郭滨

细胞器应激与组织再生课题组

电话：021-63846590-776936

邮箱：jybinguo@shsmu.edu.cn

本课题组的主要研究兴趣是细胞器应激在疾病发生与组织再生中的功能及调控机制。我们的研究体系包括小鼠和人的造血干细胞、白血病干细胞；聚焦的科学问题包括线粒体应激与造血干细胞再生以及白血病的发生与发展；内质网应激与造血干细胞命运决定；核仁应激与造血及骨髓再生；人类造血干细胞体外扩增小分子药物筛选及其衍生细胞产品开发。我们的研究对于各种恶性或非恶性血液系统相关疾病的治疗具有重要意义。

郭滨，生物化学与分子生物学博士，上海交通大学基础医学院病理生理系、细胞分化与凋亡教育部重点实验室研究员、博士生导师；入选国家海外高层次人才计划青年项目，上海市海外高层次人才特聘专家、东方学者特聘教授。主持国家重点研发计划“干细胞及转化研究”青年项目、国家自然科学基金重大研究计划培育项目、国家自然科学基金面上项目等。相关研究成果发表在Nature Medicine、Nature Cell Biology、Journal of Clinical Investigation、Leukemia、Nature Communications、Autophagy、EMBO Reports等期刊上。

1. Jin Y*, Wang Q*, Ding Q*, Yao C, Jiang R^#, Guo B^#, Meng Q^#. H6PD overexpression promotes ex vivo expansion of human cord blood hematopoietic stem cells. Stem Cell Reviews and Reports. (2022). https://doi.org/10.1007/s12015-022-10352-w (#Corresponding author)

2. Chen Y*, Fang S*, Ding Q*, Jiang R*, He J, Wang Q, Jin Y, Huang X, Liu S, Capitano ML, Trinh T., Teng Y^#, Meng Q^#, Wan J^#, Broxmeyer HE^#, and Guo B^#. (2021). ADGRG1 enriches for functional human hematopoietic stem cells following ex vivo expansion-induced mitochondrial oxidative stress. J. Clin. Invest. 131(20):e148329. doi: 10.1172/JCI148329. (#Corresponding author)

3. Jin Y*, Huang J*, Wang Q, He J, Teng Y, Jiang R^#, Broxmeyer HE^#, Guo B^#. RXR Negatively Regulates Ex Vivo Expansion of Human Cord Blood Hematopoietic Stem and Progenitor Cells. (2021). Stem Cell Reviews and Reports. 17(4):1456-1464. https://doi.org/10.1007/s12015-021-10124-y (^#Corresponding author)

4. Chen Y*, Yao C*, Teng Y, Jiang R, Huang X, Liu S, Wan J, Broxmeyer HE^#, Guo B^#. (2019). Phorbol ester induced ex vivo expansion of rigorously-defined phenotypic but not functional human cord blood hematopoietic stem cells: a cautionary tale demonstrating that phenotype does not always recapitulate stem cell function Leukemia 33:2962-2966. (^#Corresponding author)

5. Huang X*, Guo B*, Liu S, Wan J, Broxmeyer HE. (2018). Neutralizing negative epigenetic regulation by HDAC5 enhances human hematopoietic stem cell homing and engraftment. Nature Communications 9:2741. (*Co-first author)

6. Guo B*, Huang X*, Lee MR, Lee SA, Broxmeyer HE. (2018). Antagonism of PPAR-γ signaling expands human hematopoietic stem and progenitor cells by enhancing glycolysis. Nature Medicine 24:360-367. (*Co-first author)

7. Guo B, Huang X, Cooper S, Broxmeyer HE. (2017). Glucocorticoid hormone-induced chromatin remodeling enhances human hematopoietic stem cell homing and engraftment. Nature Medicine 23:424-428 (Top Story of Cell Therapy News 18.07 March 6, 2017; Top Story of Cord Blood News 9.09 March 9, 2017).

8. Guo B*, Liang Q*, Li L, Hu Z, Wu F, Zhang P, Ma Y, Zhao B, Kovas AL, Zhang Z, Feng D, Chen S, Zhang H. (2014). O-GlcNAc-modification of SNAP-29 regulates autophagosome maturation. Nature Cell Biology 16:1215-1226. (*Co-first author)

9. Guo B*, Huang X*, Zhang P, Qi L, Liang Q, Zhang X, Huang J, Fang B, Hou W, Han J, Zhang H. (2014). Genome-wide screen identifies signaling pathways that regulate autophagy during C. elegans development. EMBO reports 15:1001-1102. (*Co-first author)

10. Guo B*, Huang J*, Wu W, Feng D, Wang X, Chen Y, Zhang H. (2014). The nascent polypeptide-associated complex is essential for autophagic flux. Autophagy 10:1738-1748. (*Co-first author)

11. Zhang H, Chang J, Guo B, Hansen M, Jia K, Kovacs AL, Kumsta C, Lapierre LR, Legouis R, Lin L, Lu Q, Melendez A, O’Rourke AJ, Sato K, Sato M, Wang X, Wu F. (2015). Guidelines for monitoring autophagy in C. elegans. Autophagy. 11:9-27.

12. Lu Q, Yang P, Huang X, Hu W, Guo B, Wu F, Lin L, Kovács AL, Yu L, Zhang H. (2011). The WD40 repeat PtdIns(3)P-binding protein EPG-6 regulates progression of omegasomes to autophagosomes. Developmental Cell 21: 343-357.