王兆军

 感染与免疫研究组

 电话：18621215100 

 邮箱：zjwang@sjtu.edu.cn

感染与免疫

上海交通大学免疫学博士，美国宾夕法亚尼大学医学院博士后。现任上海交通大学医学院免疫学与微生物学系教授、博士生导师，上海市免疫学研究所课题组长，医学院党委教师工作部副部长，上海交通大学致远荣誉教师。受聘为中国疾控中心寄生虫病所（国家热带病研究中心）兼职学术带头人，国家卫生健康委人才交流服务中心高级人才评价项目专家。

致力于感染免疫相关的研究工作，主待国家及省部级课题十余项。主要研究成果发表于Nature Immunology、PNAS、The Journal of clinical investigation等。实验室主要以人类重大感染性疾病为研究对象，通过建立感染动物模型或采集病人样本，对病原体和宿主之间的相互作用、机体免疫细胞和效应分子的活化和表达、免疫应答过程的信号传导、免疫反应的分子调控等方面进行理论和应用基础研究。实验室现主要的研究方向1）炎症与感染状态下天然免疫细胞的活化与调控；2）蠕虫感染的免疫致病机制。

从事基础医学教育教学工作，医学院病原生物学课程组组长。上海市本科一流课程《疾病学基础》负责人，主编人民卫生出版社《疾病学基础》教材、科学出版社《病原生物学——医学寄生虫学》等，发表教学论文十余篇，获交大教学成果奖四项。

1. Hu W*, Yan Q*, Shen DK*, Liu F, Zhu ZD, Song HD, Xu XR, Wang ZJ, Rong YP, Zeng LC, Wu J, Zhang X, Wang JJ, Xu XN, Wang SY, Fu G, Zhang XL, Wang ZQ#, Brindley PJ, McManus DP, Xue CL, Feng Z, Chen Z, Han ZG. 2003. Evolutionary and biomedical implications of a Schistosoma japonicum complementary DNA resource. Nat Genet 35: 139-47

2. Wang Z*, Hong J*, Sun W, Xu G, Li N, Chen X, Liu A, Xu L, Sun B, Zhang JZ. 2006. Role of IFN-gamma in induction of Foxp3 and conversion of CD4+ CD25- T cells to CD4+ Tregs. J Clin Invest 116: 2434-41

3. Wang Z*, Qiu J*, Guo TB, Liu A, Wang Y, Li Y, Zhang JZ#. 2007. Anti-inflammatory properties and regulatory mechanism of a novel derivative of artemisinin in experimental autoimmune encephalomyelitis. J Immunol 179: 5958-65

4. Chen G*, Hao J, Xi Y, Wang W, Wang Z, Li N, Li W#. 2008. The therapeutic effect of vasoactive intestinal peptide on experimental arthritis is associated with CD4+CD25+ T regulatory cells. Scand J Immunol 68: 572-8

5. Wu CY*, Feng Y*, Qian GC, Wu JH, Luo J, Wang Y, Chen GJ, Guo XK#, Wang ZJ#. 2010. alpha-Galactosylceramide protects mice from lethal Coxsackievirus B3 infection and subsequent myocarditis. Clin Exp Immunol 162: 178-87

6. Sun H*, Zhuang G, Chai L, Wang Z, Johnson D, Ma Y, Chen YH#. 2012. TIPE2 controls innate immunity to RNA by targeting the phosphatidylinositol 3-kinase-Rac pathway. J Immunol 189: 2768-73

7. Wang Z*, Fayngerts S, Wang P, Sun H, Johnson DS, Ruan Q, Guo W, Chen YH#. 2012. TIPE2 protein serves as a negative regulator of phagocytosis and oxidative burst during infection. Proc Natl Acad Sci U S A 109: 15413-8

8. Fayngerts SA*, Wu J, Oxley CL, Liu X, Vourekas A, Cathopoulis T, Wang Z, Cui J, Liu S, Sun H, Lemmon MA, Zhang L, Shi Y, Chen YH#. 2014. TIPE3 Is the Transfer Protein of Lipid Second Messengers that Promote Cancer. Cancer Cell 26: 465-78

9. Wu C*, Chen Q*, Fang Y, Wu J, Han Y, Wang Y, Yang Y, Chu M, Feng Y, Tan L, Guo X, Hu W, Wang Z#. 2014. Schistosoma japonicum egg specific protein SjE16.7 recruits neutrophils and induces inflammatory hepatic granuloma initiation. PLoS Negl Trop Dis 8: e2703

10. Cheng W*, Zhao Q*, Xi Y, Li C, Xu Y, Wang L, Niu X, Wang Z#, Chen G#. 2015. IFN-beta inhibits T cells accumulation in the central nervous system by reducing the expression and activity of chemokines in experimental autoimmune encephalomyelitis. Mol Immunol 64: 152-62

11. Fang Y*, Wu C, Chen Q, Wu J, Yang Y, Guo X, Chen G, Wang Z#. 2015. SjE16.7 activates macrophages and promotes Schistosoma japonicum egg-induced granuloma development. Acta Trop 149: 49-58

12. Porturas TP*, Sun H, Buchlis G, Lou Y, Liang X, Cathopoulis T, Fayngerts S, Johnson DS, Wang Z, Chen YH#. 2015. Crucial roles of TNFAIP8 protein in regulating apoptosis and Listeria infection. J Immunol 194: 5743-50

13. Zhang Z*, Liang X, Gao L, Ma H, Liu X, Pan Y, Yan W, Shan H, Wang Z, Chen YH#, Ma C#. 2015. TIPE1 induces apoptosis by negatively regulating Rac1 activation in hepatocellular carcinoma cells. Oncogene 34: 2566-74

14. Niu X*, Deng S*, Li S, Xi Y, Li C, Wang L, He D, Wang Z#, Chen G#. 2016. Therapeutic effect of ergotope peptides on CIA by down-regulation of inflammatory and Th1/Th17 responses and induction of regulatory T cells. Mol Med 22: 608-20

15. Fayngerts SA*, Wang Z*, Zamani A, Sun H, Boggs AE, Porturas TP, Xie W, Lin M, Cathopoulis T, Goldsmith JR, Vourekas A, Chen YH#. 2017. Direction of leukocyte polarization and migration by the phosphoinositide-transfer protein TIPE2. Nat Immunol 18: 1353-60 (co-first author)

16. Lao Y*, Yang K, Wang Z, Sun X, Zou Q, Yu X, Cheng J, Tong X, Yeh ETH, Yang J#, Yi J#. 2018. DeSUMOylation of MKK7 kinase by the SUMO2/3 protease SENP3 potentiates lipopolysaccharide-induced inflammatory signaling in macrophages. J Biol Chem 293: 3965-80

17. Yin C*, Wu C, Du X, Fang Y, Pu J, Wu J, Tang L, Zhao W, Weng Y, Guo X, Chen G#, Wang Z#. 2018. PRL2 Controls Phagocyte Bactericidal Activity by Sensing and Regulating ROS. Front Immunol 9: 2609

18. Du XY*, Zhang Y*, Li X, Li Q, Wu CY, Chen GJ, Guo XK, Weng YQ#, Wang ZJ#. 2019. PRL2 serves as a negative regulator in cell adaptation to oxidative stress. Cell and Bioscience 9

19. Wu C*, Du X*, Tang L, Wu J, Zhao W, Guo X, Liu D, Hu W, Helmby H, Chen G#, Wang Z#. 2020. Schistosoma japonicum SjE16.7 Protein Promotes Tumor Development via the Receptor for Advanced Glycation End Products (RAGE). Front Immunol 11: 1767

20. Cai F*, Liu S*, Lei Y, Jin S, Guo Z, Zhu D, Guo X, Zhao H, Niu X, Xi Y, Wang Z#, Chen G#. 2021. Epigallocatechin-3 gallate regulates macrophage subtypes and immunometabolism to ameliorate experimental autoimmune encephalomyelitis. Cellular Immunology 368