姓名：修乐山  职称：助理研究员

联系方式：

办公室地址：上海市黄浦区重庆南路280号上海交通大学医学院西区老红楼412

办公室电话：021-63846590

邮箱：xiuls@sjtu.edu.cn

教育经历（从本科开始）

2011年09月至2015年06月，华北理工大学，本科

2015年09月至2018年06月，清华大学-北京协和医学院，硕士

2018年09月至2021年06月，清华大学-北京协和医学院，博士

2019年09月至2020年09月，美国杜克大学，联合培养博士

工作经历

2021年07月至今, 上海交通大学医学院，教师

社会/学术任职和活动

Frontiers in Cellular and Infection Microbiology杂志客座编辑

科研方向/主要研究内容

病原体鉴定和耐药性检测方法的研发；One Health理念在传染病和耐药研究中的应用；基于光学传感器的新型疾病诊断工具的开发

科研项目

发表论文

1 Xiu L, Wang L, Li Y, Hu L, Huang J, Yong G, Wang Y, Cao W, Dong Y, Gu W*, Peng J*. Multicentre Clinical Evaluation of a Molecular Diagnostic Assay to Identify Neisseria gonorrhoeae Infection and Detect Antimicrobial Resistance. Int J Antimicrob Agents. 2023, 61(5):106785

2 Xiu L, Li Y, Wang F, Zhang C, Li Y, Zeng Y, Yin Y, Peng J. Multiplex High-Resolution Melting Assay for Simultaneous Identification of Molecular Markers Associated with Extended-Spectrum Cephalosporins and Azithromycin Resistance in Neisseria gonorrhoeae. J Mol Diagn. 2020, 22(11):1344-1355

3 Xiu L, Li Y, Zhang C, Li Y, Zeng Y, Wang F, Peng J. A molecular screening assay to identify Chlamydia trachomatis and distinguish new variants of C. trachomatis from wild-type. Microb Biotechnol, 2021, 14:668-676

4 Xiu L, Binder RA, Alarja NA, Kochek K, Coleman KK, Than ST, Bailey ES, Bui VN, Toh T, Erdman DD, Grey GC. A RT-PCR assay for the detection of coronaviruses from four genera. J Clin Virol. 2020,128:104391

5 Xiu L, Yuan Q, Li Y, Zhang C, Tang L, Peng J. Emergence of ceftriaxone-resistant Neisseria gonorrhoeae strains harbouring a novel mosaic penA gene in China. J Antimicrob Chemother. 2020, 75(4):907-910

6 Xiu L, Zhang C, Li Y, Wang F, Peng J. High-resolution melting analysis for rapid detection of the internationally spreading ceftriaxone-resistant Neisseria gonorrhoeae FC428 clone. J Antimicrob Chemother. 2020, 75(1):106-109

7 Xiu L, Zhang C, Li Y, Wang F, Peng J. Simultaneous detection of eleven sexually transmitted agents using multiplexed PCR coupled with MALDI-TOF analysis. Infect Drug Resist. 2019, 12:2671-2682

8 Xiu L, Zhang C, Wu Z, Peng J. Establishment and Application of a Universal Coronavirus Screening Method using MALDI-TOF mass spectrometry. Front Microbiol. 2017, 8:1510

9 Xie Y^#, Li H^#, Chen F, Udayakumar S, Arora K, Chen H, Lan Y, Hu Q, Zhou X, Guo X*, Xiu L*, Yin K*. Clustered Regularly Interspaced short palindromic repeats-Based Microfluidic System in Infectious Diseases Diagnosis: Current Status, Challenges, and Perspectives. Adv Sci (Weinh). 2022, 9(34):e2204172 (共同通讯)

10 Li Y^#, Xiu L^#, Wang L, Zhang L, Wang F, Peng J*. Rapid Detection of Antimicrobial Resistance in Mycoplasma genitalium by High-Resolution Melting Analysis with Unlabeled Probes. Microbiol Spectr. 2022, 10(4):e0101422 (共同一作)

11 Sun L^#, Xiu L^#, Zhang C^#, Xiao Y, Li Y, Zhang L, Ren L*, Peng J*. Detection and classification of SARS-CoV-2 using high-resolution melting analysis. Microb Biotechnol, 2022, 15(6):1883-1894 (共同一作)

12 Li Y^#, Zhang L^#, Xiu L^#, Wang D, Zeng Y, Wang F, Yin Y, Peng J*. A Multiplex Molecular Assay for Detection of Six penA Codons To Predict Decreased Susceptibility to Cephalosporins in Neisseria gonorrhoeae. Antimicrob Agents Chemother. 2022, 66(3):e0170921 (共同一作)

13 Zhang C^#, Song F^#, Xiu L^#, Liu Y, Yang J, Yao L, Peng J. Identification and characterization of a novel rodent bocavirus from different rodent species in China. Emerg Microbes Infect. 2018, 7(1):48 (共同一作)

14 Zhang C^#, Xiu L^#, Xiao Y, Xie Z, Ren L, Peng J. Simultaneous Detection of Key Bacterial Pathogens Related to Pneumonia and Meningitis Using Multiplex PCR Coupled With Mass Spectrometry. Front Cell Infect Microbiol. 2018, 8:107 (共同一作)

15 Li Y, Xiu L, Liu J, Zhang C, Wang F, Yin Y, Peng J. A multiplex assay for characterization of antimicrobial resistance in Neisseria gonorrhoeae using multi-PCR coupled with mass spectrometry. J Antimicrob Chemother. 2020, 75(10):2817-25

16 Binder RA, Alarja NA, Robie ER, Kochek KE, Xiu L, Rocha-Melogno L, Abdelgadir A, Goli SV, Farrell AS, Coleman KK, Turner AL, Lee MJ, Polage CR, Anderson BD, Gray GC. Environmental and Aerosolized SARS-CoV-2 Among Hospitalized COVID-19 Patients. J Infect Dis. 2020, 222(11):1798-1806

17 Zhang C, Wang F, Zhu C, Xiu L, Li Y, Li L, Liu B, Li Y, Zeng Y, Guo B, Peng J. Determining antimicrobial resistance profiles and identifying novel mutations of Neisseria gonorrhoeae genomes obtained by multiplexed MinION sequencing. Sci China Life Sci. 2020, 63:1063-70

18 Yuan Q, Li Y, Xiu L, Zhang C, Fu Y, Jiang C, Tang L, Peng J. Identification of multidrug-resistant Neisseria gonorrhoeae isolates with combined resistance to both ceftriaxone and azithromycin, China, 2017-2018. Emerg Microbes Infect. 2019, 8:1546-9

19 Zhang C, Hu T, Xiu L, Li Y, Peng J. Use of Ultra-Deep Sequencing in a Patient with Tuberculous Coxitis Shows Its Limitations in Extrapulmonary Tuberculosis Diagnostics: A Case Report. Infect Drug Resist. 2019, 12:3739-43

20 Peng J, Yin Y, Chen S, Yang J, Dai X, Zheng H, Gu W, Zhu B, Yong G, Zhong N, Hu L, Cao W, Zheng Z, Wang F, Zhi Q, Zhang C, Xiu L, Liu B, Dong J, Sun L, Zhu Y, Chen X, Jin Q. A Whole-genome Sequencing Analysis of Neisseria gonorrhoeae Isolates in China: An Observational Study. EClinicalMedicine, 2019,7:47-54

21 Zhang C, Xiu L, Li Y, Sun L, Ren L, Li Y, Zeng Y, Wang F, Peng J. Multiplex PCR and Nanopore Sequencing of Genes Associated with Antimicrobial Resistance in Neisseria gonorrhoeae Directly from Clinical Samples. Clin Chem. 2021, 67(4):610-620

22 Li Y, Li Y, Xiu L, Zeng Y, Zhang C, Sun L, Zhang L, Wang F, Peng J. Typing of Neisseria Gonorrhoeae isolates in Shenzhen, China from 2014-2018 reveals the shift of genotypes associated with antimicrobial resistance. Antimicrob Agents Chemother. 2021, 65(5):e02311-20

23 Li H, Xie Y, Chen F, Bai H, Xiu L, Zhou X, Guo X, Hu Q, Yin K. Amplification-free CRISPR/Cas detection technology: challenges, strategies, and perspectives. Chem Soc Rev. 2023, 52(1):361-382

24 Sun L, Zhang C, An S, Chen X, Li Y, Xiu L, Xu B, Xie Z, Peng J. Comprehensive Description of Pathogens and Antibiotic Treatment Guidance in Children with Community-acquired Pneumonia Using Combined Mass Spectrometry Methods. Front Cell Infect Microbiol. 2021, 11:695134

25 Vlasova AN, Diaz A, Damtie D, Xiu L, Toh TH, Lee JS, Saif LJ, Gray GC. Novel Canine Coronavirus Isolated from a Hospitalized Pneumonia Patient, East Malaysia. Clin Infect Disl. 2022, 74(3):446-454

26 Wang X, Xiu L, Binder RA, Toh TH, Lee JS, Ting J, Than ST, Qi W, Coleman KK, Perera D, Ma M, Gray GC. A pan-coronavirus RT-PCR assay for rapid viral screening of animal, human, and environmental specimens. One Health. 2021, 13:100274

27 Chen F, Hu Q, Li H, Xie Y, Xiu L, Zhang Y, Guo X, Yin K. Multiplex Detection of Infectious Diseases on Microfluidic Platforms.Biosensors (Basel). 2023, 13(3):410

28 Liu T, Xiu L, Yin K, Li S. Detection and classification of SARS-CoV-2 using high-resolution melting analysis. Clin Transl Discov. 2022, 2(1):e23

Name：Leshan Xiu

Degree： MD

Title：  Assistant Professor

Email Address: xiuls@sjtu.edu.cn

Office Address: Rm 412, Building 1, 280 South Chongqing Road, Shangha

Office Tel: 021-63846590

Education：

2011.09 – 2015.06, North China University of Science and Technology, Bachelor

2015.09 – 2018.06, Peking Union Medical College, Tsinghua University, Master

2018.09 – 2021.06, Peking Union Medical College, Tsinghua University, MD

2019.09 – 2020.09, Duke University, Joint PhD student

Appointments：

2021.07-present, Shanghai Jiao Tong University School of Medicine, Assistant Professor

Academic Participation and Activities：

Guest Editor for Frontiers in Cellular and Infection Microbiology

Research Interest：

Molecular methods for pathogen identification and AMR detection; Combating infectious diseases and antimicrobial resistance using One Health approach; Development of novel tools for disease diagnostics based on optical biosensors