师资队伍
郭晓奎
  作者:  2018-12-31
基本信息 >>>

 郭晓奎
  免疫学与微生物学系
  电话:63846590-776712
  邮箱:xkguo@shsmu.edu.cn

研究方向>>>

   耐药细菌控制技术、钩短螺旋体分子生物学及人体微生态学与益生菌安全性研究。

个人简历 >>>

    郭晓奎,教授,博士生导师。1986年8月参加工作,1986年7月加入中国共产党。

        1986年毕业于四川大学,1991年于哈尔滨医科大学获硕士学位,2000年于日本爱知学院大学获生物化学博士学位。现为国家级教学名师,全国教育科研先进工作者,全国优秀教师,上海市优秀学科带头人。

        现任:上海交通大学医学院基础医学院副院长,上海交通大学医学科学研究院“医学分子微生物学”研究组课题组长。

        兼任:中华预防医学会微生态学分会副主任委员,中国微生物学会教育与普及工作委员会副主任委员,上海市微生物学会副理事长以及食品微生物学专委会主任委员,上海市预防医学会理事以及微生态学专委会主任委员,上海市食品科学学会理事及乳酸菌专委会副主任委员,《中国人兽共患病学报》副主编。

        长期从事医学分子微生物学和病原基因组学研究,主要内容有钩端螺旋体和分枝杆菌基因组学和蛋白质组学及其致病机制和疫苗的研究,耐药细菌控制技术,人体呼吸道感染微生态学与益生菌等。

科研项目 >>>

8126116032 钩端螺旋体与宿主细胞相互作用及其分子致病机制的研究 国家自然科学基金 2013-01~2015-12  52万元   子课题负责人

81271793 不同动物源性致病性钩端螺旋体遗传变异规律和致病差异的分子机制研究 国家自然科学基金 2013-01~2016-12  60万元   课题负责人

2012EP001004 超级细菌的预警监控和临床防治综合评价信息化平台的建立 科技部支撑计划 2012-01~2015-12  75万元   子课题负责人

81171587 基于Pan-genome技术探究问号钩端螺旋体不同血清型致病性差异的遗传基础 国家自然科学基金 2012-01~2015-12  58万元   课题负责人

2011AA02A100 自动化临床微生物分析检测仪器的研制 863重大专项 2011-09~2015-12  300万元   课题负责人

10JC1408200 重要人兽共患病钩端螺旋体病通用疫苗的基础研究 上海市科委 2010-10~2012-09  30万元   课题负责人

09XD1402700 钩端螺旋体rel基因致病机理的研究 上海市科委 2009-07~2011-06  40万元   课题负责人

2008ZX10004-002 呼吸道感染和感染性腹泻病原体诊断和组合检测技术 “十一五”重大专项子课题 2008-01~2010-12  300万元   子课题负责人

30770111 钩端螺旋体比较蛋白质组学研究 国家自然科学基金 2008-01~2010-12  30万元   课题负责人

30670102 钩体血清型相关基因的研究 国家自然科学基金 2007-01~2009-12  26万元   课题负责人

2006AA02Z176 钩端螺旋体重要功能基因的发掘、鉴定和应用 国家科技部 “863”计划 2006-01~2008-12  330万元   课题负责人

2003AA223030 钩端螺旋体致病及免疫机理的功能基因组学研究 国家科技部 “863”计划 2004-01~2005-12  157.3万元   课题负责人

30370071 钩端螺旋体溶血素基因结构、表达及功能的研究 国家自然科学基金 2004-01~2006-12  20万元   课题负责人

2001AA223030 钩端螺旋体致病及免疫机理的功能基因组学研究 国家科技部 “863”计划 2001-01~2003-12  141.1万元   课题负责人

论文与专著 >>>

Yinghua Xu, Yongzhang Zhu,Yuezhu Wang, Yung-Fu Chang, Ying Zhang, Xiugao Jiang, Xuran Zhuang, Yongqiang Zhu, Jinlong Zhang, Lingbing Zeng, Minjun Yang, Shijun Li, Shengyue Wang, Qiang Ye, Xiaofang Xin, Guoping Zhao, Huajun Zheng, Xiaokui Guo* (通讯作者), Junzhi Wang*   Whole genome sequencing revealed virulence-relatedproteins expansion and host adaptation of pathogenic Leptospira   Scitific Reports   2016   6:20020   

Zhu W, Wang J, Zhu Y, Tang B, Zhang Y, He P, Zhang Y, Liu B, Guo X* (通讯作者), Zhao G*, Qin J*   Identification of three extra-chromosomal replicons in Leptospira pathogenic strain and development of new shuttle vectors   BMC Genomics   2015   16:90   

Yanzhuo Wang, Xuran Zhuang, Yi Zhong, Cuicai Zhang, Yan Zhang, Lingbing Zeng, Yongzhang Zhu, Ping He, Dong Ke, Utpal Pal, Xiaokui Guo* (通讯作者), Jinhong Qin*   Distribution of Plasmids in Distinct Leptospira Pathogenic Species   PLoS Negl Trop Dis   2015   9(11):e0004220   

Zhang C, Yang H, Li X, Cao Z, Zhou H, Zeng L, Xu J, Xu Y, Chang YF, Guo X* (通讯作者), Zhu YZ*, Jiang X*. . . 2015; 9(5):e0003762.   Molecular Typing of Pathogenic Leptospira Serogroup Icterohaemorrhagiae Strains Circulating in China during the Past 50 Years   PLoS Negl Trop Dis   2015   9(5):e0003762   

Wei YX, Ye L, Liu DB, Zhang ZY, Liu C*, Guo XK* (通讯作者)   Activation of the chromosomally encoded mazEF(Bif) locus of Bifidobacterium longum under acid stress   Int J Food Microbiol   2015   207:16-22   

Zhao JW, Sun ZQ, Zhang XY, Zhang Y, Liu J, Ye J, Chen CC, Samten B, Wang HH, Guo XK* (通讯作者), Zhang SL*   Mycobacterial 3-hydroxyacyl-l-thioester dehydratase Y derived from Mycobacterium tuberculosis induces COX-2 expression in mouse macrophages through MAPK-NF-κB pathway   Immunol Lett   2014   161(1):125-132   

Ling-Bing Zeng, Xu-Ran Zhuang, Li-Li Huanga, Yun-Yi Zhang, Chun-Yan Che,Ke Dong, Yan Zhang, Ze-Lin Cui, Xia-Li Ding, Yung-Fu Chang, Xiao-Kui Guo* (通讯作者), Yong-Zhang Zhu*   Comparative subproteome analysis of three representative Leptospira interrogans vaccine strains reveals cross-reactive antigens and novel virulence determinants   J Proteomics   2014   112C:27-37   

Yuan L, Cui Z, Wang Y, Guo X* (通讯作者), Zhao Y*   Complete genome sequence of virulent bacteriophage SHOU24, which infects foodborne pathogenic Vibrio parahaemolyticus   Arch Virol   2014   159(11):3089-3093   

Jiyun Fan, Ying Wang, Hui Xiong, Xiaokui Guo* and Yung-chi Cheng* (通讯作者)   Impact of the rtI187V polymerase substitution of hepatitis B virus on viral replication and antiviral drug susceptibility   J Gen Virol   2014   95(Pt 11):2523-2530   

Wei-Nan Zhu, Li-Li Huang, Ling-Bing Zeng, Xu-Ran Zhuang, Chun-Yan Chen, Yan-Zhuo Wang, Jin-Hong Qin, Yong-Zhang Zhu*, Xiao-Kui Guo*... 2014;. (通讯作者)   Isolation and Characterization of Two Novel Plasmids from Pathogenic Leptospira interrogans Serogroup Canicola Serovar Canicola Strain Gui44   PLoS Negl Trop Dis   2014   8(8):e3103   

Zhang ZY, Sun ZQ, Wang ZL, Hu HR, Wen ZL, Song YZ, Zhao JW, Wang HH, Guo XK* (通讯作者),Zhang SL*   Identification and pathogenicity analysis of a novel non-tuberculous mycobacterium clinical isolate with nine-antibiotic resistance   Clin Microbiol Infect   2013   19:91-3   

Yaoxia Kang, Enhou Jia, Liang Lin, Xiangyang Duan, Pei Xiao, Jingxian Peng, Wei Gao, Chaobao Zhang, Xiaokui Guo* (通讯作者), Buyun Cui*, and Xiangqi Li*   Simultaneous emergence of several biotypes of Brucella among Baotou’s brucellosis patients by combined diagnostic strategy   Acta Biochim Biophys Sin (Shanghai)   2013   45: 893–895    

Zhang Y, Dong K, Zeng L, Li Q, Liu C, Wang J, Guo X* (通讯作者), Zhao GP*   .Genetic and molecular biological characterization of two homologous cheR genes from Leptospira interrogans   Acta Biochim Biophys Sin (Shanghai)   2013   45(10):806-816   

Zelin Cui, Yuhua Zhou, Hong Li, Yan Zhang, Shenjie Tang, Xiaokui Guo* (通讯作者)   Complex sputum microbial composition in patients with pulmonary tuberculosis   BMC microbiology   2012   12:276   

Zelin Cui, Zhen Song, Yanchun Wang, LingbingZeng, WenbinShen, Zheng Wang, Qingtian Li, Ping He, Jinhong Qin*, and Xiao-Kui Guo* (通讯作者)   Complete Genome Sequence of wide host-range Staphylococcus aureus phage JD007   Journal of Virology   2012   86(24):13880   

Zhou Y, Tao J, Yu H, Ni JJ, Zeng LB, Teng QH, Kim K, Zhao GP, Guo XK* (通讯作者), and Yao YF*   Hcp-family proteins secreted via type VI secretion system coordinately regulate Escherichia coli K1 interaction with human brain microvascular endothelial cells   Infection and Immunity   2012   80(3):1243-51   

Zhang ZY, Liu C, Zhu YZ, Wei YX, Tian F, Zhao GP, Guo XK* (通讯作者)   Safety assessment of Lactobacillus plantarumJDM1 based on the complete genome   Int J Food Microbiol   2012   153(1-2):166-70   

Zelin Cui, WenbinShen, Zheng Wang, Haotian Zhang, Rao Me, Yanchun Wang, LingbingZeng, Yongzhang Zhu, Jinhong Qin, Ping He*, and Xiao-Kui Guo* (通讯作者)   Complete Genome Sequence of Klebsiellapneumoniae phage JD001   Journal of Virology   2012   86(24):13843   

Wei YX, Zhang ZY, Liu C, Malakar PK, Guo XK* (通讯作者)   Safety assessment of Bifidobacterium longum JDM301 based on complete genome sequences   World J Gastroenterol   2012   18(5):479-88   

Zhong Y, Chang X, Cao XJ, Zhang Y, Zheng H, Zhu Y, Cai C, Cui Z, Zhang Y, Li YY, Jiang XG, Zhao GP, Wang S, Li Y, Zeng R, Li X, Guo XK (通讯作者)   Comparative proteogenomic analysis of the Leptospira interrogans virulence-attenuated strain IPAV against the pathogenic strain 56601   Cell Research   2011   21(8):1210-1229   

Zhang ZY, Sun ZQ, Wang ZL, Wen ZL, Sun QW, Zhu ZQ, Song YZ, Zhao JW, Wang HH, Zhang SL, Guo XK (通讯作者)   Complete genome of a novel clinical isolated non-tuberculous mycobacterium strain JDM601.. 2011, 193 (16): 4300-1   J Bacteriol   2011   193 (16):4300-4301   

Zhang SM, Tian F, Huang QF, Zhao YF, Guo XK (通讯作者), Zhang FQ   Bacterial diversity of subgingival plaque in 6 healthy Chinese individuals   Exp Ther Med   2011   2(5):1023-1029   

Li QT, Zhou YH, Dong K, Guo XK. (通讯作者)   Potential therapeutic efficacy of a bactericidal-immunomodulatory fusion peptide against methicillin-resistant Staphylococcus aureus skin infection.    Appl Microbiol Biotechnol.   2010   86(1):305-9   

Yan-Xia Wei, Zhuo-Yang Zhang, Chang Liu,Yong-Zhang Zhu, Yong-Qiang Zhu, Hua-Jun Zheng, Guo-Ping Zhao, Sheng-Yue Wang, and Xiao-Kui Guo (通讯作者)   Complete Genome Sequence of Bifidobacterium longum JDM301.    J. Bacteriol   2010   192(15):4076-4077   

Liu C, Zhang ZY, Dong K, Guo XK (通讯作者)   Adhesion and immunomodulatory properties of Bifidobacterium lactis HN019 to intestinal epithelial cells INT-407.    World Journal of Gastroenterology   2010   16 (18):2283-2290   

Dong K, Li QT, Liu C, Zhang YY, Zhao GP, Guo XK. (通讯作者)   Cloning and characterization of three cheB genes in Leptospira interrogans    Acta Biochim Biophys Sin (Shanghai)   2010   42 (3):216-223   

Yuhua Zhou, Qingtian Li, Lizhong Han, Ping Lin, Huajun Zheng, Yanxia Wei, Zelin Cui, Yuxing Ni, Xiaokui Guo (通讯作者)   The microbiota analyses of sputum from the patients of lower respiratory tract infection using 16S rDNA pyro-sequencing. 42 :754-761   Acta Biochim Biophys Sin   2010   42:754-761   

Zhu YZ, Cai CS, Zhang W, Guo HX, Zhang JP, Ma GY, Ji YY, Wu JL, Li QT, Lu CP, Guo XK (通讯作者)   Immunoproteomic Analysis of Human Serological Antibody Responses to Vaccination with Whole-Cell Pertussis Vaccine (WCV)   PLoS ONE   2010   5(11):13915-13915   

Cai CS, Zhu YZ, Zhong Y, Xin XF, Jiang XG, Lou XL, He P, Qin JH, Zhao GP, Wang SY, Guo XK (通讯作者)   Development of O-antigen gene cluster-specific PCRs for rapid typing six epidemic serogroups of Leptospira in China.    BMC microbiology   2010   10(67):1230-1236   

Yuan JP, Li P, Tao J, Shi XD, Hu BY, Chen HB, Guo XK (通讯作者)   H.pylori Escape Host Immunoreaction Through Inhibiting ILK Expression By VacA.    Cellular & Molecular Immunology   2009   6(3):91-97   

Zhao W, Chen CY, Zhang XY, Lai WQ, Hu BY, Zhao GP, Qin JH, Guo XK (通讯作者)   Molecular characterization of the pL40 protein in Leptospira interrogans    Can. J. Microbiol   2009   55 (6):739-749   

Zhang SM, Tian F, Jiang XQ, Li J, Xu C,Guo XK (通讯作者), Zhang FQ.    Evidence for calcifying nanoparticles in gingival crevicular fluid and dental calculus in periodontitis.   Journal of Periodontology   2009   80 (9):1462-1470   

Tian F, Yu Y, Chen B, Li HR, Yao YF, Guo XK (通讯作者)   Bacterial, archaeal and eukaryotic diversity in Arctic sediment as revealed by 16S rRNA and 18S rRNA gene clone libraries analysis.    Polar Biology   2009   32 (1):93-103   

Zhang ZY, Liu C, Zhu YZ, Zhong Y, Zhu YQ, Zheng HJ, Zhao GP, Wang SY, Guo XK (通讯作者)   Complete genome sequence of Lactobacillus plantarum JDM1.   J. Bacteriol.   2009   191(15):5020-5021   

Liu C, Zhang ZY, Dong K, Yuan JP,Guo XK (通讯作者)   Antibiotic resistance of probiotic strains of lactic acid bacteria isolated from marketing food and drugs.   Biomedical and Enviromental Science   2009   22(5):401-412   

Feng CY, Li QT, Zhang XY, Dong K, Hu BY, Guo XK (通讯作者)   Immune strategies on single component LipL32 and multi-components recombinant LipL32-41-OmpL1 vaccines against Leptospira.    Brazilian Journal of Medical and Biological Research   2009   42(9):796-803   

He P, Sheng YY, Shi YZ, Jiang XG, Qin JH, Zhang ZM, Zhang GP, Guo XK (通讯作者)   Genetic diversity among major endemic strains of Leptospira interrogans in China   BMC Genomics   2008   8(14):204-7   

Qin JH, Zhang Q, Zhang ZM, Zhong Y, Yang Y, Hu BY, Zhao GP, Guo XK (通讯作者)   Identification of a novel prophage-like gene cluster actively expressed in both virulent and avirulent strains of Leptospira interrogans serovar lai.   Infect Immun   2008   76(6):2411-9   

Zhu YZ, Li QT, Wang L, Zhong Y, Ding GH, Li G, Jia PL, Shi TL, Guo XK (通讯作者)   Gene Expression Profiling-Based In Silico Approach to Identify Potential Vaccine Candidates and Drug Targets against B. pertussis and B. parapertussis.   OMICS   2008   12 (3):161-169   

Guo XK (共同第一作者), Zhao WQ, Kondo C, Shimojo N, Yamashita K, Aoki T, Hayakawa T   Tissue inhibitors of metalloproteinases-1 (TIMP-1) and-2(TIMP-2) are major serum factors that stimulate the TIMP-1 gene in human gingival fibroblasts.    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH   2007   1763(3):296-304   

Li ZH, Dong K, Yuan JP, Hu BY, Liu JX, Zhao GP, Guo XK (通讯作者)   Characterization of the cheY genes from Leptospira interrogans and their effects on the behavior of Escherichia coli.    Biochem Biophys Res Commun   2006   345(2):858-866   

Li QT, Zhu YZ, Chu JY, Wang YY, Xu YH, Hou QM, Zhang SM, Guo XK (通讯作者)   Protective immunity against Bordetella pertussis by a recombinant DNA vaccine and the effect of coinjection with a granulocyte-macrophage colony stimulating factor gene.    Microbiol Immunol   2006   50(12):929-36.   

Sun JC, Xu JL, Cao JP, Liu Q, Guo XK (通讯作者), Shi TL   Prediction and systematic study of protein-protein interaction networks of Leptospira interrogans.   Chinese science Bulletin   2006   51(1):1-10   

Li QT, Zhu YZ, Chu JY, Dong K, He P, Feng CY, Hu BY, Zhang SM, Guo XK (通讯作者)   Granulocyte-macrophage Colony-stimulating Factor DNA Prime-protein Boost Strategy to Enhance the Efficacy of a Recombinant Pertussis DNA Vaccine    Acta Pharmacologica Sinica   2006   27 (11):1487-1494   

Li ZH, Dong K, Sun JC, Yuan JP, Hu BY, Liu JX, Zhao GP, Guo XK (通讯作者)   Characterization of cheW Genes of Leptospira interrogans and Their Effects in Escherichia coli.    Acta Biochim Biophys Sin   2006   38(2):79-88   

Yang HL, Jiang XC, Zhang XY, Li WJ, Hu BY, Zhao GP, Guo XK (通讯作者)   Thrombocytopenia in the experimental leptospirosis of guinea pig is not related to disseminated intravascular coagulation.    BMC Infect Dis   2006   6(1):19-25   

Yang HL, Zhu YZ, Qin JH, He P, Jiang XC, Zhao GP, Guo XK (通讯作者)   In silico and microarray-based genomic approaches to identifying potential vaccine candidates against Leptospira interrogans.    BMC Genomics   2006   16(7):239-240   

Qin JH, Sheng YY, Zhang ZM, Shi XZ, He P, Hu BY, Yang Y, Liu SG, Zhao GP, Guo XK (通讯作者)   Genome-wide tranional analysis of temperature shift in L. interrogans serovar lai strain 56601   BMC Microbiology   2006   6(51):1-10   

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