杨烁

上海交通大学医学院全球健康学院 课题组长

联系方式

办公室：上海市重庆南路280号老红楼，邮编200025

邮箱：lmys2356@sjtu.edu.cn；lmys2356@live.cn

教育经历

2018/1 中国科学院生物物理研究所，博士

2011/6 中国农业大学，学士

工作经历

2026/4-至今            上海交通大学医学院全球健康学院，课题组长

2023/2-2026/3       复旦大学生命科学学院，课题组长

2018/9-2023/1       华盛顿大学医学院发育生物学系, 博士后研究人员

研究方向

课题组长期从事感染过程中跨器官信号传递研究(Inter-organ communication networks, ICNs)：⑴鉴定出糖醇分子可作为第二信使介导“肠-肝”交流，是免疫-代谢转换的时空枢纽，为干预系统性炎症风暴提出了理论依据(Cell Host&Microbe, 2019)；⑵细菌、病毒以及神经退行性疾病可诱发神经炎症和肌无力共病，脑源性炎症因子IL-6作为桥梁促使肌肉失能并维持低代谢水平，从而调节能量在免疫系统、运动系统和神经系统中的分配平衡(Science Immunology, 2024)，鉴定出了首个不依赖于神经连接体的“大脑-肌肉”信号轴；⑶发现外源性FGF信号作为“外胚层-肌肉”跨器官桥梁，配合内源性激酶Bsd，共同调控肌肉形态发生，并提出了肌肉发育的双重调控网络理论 (Nature Communications, 2022; Development, 2020; Developmental Biology, 2023)。获得国家自然科学基金优秀青年基金(海外)、上海市领军人才、国家自然科学基金面上项目的资助。

Name

Shuo Yang

Title

Principal Investigator

Contact Information

Office Address: The red mansion，280 South Chongqing Road

Email Address:  lmys2356@sjtu.edu.cn；lmys2356@live.cn

Education

2018/1 Institute of Biophysics Chinese Academic of Science，Ph.D

2011/6 China Agriculture University，Academic of Science，Bachelor

Employment

2026/4-now            School of Global Health, Shanghai Jiao Tong University，PI

2023/2-2026/3  School of Life Science, Fudan University，PI

2018/9-2023/1     Washtington University School of Medicine, Postdoctoral fellow

Research Interest

Our lab focused on Interorgan communication networks (ICNs) during infection: (1) Identified that sugar alcohol act as second messengers mediating gut–liver crosstalk, which serve as spatiotemporal hubs governing immune-metabolic switching. This finding provides a theoretical basis for intervening in systemic inflammatory storms (Cell Host & Microbe, 2019); (2) Demonstrated that bacterial infections, viral infections, and neurodegenerative diseases can trigger comorbid neuroinflammation and muscle weakness. The brain-derived inflammatory cytokine IL-6 functions as a molecular bridge to drive muscle dysfunction and sustain hypometabolism, thereby balancing energy allocation among the immune, motor, and nervous systems. This work uncovered the first systemic brain–muscle signaling axis independent of connectome (Science Immunology, 2024); (3) Unveiled that exogenous FGF signaling acts as an ectoderm–muscle inter-organ messenger, collaborating with the endogenous kinase Bsd to coordinately regulate myogenesis, suggesting a dual regulatory network model for muscle development was accordingly proposed (Nature Communications, 2022; Development, 2020; Developmental Biology, 2023). PI has been funded by the Excellent Young Scientists Fund (Overseas) of the National Natural Science Foundation of China, the Shanghai Leading Talents Program, and General Programs of the National Natural Science Foundation of China.