠道原虫病原和分子检测关键技术研究及应用,2019年,以第一完成人获中华医学科技奖二等奖(中华医学会)、上海市科技进步奖二等奖(上海市人民政府)和华夏医学科技奖三等奖(中国医疗保健国际促进交流会)

2. 我国隐孢子虫核酸检测和基因分型技术的研究及应用,以第一完成人获中华预防医学科技奖三等奖(中华预防医学会,2015

 

开设课程

    讲授研究生课程包括《寄生虫感染免疫学》、《专业英语免疫学》、《被忽视热带病》、《新发肠道原虫病流行与挑战》、《实验室生物安全管理》、《动物疾病与人类健康》等

 

Profile

 

 

 

曹建平

 

NameCao Jianping  

Gender: male               

Date of birth14 Oct,1964   

DegreeDoctor        

TitleProfessor, Doctoral Supervisor

Present PositionDeputy Director,   National Institute of Parasitic Diseases, Chinese Center for Disease Control   and Prevention (Chinese Center for Tropical Diseases Research); Deputy   Director,  NHC Key   Laboratory of Parasite and Vector Biology, China; Editor-in-chief, Chinese   Journal of Parasitology and Parasitic Diseases; Associate Editor, Disease   Surveillance.

Emailcaojpcdc@163.com, caojp@yahoo.com

AddressNo.207, Rui Jin 2nd   Road, Shanghai, China                 

Office Tel+8621-64735258+86 13651811278

Education

1982.9-1987.7   Nanjing Medical University, bachelor, clinical medicine

1989.9-1992.7   Nanjing Medical University, master, basic medicine

1995.9-1998.7   Chinese   Academy of Preventive Medicine, Ph.D.,Pathogen Biology

          

Appointments

Aug 1987   to Dec 1999 Zhenjiang   Medical College

Jan 2000   to present National   Institute of Parasitic Diseases, Chinese Center for Disease Control and   Prevention (Chinese Center for Tropical Diseases Research)

 

Academic Participation and Activities

Member, Chinese Medical Science and Technology Award   Committee;

President, Shanghai Association for Parasitology;

Deputy President, Branch of Tropical Diseases   and Parasitology, Chinese Medical Association;

Deputy President, Committee on   Aetiology of Zoonoses, Chinese Society for Microbiology;

Member, Shanghai Immunology Association;

Expert, Technology Foresight in Key areas of Science   and Technology Development, Shanghai.

 

Research Interest

1. Mechanisms involved in the   interaction between parasite and the host

2. Infection and immunity, Development   of vaccine

3. Molecular   epidemiology, pathogenic mechanism, cross-species transmission, key   techniques for surveillance and risk assessment of emerging infectious parasitic   diseases

 

Projects

1. Study on the role and its mechanism of microRNA-1 of exosome from   Schistosoma japonicum egg in promoting liver fibrosis. National Natural   Science Foundation of China, No.81971969, 2020-2023,

2.Study on the mechanism of Vγ2γδT cells derived from mice   infected with Schistosoma japonicum facilicate the liver fibrosis. National   Natural Science Foundation of China, No.81772225, 2018-2021

3.Study on the mechanism of re-generated spleen lymphoid follicles   in mice during advanced schistosomiasis japonica. National Natural Science   Foundation of China, No.81371841, 2014-2017

4. Study on the destruction of the spleen’s lymphoid follicles   in mice infected with Schistosoma japonicum by the schistosome-derived   molecules. National Natural Science Foundation of China, No.308722122009-2011

5. Study on the molecular mechanism of immune evasion in mice   infected with Schistosoma japonicum. National Natural Science   Foundation of China, No.303712622004-2006

6. Study and application of the key technologies for monitoring   and risk assessment of meat-borne and water-borne parasitic diseases. Chinese   Special Program for Scientific Research of Public Health, 201502021,2016-2018

7. Study on genetic engineering polyvalent vaccine against   schistosomiasis japonica. National High Technology Research and Development   Programme of China (863 Programme), 2006AA02Z444, 2006-2010

8. Development of genetic engineering vaccine against Schistosoma   japonicum. National High Technology Research and Development Programme of   China (863 Programme), 2001AA215151, 2001-2003; 2004AA215240, 2004-2005

9. Development of geneticengineering polyvalent vaccine and DNA   vaccine against schistosomiasis japonica, National Science and Technology   Major Program of China, 2004AA2Z3520, 2004-2005

10. Study on rapid detection and identification techniques of Cryptosporidium.   National Programs for Science and Technology Development, 2003BA712A03-06, 2003-2005

11. Study on prevalence and variation of the pathogen spectrum   of parasitic diseases. National Science and Technology Major Program of   China, 2012ZX10004-201-004, 2012-2015

12. Development of reference materials for special infectious   disease diagnostic reagent enterprise R & D/product evaluation. National   Science and Technology Major Program of China, 2013ZX10004-805, 2012-2015

13. Study on prevalence and variation of the pathogen spectrum   of parasitic diseases. National Science and Technology Major Program of   China, 2009ZX10004-201-004, 2009-2011

14. Control of parasitic diseases and vectors. Key Discipline   Project of the Three-year Action Plan (2020-2022) for the Construction of   Shanghai Public Health System, No.GWV-10.1-XK13, 2020-2022

15. Tropical Medicine. Key Discipline Project of the Three-year Action   Plan for the Construction of Shanghai Public Health System, 15GWZK01012016-2019

17. Preclinical study of genetic engineering vaccine against   schistosomiasis japonica. Key Biomedical Project Shanghai, 064319026, 2007-2009

16. Development of genetic engineering vaccine against pairing   of female and male of Schistosoma japonicum. Shanghai Science and Technology   Major Program, 03DZ19231, 2004-2006

 



 

Books

1.Manual of   Clinical Microbiology (12th Edition), Co-Chief-Translator, Chinese Medical Multimedia   Press, Beijing, 2020

2.Manson’s   Tropical Diseases(23rd   Edition), Deputy Chief-translator, Shanghai Science & Technology   Publishers, Shanghai, 2020

3.Pathogen   Surveillance and Detection Techniques: Diarrhea Syndrome,Associate   Editor, Sun Yat-sen University Press, Guangzhou, 2016

4.Modern   Parasitology(2nd Edition), Associate   EditorPeople's   Military Medical Press, Beijing, 2015

 

Patents

1. Yujuan ShenJianping CaoHua LiuZhongyin YuanYanyan JiangJianhai YinYanjuan Wang.   Multiplex PCR kit and detection method for detecting emerging intestinal protozoan. ZL   201510093500.9, 2017

2. Yujuan ShenShengxia ChenHong JinFeng LiYuqin PanQiyan SunLiang WuJianping Cao. Recognition   Method for Parasite Egg Based Shape Image. ZL 201110022426.3, 2012

3. Jianhai YinJianping Caocongshan LiuHaobing ZhangYujuan Shen.   Application of ursolic acid in preparation of anti-hydatid drugs. ZL 2016 1   0517861.6, 2019.

4. Jianping Cao, Ugwu   Chidiebere Emmanuel, Yujuan ShenYanyan   JiangLiping Duan,   Zhongying Yuan. Application of ginkgo acid against cryptosporidium. ZL   201310539693.7, 2016

5. Jianping Cao, Huixia Cai,   Yujuan ShenXiumin HanYuan HuHu WangWeiyuan LuYuxin XuYayi Guang.   Recombinant antigen protein for diagnosis of echinococcus granulosus, its   preparation method and application. ZL 201010284913.2, 2012

 

Honors and Awards

1. Study on the pathogens and key techniques of   molecular detection for important emerging intestinal protozoan and their   application in China. Second Prize of China Medical Science   and Technology Award, second Prize of Shanghai Science and Technology   Progress Award, and third Prize in the Huaxia Medical Technology Awards in 2019.

2. Establishment and application of   nucleic acid assays and genotyping techniques for Cryptosporidium in   China. Third prize of China Preventive Medicine Science and Technology Award   (2015)

 

Lectures

Parasitic   infection and immunity, Professional English -- Immunology, Neglected tropical   diseases, Epidemiology and challenges of emerging infectious parasitic   diseases, Laboratory Biosafety Management, Zoonotic parasitic diseases

 

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