基本信息 >>>
贺明
衰老与肝脏代谢研究组
研究方向: 衰老及代谢疾病机制研究
电话：021-63846590-776907
邮箱：heming@shsmu.edu.cn
研究方向与进展 >>>
本研究组致力于研究衰老及肝脏代谢疾病的调控机制。具体包括：
1、衰老分子机制研究；
2、脂肪肝（MASLD和ALD）、肝癌等肝脏疾病的发病机制及治疗策略：
3、儿童早衰症（HGPS）机制研究及治疗新策略；
4、器官间通讯机制及病理生理学意义（肝-骨通讯、肝-心通讯、肝-脂通讯等）。
研究组长介绍 >>>
贺明，上海交通大学医学院教授、博士生导师，宝钢优秀教师、上海市教学能手、上海市五一劳动奖章、上海市青年五四奖章获得者，入选上海市“东方英才（拔尖计划）”及“浦江人才”计划，现任上海市细胞稳态调控与疾病前沿科学研究基地副主任，中国老年学和老年医学学会抗衰老分会委员、中国遗传学会衰老遗传分会委员、中国病理生理学会内分泌与代谢专业委员会委员、Life Medicine 杂志编委等。长期聚焦衰老及肝脏代谢机制及干预策略研究，深度解析长寿基因在衰老相关肝脏代谢紊乱起源和调控网络中的新功能，并以此发掘干预新手段。共主持6项国家自然科学基金和5项上海市基金，在国际主流期刊 Cell Metabolism，Nature Metabolism，Journal of Clinical Investigation，Cell Discovery等发表四十余篇研究论文，多篇论文被选为高被引论文。
科研项目 >>>
1. 国家自然科学基金（面上项目），2024.01-2027.12，32371244，50万元，胆汁酸合成替代途径在NAFLD-HCC发生与演进中的作用，主持
2. 国家自然科学基金委员会重大研究计划培育项目，2021.01-2023.12，92057118，78万元，NAFLD-HCC转化中胆固醇代谢调控机制及作用研究
3. 国家自然科学基金（面上项目），2021.01-2024.12，82070603，55万元，SIRT2抑制酒精性肝病发生发展的机制研究，主持
4. 国家自然科学基金（面上项目） ，2015.01-2018.12，81470841，73万元，SIRT7 抑制非酒精性脂肪肝病发生发展的机制研究，主持
5. 国家自然科学基金（面上项目），2012.01-2015.12，81170505， 60万元，MiR-17和 miR-20a在低氧诱导因子-1α诱导白血病细胞分化中的作用，主持
6. 国家自然科学基金（青年基金），2009.01-2011.12，30800380，20万元，温度敏感性TRP离子通道在哮喘大鼠气道平滑肌表型转化中的作用 ，主持
7. 上海市科委自然科学基金，2019.07-2022.06，19ZR1428400，20万元，SIRT2对NLRP3炎症小体活性的调控及其在衰老相关胰岛素抵抗中的作用，主持
8. 上海市浦江人才计划（A类），2016.07-2018.06，16PJ1405400，20万元，SIRT7在非酒精性脂肪肝病发生发展中的作用及机制，主持
9.上海市教委科研创新项目，2009.01-2011.12，09YZ96，肾素受体在大鼠肾小球系膜细胞中表达的调节机制的研究，8万元，主持
10.上海市教委优秀青年教师科研专项基金，2008.01-2010.12，jdy07004，温度敏感性TRP 离子通道在高反应性气道组织中表达的变化及意义，3万元，主持
论文与专著 >>>
（#通讯作者，*第一作者）
1. Fu Y, Peng X, Song H, Li X, Zhi Y, Tang J, Liu Y, Chen D, Li W, Zhang J, Ma J, He M#, Mao Y#, Zhao X#. Disrupted minor intron splicing activates reductive carboxylation-mediated lipogenesis to drive metabolic dysfunction-associated steatotic liver disease progression. J Clin Invest. 2025 Mar 18:e186478. doi: 10.1172/JCI186478.
2. Huang Y*, He W*, Zhang Y, Zou Z, Han L, Luo J, Wang Y, Tang X, Li Y, Bao Y, Huang Y, Long X#, Fu Y#, He M#. Targeting SIRT2 in aging-associated fibrosis pathophysiology. Aging Dis. 2024; doi: 10.14336/AD.202.0513.
3. Tang X*, Fu Y*, Zou Z, Li Y, He M#. Androgens exert multifaceted functions in sex differences analyzed through single-cell transcriptome. Sci China Life Sci.2024; doi：10.1007/s11427-024-2652-y.
4. Luo J*, Zhang Y*, Fu Y, Huang Y, Zou Z, Han L, Bao Y, Huang Y, Long X#, He M#. The regulation of bone metabolism by the liver. Nat Cell Sci. 2024;2(1):1-9.
5. Lin L, Guo Z, He E, Long X, Wang D, Zhang Y, Guo W, Wei Q, He W, Wu W, Li J, Wo L, Hong D, Zheng J, He M#, Zhao Q#. SIRT2 regulates extracellular vesicle-mediated liver-bone communication. Nat Metab.2023; 5(5):821-841. doi: 10.1038/s42255-023-00803-0.
See also Research Highlight, Nat Rev Endocrinol. Liver-bone crosstalk implicated in osteoporosis progression (2023) doi: 10.1038/s41574-023-00859-8.
6. He Y, Su Y, Duan C, Wang S, He W, Zhang Y, An X#, He M#. Emerging role of aging in the progression of NAFLD to HCC. Ageing Res Rev. 2023; doi: 10.1016/j.arr.2023.101833.
7. Wo L, Zhang X, Ma C, Zhou C, Li J, Hu Z, Gong X, Zhan M, He M#, Zhao Q#. LncRNA HABON promoted liver cancer cells survival under hypoxia by inhibiting mPTP opening. Cell Death Discov. 2022; 8(1):171. doi: 10.1038/s41420-022-00917-6.
8. Zhou C, Wang D, Li J, Wang Q, Wo L, Zhang X, Hu Z, Wang Z, Zhan M, He M, Hu G, Chen X, Shen K, Chen GQ, Zhao Q. TGFB2-AS1 inhibits triple-negative breast cancer progression via interaction with SMARCA4 and regulating its targets TGFB2 and SOX2. Proc Natl Acad Sci USA. 2022;119(39):e2117988119.doi: 10.1073/pnas.2117988119.
9. Zhang Y*, Long X*, Ruan X*, Wei Q, Zhang L, Wo L, Huang D, Lin L, Wang D, Xia L, Zhao Q, Liu J, Zhao Q#, He M#. SIRT2-mediated deacetylation and deubiquitination of C/EBPβ prevents ethanol-induced liver injury. Cell Discov. 2021; 7(1):93. doi: 10.1038/s41421-021-00326-6.
10. Ma C*, Wo L*, Wang D, Zhou C, Li J, Zhang X, Gong X, Wang C, Chen G, He M#, Zhao Q#. Hypoxia activated long non-coding RNA HABON regulates the growth and proliferation of hepatocarcinoma cells by binding to and antagonizing HIF-1 alpha. RNA Biol. 2021; 21:1-16. doi: 10.1080/15476286.2020.1871215. (# Corresponding author)
11. He M*, Chiang H*, Luo H*, Zheng Z*, Qiao Q, Wang L, Tan M, Ohkubo R, Mu W, Zhao S, Wu H, Chen D. An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance. Cell Metab. 2020; 31(3): 580-591.e5. doi: 10.1016/j.cmet.2020.01.009. (*equal contribution)
See also In Brief, Nature Reviews Drug Discovery. Reversing inflammaging. (2020) doi:10.1038/d41573-020-00019-x.
See also Research Highlight, Nature Immunology. Sirtuin regulation of NLRP3. (2020) 21(4):358. doi: 10.1038/s41590-020-0657-x
12. Lin S, Xing H, Zang T, Ruan X, Wo L, He M#. Sirtuins in mitochondrial stress: indispensable helpers behind the scenes. Ageing Res Rev.2018; 44:22-32. doi: 10.1016/j.arr.2018.03.006.
13. Gong X, Yu A, Tang J, Wang C, He J, Chen G, Zhao Q,He M#, Zhou C#. MicroRNA-630 inhibits breast cancer progression by directly targeting BMI1. Exp Cell Res.2018; 362(2):378-385. doi: 10.1016/j.yexcr.2017.11.039.
14. Zhang L, An X, Ruan X, Huang D, Zhou L, Xue H, Lu L#, He M#. Inhibition of (pro)renin receptor contributes to renoprotective effects of angiotensin II type 1 receptor blockade in diabetic nephropathy. Front. Physiol. 2017;8:758. doi: 10.3389/fphys.2017.00758. eCollection 2017.
15. An X, Zhang L, Yuan Y, Wang B, Yao Q, Li L, Zhang J#, He M#, Zhang J#. Hyperoside pre-treatment prevents glomerular basement membrane damage in diabetic nephropathy by inhibiting podocyte heparanase expression. Sci Rep.2017;7(1):6413. doi: 10.1038/s41598-017-06844-2.
16. An X, Zhang L, Yao Q, Li L, Wang B, Zhang J#,He M#, Zhang J#. The receptor for advanced glycation endproducts mediates podocyte heparanase expression through NF-κB signaling pathway. Mol Cell Endocrinol. 2017;470:14-25.doi: 10.1016/j.mce.2017.05.004.
17. Zhang L, An XF, Wang QY, He M#. Activation of cold-sensitive channels TRPM8 and TRPA1 inhibits the proliferative airway smooth muscle cell phenotype. Lung.2016;194(4):595-603.doi: 10.1007/s00408-016-9901-4.
18. He M*, Wang QY*, Yin QQ, Tang J, Lu Y, Zhou CX, Duan CW, Hong DL, Tanaka T, ChenGQ, Zhao Q. HIF-1a down-regulates miR-17/20a directly targeting p21 and STAT3: a role in myeloid leukemic cell differentiation. Cell Death Differ. 2013;20(3):408-418. doi: 10.1038/cdd.2012.130.
19. Shin J*, He M*, Liu Y*, Paredes S*, VillanovaL, BrownK, Qiu X, Nabavi N, Mohrin M, Wojnoonski K, Li P, Cheng HL, Murphy AJ, Valenzuela DM, Luo H, Kapahi P, Krauss R, Mostoslavsky R, Yancopoulos GD, Alt FW, Chua KF, Chen D.SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease.Cell Rep. 2013;5(3): 654-665. doi: 10.1016/j.celrep.2013.10.007.
