1．蛋白质修饰调控肿瘤发生发展

2．蛋白质修饰调控miRNA的生物合成与作用效率

3．RNA降解机制

4．蛋白质修饰调控RNA修饰及其功能

余健秀, 男，博士，现任上海交通大学医学院PI、特聘教授、博士生导师、生物化学与分子细胞学系科研副主任。

1990年-华南农业大学学士

1996年-中山大学理学硕士

2000年-中山大学理学博士

2000年-2002年中山大学生命科学学院副教授

2002年-2007年美国Sanford-Burnham Medical Research Institute/UCSD博士后

2007年-2008年美国Sanford-Burnham Medical Research Institute/UCSD, Staff Scientist

2008年-2009年美国纽约大学Langone Medical Center研究助理教授

2009年-至今上海交通大学医学院PI、研究员

2016年-至今上海交通大学医学院特聘教授

2018年-至今生物化学与分子细胞学系科研副主任

2018年-至今担任中国抗癌协会肿瘤标志专业委员会“非编码与肿瘤研究”专家委员会副组长

2018年-至今中国细胞生物学医学细胞生物学分会常委

1． 国家自然科学基金重点项目， AT2细胞Fbxo45缺失影响组蛋白水平和染色质稳定性导致肺腺癌发生，#82230100，主持人, 2023.01~2027.12。

2． 国家自然科学基金面上项目，应激压力下PABPC1类泛素化调控应激颗粒形成及基因表达，#32271310，主持人，2023.01~2026.12。

3． 国家重点研发计划政府间国际科技创新合作项目，恶性肿瘤发生发展中关键表观遗传与转录调控因子的蛋白质修饰及其功能，#2019YFE0110600，主持人，2020.12~2023.11。

4． 国家自然科学基金重点项目，PTEN在DNA损伤修复中介导组蛋白H2A/H3修饰调控前列腺癌发生发展， #81630075，主持人，2017.01~2021.12。

5． 国家自然科学基金面上项目，Ago2乙酰化在miRNA途径中的功能与机制，#31671345，主持人，2017.01~2020.12。

6． 国家自然基金面上项目， Shp2类泛素（SUMO）化修饰促进ERK信号通路激活而加速肝癌发生发展，# 81472571，主持人，2015.01~2018.12。

1. Fang J, Zhang Y, Huang C, Lu R, Yu J, Chen R, Wang Y, Zhao X, Yu J*, Huang J*. Glucose-mediated N-glycosylation of RPTPα affects its subcellular localization and Src activation. Oncogene. 2023 Feb 10. doi: 10.1038/s41388-023-02622-9. Online ahead of print. PMID: 36765146.

2. Guo Y, He J, Zhang H, Chen R, Li L, Liu X, Huang C, Qiang Z, Zhou Z, Wang Y, Huang J, Zhao X, Zheng J, Chen GQ, Yu J*. Linear ubiquitination of PTEN impairs its function to promote prostate cancer progression. Oncogene. 2022 Oct;41(44):4877-4892.

3. Zhang H, Zhao X, Guo Y, Chen R, He J, Li L, Qiang Z, Yang Q, Liu X, Huang C, Lu R, Fang J, Cao Y, Huang J, Wang Y, Huang J, Chen GQ*, Cheng J*, Yu J*. Hypoxia regulates overall mRNA homeostasis by inducing Met1-linked linear ubiquitination of AGO2 in cancer cells. Nat Commun. 2021 Sep 13;12(1):5416.

4. Wang Y, Yu Y, Pang Y, Yu H, Zhang W, Zhao X, Yu J*. The distinct roles of zinc finger CCHC-type (ZCCHC) superfamily proteins in the regulation of RNA metabolism. RNA Biol. 2021 Dec;18(12):2107-2126.

5. Wang Y, Yu J*. Dissecting multiple roles of SUMOylation in prostate cancer. Cancer Lett. 2021 Aug 28;521:88-97.

6. Hou G, Zhao X, Li L, Yang Q, Liu X, Huang C, Lu R, Chen R, Wang Y, Jiang B*, Yu J*. SUMOylation of YTHDF2 promotes mRNA degradation and cancer progression by increasing its binding affinity with m6A-modified mRNAs. Nucleic Acids Res. 2021 Mar 18;49(5):2859-2877.

7. Deng R, Guo Y, Li L, He J, Qiang Z, Zhang H, Chen R, Wang Y, Zhao X*, Yu J*. BAP1 suppresses prostate cancer progression by deubiquitinating and stabilizing PTEN.  Mol Oncol. 2021 Jan;15(1):279-298.

8. Zhao X, Wang Y, He J, Deng R, Huang X, Guo Y, Li L, Xie R*, Yu J*. LncRNA UCA1 maintains the low-tumorigenic and nonmetastatic status by stabilizing E-cadherin in primary prostate cancer cells. Mol Carcinog. 2020 Oct;59(10):1174-1187.

9. Dou J, Zhang H, Chen R, Shu Z, Yuan H, Zhao X, Wang Y, Huang J, Zhou A*, Yu J*.  SUMOylation modulates the LIN28A-let-7 signaling pathway in response to cellular stresses in cancer cells. Mol Oncol. 2020 Sep;14(9):2288-2312.

10. Lin R, Zhan M, Yang L, Wang H, Shen H, Huang S, Huang X, Xu S, Zhang Z, Li W, Liu Q, Shi Y, Chen W, Yu J*, Wang J*. Deoxycholic acid modulates the progression of gallbladder cancer through N6-methyladenosine-dependent microRNA maturation. Oncogene. 2020 Jun; 39(26):4983-5000.

11. Liu T, Zhang H, Fang J, Yang Z, Chen R, Wang Y, Zhao X, Ge S, Yu J*, Huang J*. AGO2 phosphorylation by c-Src kinase promotes tumorigenesis. Neoplasia. 2020 Mar;22(3):129-141.

12. Cui N, Liu T, Guo Y, Dou J, Yang Q, Zhang H, Chen R, Wang Y, Zhao X, Yu J*, Huang J*. SUMOylation of Csk Negatively Modulates its Tumor Suppressor Function. Neoplasia. 2019 May 21; 21(7):676-688.

13. Zhang H, Wang Y, Dou J, Guo Y, He J, Li L, Liu X, Chen R, Deng R, Huang J, Xie R, Zhao X*, Yu J*. Acetylation of AGO2 promotes cancer progression by increasing oncogenic miR-19b biogenesis. Oncogene. 2019 Feb; 38(9):1410-1431.

14. Du Y, Hou G, Zhang H, Dou J, He J, Guo Y, Li L, Chen R, Wang Y, Deng R, Huang J, Jiang B, Xu M, Cheng J, Chen GQ, Zhao X*, Yu J*.SUMOylation of the m⁶A-RNA methyltransferase METTL3 modulates its function. Nucleic Acids Res. 2018, 46(10) 5195-5208.

15. Yuan H, Deng R, Zhao X, Chen R, Hou G, Zhang H, Wang Y, Xu M, Jiang B*, Yu J*. SUMO1 modification of KHSRP regulates tumorigenesis by preventing the TL-G-Rich miRNA biogenesis. Mol Cancer. 2017 Oct 11; 16(1):157.

16. Wang J, Deng R, Cui N, Zhang H, Liu T, Dou J, Zhao X, Chen R, Wang Y, Yu J*, Huang J*. Src SUMOylation Inhibits Tumor Growth Via Decreasing FAK Y925 Phosphorylation. Neoplasia. 2017 Oct 22; 19(12):961-971.

17. Jiang H, Deng R, Yang X, Shang J, Lu S, Zhao Y, Song K, Liu X, Zhang Q, Chen Y, Chinn YE, Wu G, Li J, Chen G, Yu J*, Zhang J*. Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.Nature Chem Biol. 2017, 13(9):994-1001.

18. Zhao X, Deng R, Wang Y, Zhang H, Dou J, Li L, Du Y, Chen R, Cheng J, Yu J*. Twist1/Dnmt3a and miR186 establish a regulatory circuit that controls inflammation-associated prostate cancer progression. Oncogenesis. 2017, 6(4): e315.

19. Zhu C, Chen C, Chen R, Deng R, Zhao X, Zhang H, Duo J, Chen Q, Jin H, Wang Y, Huang J, Xu M*, Yu J*. K259-SUMOylation of DGCR8 promoted by p14ARF exerts a tumor-suppressive function. J Mol Cell Biol. 2016 Oct 07, 8(5):456-458.

20. Chen C, Zhu C, Huang J, Zhao X, Deng R, Zhang H, Dou J, Chen Q, Xu M, Yuan H, Wang Y, Yu J*. SUMOylation of TARBP2 regulates miRNA/siRNA efficiency.Nature Communications. 2015, 6:8899.

21. Lu S, Deng R, Jiang H, Song H, Li S, Shen Q, Huang W, Nussinov R, Yu J*, Zhang J*. The Mechanism of ATP-Dependent Allosteric Protection of Akt Kinase Phosphorylation.Structure. 2015, 23(9):1725-34.

22. Zhu C, Chen C, Huang J, Zhang H, Zhao X, Deng R, Dou J, Jin H, Chen R, Xu M, Chen Q, Wang Y, Yu J*. SUMOylation at K707 of DGCR8 controls direct function of primary microRNA.Nucleic Acids Res. 2015, 43(16):7945-60.

23. Chen Q, Zhao X, Zhang H, Yuan H, Zhu M, Sun Q, Lai X, Wang Y, Huang J, Yan J, Yu J*. MiR-130b suppresses prostate cancer metastasis through down-regulation of MMP2. Mol Carcinogen. 2015, 54(11):1292-300.

24. Lai  X, Chen Q, Zhu C, Deng R, Zhao X, Chen C, Wang Y, Yu J*, Huang J*. Regulation of RPTPα-c-Src signalling pathway by miR-218.FEBS J. 2015, 282(14):2722-34.

25. Sun Q, Zhao X, Liu X, Wang Y, Huang J, Jiang B, Chen Q*, Yu J*. miR-146a functions as a tumor suppressor in prostate cancer by targeting Rac1.Prostate. 2014, 74(16):1613-21.

26. Zhu M, Chen Q, Liu X, Sun Q, Zhao X, Deng R, Wang Y, Huang J, Xu M, Yan J, Yu J*. lncRNA H19/miR-675 axis represses prostate cancer metastasis by targeting TGFBI.FEBS J. 2014, 281:3766-3775.

27. Qu Y, Chen Q, Lai X, Zhu C, Chen C, Zhao X, Deng R, Xu M, Yuan H, Wang Y, Yu J*, Huang J*. SUMOylation of Grb2 enhances the ERK activity by increasing its binding with Sos1.Mol Cancer, 2014, 13(1):95.

28. Liu X, Chen Q, Yan J, Wang Y, Zhu C, Chen C, Zhao X, Xu M, Sun Q, Deng R, Zhang H, Qu Y, Huang J, Jiang B, Yu J*. MiRNA-296-3p-ICAM-1 axis promotes metastasis of prostate cancer by possible enhancing survival of natural killer cell-resistant circulating tumour cells. Cell Death Dis. 2013, 4:e928.

29. Yu J*, Deng R, Zhu HH, Zhang SS, Zhu C, Montminy M, Davis R, Feng GS*. Modulation of fatty acid synthase degradation by concerted action of p38 MAP kinase, E3 ligase COP1 and SH2-tyrosine phosphatase Shp2. J Biol Chem. 2013, 288(6):3823-30.

30. Huang J, Yan J, Zhang J, Zhu S, Wang Y, Shi T, Zhu C, Chen C, Liu X, Cheng J, Mustelin T, Feng GS, Chen G, Yu J*. SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane. Nature Communications. 2012, 3:911.

31. Liu X, Wang Y, Sun Q, Yan J, Huang J, Zhu S, Yu J*. Identification of microRNA transcriptome involved in human natural killer cell activation. Immunol Lett. 2012, 143(2):208-17.

32. Yu J*, Zhang SS, Saito K, Williams S, Arimura Y, Ma Y, Ke Y, Baron V, Mercola D, Feng GS, Adamson E*, Mustelin T. PTEN regulation by Akt-EGR1-ARF-PTEN axis. EMBO J. 2009, 28(1):21-33.

33. Yu J, Baron V, Mercola D, Mustelin T, Adamson ED*. A network of p73, p53 and Egr1 is required for efficient apoptosis in tumor cells. Cell Death and Differentiation. 2007, 14(3):436-46.

34. Yu J, de Belle I, Liang H, Adamson ED*. Coactivating factors p300 and CBP are transcriptionally crossregulated by Egr1 in prostate cells, leading to divergent responses. Molecular Cell, 2004, 15(1): 83-94.