姓名：殷堃  研究员/硕士生导师 (兼职博士生导师)

联系方式：

办公室地址：老红楼410办公室

办公室电话：021-63846590*776972

邮箱：kunyin@sjtu.edu.cn

教育经历（从本科开始）

2007年9月至2011年7月，中国农业大学 水产养殖学学士

2011年3月至2016年7月，中国科学院大学 环境工程博士

工作经历

2021年2月至今             上海交通大学医学院，全球健康学院  研究员

2018年10月至2021年1月   美国康涅狄格大学，生物医学工程系  博士后

2017年10月至2018年9月   美国宾夕法尼亚大学，机械工程与应用力学系 博士后

2017年1月至2017年9月    美国俄亥俄州立大学，生物医学工程系 博士后

社会/学术任职和活动

中华预防医学会全球卫生分会委员、中国医学装备协会应急救治装备分会常委、上海市食品协会食品安全分会委员；Science in One Health 副编审；Zoonoses 青年编委；Frontiers in Public Health、Frontiers in Medicine、Biosensors、Sensors客座编辑；ACS Nano、Theranostics、Biosensors and Bioelectronic、ACS Sensors、Sensors and Actuators B: Chemical 等中科院一区期刊审稿人。

科研方向/主要研究内容

1）光学生物传感；

2）微流控器件与便携式检测平台；

3）即时诊断；

4）环境健康与耐药防控。

科研项目

项目编号	项目类型	项目名称	起止年月	备注
22104090	国家自然科学基金	基于CRISPR/Cas识别机理的新型冠状病毒多靶位可视化诊断方法研究	202201-202412	项目负责人
22ZR1436200	上海市自然科学基金	基于全健康的新发突发传染病移动互联快速诊断与监测预警平台	202204-202503	项目负责人
ZDYF2022SHFZ321	海南省自然科学基金	全健康视角下微塑料污染环境风险预警及对人体危害评估技术的研究	202209-202509	课题负责人

发表论文（格式：国标GB／T7714-2015）

1. Huimin Li, Yi Xie, Fumin Chen, Huiwen Bai, Leshan Xiu, Xiaonong Zhou, Xiaokui Guo, Qinqin Hu and Kun Yin*. Amplification-free CRISPR/Cas detection technology: challenges, strategies, and perspectives. Chemical Society Reviews, 2023. (IF=60.615)

2. Yi Xie, Huimin Li, Fumin Chen, Srisruthi Udayakumar, Khyati Arora, Hui Chen, Yang Lan, Qinqin Hu, Xiaonong Zhou, Xiaokui Guo, Leshan Xiu and Kun Yin*. Clustered Regularly Interspaced short palindromic repeats‐Based Microfluidic System in Infectious Diseases Diagnosis: Current Status, Challenges, and Perspectives. Advanced Science, 2022 (IF=17.521)

3. Kun Yin, Qiaoning Wang, Min Lv, Lingxin Chen*. Microorganism remediation strategies towards heavy metals. Chemical Engineering Journal, 2019, 360: 1553-1563. (IF= 16.744)

4. Kun Yin, Min Lv, Qiaoning Wang; Yixuan Wu; Chunyang Liao*, Lingxin Chen. Simultaneous Bioremediation and Biodetection of Mercury Ion through Surface Display of Carboxylesterase E2 from Pseudomonas Aeruginosa PA1. Water Research, 2016. 103: 383-390. (IF= 13.400)

5. Kun Yin, Fabiao Yu*, Weiwei Zhang, and Lingxin Chen*. A near-infrared ratiometric fluorescent probe for cysteine detection over glutathione indicating mitochondrial oxidative stress in vivo. Biosensors and Bioelectronics, 2015, 74: 156-164. (IF=12.545)

6. Kun Yin, Bowei Li, Xiaochun Wang, Weiwei Zhang* and Lingxin Chen*. Ultrasensitive colorimetric detection of Cu²⁺ ion based on catalyticoxidation of L-cysteine. Biosensors and Bioelectronics, 2015, 64: 81-87. (IF=12.545)

7. Kun Yin, Weiwei Zhang and Lingxin Chen*. Pyoverdine secreted by Pseudomonas aeruginosa as a biological recognition element for the fluorescent detection of furazolidone. Biosensors and Bioelectronics, 2014, 51: 90-96. (IF=12.545)

8. Kun Yin, Vikram Pandian, Karteek Kadimisetty, Carlos Ruiz, Kumarasen Cooper, Jianxin You, and Changchun Liu*. Synergistically enhanced colorimetric molecular detection using smart cup: a case for instrument-free HPV-associated cancer screening. Theranostics, 2019, 9: 2637-2645. (IF= 11.600)

9. Kun Yin, Xiong Ding, Zhiheng Xu, Ziyue Li, Xingyu Wang, Hui Zhao, Clifford Otis, Baikun Li, Changchun Liu*. Multiplexed colorimetric detection of SARS-CoV-2 and other pathogens in wastewater on a 3D printed integrated microfluidic chip. Sensors and Actuators B: Chemical, 2021, 130242. (IF=9.221)

10. Kun Yin, Yixuan Wu, Shasha Wang and Lingxin Chen*. A sensitive fluorescent biosensor for the detection of copper ion inspired by biological recognition element pyoverdine. Sensors and Actuators B: Chemical, 2016, 232: 257-263. (IF=9.221)

11. Kun Yin, Fabiao Yu, Dongyan Liu, Zhihong Xie and Lingxin Chen*. Cyanine-based colorimetric and fluorescent probe for the selective detection of diethylstilbestrol in seawater, shrimp and fish samples. Sensors and Actuators B: Chemical, 2016, 223: 799-805. (IF=9.221)

12. Kun Yin, Xiong Ding, Ziyue Li, Hui Zhao, Kumarasen Cooper, Changchun Liu*. Dynamic aqueous multiphase reaction system for one-pot CRISPR-Cas12a based ultrasensitive and quantitative molecular diagnosis. Analytical Chemistry, 2020, 92:8561-8568. (IF= IF=8.008)

13. Kun Yin, Xiong Ding, Ziyue Li, Maroun M. Sfeir, Enrique Ballesteros, Changchun Liu*. Autonomous lab-on-paper for multiplexed, CRISPR-based diagnostics of SARS-CoV-2. Lab on a Chip, 2021, (IF=7.517)

小组成员

胡沁沁、修乐山

英文：

Name：Kun YIN

Degree：Ph.D                

Title: Professor

Email Address: kunyin@sjtu.edu.cn  

Office Address: Laohong Building 410

Office Tel: 021-63846590*776972

Education：

2007. 09-2011. 07，Chinese Agriculture University, Bachelor, Aquaculture

2011. 03-2016. 07，University of Chinese Academy of Sciences, Ph.D, Environmental Engineering

Appointments：

2021. 02- Now       Shanghai Jiao Tong University Medical School，Professor

2018. 10-2021. 01      University of Connecticut，Postdoctoral Researcher

2017. 10-2018. 09     University of Pennsylvania，Postdoctoral Researcher

2017. 01-2017. 09      The Ohio State University，Postdoctoral Researcher

Academic Participation and Activities：

1. Huimin Li, Yi Xie, Fumin Chen, Huiwen Bai, Leshan Xiu, Xiaonong Zhou, Xiaokui Guo, Qinqin Hu and Kun Yin*. Amplification-free CRISPR/Cas detection technology: challenges, strategies, and perspectives. Chemical Society Reviews, 2023. (IF=60.615)

2. Yi Xie, Huimin Li, Fumin Chen, Srisruthi Udayakumar, Khyati Arora, Hui Chen, Yang Lan, Qinqin Hu, Xiaonong Zhou, Xiaokui Guo, Leshan Xiu and Kun Yin*. Clustered Regularly Interspaced short palindromic repeats‐Based Microfluidic System in Infectious Diseases Diagnosis: Current Status, Challenges, and Perspectives. Advanced Science, 2022 (IF=17.521)

3. Kun Yin, Qiaoning Wang, Min Lv, Lingxin Chen*. Microorganism remediation strategies towards heavy metals. Chemical Engineering Journal, 2019, 360: 1553-1563. (IF= 16.744)

4. Kun Yin, Min Lv, Qiaoning Wang; Yixuan Wu; Chunyang Liao*, Lingxin Chen. Simultaneous Bioremediation and Biodetection of Mercury Ion through Surface Display of Carboxylesterase E2 from Pseudomonas Aeruginosa PA1. Water Research, 2016. 103: 383-390. (IF= 13.400)

5. Kun Yin, Fabiao Yu*, Weiwei Zhang, and Lingxin Chen*. A near-infrared ratiometric fluorescent probe for cysteine detection over glutathione indicating mitochondrial oxidative stress in vivo. Biosensors and Bioelectronics, 2015, 74: 156-164. (IF=12.545)

6. Kun Yin, Bowei Li, Xiaochun Wang, Weiwei Zhang* and Lingxin Chen*. Ultrasensitive colorimetric detection of Cu²⁺ ion based on catalyticoxidation of L-cysteine. Biosensors and Bioelectronics, 2015, 64: 81-87. (IF=12.545)

7. Kun Yin, Weiwei Zhang and Lingxin Chen*. Pyoverdine secreted by Pseudomonas aeruginosa as a biological recognition element for the fluorescent detection of furazolidone. Biosensors and Bioelectronics, 2014, 51: 90-96. (IF=12.545)

8. Kun Yin, Vikram Pandian, Karteek Kadimisetty, Carlos Ruiz, Kumarasen Cooper, Jianxin You, and Changchun Liu*. Synergistically enhanced colorimetric molecular detection using smart cup: a case for instrument-free HPV-associated cancer screening. Theranostics, 2019, 9: 2637-2645. (IF= 11.600)

9. Kun Yin, Xiong Ding, Zhiheng Xu, Ziyue Li, Xingyu Wang, Hui Zhao, Clifford Otis, Baikun Li, Changchun Liu*. Multiplexed colorimetric detection of SARS-CoV-2 and other pathogens in wastewater on a 3D printed integrated microfluidic chip. Sensors and Actuators B: Chemical, 2021, 130242. (IF=9.221)

10. Kun Yin, Yixuan Wu, Shasha Wang and Lingxin Chen*. A sensitive fluorescent biosensor for the detection of copper ion inspired by biological recognition element pyoverdine. Sensors and Actuators B: Chemical, 2016, 232: 257-263. (IF=9.221)

11. Kun Yin, Fabiao Yu, Dongyan Liu, Zhihong Xie and Lingxin Chen*. Cyanine-based colorimetric and fluorescent probe for the selective detection of diethylstilbestrol in seawater, shrimp and fish samples. Sensors and Actuators B: Chemical, 2016, 223: 799-805. (IF=9.221)

12. Kun Yin, Xiong Ding, Ziyue Li, Hui Zhao, Kumarasen Cooper, Changchun Liu*. Dynamic aqueous multiphase reaction system for one-pot CRISPR-Cas12a based ultrasensitive and quantitative molecular diagnosis. Analytical Chemistry, 2020, 92:8561-8568. (IF= IF=8.008)

13. Kun Yin, Xiong Ding, Ziyue Li, Maroun M. Sfeir, Enrique Ballesteros, Changchun Liu*. Autonomous lab-on-paper for multiplexed, CRISPR-based diagnostics of SARS-CoV-2. Lab on a Chip, 2021, (IF=7.517)

14. Kun Yin, Vikram Pandian, Karteek Kadimisetty, Xin Zhang, Carlos Ruiz, Kumarasen Cooper, Changchun Liu*. Real-time colorimetric Quantitative Molecular Detection of infectious Diseases on Smartphone-based Diagnostic platform. Scientific Reports, 2020, 10：1-9. (IF= 4.996)

15. Chen Chen, Qinqin Hu and Kun Yin*. Visible transparency tuning and corresponding sensing application of opal photonic crystals. Optics Express. 2022, (IF= 3.833)

16. Kun Yin, Leming Sun, Zhen Fan, Huacan Lin, Yujian Huang, Scott Galster, Jeff, Kuret, Douglas Scharre, Mingjun Zhang*. Fluorescent peptide nanoparticles to monitor Aβ oligomers. IEEE-NANO, 2017 IEEE 17th International Conference on Nanotechnology, 2017, 25-28.

Research Interest：

Dr. Kun Yin’s research focuses on the development of optical biosensors, infectious disease diagnosis, and AMR monitoring, especially at the human-environment interface under the One Health concept: 1) Bridges gaps between different fields and opens new opportunities for the development of novel biosensors with high sensitivity and selectivity, which have outstanding advantages in practical applications. 2) Applies interdisciplinary approaches to develop new tools and methods to solve current life science challenges, such as disease diagnostics, medical therapeutics, and personalized medicine. 3) Explores wastewater surveillance of antimicrobial resistance at the human-animal-environment interface to improve our understanding of the spread of antimicrobial resistance.