程金科，研究员,博士生导师，上海交通大学特聘教授。主要从事蛋白质SUMO修饰与肿瘤、衰老及炎症研究；调控去SUMO化蛋白酶SENP的分子机制及生物学功能；蛋白质SUMO化修饰与代谢性疾病的研究。负责完成与正在主持的国家自然科学基金重点项目、国家自然科学面上基金、国家科技部重大研究计划、教育部等国家级项目15项；上海市优秀学科带头人、上海市浦江人才计划、上海市领军人才等市级项目12项。曾任中国细胞生物学会理事、中国生物化学与分子生物学会理事，目前担任上海市生物化学与分子生物学会理事长。先后以第一作者或通讯作者在Cell、Molecular Cell、Cancer Research、Oncogene等国际期刊上发表SCI论文30余篇，研究成果获上海市科学技术进步奖三等奖。

1. 82230049，SENP1-Sirt3轴调控线粒体代谢重编程及抗组织器官衰老的作用与机制研究，国家自然科学基金重点项目，2023/01 -2027/12，261万元，项目负责人

2. 82030075，SENP2整合FGF21和TGF-b信号调控乳腺癌细胞脂代谢并促进EMT和肿瘤侵袭转移的研究。国家自然科学基金重点项目，2021/01 -2025/12 ，297万元，项目负责人

3.2020YFA0803600，组织器官代谢可塑性与记忆的调控机制及其生理病理意义，科技部国家重点研发计划，2020.12.01-2025.11.30，2425万元 （总项目），698万元（课题三），首席及课题三负责人

4.81730082，SENP1-Sirt3轴调控免疫细胞代谢重编程及在抗肿瘤免疫中的作用与机制。国家自然科学基金重点项目,2018/01 -2022/12，290万，项目负责人

5.2017-01-07 -00-01-E00050，蛋白质SUMO修饰对抗肿瘤免疫的调控作用及机制，上海市教育委员会科研创新计划项目-重大项目，2017/6/29-2022/6/29,300万，项目负责人

6.81430069，SUMO特异性蛋白酶3调控细胞分裂的作用及与肿瘤发生的关系。国家自然科学基金重点项目,2015/01 -2019/12，320万，项目负责人

7.91229202，SUMO特异性蛋白酶1在肿瘤炎症反应中的调节作用及分子基础,国家自然科学基金重点项目，2013/01 -2016/12，300万，项目负责人

8.91019021，SUMO特异性蛋白酶2在心脏发育过程中的作用与调控机制，国家自然科学重大研究计划重点支持项目，2011/01 -2014/12，200万，项目负责人

1. Cheng J, Kang X, Zhang S and Yeh ET. SUMO-specific protease 1 is essential for stabilization of HIF1a during hypoxia. Cell, 131:584-595, 2007.

2. Kang X, Qi Y, Zuo Y, Wang Q, Zou Y, Schwartz RJ, Cheng J ^*, and Yeh ET^*. SUMO-specific protease 2 is essential for suppression of polycomb group proteins mediated gene silencing during embryonic development, Molecular Cell,，38：191-201. 2010.

3.Kang X, Li J, Zou Y, Yi J, Zhang H, Cao M, Yeh ET, Cheng J^*. PIASy stimulates HIF1α SUMOylation and negatively regulates HIF1α activity in response to hypoxia. Oncogene, 29:5568-5578. 2010.

4. Wang Q, Xia N, Li T, Xu Y, Zou Y, Zuo Y, Fan Q, Bawa-Khalfe T, Yeh ET, Cheng J^*. SUMO-specific protease 1 promotes prostate cancer progression and metastasis. Oncogene. 32:2493-2498. 2013.

5. Cai J, Zuo Y, Wang T, Cao Y, Cai R, Chen FL, Cheng J*, Mu J*. A crucial role of SUMOylation in modulating Sirt6 deacetylation of H3 at lysine 56 and its tumor suppressive activity. Oncogene. 2016 Feb 22. doi: 10.1038/onc.2016.24.

6. Xia N, Cai J, Wang F, Dong B, Liu S, Chen F, Cheng J^*, Zuo Y. SENP1 Is a Crucial Regulator for Cell Senescence through DeSUMOylation of Bmi1. Sci Rep. 2016 Sep 23; 6:34099. doi: 10.1038/srep34099

7. Wang YP*, Zhou W, Wang J, Huang X, Zuo Y, Wang TS, Gao X, Xu YY, Zou SW, Liu YB, Cheng JK*, Lei QY*. Arginine Methylation of MDH1 by CARM1 Inhibits Glutamine Metabolism and Suppresses Pancreatic Cancer. Mol Cell. 2016 64:673-687.

8. Yu T, Zuo Y, Cai R, Huang X, Wu S, Zhang C, Chin YE, Li D, Zhang Z, Xia N, Wang Q, Shen H, Yao X, Zhang ZY, Xue S, Shen L, Cheng JK*. SENP1 regulates IFN-γ-STAT1 signaling through STAT3-SOCS3 negative feedback loop. Journal of Molecular Cell Biology , 2017, 9(2), 144–153.

9. Bo Wei, Chao Huang, Bin Liu, Yang Wang, Nansong Xia, Qiuju Fan, Guo-Qiang Chen, and Jinke Cheng*. Mitotic Phosphorylation of SENP3 Regulates DeSUMOylation of Chromosome-Associated Proteins and Chromosome Stability. Cancer Research.2018, 78(9):2171-2178.

10. Huang X, Zuo Y*, Wang, XZ, Wu, XF, Tan HS, Fan QJ, Dong BJ, Xue W, Chen GQ, Cheng JK*. SUMO-Specific Protease 1 Is Critical for Myeloid-Derived Suppressor Cell Development and Function. Cancer Research, 2019,79(15): 3891-3902.

11. Wang T, Cao Y, Zheng Q, Tu J, Zhou W, He J, Zhong J, Chen Y, Wang J, Cai R, Zuo Y, Wei B, Fan Q, Yang J, Wu Y, Yi J, Li D, Liu M, Wang C, Zhou A, Li Y, Wu X, Yang W, Chin YE, Chen G, Cheng JK*. SENP1-Sirt3 Signaling Controls Mitochondrial Protein Acetylation and Metabolism. Molecular Cell. 2019,75(4):823-834.

12. Liang QL; Zheng Q, Zuo Y,Chen YL, Ma J ,Ni PH*, Cheng JK*. SENP2 Suppresses Necdin Expression to Promote Brown Adipocyte Differentiation. Cell Reports, 2019, 28(8): 2004-2011.

13. Yang Wang ，Jing Tian, Chao Huang , Jiao Ma, Gaolei Hu， Yalan Chen, Tianshi Wang, Rong Cai,Yong Zuo, Hongsheng Tan, Qiuju Fan, Baijun Dong, Wei Xue, Jing Yi, Guoqiang Chen, Jun Tu and Jinke Cheng.P53 suppresses SENP3 phosphorylation to mediate G2 checkpoint.Cell Discovery ；( 2020) 6:21

14. Xun Shangguan , Jianli He, Zehua Ma, Weiwei zhang , Yiyi Ji, Kai Shen, Zhiying Yue, Wenyu Li ,Zhixiang Xin, Quan Zheng, Ying Cao, Jiahua Pan, Baijun Dong, Jinke Cheng*, Qi Wang* &Wei Xue*，SUMOylation Controls the Binding of Hexokinase 2 to Mitochondria and Protects against Prostate Cancer Tumorigenesis.Nature Communications. 2021 Mar 22;12(1):1812.

15. Jianli He^#, Xun Shangguan^# , Wei Zhou, Ying Cao, Quan Zheng, Jun Tu, Gaolei Hu, Zi Liang,Cen Jiang, Liufu Deng , Shengdian Wang, Wen Yang, Yong Zuo, Jiao Ma, Rong Cai, Yalan Chen,Qiuju Fan, Baijun Dong , Wei Xue, Hongsheng Tan, Yitao Qi, Jianmin Gu, Bing Su, Y. Eugene Chin,Guoqiang Chen , Qi Wang*, Tianshi Wang* & Jinke Cheng*. Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development. Nature Communications , (2021) 12:4371.

16. Wei Zhou,Gaolei Hu,Jianli He,Tianshi Wang,Yong Zuo,Ying Cao,Quan Zheng,Jun Tu,Jiao Ma,Rong Cai,Yalan Chen,Qiuju Fan,Baijun Dong,Hongsheng Tan,Qi Wang,Wei Xue*,Jinke Cheng*. SENP1-Sirt3 signaling promotes α-ketoglutarate production during M2 macrophage polarization. Cell Report.2022 Apr 12;39(2):110660.

17. Cen Jiang, Jianli He, Sunwang Xu*, Qi Wang,and Jinke Cheng*.NR4A1 promotes LEF1 expression in the pathogenesis of papillary thyroid cancer.Cell Death Discovery (2022) 8:46.

18. Gaolei Hu, Yalan Chen, Xinyu Yang, Yang Wang, Jianli He, Tianshi Wang , Qiuju Fan, Liufu Deng, Jun Tu,Hongsheng Tan* and Jinke Cheng*.Mitotic SENP3 activation couples with cGAS signaling in tumor cells to stimulate anti-tumor immunity.Cell Death and Disease (2022) 13:640.

1.2020年国务院特殊津贴

2.上海交通大学2020年度教学成果奖特等奖

3.2016年度上海领军人才

4.2013年度上海市科学技术奖三等奖

5.2011年度上海市优秀学术带头人