李乾，博士，Qian Li，Ph.D.

嗅觉系统发育及相关疾病研究组

Laboratory Of Olfactory Physiology and Pathology (LOOP)

Shanghai Jiao Tong University School of Medicine

电话（Tel）：63846590-776985

邮箱（Email）：liqian@shsmu.edu.cn

李乾研究员，博士生导师。2004年本科毕业于中国科学技术大学，2009年博士毕业于中国科学院生物化学与细胞生物学研究所，2010-2016年在美国哈佛大学从事博士后工作，并于2016年加入上海交通大学医学院基础医学院，担任“嗅觉系统发育及相关疾病”研究员组组长。主要工作以通讯或第一作者（包含共同）发表于Nature、Cell、Nature Communications、Molecular Biology and Evolution、Molecular Systems Biology、Current Biology、PNAS、eLife和Cell Reports等国际期刊。

一、在研

1. 国家自然科学基金面上项目，批准号：32371042，《Tbr1调控特异嗅觉神经元亚群发育的机制研究》，2024/01-2027/12，在研，50万元，主持。

2. 上海市科委科技创新行动计划原创探索项目，批准号：23ZR1480000，《特异嗅觉神经元亚群的发育机制研究》，2023/04-2026/03，50万元，在研，主持。

3. 国家自然科学基金优秀青年项目，批准号：32122038，《嗅觉神经元亚群命运决定》，2022/01-2024/12，200万元，在研，主持。

4. 国家自然科学基金面上项目，批准号：31970933，《ATF5调控嗅觉受体基因选择的分子机制研究》，2020/01-2023/12，58万元，在研，主持。

5. 科技部科技创新2030—“脑科学与类脑研究”重大项目2021年度项目，批准号：2021ZD203100，《感知觉与情绪相互作用的神经环路机制》，2021/12-2026/11，3500万元，在研，子课题负责人。

6. 上海市科委科技创新行动计划基础研究领域项目，批准号：21JC1404500，《嗅觉干细胞分化成嗅觉神经元亚群的机制研究》，2021/10-2024/09，100万元，在研，主持。

7. 上海市教委/教育发展基金会“曙光计划”，批准号：21SG16，2022/01-2024/12，15万元，在研，主持。

8. 上海交通大学医学院高峰高原计划启动经费，200万元，在研，主持。

二、结题

1. 国家自然科学基金面上项目，批准号：31771154，《痕量胺相关受体新型嗅觉子系统的功能和发育机制》，2018/01-2021/12，63万元，结题，主持。

2. 上海市高层次人才，批准号：QD2018017，2019/01-2021/12，60万元，结题，主持。

3. 上海市科委基础研究重点项目，批准号：18JC1420302，《感知认知神经网络的功能及其障碍机制》，2018/12-2021/11，938万元，结题，研究骨干。

4. 上海市浦江人才计划A类，批准号：17PJ1405400，《痕量胺相关受体嗅觉神经元发育的分子机制》，2017/07-2019/06，20万元，结题，主持。

5. 上海交通大学新进青年教师启动计划，20万元，结题，主持。

代表性论文：（^#co-first author, *corresponding/co-corresponding author）

（一） 通讯/共同通讯作者

1. Shang, Pan^#; Rong, Naikang^#; Jiang, Jing-Jing^#; Cheng, Jie^#; Zhang, Ming-Hui^#; Kang, Dongwei^#; Qi, Lei^#; Guo, Lulu; Yang, Gong-Ming; Liu, Qun; Zhou, Zhenzhen; Li, Xiao-Bing; Zhu, Kong-Kai; Meng, Qing-Biao; Han, Xiang; Yan, Wenqi; Kong, Yalei; Yang, Lejin; Wang, Xiaohui; Lei, Dapeng; Feng, Xin; Liu, Xinyong; Yu, Xiao; Wang, Yue*; Li, Qian*; Shao, Zhen-Hua*; Yang, Fan*; Sun, Jin-Peng*. “Structural and signaling mechanisms of TAAR1 enabled preferential agonist design”. Cell, 2023, 186(24):5347-5362.e24.

2. Guo, Lulu^#; Cheng, Jie^#; Lian, Shuo^#; Liu, Qun^#; Lu, Yan^#; Zheng, Yuan^#; Zhu, Kongkai^#; Zhang, Minghui;Kong, Yalei; Zhang, Chao; Rong, Naikang; Zhuang, Yuming; Fang, Guoxing; Jiang, Jingjing; Zhang, Tianyao;Han, Xiang; Liu, Zili; Xia, Ming; Liu, Shangming; Zhang, Lei; Liberles, Stephen D; Yu, Xiao; Xu, Yunfei*; Yang, Fan*; Li, Qian*; Sun, Jin-Peng*. “Structural basis of amine odorant perception by a mammal olfactory receptor”. Nature, 2023, 618(7963):193.

3. Guo, Lingna^#; Dai, Wenxuan^#; Xu, Zhengrong^#; Liang, Qiaoyi; Miller, Eliot T; Li, Shengju; Gao, Xia; Baldwin, Maude W; Chai, Renjie*; Li, Qian*. “Evolution of brain-expressed biogenic amine receptors into olfactory trace amine-associated receptors”. Molecular Biology and Evolution, 2022, 39(3):msac006.

4. Zhou, Haiqian^#; Zhuang, Liujing^#; Bao, Hongqiang^#; Li, Shengju; Dai, Fengyan; Wang, Ping; Li, Qian*; Yin, Dongmin*. “Olfactory regulation by dopamine and DRD2 receptor in the nose”. PNAS, 2022, 119(11):e2118570119.

5. Song, Chunxue; Zeng, Xianting; Zeng, Wanxin; Liu, Rong; Tong, Xiajing*; Li, Qian*. “A WDR47 homolog facilitates ciliogenesis by modulating intraflagellar transport”. Journal of Cell Science, 2022, 135(24):jcs260303.

6. Zhang, Qianwen^#; Ding, Yu^#; Feng, Biyun; Tang, Yijun; Chen, Yao; Wang, Yirou; Chang, Guoying; Liu, Shijian; Wang, Jian; Li, Qian*; Fu, Lijun*; Wang, Xiumin*. “Molecular and phenotypic expansion of Alström syndrome in Chinese patients”. Frontiers in Genetics, 2022, 13:808919.

7. Xu, ZhengRong^#; Guo, LingNa^#; Qian, XiaoYun^#; Yu, ChenJie^#; Li, ShengJu; Zhu, ChengWen; Ma, XiaoFeng; Li, Hui; Zhu, GuangJie; Zhou, Han; Dai, WenXuan*; Li, Qian*; Gao, Xia*. “Two entry tunnels in mouse TAAR9 suggest the possibility of multi-entry tunnels in olfactory receptors”. Scientific Reports, 2022, 12(1):2691.

8. Fei, Aimei^#; Wu, Wanqing^#; Tan, Longzhi^#; Tang, Cheng^#; Xu, Zhengrong; Huo, Xiaona; Bao, Hongqiang; Johnson, Mark; Hartmann, Griffin; Talay, Mustafa; Yang, Cheng; Riegler, Clemens; Joseph, Kristian; Engert, Florian; Xie, X Sunney; Barnea, Gilad; Liberles, Stephen D; Yang, Hui; Li, Qian*. “Coordination of two enhancers drives expression of olfactory trace amine-associated receptors”. Nature Communications, 2021, 12(1): 3798.

9. Qian, Kang-Ying; Zeng, Wan-Xin; Hao, Yue; Zeng, Xian-Ting; Liu, Haowen; Li, Lei; Chen, Lili; Tian, Fu-Min; Chang, Cindy; Hall, Qi; Song, Chun-Xue; Gao, Shangbang; Hu, Zhi-Tao; Kaplan, Josh M; Li, Qian*; Tong, Xia-Jing*. “Male pheromones modulate synaptic transmission at the C. elegans neuromuscular junction in a sexually dimorphic manner”. eLife, 2021, 10: e67170.

10. Jia, Liang^#; Li, Shengju^#; Dai, Wenxuan; Guo, Lingna; Xu, Zhengrong; Scott, Anne M; Zhang, Zhe; Ren, Jianfeng; Zhang, Qinghua; Dexheimer, Thomas S; Chung-Davidson, Yu-Wen; Neubig, Richard R*; Li, Qian*; Li, Weiming*. “Convergent olfactory trace amine-associated receptors detect biogenic polyamines with distinct motifs via a conserved binding site”. Journal of Biological Chemistry, 2021, 297(5): 101268.

11. Gan, Linhua^#; Sun, Jingjing^#; Yang, Shuo; Zhang, Xiaocui; Chen, Wu; Sun, Yiyu; Wu, Xiaohua; Cheng, Cheng; Yuan, Jing; Li, Anan; Corbett, Mark A.; Dixon, Mathew P.; Thomas, Tim; Voss, Anne K.; Gecz, Jozef; Wang, Guang-Zhong; Bonni, Azad; Li, Qian*; Huang, Ju*. “Chromatin-binding protein PHF6 regulates activity-dependent transcriptional networks to promote hunger response”. Cell Reports, 2020, 30(11): 3717-3728.e6.

12. Xu, Zhengrong; Li, Qian*. “TAAR agonists”. Cellular and Molecular Neurobiology, 2020, 40(2): 257-272.

（二） 第一/共同第一作者

1. Tan, Longzhi^#; Li, Qian^#; Xie, X Sunney*. “Olfactory sensory neurons transiently express multiple olfactory receptors during development”. Molecular Systems Biology, 2015, 11(12): 844. (Highlighted in Nature Chemical Biology)

2. Li, Qian; Tachie, Baffour Yaw; Liu, Zhikai; Baldwin, Maude W; Kruse, Andrew C; Liberles, Stephen D*. “Non-classical amine recognition evolved in a large clade of olfactory receptors”. eLife, 2015, 4: e10441.

3. Li, Qian; Liberles, Stephen D*. “Aversion and attraction through olfaction”. Current Biology, 2015, 25(3): 120-129.

4. Li, Qian; Korzan, Wayne J; Ferrero, David M; Chang, Rui B; Roy, Dheeraj S; Buchi, Melanie; Lemon, Jamie K; Kaur, Angeldeep W; Stowers, Lisa; Fendt, Markus; Liberles, Stephen D*. “Synchronous evolution of an odor biosynthesis pathway and behavioral response”. Current Biology, 2013, 23(1): 11-20. (Commented in Current Biology)

5. Li, Qian; Su, Yuan Yuan; Wang, Hao; Li, Lei; Wang, Qiong; Bao, Lan*. “Transmembrane segments prevent surface expression of sodium channel Na(v)1.8 and promote calnexin-dependent channel degradation”. Journal of Biological Chemistry, 2010, 285(43): 32977-32987.

6. Zhang, Zhen Ning^#; Li, Qian^#; Liu, Chao; Wang, Hai Bo; Wang, Qiong; Bao, Lan*. “The voltage-gated Na(+) channel Na(v)1.8 contains an ER-retention/retrieval signal antagonized by the beta 3 subunit”. Journal of Cell Science, 2008, 121(19): 3243-3252.

（三） 专著

1. Li, Qian; Liberles, Stephen D*. “Odor sensing by trace amine-associated receptors”. Book Chemosensory transduction: the detection of odors, tastes, and other chemostimuli, Chapter 4, 2016.

2. Li, Qian*. “Deorphanization of olfactory trace amine-associated receptors”. Book Olfactory receptors: methods and protocols, Chapter 2, 2018.