师资队伍
李斌
  作者:  2018-12-31

基本信息 >>>

                                                                                                                                                                                                                 

 李斌

 分子免疫学研究组

 电话:63846590-776783 

 邮箱:binli@shsmu.edu.cn

研究方向>>>

免疫调节、FOXP3+Treg、肿瘤免疫、自身免疫、移植免疫、抗感染免疫及免疫代谢与疾病

个人简历 >>>

李斌,二级研究员,教授,博士生导师

分子与免疫学课题组课题组长

上海市免疫学研究所副所长

上海交通大学特聘教授

国家基金委免疫学杰青

上海市领军人才

上海市优秀学科带头人


1992.9-1996.7 安徽师范大学,学士

1996.9-2001.7 北京大学,博士

2001.9-2006.7 宾夕法尼亚大学医学院,博士后

2002.10-2003.7 牛津大学,访问学者

2006.7-2009.2 宾夕法尼亚大学医学院,高级研究助理

2009.2-2016.9 中国科学院上海巴斯德研究所,研究员、博士生导师,课题组长

2016.9-至今 上海交通大学医学院上海免疫学研究所,资深研究员、余㵑学者、特聘教授,科研副所长,分子免疫学课题组组长

科研项目 >>>

1. 国家自然科学基金重点目,32130041,“系统性鉴定脂肪组织调节性T细胞亚型及其生理功能”,20221-202612月,291万元,项目主持

2. 科技部重点研发专项2019YFA0906102,“抵抗Treg 抑制的工程性CAR-T 细胞构建及功能研究”,20201-202412月,217万元,课题负责

3. 国家自然科学基金中波国际合作项目,31961133011“Th17/Treg免疫平衡调控抗肿瘤免疫疾病的新策略研究20197-20226月,140万元,项目主持

4. 国家自然科学基金重点项目,81810051“Th17/Treg免疫平衡调控自身免疫疾病的新策略研究20191-202212月,294万,项目负责人

5. 国家自然科学基金杰出青年31525008分子免疫学20161-202012月,400万元,项目主持

6. 国家自然科学基金重点项目,81330072炎症因子对FOXP3+调节性T细胞分化与功能的动态影响及其机理研究20141-201812月,290万元,项目主持

7. 国家自然科学基金面上项目,31370863“FOXP3蛋白泛素化与去泛素化修饰调控Treg细胞功能的机理研究20141-201712月,80万元,项目主持

8. 国家自然科学基金面上项目,31170825转录因子IRF4蛋白甲基化修饰及其转录调节功能的分子机理研究20121-201512月,65万元,项目主持

9. 国家自然科学基金面上项目,30972702调节性T细胞中FOXP3蛋白修饰及转录复合体动态组装的机理研究200910-201210月,32万元,项目主持

10.国家重点基础研究计划(973计划),2014CB54180320141-201812月,260万元,课题负责人

论文与专著 >>>

1Liu Q, Zhu F, Liu X, Lu Y, Yao K, Tian N, Tong L, Figge DA, Wang X, Han Y, Li Y, Zhu Y, Hu L, Ji Y, Xu N, Li D, Gu X, Liang R, Gan G, Wu L, Zhang P, Xu T, Hu H, Hu Z, Xu H, Ye D, Yang H, Li B, Tong X. Non-oxidative pentose phosphate pathway controls regulatory T cell function by integrating metabolism and epigenetics. Nat Metab. 2022 May 23. doi: 10.1038/s42255-022-00575-z.

2Li Y, Lu Y, Lin SH, Li N, Han Y, Huang Q, Zhao Y, Xie F, Guo Y, Deng B, Tsun A, Du J, Li D, Sun J, Shi G, Zheng F, Su X, Duan S, Zheng SG, Wang G, Tong X, Li B. Insulin signaling establishes a developmental trajectory of adipose regulatory T cells. Nat Immunol. 2021 Sep;22(9):1175-1185.

3Lu Y, Li Y, Liu Q, Tian N, Du P, Zhu F, Han Y, Liu X, Liu X, Peng X, Wang X, Wu Y, Tong L, Li Y, Zhu Y, Wu L, Zhang P, Xu Y, Chen H, Li B, Tong X. MondoA-Thioredoxin-Interacting Protein Axis Maintains Regulatory T-Cell Identity and Function in Colorectal Cancer Microenvironment. Gastroenterology. 2021 Aug;161(2):575-591.e16.

4Cheng H, Wang L, Yang B, Li D, Wang X, Liu X, Tian N, Huang Q, Feng R, Wang Z, Liang R, Dai SM, Lv L, Wu J, Zang YS, Li B. Cutting Edge: Inhibition of Glycogen Synthase Kinase 3 Activity Induces the Generation and Enhanced Suppressive Function of Human IL-10+ FOXP3+-Induced Regulatory T Cells. J Immunol. 2020 Sep 15;205(6):1497-1502.

5Yang J, Wei P, Barbi J, Huang Q, Yang E, Bai Y, Nie J, Gao Y, Tao J, Lu Y, Xie C, Hou X, Ren J, Wu X, Meng J, Zhang Y, Fu J, Kou W, Gao Y, Chen Z, Liang R, Tsun A, Li D, Guo W, Zhang S, Zheng SG, Niu J, Galardy P, Tong X, Shi G, Li H, Pan F, Li B. The deubiquitinase USP44 promotes Treg function during inflammation by preventing FOXP3 degradation. EMBO Rep. 2020 Sep 3;21(9):e50308.

6Yi G, Zhao Y, Xie F, Zhu F, Wan Z, Wang J, Wang X, Gao X, Cao L, Li X, Chen C, Kuang Y, Qiu X, Yang H, Wang J, Su B, Chen L, Zhang W, Hou Y, Xu X, He Y, Tsun A, Liu X, Li B, Single-cell RNA-seq unveils critical regulators of human FOXP3+ regulatory T cell stability. Science Bulletin, 2020, 65(13):1114-1124.

7Yi G, Guo S, Liu W, Wang H, Liu R, Tsun A, Jin G, Li B. Identification and functional analysis of heterogeneous FOXP3+ Treg cell subpopulations in human pancreatic ductal adenocarcinoma. Science Bulletin, 2018,63(15):972-981.

8Fang, S. Huang, Y. Wang, N. Zhang, S. Zhong, S. Li, Y. Sun, J. Liu, X. Wang, Y. Gu, P. Li, B. Zhou, H. Fan, X. Insights into Local Orbital Immunity: Evidence for the Involvement of the Th17 Cell Pathway in Thyroid-Associated Ophthalmopathy. J Clin Endocrinol Metab., 2018, doi: 10.1210.

9Fang S, Huang Y, Zhong S, Li Y, Zhang Y, Li Y, Sun J, Liu X, Wang Y, Zhang S, Xu T, Sun X, Gu P, Li D, Zhou H, Li B, Fan X. Regulation of Orbital Fibrosis and Adipogenesis by Pathogenic Th17 Cells in Graves Orbitopathy. J Clin Endocrinol Metab., 2017,102(11):4273-4283.

10Fang S, Huang Y, Wang S, Zhang Y, Luo X, Liu L, Zhong S, Liu X, Li D, Liang R, Miranda P, Gu P, Zhou H, Fan X, Li B. IL-17A exacerbates fibrosis by promoting the proinflammatory and profibrotic function of orbital fibroblasts in TAO. J Clin Endocrinol Metab., 2016,101(8):2955-65.

11Shan J, Zhao B, Shan Z, Nie J, Deng R, Xiong R, Tsun A, Pan W, Zhao H, Chen L, Jin Y, Qian Z, Lui K, Liang R, Li D, Sun B, Lavillette D, Xu K, Li B. Histone demethylase LSD1 restricts influenza A virus infection by erasing IFITM3-K88 monomethylation. PLoS Pathog., 2017,13(12):e1006773.

12Shan Z, Han Q, Nie J, Cao X, Chen Z, Yin S, Gao Y, Lin F, Zhou X, Xu K, Fan H, Qian Z, Sun B, Zhong J, Li B, Tsun A. Negative regulation of interferon-induced transmembrane protein 3 by SET7-mediated lysine monomethylation. J Biol Chem., 2013,288(49):35093-103.

13Luo X, Nie J, Wang S, Chen Z, Chen W, Li D, Hu H, Li B. Poly(ADP-ribosyl)ation of FOXP3 Protein Mediated by PARP-1 Protein Regulates the Function of Regulatory T Cells. J Biol Chem., 2016,291(3):1201.

14Li Y, Lu Y, Wang S, Han Z, Zhu F, Ni Y, Liang R, Zhang Y, Leng Q, Wei G, Shi G, Zhu R, Li D, Wang H, Zheng SG, Xu H, Tsun A, Li B. USP21 prevents the generation of T-helper-1-like Treg cells. Nat Commun., 2016,7: 13559.

15Gao Y, Tang J, Chen W, Li Q, Nie J, Lin F, Wu Q, Chen Z, Gao Z, Fan H, Tsun A, Shen J, Chen G, Liu Z, Lou Z, Olsen NJ, Zheng SG, Li B. Inflammation negatively regulates FOXP3 and regulatory T-cell function via DBC1. Proc Natl Acad Sci U S A., 2015,112(25): E3246-54.

16Yang J, Xu P, Han L, Guo Z, Wang X, Chen Z, Nie J, Yin S, Piccioni M, Tsun A, Lv L, Ge S, Li B. Cutting edge: Ubiquitin-specific protease 4 promotes Th17 cell function under inflammation by deubiquitinating and stabilizing RORγt. J Immunol. 2015 May 1;194(9):4094-7.

17Wang X, Yang J, Han L, Zhao K, Wu Q, Bao L, Li Z, Lv L, Li B. TRAF5-mediated Lys-63-linked Polyubiquitination Plays an Essential Role in Positive Regulation of RORγt in Promoting IL-17A Expression. J Biol Chem., 2015,290(48):29086-94.

18Li Z, Lin F, Zhuo C, Deng G, Chen Z, Yin S, Gao Z, Piccioni M, Tsun A, Cai S, Zheng SG, Zhang Y, Li B. PIM1 kinase phosphorylates the human transcription factor FOXP3 at serine 422 to negatively regulate its activity under inflammation. J Biol Chem., 2014,289(39):26872-81.

19Han L, Yang J, Wang X, Wu Q, Yin S, Li Z, Zhang J, Xing Y, Chen Z, Tsun A, Li D, Piccioni M, Zhang Y, Guo Q, Jiang L, Bao L, Lv L, Li B. The E3 deubiquitinase USP17 is a positive regulator of retinoic acid-related orphan nuclear receptor γt (RORγt) in Th17 cells. J Biol Chem., 2014,289(37):25546-55.

20Li Y, Tsun A, Gao Z, Han Z, Gao Y, Li Z, Lin F, Wang Y, Wei G, Yao Z, Li B. 60-kDa Tat-interactive protein (TIP60) positively regulates Th-inducing POK (ThPOK)-mediated repression of eomesodermin in human CD4+ T cells. J Biol Chem. 2013 May 31;288(22):15537-46.

21Zhang J, Chen C, Hou X, Gao Y, Lin F, Yang J, Gao Z, Pan L, Tao L, Wen C, Yao Z, Tsun A, Shi G, Li B. Identification of the E3 deubiquitinase ubiquitin-specific peptidase 21 (USP21) as a positive regulator of the transcription factor GATA3. J Biol Chem. 2013 Mar 29;288(13):9373-82.

22Chen Z, Barbi J, Bu S, Yang HY, Li Z, Gao Y, Jinasena D, Fu J, Lin F, Chen C, Zhang J, Yu N, Li X, Shan Z, Nie J, Gao Z, Tian H, Li Y, Yao Z, Zheng Y, Park BV, Pan Z, Zhang J, Dang E, Li Z, Wang H, Luo W, Li L, Semenza GL, Zheng SG, Loser K, Tsun A, Greene MI, Pardoll DM, Pan F, Li B. The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3. Immunity, 2013,39(2):272-85.

荣誉与奖励 >>>

2018 上海医学科技奖二等奖

2018 国家科学技术进步二等奖

2016 上海医学科技奖二等奖

2015 中科院优秀研究生指导教师奖

2012 中华医学科技奖二等奖