癌症表观遗传学与药物开发组
办公室地址：上海市浦东新区半夏路1号科研楼A座A707室
办公室电话：021-63150716
邮 箱：bingli@shsmu.edu.cn
实验室地址：上海市浦东新区半夏路1号科研楼A座A703室
实验室电话：021-63150716-776696
研究组长介绍
李兵，教授，现任上海交通大学医学院组织胚胎学与遗传发育系主任、上海市生殖医学重点实验室主任。其课题组长期专注于表观遗传学的基础研究及其转化应用，深入探索精子发生的分子机制。在Science、Nature、Cell、Nature Structural & Molecular Biology等国际顶级学术期刊发表论文60余篇，总引用次数超过14,000次。曾荣获美国March of Dimes基金会Basil O’Connor Scholar Research Award、宾夕法尼亚州立大学保罗·伯格分子生物学奖、上海市海外高层次人才等多项荣誉。长期担任Cell、Science、Molecular Cell、Nature Chemical Biology等国际期刊的审稿人，并现任上海市生物化学与分子生物学学会第十五届理事会副理事长。主持多项国家自然科学基金重点项目、面上项目以及科技部国家重点研发计划项目子课题。作为课程负责人，主持的项目曾获评2018年“上海市高校示范性全英语教学课程建设”项目立项。
研究方向与进展
1. 表观遗传学的基础研究与转化应用
2. 精子发生的分子机制
科研项目
国家重点研发计划“生物大分子与微生物组”专项-子课题，2021YFA1300102，转录延伸及其调控的分子机制研究，2021.12-2026.11，416万元，在研，主持（子课题负责人）
国家自然科学基金重点项目，32030019，共转录表观遗传复合物在移动中聚合酶上功能调节的机制研究，2021.01-2025.12，284万元，结题，主持
国家自然科学基金面上项目，31872817，RNA聚合酶II CTD相互作用组功能调控的分子机理，2019.01-2022.12，60万元，结题，主持
国家重点研发计划“生殖健康及重大出生缺陷防控研究”重点专项-子课题，2018YFC1004504，获得性性状遗传相关重要分子的作用，2018.12-2021.12，122万元，结题，主持（子课题负责人）
代表性论文、专著与专利
Jingdong Xue, Kai Tian, Xiang Xu, Yuqian Feng, Ming Yu, Min Hao, Mingqian Hu, Wenhan Wang, Jiao Ma, Yixuan Pan, Mengyuan Peng, Jun Wu, Shuang He, Xizi Chen, Yanhui Xu, Wenjuan Wang, Yimin Lao and Bing Li* (2026) BCL7A's arginine anchor links nucleosome recognition to chromatin remodeling and DLBCL tumor suppression. Protein & Cell doi: 10.1093/procel/pwaf114
Yixuan Pan#, Mengyuan Peng#, Mindan Tong, Qing Zhong, Xiaoxia Liu* and Bing Li* (2025) The Globular Domain of Extracellular Histones Mediates Cytotoxicity via Membrane Disruption Mechanism. Journal of Biological Chemistry 301(1) 108038. doi: 10.1016/j.jbc.2024.108038
Yixuan Pan, Meiyang Liu, Chun Ruan, Mengyuan Peng, Min Hao, Qi Zhang, Jingdong Xue, Ningzhe Li, Haipeng Guan, Pei Wang, Mingqian Hu, Haitao Li, Wenjuan Wang, Juan Song, Yanhua Yao, Yimin Lao* and Bing Li* (2025) Inherent Asymmetry of Rpd3S Coordinates Its Nucleosome Engagement and Association with Elongating RNA Polymerase II. Nature Structural & Molecular Biology 32(4):687-697. doi: 10.1038/s41594-024-01453-w.
Jingdong Xue, Siang Lv, Ming Yu, Yixuan Pan, Ningzhe Li, Xiang Xu, Qi Zhang, Mengyuan Peng, Fang Liu, Xuxu Sun, Yimin Lao, Yanhua Yao, Juan Song, Jun Wu* and Bing Li* (2025) ARID1A IDR Targets EWS-FLI1 Condensates and Finetunes Chromatin Remodeling Protein Cell 16(1):64-71. doi: 10.1093/procel/pwae029.
Ning-Zhe Li, Zi-Xuan Wang, Fan Zhang, Chang-Zhou Feng, Yi Chen, Dian-Jia Liu, Shu-Bei Chen, Yi Jin, Yuan-Liang Zhang, Yin-Yin Xie, Qiu-Hua Huang, Lan Wang, Bing Li*, Xiao-Jian Sun* (2024) Threonine dehydrogenase regulates neutrophil homeostasis but not H3K4me3 levels in zebrafish FEBS J. 291(15):3367-3383. doi: 10.1111/febs.17138. (*co-correspondence)
Haipeng Guan, Pei Wang, Pei Zhang, Chun Ruan, Yutian Ou, Bo Peng, Xiangdong Zheng, Jianlin Lei, Bing Li, Chuangye Yan and Haitao Li (2023) Diverse modes of H3K36me3-guided nucleosomal deacetylation by Rpd3S Nature 620(7974):669-675. DOI:10.1038/s41586-023-06349-1
Ziling Liu, Aiwei Wu, Zhen Wu, Talang Wang, Yixuan Pan, Bing Li, Xumin Zhang and Ming Yu (2022) TOX4 facilitates promoter-proximal pausing and C-terminal domain dephosphorylation of RNA polymerase II in human cells Commun Biol 5(1):300. doi: 10.1038/s42003-022-03214-1.
Caiqing Hao, Xianyu Shao, Juan Song , Mengyuan Peng, Yimin Lao, Ryan Mack, Lei Zhang, Wei Wei, Na Liu, Tian Wang, Yuanyuan Wu, Lanyao Feng, Lijun Yin, Shouxin Wang, Xiaojian Sun, Jiwang Zhang*, Bing Li*（2022）SIRT2 regulates proliferation and chemotherapy response of MLL-ENL-driven acute myeloid leukemia。 Biochem. Biophys. Res. Commun.596:36-42. doi: 10.1016/j.bbrc.2022.01.081.
Wen Shao, Xianju Bi, Yixuan Pan, Boyang Gao1, Jun Wu, Yafei Yin, Zhimin Liu, Mengyuan Peng, Wenhao Zhang, Xu Jiang, Wenlin Ren, Yanhui Xu, Zhongyang Wu, Kaili Wang, Ge Zhan,J. Yuyang Lu, Xue Han, Tong Li, Jianlong Wang, Guohong Li, Haiteng Deng, Bing Li*, Xiaohua Shen* (2022) Phase separation of RNA-binding protein promotes polymerase binding and transcription Nature Chemical Biology 18(1):70-80. doi: 10.1038/s41589-021-00904-5. (*co-correspondence)
Jingdong Xue, Wanli Yang, Mengyuan Peng and Bing Li (2021) The TFIID Pivot of Preinitiation Complex SCIENCE CHINA Life Sciences (12):2214-2217 doi: 10.1007/s11427-021-2015-6
Tao Wang, Juan Song, Min Qu, Xu Gao, Wenhui Zhang, Ziwei Wang, Lin Zhao, Yan Wang, Bing Li*, Jing Li* and Jinjian Yang* (2021) Integrative Epigenome Map of the Normal Human Prostate Provides Insights Into Prostate Cancer Predisposition Front. Cell Dev. Biol. 9:723676. doi.org/10.3389/fcell.2021.723676 (*co-correspondence)
Hongye Wang, Yile Huang, Ming Yu, Yang Yu, Sheng Li, Huating Wang, Hao Sun, Bing Li, Guoliang Xu, Ping Hu (2021) Muscle regeneration controlled by a designated DNA dioxygenase Cell Death & Disease 12(6):535
Dian-Jia Liu, Fan Zhang, Yi Chen, Yi Jin, Yuan-Liang Zhang, Shu-Bei Chen, Yin-Yin Xie, Qiu-Hua Huang, Wei-Li Zhao, Lan Wang, Peng-Fei Xu, Zhu Chen, Sai-Juan Chen, Bing Li, Aijun Zhang, Xiao-Jian Sun (2020) setd2 knockout zebrafish is viable and fertile: differential and developmental-stress-related requirements for Setd2 and histone H3K36 trimethylation in different vertebrate animals Cell Discovery 6:72
Xu Zhu*, Bingxue Lan*, Xianfu Yi*, Chaoran He, Lin Dang, Xingquan Zhou, Yumei Lu, Yongzhan Sun, Zhiheng Liu, Xue Bai, Kai Zhang, Bing Li, Mulin Jun Li, Yupeng Chen, Lirong Zhang (2020) HRP2-DPF3a-BAF complex coordinates histone modification and chromatin remodeling to regulate myogenic gene transcription Nucleic Acids Research 48(12):6563-6582
Julia V. DiFiore, Travis S. Ptacek, Yi Wang, Bing Li, Jeremy Simon and Brian D. Strahl (2020) Unique and Shared Roles for Histone H3K36 Methylation States in Transcription Regulation Functions Cell Reports 31(10):107751
Yanhua Du, Jun Lin, Rulin Zhang, Wanli Yang, Heng Quan, Lijuan Zang, Yaqin Han, Bing Li, Hong Sun and Jun Wu (2019) Ubiquitin Specific Peptidase 5 Promotes Ovarian Cancer Cell Proliferation Through Deubiquitinating HDAC2 Aging 11(21):9778-9793
Wei Wang, Jun Xu, Oliver Limbo, Jia Fei, George A. Kassavetis, Jenny Chong, James T. Kadonaga, Paul Russell, Bing Li* and Dong Wang (2019) Molecular basis of chromatin remodeling by Rhp26, a yeast CSB ortholog Proc Natl Acad Sci USA. 116(13):6120-6129. doi: 10.1073/pnas.1818163116. (*co-correspondence)
Jun Wu, Yimin Lao and Bing Li (2019) Nuclear actin switch of the INO80 remodeler J Mol Cell Biol. 2019 May 1;11(5):343-344
Buki Kwon, Palinda Ruvan Munashingha, Yong-Keol Shin, Chul-Hwan Lee, Bing Li and Yeon-Soo Seo (2016) Physical and functional interactions between nucleosomes and Rad27, a critical component of DNA processing during DNA metabolism The FEBS Journal 283(23):4247-4262
Stephen McDaniel, Jennifer Fligor, Chun Ruan, Haochen Cui, Joseph Bridgers, Julia DiFiorea, Angela Gud, Bing Li, and Brian Strahl (2016) Combinatorial histone readout by the dual PHD domains of Rco1 mediates Rpd3S chromatin recruitment and the maintenance of transcriptional fidelity J. Biol. Chem. 291(28):14796-802
Andria Schibler, Evangelia Koutelou, Junya Tomida, Marenda Wilson-Pham, Li Wang, Yue Lu, Alexa Parra Cabrera, Renee J. Chosed, Wenqian Li, Bing Li, Xiaobing Shi, Richard D. Wood, and Sharon Y.R. Dent (2016) Histone H3K4 methylation regulates deactivation of the Spindle Assembly Checkpoint through direct binding of Mad2 Genes& Development 30(10):1187-97
Chun Ruan, Haochen Cui, Chul-Hwan Lee, Sheng Li and Bing Li (2016) Homodimeric PHD-domain containing Rco1 constitutes a critical interaction hub within the Rpd3S histone deacetylase complex J. Biol. Chem. 291(10):5428-38. doi: 10.1074/jbc.M115.703637.
Joshua Mayfield, Shuang Fan, Shuo Wei, Mengmeng Zhang, Bing Li, Andrew Ellington, Felicia Etzkorn, and Yan Jessie Zhang (2015) Chemical Tools To Decipher Regulation of Phosphatases by Proline Isomerization on Eukaryotic RNA Polymerase II ACS Chem Biol. 10(10):2405-14. doi: 10.1021/acschembio.5b00296.
Yi Wang, Yanling Niu and Bing Li (2015) Balancing acts of SRI and an auto-inhibitory domain specify Set2 function at transcribed chromatin Nucleic Acids Research 43(10):4881-92. doi: 10.1093/nar/gkv393. PMCID: PMC4446442
Chun Ruan, Chul-Hwan Lee, Haochen Cui, Sheng Li and Bing Li (2015) Nucleosome contact triggers conformational changes of Rpd3S driving high affinity H3K36me nucleosome engagement Cell Reports 10(2): 204-215. doi: 10.1016/j.celrep.2014.12.027.
Chun Ruan and Bing Li (2014) Reading Histone Modifications Fundamentals of Chromatin, edited by J.L. Workman and S.M. Abmayr
Daniel S. Ginsburg, Timi Elvuchio Anlembom, Jianing Wang, Sanket R. Patel, Bing Li, and Alan G. Hinnebusch (2014) NuA4 links methylation of histone H3 lysines 4 and 36 to acetylation of histones H4 and H3 J. Biol. Chem. 289(47):32656-70 PMCID: PMC4239618
Hong Wen, Yuanyuan Li, Yuanxin Xi, Shiming Jiang, Sabrina Stratton, Danni Peng, Kaori Tanaka, Yongfeng Ren, Zheng Xia, Jun Wu, Bing Li, Michelle Barton, Wei Li, Haitao Li and Xiaobing Shi (2014) ZMYND11 links histone H3.3 K36 trimethylation to transcription elongation and tumor suppression Nature 508(7495):263-8 PMCID: PMC4142212
Chul-Hwan Lee, Jun Wu and Bing Li (2013) Chromatin remodelers fine-tune H3K36me-directed deacetylation of neighbor nucleosomes by Rpd3S. Molecular Cell 52(2):255-63. doi: 10.1016/j.molcel.2013.08.024.
Miyong Yun, Chun Ruan, Jae-Wan Huh and Bing Li (2012) Reconstitution of modified chromatin templates for in vitro functional assays. Methods Mol Biol. 833:237-53.
Jae-Wan Huh, Jun Wu, Chul-Hwan Lee, Miyong Yun, Daniel Gilada, Chad A. Brautigam and Bing Li (2012) Multivalent di-nucleosome recognition enables the Rpd3S histone deacetylase complex to tolerate decreased H3K36 methylation levels. EMBO J. 31(17):3564-74. doi: 10.1038/emboj.2012.221.
Xiao-Fen Chen, Benjamin Kuryan, Tasuku Kitada, Nancy Tran, Jing-Yu Li, Siavash Kurdistani, Michael Grunstein, Bing Li and Michael Carey (2011) The Rpd3 Core Complex Is a Chromatin Stabilization Module Curr Biol. 22(1):56-63
Yuwen Ke, Jae-Wan Huh, Ross Warrington, Bing Li, Nan Wu, Mei Leng, Junmei Zhang, Haydn L Ball, Bing Li and Hongtao Yu (2011) PICH and BLM limit histone association with anaphase centromeric DNA threads and promote their resolution. EMBO J 30(16):3309-21
Miyong Yun, Jun Wu, Jerry Workman and Bing Li (2011) Readers of histone modifications. Cell Research 21:564–578. doi: 10.1038/cr.2011.42.
Ling Cai, Benjamin Sutter, Bing Li and Benjamin P. Tu (2011) Acetyl-CoA Induces Cell Growth and Proliferation by Promoting the Acetylation of Histones at Growth Genes. Molecular Cell 42, 426-437
Chhabi Govind, Hongfang Qiu, Daniel Ginsburg, Chun Ruan, Kimberly Hofmeyer, Cuihua Hu, Venkatesh Swaminathan, Jerry Workman, Bing Li and Alan G. Hinnebusch (2010) Phosphorylated Pol II CTD recruits multiple HDACs, including Rpd3C(S), for methylation-dependent deacetylation of ORF nucleosomes Molecular Cell 39, 234-246
Mihaela Sardiu, Joshua Gilmore, Michael Carrozza, Bing Li, Jerry Workman, Laurence Florens, Michael Washburn (2009) Determining Protein Complex Connectivity Using a Probabilistic Deletion Network Derived from Quantitative Proteomics. PLoS One 4(10):e7310
Raymond Camahort, Manjunatha Shivaraju, Mark Mattingly, Bing Li, Shima Nakanishi, Dongxiao Zhu, Ali Shilatifard, Jerry L. Workman and Jennifer L. Gerton (2009) Cse4 is Part of an Octameric Nucleosome in Budding Yeast. Molecular Cell 35(6):794-805
Bing Li, Jessica Jackson, Matthew D. Simon, Brian Fleharty, Madelaine Gogol, Chris Seidel, Jerry L. Workman and Ali Shilatifard (2009) Histone H3 lysine 36 di-methylation (H3K36me2) is sufficient to recruit the Rpd3S histone deacetylase complex and to repress spurious transcription. J. Biol. Chem. 284(12):7970-6
Chia-Hui Lin, Bing Li, Selene Swanson, Ying Zhang, Laurence Florens, Michael P. Washburn, Susan M. Abmayr and Jerry L. Workman (2008) Heterochromatin Protein 1a stimulates histone H3 lysine 36 demethylation by the Drosophila KDM4A demethylase. Molecular Cell 32(5):696-706
Tuba Sural, Shouyong Peng, Bing Li, Jerry L. Workman, Peter J. Park, Mitzi I. Kuroda (2008) The MSL3 chromodomain directs a key targeting step for dosage compensation of the Drosophila X chromosome Nature Structural & Molecular Biology (12):1318-25
Tamaki Suganuma, Jose L.Gutierrez, Bing Li, Laurence Florens, Selene K. Swanson, Michael P. Washburn, Susan M. Abmayr and Jerry L. Workman (2008) ATAC is a Double Histone Acetyltransferase Complex that Stimulates Nucleosome Sliding Nature Structural & Molecular Biology 15(4):364-72
Erica Larschan, Artyom A. Alekseyenko, Andrey A. Gortchakov, Shouyong Peng, Bing Li, Pok Yang, Jerry L. Workman, Peter J. Park, and Mitzi I. Kuroda (2007) MSL Complex Is Attracted to Genes Marked by H3K36 Trimethylation Using a Sequence-Independent Mechanism Molecular Cell 28(1): 121-133
Bing Li, Michael Carey and Jerry Workman (2007) The role of chromatin during transcription Cell 128(4):707-19. doi: 10.1016/j.cell.2007.01.015.
Raymond Camahort, Bing Li, Laurence Florens, Selene Swanson, Michael Washburn, and Jennifer Gerton (2007) Scm3 is essential to recruit the histone H3 variant Cse4 to centromeres and to maintain a functional kinetochore Molecular Cell 26(6):853-65
Bing Li, Madelaine Gogol, Mike Carey, Samantha Pattenden, Chris Seidel and Jerry Workman (2007) Infrequently transcribed long genes depend on the Set2/Rpd3S pathway for accurate transcription Genes& Development 21(11):1422-30
Bing Li, Madelaine Gogol, Mike Carey, Daeyoup Lee, Chris Seidel and Jerry Workman (2007) Combined action of PHD and Chromo domains directs the Rpd3S HDAC to transcribed chromatin. Science 316, 1050-1054. doi: 10.1126/science.1139004.
Michael Carey, Bing Li, Jerry L. Workman (2006) RSC Exploits Histone Acetylation to Abrogate the Nucleosomal Block to RNA Polymerase II Elongation Molecular Cell 24, 481-487
Wei-Jong Shia, Bing Li, and Jerry L. Workman (2006) SAS-mediated acetylation of histone H4 Lys 16 is required for H2A.Z incorporation at subtelomeric regions in Saccharomyces cerevisiae Genes &Development 20: 2507-2512
Jingji Jin, Yong Cai, Bing Li, Ronald C. Conaway, Jerry L. Workman, Joan W.Conaway and Thomas Kusch (2005) In and out: histone variant exchange in chromatin. Trends in Biochem Sci. 30(12): 680-687
Bing Li, Chun Ruan and Jerry Workman (2005) Histones: should I stay or should I go? Genome Biology 6:306
Bing Li, Samantha Pattenden, Daeyoup Lee, José Gutiérrez, Jie Chen, Chris Seidel, Jennifer Gerton and Jerry Workman (2005) Preferential occupancy of histone variant H2AZ at inactive promoters influence local histone modifications and chromatin remodeling Proc. Natl. Acad. Sci. USA 102(51): 18385-18390. doi: 10.1073/pnas.0507975102.
Michael. Carrozza, Bing Li, Laurence Florens, Tamaki Suganuma, Selene Swanson, Kenneth Lee,Wei-Jong Shia, Scott Anderson, John Yates, Michael Washburn and Jerry Workman (2005) Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription Cell 123(4):581-92. doi: 10.1016/j.cell.2005.10.023.
Daeyoup Lee, Elena Ezhkova, Bing Li, Samantha Pattenden, William Tansey, Jerry Workman (2005) The Proteasome Regulatory Particle Alters the SAGA Coactivator to Enhance Its Interactions with Transcriptional Activators. Cell 123(3):423-36.
Yong Cai, Jing Jin, Laurence Florens, Selene Swanson, Thomas Kusch, Bing Li, Jerry Workman, Michael Washburn, Ronald Conaway, and Joan Conaway (2005) The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes. J Biol. Chem 280(14):13665-70
Philippe Prochasson, Kristen E. Neely, Ahmed H. Hassan, Bing Li and Jerry L. Workman (2003) Targeting activity is required for SWI/SNF function in vivo and is accomplished through two partially redundant activator interaction domains Molecular Cell 12(4):983-990
Bing Li, LeAnn Howe, Scott Anderson, John Yates III and Jerry Workman (2003) The Set2 histone methyltransferase functions through the phosphorylated carboxyl-terminal domain of RNA polymerase II J Biol. Chem. 278(11):8897-8903
Vishva M. Sharma, Bing Li, and Joseph Reese (2003) SWI/SNF dependent chromatin remodeling of RNR3 requires TAFIIs and the general transcription machinery Genes Dev. 17: 502-515
Bing Li and Joseph Reese (2001) Ssn6-Tup1 Regulates RNR3 by Positioning Nucleosomes and Affecting the Chromatin Structure at the Upstream Repression Sequence. J. Biol. Chem. 276(36): 33788-97.
Bing Li and Joseph Reese (2000) Derepression of DNA Damage-Regulated Genes Requires Yeast TBP-Associated Factors EMBO J. 19(15):4091-100. doi:10.1093/emboj/19.15.4091.
Bing Li, Cheng Gu and Jindong Zhao (1998) Molecular cloning and expression of pfu DNA polymerase, and its application in long-distance PCR Chinese Science Bulletin 43(10):863-867
团队介绍
伍均，博士，副研究员，邮箱：伍均<jun.wu@@shsmu.edu.cn>
劳一敏，博士，助理研究员，邮箱：劳一敏<laoyi-ming@@hotmail.com>
彭梦媛，硕士，助理实验师，邮箱：彭梦媛<mengyuan@@shsmu.edu.cn>
Aleksandra Ochirova，博士后，邮箱：Aleksandra Ochirova <aleksandra_ochirova@@outlook.com>
薛敬冬，博士后，邮箱：薛敬冬<xuejingdong02@@outlook.com>
潘奕萱，博士后，邮箱：潘奕萱<penny-pan0609@@outlook.com>
张琪，博士在读，邮箱：张琪<zhangq0319@@outlook.com>
胡铭倩，博士在读，邮箱：胡铭倩< Humq1999@@outlook.com>
刘梅洋，博士在读，邮箱：刘梅洋< liumeiyang0@@outlook.com>
冯宇千，硕士在读，邮箱：冯宇<qiange666@@@sjtu.edu.cn>
唐栉超，硕士在读，邮箱：唐栉超<tangzc212@@163.com>
曾浩墉，本科在读，邮箱：曾浩墉<troodonformosus@@sjtu.edu.cn>
龚薇，专科，科研助理，邮箱：龚薇< yf0274@@shsmu.edu.cn>
