师资队伍
赵倩
  作者:  2018-12-31

基本信息 >>>

       


  肿瘤细胞分化与凋亡研究组
  电话:63846590-776920
  邮箱:qzhao@shsmu.edu.cn

研究方向>>>

1、 microRNA在白血病细胞分化中的表达调控及其功能

2、 microRNA在乳腺癌转移中的异常表达及其功能

3、 建立转录因子-microRNA-信号分子的相互作用网络

个人简历 >>>

       赵倩,女,研究员,博士生导师。上海交通大学医学院病理生理学教研室主任,上海交通大学医学科学研究院PI。主要研究方向为肿瘤细胞分化与凋亡的分子机制研究,从信号转导途径、转录因子调控以及microRNA的转录后调控等多个层面,对肿瘤细胞尤其是白血病细胞分化与凋亡的分子机制进行深入研究。入选上海市科委 “青年科技启明星”、上海市教委“曙光学者”;作为课题负责人,获得科技部“973”项目子课题、科技部“863”项目、国家自然科学基金面上项目、上海市科委重点项目等各级课题;在国际学术期刊如《Blood》, 《Leukemia》, 《Cell Death Differ》, 《Oncogene》等杂志发表SCI论文27篇。2005年作为第二完成人分别获得中华医学科技奖一等奖,上海市科学技术进步奖一等奖和上海医学科技奖一等奖;2010年作为第二完成人获得国家自然科学奖二等奖。

科研项目 >>>

81472463 GAPDH在乳腺癌细胞EMT及乳腺癌转移中的表达与功能研究  国家自然科学基金 2015-01~2018-12  80万元   课题负责人

81172521 microRNA 在Snail/Twist诱导乳腺癌细胞发生上皮-间质转化中的表达调控及生物学功能 国家自然科学基金 2012-01~2015-12  57万元   课题负责人

  miR-124在乳腺癌细胞EMT过程和小鼠乳腺癌转移中的功能研究  上海交通大学晨星青年学者奖励计划 201112~2013-12  15万元   主要责任人

09SG18 低氧诱导因子-1α(HIF-1α)调控microRNAs的功能学研究 上海市教委曙光学者计划 2009-12~2012-12  15万元   课题负责人

30870979 低氧诱导因子-1α(HIF-1α)对microRNA的调控及其在白血病细胞分化中的作用 国家自然基金委,面上项目 2009-01~2011-12  30万元   课题负责人

08JC1413500 白血病相关蛋白AML1-ETO剪切片断的生物学功能研究 上海市基础研究重点项目 2008-10~2010-10  30万元   课题负责人

2008AA02Z301 利用小分子化合物和RNAi研究抗白血病蛋白PLSCR1的作用网络 科技部863项目 2008-01~2010-12  86万元   课题负责人

08JC1413500 白血病相关蛋白AML1-ETO剪切片断的生物学功能研究 上海市科委,基础重点项目 ~2010-09  30万元   

论文与专著 >>>

Zhan MN,Yu XT,Tang J,Zhou, CX,Wang CL,Yin QQ,Gong XF,He M,He JR,Chen GQ (通讯作者),Zhao Q#   MicroRNA-494 inhibits breast cancer progression by directly targeting PAK1   Cell Death Dis   2017   8(1):e2529   

Mi L, Zhu F, Yang X, Lu J, Zheng Y, Zhao Q, Wen X, Lu A, Wang M , Zheng M, Ji J, Sun J.   The metastatic suppressor NDRG1 inhibits EMT, migration and invasion through interaction and promotion of caveolin-1 ubiquitylation in human colorectal cancer cells.   Oncogene   2017   36(30):4323-4335   

Liu Y, Li F, Gao F, Xing L, Qin P, Liang X, Zhang J, Qiao X, Lin L, Zhao Q# (通讯作者), Du L.   Periostin promotes tumor angiogenesis in pancreatic cancer via Erk/VEGF signaling    Oncotarget.   2016   7(26):40148-40159   

Zhou CX, Wang CL, Yu An-Lu, Wang QY, Zhan MN, Tang T, Yin QQ, He M, He JR, Chen GQ, Zhao Q#. (通讯作者)   MiR-630 suppresses breast cancer progression by targeting metadherin.   Oncotarget   2016   7(2):1288-1299   

Xia X,Zhang K,Cen G,Jiang T,Cao J,Huang K,Huang C, Zhao Q# (通讯作者),Qiu Z   MicroRNA-301a-3p promotes pancreatic cancer progression via negative regulation?of?SMAD4.   Oncotarget   2015   6(25):21046-63   

M He, Q-Y Wang, Q-Q Yin, J Tang, Y Lu, C-X Zhou, C-W Duan, D-L Hong, T Tanaka, G-Q Chen, Q Zhao (通讯作者)   HIF-1α downregulates miR-17/20a directly targeting p21 and STAT3: a role in myeloid leukemic cell differentiation   Cell Death and Differentiation   2013   20(3):408-418   

Liang YJ, Wang QY, Zhou CX, Yin QQ, He M, Yu XT, Cao DX, Chen GQ, He JR, Zhao Q (通讯作者)   MiR-124 Targets Slug to Regulate Epithelial-to-Mesenchymal Transition and Metastasis of Breast Cancer   Carcinogenesis   2013   34(3):713-22   

Zhang H,Wang Q,Zhao Q# (通讯作者),Di W   MiR-124 inhibits the migration and invasion of ovarian cancer cells by targeting SphK1   J Ovarian Res.   2013   6(1):84   

Sun J, Zhang D, Zheng Y, Zhao Q, Zheng M, Kovacevic Z, Richardson DR   Targeting the Metastasis Suppressor, NDRG1, Using Novel Iron Chelators: Regulation of Stress Fiber-Mediated Tumor Cell Migration via Modulation of the ROCK1/pMLC2 Signaling Pathway   Mol Pharmacol.   2013   83(2):454-69   

Liu CX, Yin QQ, Zhou HC, Wu YL, Pu JX, Xia L, Liu W, Huang X, Jiang T, Wu MX, He LC, Zhao YX, Wang XL, Xiao WL, Chen HZ, Zhao Q, Zhou AW, Wang LS, Sun HD, Chen GQ   Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells   Nat Chem Biol   2012   8(5):486-93   

Li D, Yang H, Nan H, Liu P, Pang S, Zhao Q, Karni R, Kamps MP, Xu Y, Zhou J, Wiedmer T, Sims PJ, Wang F   Identification of key regulatory pathways of myeloid differentiation using an mESC-based karyotypically normal cell model   Blood   2012   120(24):4712-9   

Zhang B, Liu XX, He JR, Zhou CX, Guo M, He M, Li MF, Chen GQ, Zhao Q (通讯作者)   Pathologically decreased miR-26a antagonizes apoptosis and facilitates carcinogenesis by targeting MTDH and EZH2 in breast cancer   Carcinogenesis   2011   32(1):2-9   

Yan Z, Yang R, Jiang Y, Yang Z, Yang J, Zhao Q, Lu Y   Induction of Apoptosis in Human Promyelocytic Leukemia HL60 Cells by Panaxynol and Panaxydol   Molecules   2011   29;16 (7):5561-73   

Chen CW, Sowden M, Zhao Q, Wiedmer T, Sims PJ    Nuclear phospholipid scramblase 1 prolongs the mitotic expansion of granulocyte precursors during G-CSF-induced granulopoiesis   J Leukoc Biol.   2011   90 (2):221-33   

Liu XX, Li XJ, Zhang B, Liang YJ, Zhou CX, Cao DX, He M, Chen GQ, He JR, Zhao Q (通讯作者)   MicroRNA-26b is underexpressed in human breast cancer and induces cell apoptosis by targeting SLC7A11   FEBS Lett.   2011   585(9):1363-1367   

Chen GQ, Zhang J, Zhao Q   Active compounds-based discoveries about the differentiation and apoptosis of leukemic cells   Chinese Sci Bull   2009   54(18): 2759-2765   

Chen S, Han YH, Zheng Y, Zhao M, Yan H, Zhao Q, Chen GQ, Li D   NDRG1 contributes to retinoic acid-induced differentiation of leukemic cells   Leuk Res.   2009   33(8):1108-1113   

Song LP, Zhang J, Wu SF, Huang Y, Zhao Q, Cao JP, Wu YL, Wang LS, Chen GQ   Hypoxia-inducible factor-1alpha-induced differentiation of myeloid leukemic cells is its tranional activity independent    Oncogene   2008   27(4):519-27   

Zhang J, Song LP, Huang Y, Zhao Q, Zhao KW, Chen GQ   Accumulation of hypoxia-inducible factor-1{alpha} protein and its role in the differentiation of myeloid leukemic cells induced by all-trans retinoic acid   Haematologica   2008   93(10):1480-7   

Huang Y, Zhao Q (共同第一作者), Zhou CX, Gu ZM, Li D, Xu HZ, Wiedmer T, Sims PJ, Zhao KW, Chen GQ.   Antileukemic roles of human phospholipid scramblase 1 gene, evidence from inducible PLSCR1-expressing leukemic cells.   Oncogene   2006   25(50):6618-27   

Xue ZH, Jiang Y, Yu Y, Wang LS, Chen GQ,Zhao Q (通讯作者)   Metavanadate suppresses desferrioxamine-induced leukemic cell differentiation with reduced hypoxia-inducible factor-1α protein   Biochem Biophys Res Commun   2005   332(4): 1140-1145   

Yan H, Peng ZG, Wu YL, Jiang Y, Yu Y, Huang Y, Zhu YS, Zhao Q, Chen GQ   Hypoxia-simulating agents and selective stimulation of arsenic trioxide-induced growth arrest and cell differentiation in acute promyelocytic leukemic cells   Haematologica   2005   90(12): 1607-1616   

Zhao KW, Li D, Zhao Q, Huang Y, Silverman RH, Sims PJ, Chen GQ    Interferon-alpha-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of protein kinase Cdelta and JNK   J Biol Chem.   2005   280(52): 42707-42714   

Zhao Q, Tao J, Zhu Q, Jia PM, Dou AX, Li X, Cheng F, Waxman S, Chen GQ, Chen SJ, Lanotte M, Chen Z, Tong JH   Rapid induction of cAMP/PKA pathway during retinoic acid-induced acute promyelocytic leukemia cell differentiation   Leukemia   2004   18 (2): 285-92   

Zhao KW, Li X, Zhao Q (共同第一作者), Huang Y, Peng ZG, Shen WZ, Zhao J, Zhou QS, Chen Z, Sims PJ, Wiedmer T, Chen GQ    Protein Kinase Cdelta Mediates Retinoic Acid and Phorbol Myristate Acetate-induced Phospholipid Scramblase 1 Gene Expression: Its Role in Leukemic Cell Differentiation   BLOOD   2004   104(12): 3731-8.   

专利与技术许可 >>>

 

 

教学工作 >>>

 

 

荣誉与奖励 >>>