曾凡一
发育生物学研究组
电话：63846590-776667
邮箱：fzeng@vip.163.com
研究组长介绍
曾凡一，美国宾夕法尼亚大学医学/理学双博士，研究员，博导。现任上海交通大学医学院基础医学院，组织胚胎学与遗传发育学系PI，上海交通大学特聘教授、医学院特聘教授。
曾凡一教授主要从事医学遗传学和发育生物学，尤其是干细胞和哺乳动物胚胎工程等交叉领域的研究，在国际著名期刊《Nature》、《PNAS》等杂志发表SCI论文90 余篇，研究成果多次入选“中国基础研究十大新闻”以及“中国十大科技进展新闻”。近年来获得国家自然科学奖二等奖、教育部自然科学奖一等奖、首届第三世界女青年科学家奖、谈家桢生命科学奖创新奖等奖项。担任国际干细胞组织（ISCF）秘书长及伦理委员会中国代表、中国遗传学会第十届理事会常务理事以及人类与医学遗传专业委员会主任委员等职务。
研究方向与进展
医学遗传学和发育生物学，尤其是干细胞和哺乳动物胚胎工程等交叉领域的研究
科研项目
国家重点研发计划子课题“胚层形成过程细胞分子调控机制”
国家自然科学基金面上项目“克隆牛重编程的表观遗传机理研究 ”
代表性论文、专著与专利
1. Shuo Tan, Yuan Chen, Yue Gao, Jiaping He, Xinbing Guo, Simin Zhang, Jingzhi Zhang*, Fanyi Zeng*. β-Galactosidase gene codon optimization results in post-transcriptional enhancement of expression. Gene, 748: 144676, 2020
2. Yudan Fang1, Yan Cheng1, Dan Lu1, Xiuli Gong, Guanheng Yang, Zhijuan Gong, Yiwen Zhu, Xiao Sang, Shuyue Fan, Jingzhi Zhang, Fanyi Zeng. Treatment of β654-thalassaemia by TALENs in a mouse model. Cell Proliferation, 51(6): e12491, 2018
3. Zhijuan Gong1, Qingwen Ma1, Xujun Wang1, Qin Cai, Xiuli Gong, Georgi Z. Genchev, Hui Lu* and Fanyi Zeng*. A Herpes Simplex Virus Thymidine Kinase-Induced Mouse Model of Hepatocellular Carcinoma Associated with Up-Regulated Immune-Inflammatory-Related Signals. Genes, 9(8): 380, 2018
4. Jingzhi Zhang, Jingbin Yan, Fanyi Zeng. Recent Progress on Genetic Diagnosis and Therapy for β-Thalassemia in China and Around the World. Human Gene Therapy, 29(2): 197-203, 2018.2
5. Chuanliang Guo1, Yan Xue1, Guanheng Yang, Shang Yin, Wansheng Shi, Yan Cheng, Xiaoshuang Yan, Shuyue Fan, Huijun Zhang and Fanyi Zeng. Nanog RNA-binding proteins YBX1 and ILF3 affect pluripotency of embryonic stem cells. Cell Biology International, 40(8): 847-860, 2016
6. Xiaoshuang Yan, Yan Xue, Yiye Zhou, Yan Cheng, Shang Yin, Qingwen Ma, Fanyi Zeng. Activation of proHGF by St14 induces mouse embryonic stem cell differentiation. Protein&Cell, 7(8): 601-605, 2016
7. Jingbin Yan, Rong Zhang, Can Xiong, Cheng Hu, Yao Lv, Congrong Wang, Weiping Jia, Fanyi Zeng. Pyrosequencing Is an Accurate and Reliable Method for the analysis of Heteroplasmy of the A3243G Mutation in patients with Mitochondrial diabetes. The Journal of Molecular Diagnostics, 16(4): 431-439, 2014
8. Rosario Isasi*, Peter W. Andrews, Jay M. Baltz, Annelien L. Bredenoord, Paul Burton, Ing-Ming Chiu, Sara Chandros Hull, Ji-Won Jung, Andreas Kurtz, Geoffrey Lomax, Tenneille Ludwig, Michael McDonald, Clive Morris, Huck Hui Ng, Heather Rooke, Alka Sharma, Glyn N. Stacey, Clare Williams, Fanyi Zeng, and Bartha Maria Knoppers. Identifiability and Privacy in Pluripotent Stem Cell Research. Cell Stem Cell, 14(4): 427-430, 2014
9. Guanheng Yang, Wansheng Shi, Xingyin Hu, Jingzhi Zhang, Zhijuan Gong, Xinbing Guo, Zhaorui Ren, and Fanyi Zeng. Therapeutic effects of induced pluripotent stem cells in chimeric mice with β-thalassemia. Haematologica, 99(8): 1304-1311, 2014
10. Fanyi Zeng*, Shu-Zhen Huang, Zhi-Juan Gong, Mei-Jue Chen, Don A Baldwin, Wei Hu, Hui Qian, Jing-bin Yan, Juan Wang,Yan Ping Xiao, Yves Chalandon, Ashley Ringrose, Zhao-Rui Ren, Allen Eaves, Connie Eaves, Xiaoyan Jiang*. Long-term deregulated human hematopoiesis in goats transplanted in utero with BCR-ABL-transduced lin–CD34+ cord blood cells. Cell Research, 23(6): 859-862, 2013
11. Z.-J. Gong, Y.-Y. Zhou, M. Xu, Q. Cai, H. Li, J.-B. Yan, J. Wang, H.-J. Zhang, S.-Y. Fan, Q. Yuan, S.-Z. Huang*, F. Zeng*. Aberrant expression of imprinted genes and their regulatory network in cloned cattle. Theriogenology, 78(4): 858-866, 2012
12. Linlin Wang, Yan Xue, Yihang Shen, Wei Li1, Yan Cheng, Xiaoshuang Yan, Wansheng Shi, Juan Wang, Zhijuan Gong, Guanheng Yang, Chuanliang Guo, Yiye Zhou, Xiang Wang, Qi Zhou, Fanyi Zeng. Claudin 6: a novel surface marker for characterizing mouse pluripotent stem cells. Cell Research, 22(6): 1082-1085, 2012
13. Mai X. Luong*, Jonathan Auerbach, Jeremy M. Crook, Laurence Daheron, Derek Hei, Geoffrey Lomax, Jeanne F. Loring, Tenneille Ludwig, Thorsten M. Schlaeger, Kelly P. Smith, Glyn Stacey, Ren-He Xu, and Fanyi Zeng. A Call for Standardized Naming and Reporting of Human ESC and iPSC Lines. Cell Stem Cell, 8(4): 357-359, 2011
14. Zhong-hai Yan, Yi-ye Zhou, Jing Fu, Fei Jiao, Lei-wen Zhao, Peng-fei Guan, Shu-zhen Huang, Yi-tao Zeng, Fanyi Zeng. Donor-host mitochondrial compatibility improves efficiency of bovine somatic cell nuclear transfer. BMC Developmental Biology, 10: 31, 2010
15. Xiao-yang Zhao, Wei Li, Zhuo Lv, Lei Liu, Man Tong, Tang Hai, Jie Hao, Chang-long Guo, Qing-wen Ma, Liu Wang, Fanyi Zeng*, Qi Zhou*. iPS cells produce viable mice through tetraploid complementation. Nature, 461(7260): 86-90, 2009
团队介绍
目前有1名副研究员薛燕，助理研究员周一叶，实验师马姬，博士生迟亚男，博士生樊莎莎
