师资队伍
李福彬
  作者:  2018-12-31
基本信息 >>>    

 李福彬
  免疫学与微生物学系
  电话:63846590-776624
  邮箱:fubin.li@sjtu.edu.cn

研究方向>>>

    Fcγ受体在免疫应答和免疫治疗中的功能和分子作用机制,如对B细胞应答的调控及对包括激动型的各类抗体效应的影响。

个人简历 >>>

    李福彬研究员,博士生导师,体液免疫与治疗课题组课题组长;上海市教育基金会/上海市教育委员会“曙光学者”。   

        1997-2001 复旦大学 学士

        2002-2008 美国纽约城市大学 博士

        2009-2013 美国洛克菲勒大学 博士后

        2013.09-至今上海交通大学医学院上海市免疫学研究所课题组长 博士生导师

科研项目 >>>

1. 14SG16上海市教委科研创新重点项目曙光计划2015-2017项目负责人

2. 2014CB943600科技部国家重点基础研究发展计划(973计划) 淋巴细胞发育中的基金转录后调节网络研究20144月至20188科研骨干

3. 15ZR1436400上海市科委自然科学基金面上项目Fc-huCD40L融合蛋白的抗肿瘤活性及其副作用的研究2015-2018张慧慧

4. 2015上海市教委科研创新重点项目上海高层次人才2015-2017张慧慧

6. 31422020国家自然科学基金优青项目基于抗体Fc的分子靶向治疗2015-2017项目负责人

7. 31370934国家自然科学基金面上项目抑制型Fcgamma受体驱动激动型抗TNFR超家族成员抗体抗肿瘤活性的机制2014-2017项目负责人

论文与专著 >>>

1.  Dahan, R., B. C. Barnhart, F. Li, A. P. Yamniuk, A. Korman, J.V. Ravetch. .Therapeutic activity of agonistic, human anti-CD40 monoclonal Abs requires ive FcγR-engagement. .Cancer Cell ,2016,29(6):820-831.  

2.  Georgoudaki, A.M., K. Prokopec, E. Hellqvist, V. Boura, J. Östling, S. Sohn, R.A. Harris, M. Rantalainen, D. Klevebring, M. Sund, J. Fuxe, C. Rolny, F. Li, J.V. Ravetch, M.C.I. Karlsson. .Reprogramming tumor associated macrophages by antibody targeting inhibits cancer progression and metastasis. .Cell Reports ,2016,15(9):2000-11.  

3.  Deng Z, Ma S, Zhou H, Zang A, Fang Y, Li T, Shi H, Liu M, Du M, Taylor PR, Zhu HH, Chen J, Meng G, Li F, Chen C, Zhang Y, Jia XM, Lin X, Zhang X, Pearlman E, Li X, Feng GS, Xiao H. .Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses..Nature Immunology,2015,16:642-52.  

4.  Li, F#., P. Smith, and J. V. Ravetch#. .Inhibitory Fcgamma Receptor Is Required for the Maintenance of Tolerance through Distinct Mechanisms. .Journal of immunology ,2014,192:3021-8 .  

5.  Simpson, T. R., F. Li, W. Montalvo-Ortiz, M. A. Sepulveda, K. Bergerhoff, F. .Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma.The Journal of experimental medicine,2013,210: 1695-1710.  

6.  Li, F#., and J. V. Ravetch#. .Antitumor activities of agonistic anti-TNFR antibodies require differential FcgammaRIIB coengagement in vivo. .Proceedings of the National Academy of Sciences of the United States of America,2013,110: 19501-19506. 

7.  Smith, P., D.J. Dilillo, S. Bournazos, F. Li, and J.V. Ravetch.Mouse model recapitulating human Fcgamma receptor structural and functional diversity. .Proceedings of the National Academy of Sciences of the United States of America ,2012,109:6181-6186. 

8.  Li, F., and J. V. Ravetch.Apoptotic and antitumor activity of death receptor antibodies require inhibitory Fcgamma receptor engagement..Proceedings of the National Academy of Sciences of the United States of America ,2012,109: 10966-10971. 

9.  Li, F., and J. V. Ravetch.A general requirement for FcgammaRIIB co-engagement of agonistic anti-TNFR antibodies..Cell cycle ,2012,11: 3343-3344. 

10.  Li, F., and J.V. Ravetch.Inhibitory Fcgamma receptor engagement drives adjuvant and anti-tumor activities of agonistic CD40 antibodies. .Science ,2011,333:1030-1034. 

11.  Li, F., Y. Yan, J. Pieretti, D.A. Feldman, and L.A. Eckhardt. .Comparison of identical and functional Igh alleles reveals a nonessential role for Emu in somatic hypermutation and class-switch recombination. .Journal of immunology ,2010,185:6049-6057. 

12.  Li, F., and L.A. Eckhardt.A role for the IgH intronic enhancer E mu in enforcing allelic exclusion.The Journal of experimental medicine ,2009,206:153-167. 

13.  Zhang, B., A. Alaie-Petrillo, M. Kon, F. Li, and L.A. Eckhardt.Tranion of a productively rearranged Ig VDJC alpha does not require the presence of HS4 in the IgH 3 regulatory region. .Journal of immunology ,2007,178:6297-6306. 

14.  Romov, P.A., F. Li, P.N. Lipke, S.L. Epstein, and W.G. Qiu..Comparative genomics reveals long, evolutionarily conserved, low-complexity islands in yeast proteins. .Journal of molecular evolution,2006,63:415-425. 

15.  Garrett, F.E., A.V. Emelyanov, M.A. Sepulveda, P. Flanagan, S. Volpi, F. Li, D. Loukinov, L.A. Eckhardt, V.V. Lobanenkov, and B.K. Birshtein.Chromatin architecture near a potential 3 end of the igh locus involves modular regulation of histone modifications during B-Cell development and in vivo occupancy at CTCF sites.Molecular and cellular biology,2005,25:1511-1525. 

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