师资队伍
孙序序
  作者:  2023-03-01

基本信息 >>>

                                                               

孙序序 研究员

组织再生与肿瘤分子机制研究组

电话:63846590-776517

邮箱:xuxu.sun@outlook.com

研究方向>>>

研究肝脏再生及肝脏肿瘤的分子机制。聚焦染色质重塑表观遗传调控改变细胞行为及染色质结构的分子机制。

个人简历 >>>

  孙序序,上海交通大学基础医学院生物化学与分子细胞生物学系研究员,博士生导师。2010年获得上海交通大学医学院细胞生物学博士。20102012年曾在上海东方肝胆外科医院及香港中文大学中药研究所从事肝癌分子诊断及脂肪肝方面研究。20132018年在美国德克萨斯大学西南医学中心从事表观遗传调控肝再生与肝癌方面博士后研究工作。现兼任上海市东方学者特聘教授、中华医学会医学细胞生物学分会第六届青年委员会委员。入选上海市国际人才蓄水池计划,主持国家自然基金面上项目2,参与国家重点研发计划1项。相关研究成果发表在Cell Stem Cell, Cancer Cell, EMBO J, Elife, Hepatology, Cell Reports等期刊上。

科研项目 >>>

(1) 国家自然科学基金委员会, 面上项目, 32170609, 染色质重塑基因Arid1a缺失促进肝细胞向肝内胆管癌恶性转化的分子机制研究, 2022-01-01 至 2025-12-31, 58万元, 在研, 主持

(2) 国家自然科学基金委员会, 面上项目, 31970587, 染色质重塑因子ARID1A四种热点突变在肝癌中的功能及分子机制研究, 2020-01-01 至 2023-12-31, 60万元, 结题, 主持

(3) 国家卫生健康委医药卫生科技发展研究中心, 国家重点研发计划, 2021YFC2700800, 致命出生缺陷的基因治疗产品研发和临床研究研发, 2021-12 至 2024-11, 37.35万元, 结题, 参与

论文与专著 >>>

 

1. Fang Liu; Jun Ying; Kai Yang; Xinyuan Xiong; Nan Yang; Shu Wang; Wenzhen Zhao; Huiqin Zhu; Ming Yu; Jun Wu; Jie Yang; Xiaonan Wang; Xuxu Sun ; Deciphering the regulatory mechanisms and biological implications of ARID1A missense mutations in cancer, Cell Reports, 2024, 43(11): 114916. (代表作)

2. Yongxing Zhang; Hangxiang Sun; Fei Huang; Yang Chen; Xiying Ding; Chenhe Zhou; Yan Wu;Qing Zhang; Xiao Ma; Jun Wang; Rui Yue; Li Shen; Xuxu Sun; Zhaoming Ye ; The chromatin remodeling factor Arid1a cooperates with Jun/Fos to promote osteoclastogenesis by epigenetically upregulating Siglec15 expression, Journal of Bone and Mineral Research, 2024, 39(6): 775-790. (代表作)

3. Cemre Celen; Jen-Chieh Chuang; Shunli Shen; Lin Li; Gianna Maggiore; Yuemeng Jia; Xin Luo; Austin Moore; Yunguan Wang; Jordan E. Otto; Clayton K. Collings; Zixi Wang; Xuxu Sun; Ibrahim Nassour; Jiyoung Park; Alexandra Ghaben; Tao Wang; Sam C. Wang; Philipp E. Scherer; Cigall Kadoch; Hao Zhu ; Arid1a loss potentiates pancreatic β-cell regeneration through activation of EGF signaling, Cell Reports, 2022, 41(5): 111581. (代表作)

4. Zixi Wang, Kenian Chen, Yuemeng Jia, Jen-Chieh Chuang, Xuxu Sun, Yu-Hsuan Lin, Cemre Celen, Lin Li, Fang Huang, Xin Liu, Diego H. Castrillon, Tao Wang, Hao Zhu. Dual ARID1A/ARID1B loss leads to rapid carcinogenesis and disruptive redistribution of BAF complexes. Nature Cancer 2020 September, 1, 909–922.

5. Yongxing Zhang, Kai Yang, Jie Yang, Yimin Lao, Lianfu Deng, Guoying Deng, Jing Yi, Xuxu Sun (co-corresponding author), Qiugen Wang. SENP3 Suppresses Osteoclastogenesis by De-conjugating SUMO2/3 from IRF8 in Bone Marrow-Derived Monocytes. Cell Reports 2020 February 11; 30, 1951–1963. e4

6. Xuxu Sun,* Sam C. Wang,* Yonglong Wei, Xin Luo, Yuemeng Jia, Lin Li, Purva Gopal, Min Zhu, Ibrahim Nassour, Jen-Chieh Chuang, Thomas Maples, Cemre Celen, Liem H. Nguyen, Linwei Wu, Shunjun Fu, Weiping Li, Lijian Hui, Feng Tian, Yuan Ji, Shuyuan Zhang, Mahsa Sorouri, Tae Hyun Hwang, Lynda Letzig, Laura James, Zixi Wang, Adam C. Yopp, Amit G. Singal, Hao Zhu. Arid1a has context-dependent oncogenic and tumor suppressor functions in liver cancer. Cancer Cell 2017, Nov 13; 32 (5), p574–589. e6. (代表作)

7. Xuxu Sun, Jen-Chieh Chuang, Mohammed Kanchwala, Linwei Wu, Cemre Celen, Lin Li, Hanquan Liang, Shuyuan Zhang, Thomas Maples, Liem H. Nguyen, Sam C. Wang, Robert A.J. Signer, Mahsa Sorouri, Ibrahim Nassour, Xin Liu, Jian Xu, Meng Wu, Yong Zhao, Yi-Chun Kuo, Zhong Wang, Chao Xing, Hao Zhu. Suppression of the SWI/SNF component Arid1a promotes mammalian regeneration. Cell Stem Cell 2016 Apr 7; 18(4):456-466. (代表作)

8. Shan Yan*, Xuxu Sun*, Binggang Xiang, Hui Cang, Xunlei Kang, Yuying Chen, Hui Li, Guiying Shi, Edward T H Yeh, Beilei Wang, Xiangrui Wang, Jing Yi. Redox regulation of the stability of the SUMO protease SENP3 via interactions with CHIP and Hsp90. EMBO J 2010 Nov17; 29(22):3773-86. (*Co-first author)

9. Sam C Wang, Ibrahim Nassour, Shu Xiao, Shuyuan Zhang, Xin Luo, Jeon Lee, Lin Li, Xuxu Sun, Liem H Nguyen, Jen-Chieh Chuang, Lan Peng, Scott Daigle, Jeanne Shen, Hao Zhu. SWI/SNF component ARID1A restrains pancreatic neoplasia formation. Gut 2019 Jul;68(7):1259-1270.

10. Austin Moore,Linwei Wu, Jen-Chieh Chuang, Xuxu Sun, Xin Luo, Purva Gopal, Lin Li, Cemre Celen, Michael Zimmer, Hao Zhu. Arid1a loss drives non-alcoholic steatohepatitis in mice via epigenetic dysregulation of hepatic lipogenesis and fatty acid oxidation. Hepatology 2019 May; 69(5):1931-1945.