肖泽宇 教授

可视化药物递送研究组

电话：63846590-776415

邮箱：xiaozeyu@shsmu.edu.cn

研究方向

分子影像，药物递送，纳米医学

主要包括：

用于分子影像学、分析化学、化学生物学、纳米医学手段开展转化医学研究：

1. 发展基于活体拉曼光学影像、核酸（核酸适体、DNA自组装）化学的诊疗一体化纳米体系，用于肿瘤的可视化检测和治疗，如术中诊疗残余肿瘤、药物剂量监控、克服靶向药物耐药、分子靶向治疗可视化诊治等。

2. 利用生物可降解，生物安全的高分子聚合物构建纳米缓控释药物输送体系，开发其在口服结肠靶向给药中的应用

个人简历

上海交通大学医学院特聘教授，博士生导师，国家海外高层次青年人才，上海市卫生健康学科带头人，上海市高层次人才。北京大学医学部药学院学士；中国科学院化学所与美国佛罗里达大学联合培养博士；美国麻省理工学院与哈佛大学医学院癌症纳米交叉研究中心Robert Langer实验室博士后；2014年底起在上海交通大学医学院任现职至今。从事活体拉曼成像分析及疾病诊疗应用的研究，发表论文60余篇，总引用达8000余次; 近年来以通讯作者在Nat Biotechnol, Chem, J Am Chem Soc, Nat Commun. Adv Sci, Nano Lett., ACS Nano, Anal Chem等杂志发表论文, 代表性工作被Nat Biotechnol以Research Briefing进行亮点介绍和评述。申请国际国内专利13件，授权7件（含PCT2件），其中1件专利成果在人体临床研究中展示安全及有效性。主持国家重点研发计划课题、国自然国际地区合作项目等国家级项目7项。获哈佛大学华人科学家奖，美国癌症研究协会青年女科学家奖、全国颠覆性技术创新大赛总决赛最高奖、上药杏林育才奖等。现任美国化学会Anal Chem 杂志顾问委员，中国化学会分子医学专委会委员；中国抗癌协会纳米肿瘤学专委会委员；中国化学会女化学工作者委员会委员。

科研项目

1. 国家重点研发计划纳米科技重点专项，多模块可编程纳米药物的活体动态可视化研究，2020.11 ～ 2025.10，212万元，课题负责人；

2. 国家自然科学基金国际(地区）合作项目，功能模块化光动力药物用于克服非小细胞肺癌旁路激活耐药及序贯疗效监控，2022.01 ～ 2024.12，140万元，课题负责人

3. 国家自然科学基金面上项目，DNA模块化核酸纳米递送系统激活巨噬细胞cGAS-STING增效抗肿瘤免疫，2025.01 ～ 2028.12，50万元，课题负责人

4. 国家自然科学基金面上项目，拉曼纳米探针用于活性氧异常疾病的医学分析研究，2019.01 ～ 2022.12，64万元，课题负责人；

5. 国家自然科学基金面上项目，核酸识体纳米药物在组织脏器的三维精准分布及靶向识别，2017.01 ～ 2020.12，62万元，课题负责人；

6. 国家自然科学基金面上项目，DNA自主装纳米诊疗系统：构建及术中成像介导下前列腺癌细胞清除的问题研究，2015.01 ～ 2018.12，73万元，课题负责人；

7. 国家自然科学基金应急管理项目，SP-A核酸适体拉曼纳米探针用于胎肺发育及异常的产前诊断研究，2018.01 ～ 2018.12，20万元，课题负责人；

8. 国家重点研发计划，新型冠状病毒（2019-nCoV）核酸现场快速检测设备及试剂的研发，2020.01 ～ 2020.04，100万元，学术骨干；

论文与专著

5篇代表作：

1. Gao S, Zhang Y, Cui K, Zhang S, Qiu Y, Liao Y, Wang H, Yu S, Ma L, Chen H, Ji M, Fang X*, Lu W*, Xiao Z*. Self-stacked small molecules for ultrasensitive substrate-free Raman imaging in vivo . Nat Biotechnol 2024, doi: 10.1038/s41587-024-02342-9.Highlighted by research briefing of Nat Biotechnol

2. Zhang Y, Zhang W, Qiu Y, Cui K, Li X, Hao W, Luo A, Xiao Z*. Molecular engineering of a SICTERS small molecule with superior in vivo Raman imaging and photothermal performance. J Am Chem Soc. 2025, doi: 10.1021/jacs.4c16411

3.  Zhao N, Wu W, Wang Y, Song K, Chen G, Chen Y, Wang R, Xu J, Cui K, Chen H, Tan W,  Zhang J*,Xiao Z*. DNA-modularized construction of bivalent ligands precisely regulates receptor binding and activation. Chem 2023, 9, 1-23

4. Chen G, Li X, Xu W, Wang H, Jiang Y, Shi R, Zhu C, Xiao Z*. Inflammation Targeting-Triggered Healing Hydrogel for In Situ Reconstruction of Colonic Mucosa. Adv Sci 2025, doi: 10.1002/advs.202411010

5. Chen Y, Li R, Duan Q, Wu L, Li X, Luo A, Zhang Y, Zhao N, Cui K, Wu W, Liu T, Wan J, Deng L, Li G*, Hou L*, Tan W*, and Xiao Z*. A DNA-modularized STING agonist with macrophage-selectivity and programmability for enhanced anti-tumor immunotherapy. Adv Sci 2024, 11(32):e2400149. (front over)

其它通讯作者论文：

6.  Xu J, Li Z, Tong Q, Zhang S, Fang J, Wu A, Wei G, Zhang C, Yu S, Zheng B, Lin H, Liao X, Xiao Z*, Lu W. CD133+PD-L1+ cancer cells confer resistance to adoptively transferred engineered macrophage-based therapy in melanoma. Nat Commun. 2025, 16(1):895.

7. Covalent Organic Framework-Structured Raman Probes for Ultrasensitive In Vivo Bioimaging. Cui K, Li R, Li M, Qiu Y, Wang H, Wu W, Liu T, Zhang W, Xiao Z*. Anal Chem. 2024; 96(29):11800-11808.

8. Ding D, Zhao H, Wei D, Yang Q, Yang C, Wang R, Chen Y, Li L, An S, Xia Q, Huang G, Liu J*, Xiao Z*, Tan W*, The First-in-human Whole-body Dynamic Pharmacokinetics Study of Aptamer. Research, A Science Partner Journal, 2023, 6: 0126. 

9.  Molecular Engineering of Aptamer to Solubilize Hydrophobic NIR Photosensitizer for Enhanced Cancer Photodynamic Therapy, Zhang R, Ji D*, Yao D, Xiao Z*, Tan W*. CCS Chemistry, 2024, 6, 1240–1254，

10. Cui K, Li R, Zhang Y, Qiu Y, Zhao N, Cui Y, Wu W, Liu T, Xiao Z*. Molecular planarization of Raman probes to avoid background interference for high-precision intraoperative imaging of tumor micrometastases and lymph nodes. Nano Lett. 2022, 22(23), 9424–9433

11. Zhang Y, Cui Y, Li M, Cui K, Li R, Xie W, Liu L, Xiao Z*. DNA-assembled visible nanodandelions with explosive hydrogen-bond breakage achieving uniform intra-tumor distribution (UITD)-guided photothermal therapy. Biomaterials 2022, 282, 121381.

12. Cui K, Zhang Y, Chen G, Cui Y, Wu W, Zhao N, Liu T, Xiao Z*. Molecular regulation of polymeric Raman probes for ultrasensitive microtumor diagnosis and noninvasive microvessle imaging. Small 2022, 18(41):e2203227

13. Xia F, He A, Zhao H, Sun Y, Duan Q, Abbas S J, Liu J*, Xiao Z*, Tan W*. Molecular Engineering of Aptamer Self-assemblies Increases in Vivo Stability and Targeted Recognition. ACS Nano 2022,16,1,169-179

14. Fan C, Zhao N, Cui K, Chen G, Chen Y, Wu W, Li Q, Cui Y, Li R, Xiao Z*. Ultrasensitive Exosome Detection by Modularized SERS Labeling for Postoperative Recurrence Surveillance. ACS Sens. 2021 6(9):3234-3241.

15. Gao S, Yu S, Zhang Y, Wu A, Zhang S, Wei G, Wang H*, Xiao Z*, Lu W*. Molecular engineering of near-Infrared-II photosensitizers with steric-hindrance effect for image-guided cancer photodynamic therapy. Adv. Func. Mater. 2021, 31(14), 2008356

16. Gao S, Wei G, Zhang S, Zheng B, Xu J, Chen G, Li M, Song S, Fu W, Xiao Z*, Lu W* Albumin tailoring fluorescence and photothermal conversion effect of near-infrared-II fluorophore with aggregation-induced emission characteristics. Nat Commun. 2019,10(1):2206.

17. Gu X, Qiu Y, Lin M, Cui K, Chen G, Chen Y, Fan C, Zhang Y, Xu L, Chen H, Wan JB, Lu W*, Xiao Z*. CuS Nanoparticles as a Photodynamic Nanoswitch for Abrogating Bypass Signaling To Overcome Gefitinib Resistance. Nano Lett. 2019,19(5):3344-3352 Qiu

18.  Y, Lin M, Chen G, Fan C, Li M, Gu X, Cong S, Zhao Z, Fu L, Fang X*, Xiao Z*. Photodegradabl CuS SERS probes for intraoperative residual tumor detection, ablation and self-clearance. ACS Appl Mater Interfaces 2019, 11(26):23436-23444

19. Zheng B, Xu J, Chen G, Zhang S, Xiao Z*, Lu W*. Bacterium-Mimicking Vector with Enhanced Adjuvanticity for Cancer Immunotherapy and Minimized Toxicity. Adv. Func. Mater. 2019, 29(33):1901437

20. Wu W, Xiao Z*. A deep learning “ticket” for single-molecule analysis of protein stoichiometry. Sci China Chem 2019. 62(10): 1269-1270

21. Xu J, Yu S, Wang X, Qian Y, Wu W, Zhang S, Zheng B, Wei G, Gao S, Cao Z, Fu W, Xiao Z*, Lu W*. High Affinity of Chlorin e6 to Immunoglobulin G for Intraoperative Fluorescence Image-Guided Cancer Photodynamic and Checkpoint Blockade Therapy. ACS Nano 2019, 13,10242-10260

22. Qiu Y, Zhang Y, Li M, Chen G, Fan C, Cui K, Wan J, Han A, Ye J*, Xiao Z* Intraoperative detection and eradication of residual microtumors with gap-enhanced Raman tags. ACS Nano 2018, 12(8):7974-7985.

23. Cui K, Fan C, Chen G, Qiu Y, Li M, Lin M, Wan JB, Cai C, Xiao Z*. para-Aminothiophenol Radical Reaction-Functionalized Gold Nanoprobe for One-to-All Detection of Five Reactive Oxygen Species in Vivo. Anal Chem. 2018, 90, 12137-12144

24. Li M, Qiu Y, Fan C, Cui K, Zhang Y, Xiao Z*Design of SERS nanoprobes for Raman imaging: materials, critical factors and architectures. Acta Pharm Sin B. 2018, 8(3):381-389

25. Lu L, Chen G, Qiu Y, Li M, Liu D, Hu D, Gu X, Xiao Z* Nanoparticle-based oral delivery systems for colon targeting: principles and design strategies. Sci Bull 2016, 61(9):670-681

专著：

1. Hu W, Wang H, Xu W, Li M, Su H, Zhang Y, Li R, Xiao Z*(Corresponding Author) Raman Nanoprobes for In Vivo Medical Applications. Encyclopedia of Nanomaterials, Elsevier Ltd, 2023, vol. 3, pp. 391–410. ISBN：B978-0-12-822425-0.00098-1

2. Qiu Y, Lu L, Hu D, Xiao Z*(Corresponding Author) Copper Sulfide nanoparticles: from synthesis to biomedical applications. Nano Based Drug Delivery, IAPC Publishing, 2015, 516-534, ISBN 978-953-56942-2-9