Research
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  • Name:Bing Su

  • Office Location:Room 1101, No.5 Bldg., West Campus, 280 South Chongqing Rd.,Shanghai

  • Telephone:86-021-63846590-776207

  • Email:bingsu@sjtu.edu.cn


Education

1984

Peking University

B.S.

1987

Yale University

M.Ph.

1991

Yale University

Ph.D.

Career

1991-1995

University of California at San Diego Postdoctoral Fellow

1995-2006

The University of Texas Health Science Center Assistant, Associate, and Full Professor,

2006-2006

The University of Texas, MD Anderson Cancer Center Professor with Tenure

2007-2014

Yale School of Medicine and Graduate School of Arts & Sciences Associate Professor (Tenure)

2014-present

Yale School of Medicine Adjunct Professor

2009-2012

Shanghai Jiaotong University School of Medicine Guest Professor

2012-Present

Shanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine Director and Principal Investigator

2013-Present

Department of Immunology and Microbiology, Shanghai Jiaotong University School of Medicine Professor and Chair

2014-Present

Shanghai Jiaotong University KC Wong Endowed Chair Professor

2014-present

Department of Immunobiology and the Vascular Biology and Therapeutics Program, Yale School of Medicine Adjunct Professor

2016-Present

Immune and Microbiota Related Diseases Research Center of Shanghai Institute of Immunology & Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China. Director

2018-Present

Shanghai Jiao Tong University School of Medicine-Yale University Immunometabolism Research Center (SYIRC) Director

Research Interests

The research in my laboratory focuses on the biology of signal transduction mediated by the intracellular protein kinase network such as the mitogen-activated protein kinase (MAPK) cascades and the mammalian target of rapamycine (mTOR) pathway in gut immune responses and in blood vessel function/development. We study the genes that encode either the serine/threonine kinases or their regulators in the kinase pathways. Our studies have revealed the roles of these kinase pathways in transducing various receptor signals and in regulating cell growth, differentiation, and apoptosis.

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1.  M Li, AS Lazorchak, X Ouyang, H Zhang, H Liu, O.A Arojo, G Qu, X Xu, X Liu, W Zhang, Q Wang, D Liu, F Li,B Su(Corresponding author).Sin1/mTORC2 regulates B cell growth and metabolism via mTORC1 and Myc activation.Cell Mol Immunol,2019,10.1038/s41423-018-0185-x.   [Link]

2.   X Ouyang, Y Han, G Qu, M Li, O Arojo, H Sun, X Liu, D Liu, LChen, Q Zou, Bing Su.(Corresponding author). Metabolic regulation of T cell development by Sin1-mTORC2 is mediated by pyruvate kinase M2 .J Mol Cell Biol,2018,11(2):93-106.   [Link]

3.  Xu YY, Ouyang XX, Yan LC, Zhang ML, Hu ZL, Gu JM, Fan XM, Zhang L, Zhang JF, Xue S, Chen GQ, Su B(Corresponding author), and Liu JL..Sin1 regulates ischaemia-induced microthrombosis through integrin αIIbβ3-mediated outside-in signaling and hypoxia responses in platelet.Arteriosclerosis, Thrombosis, and Vascular Biology,2018,(in press).   [Link]

4.  Wu ZR, Yan LC, Liu YT, Cao L, Guo YH, Zhang Y, Yao H, Cai L, Shang HB, Rui WW, Yang G, Zhang XB, Tang H, Wang Y, Huang JY, Wei YX, Zhao WG, Su B (Corresponding author) and Wu ZB..Selective mTORC1 inhibition by lncRNA H19 via disruption of the 4E-BP1 and Raptor interaction in pituitary tumors.Nature Communications,2018,9:4624.   [Link]

5.  OA. Arojo, X Ouyang, D Liu, T Meng, SM. Kaech, JP. Pereira and B Su.(Corresponding author).Active mTORC2 Signaling in Naive T Cells Suppresses Bone Marrow Homing by Inhibiting CXCR4 Expression .J Immunol,2018,201:908-915..   [Link]

6.  Xuemei Fan, Conghui Wang, Panlai Shi, Wen Gao, Jianmin Gu, Yan Geng, Wenlong Yang, Ningbo Wu, Yang Wang, Yanyan Xu, Xue Chen, Lin Zhang, Kemin Wang,Bing Su(Corresponding author) and Junling Liu.Platelet MEKK3 regulates arterial thrombosis and myocardial infarct expansion in mice.Blood Adv,2018,26;2(12):1439-1448..   [Link]

7.  Zepp JA, Zhao J, Liu C, Bulek K, Wu L, Chen X, Hao Y, Wang Z, Wang X, Ouyang W, Kalady MF, Carman J, Yang WP, Zhu J, Blackburn C Huang YH, Hamilton TA1,2, Su B(Corresponding author) and LiX..IL-17A-Induced PLET1 Expression Contributes to Tissue Repair and Colon Tumorigenesis.J Immuno l,2017,199(11):3849-3857.   [Link]

8.  Tan R, Nakajima S, Wang Q, Sun H,Xue J, Wu J, Hellwig S, Zeng X, Yates NA7, Smithgall TE, Lei M, Jiang Y, Levine AS, Su B(Corresponding author), Lan L..Nek7 Protects Telomeres from Oxidative DNA Damage by Phosphorylation and Stabilization of TRF1.Mol Cell,2017 ,65(5):818-831.   [Link]

9.  Wang Q, Tan R, Zhu X, Zhang Y, Tan Z, Su B(Corresponding author), Li Y ..Oncogenic K-ras confers SAHA resistance by up-regulating HDAC6 and c-myc expression .Oncotarget,2016,7(9):10064-72.   [Link]

10.  Fisher OS, Deng H, Liu D, Zhang Y, Wei R, Deng Y, Zhang F, Louvi A, Turk BE, Boggon TJ, Su B.(Corresponding author).Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex.Nat Commun,2015,6: 1-11.   [Link]

11.  Liu P, Gan W, Chin YR, Ogura K, Guo J, Zhang J, Wang B, Blenis J, Cantley LC, Toker A, Su B(Corresponding author), Wei W.PtdIns (3,4,5)P3-dependent activation of the mTORC2 kinase complex.Cancer Discov,2015,5(11):1194-209.   [Link]

12.  Chang X, Liu F, Wang X, Lin A, Zhao H, Su B.(Corresponding author).The kinases MEKK2 and MEKK3 regulate transforming growth factor-β-mediated helper T cell differentiation.Immunity,2011,34(2):201-12.   [Link]

13.  Valeria Facchinetti, Weiming Ouyang, Hua Wei, Nelyn Soto, Adam Lazorchak, Christine Gould, Carolyn Lowry, Alexandra C. Newton, Yuxin Mao, Robert Q. Miao, William C. Sessa, Jun Qin, Pumin Zhang, Su B(Corresponding author), and Estela Jacinto. . The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J,2008, 27(14):1932-43.   [Link]

14.  Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung SY, Huang Q, Qin J, Su B.(Corresponding author) .SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. . Cell, 2006, 127(1):125-37.   [Link]

15.  Qiaojia Hunag, Jianhua Yang, Jinke Cheng, CM Walker, Z.G. Liu, and Su B. (Corresponding author).Differential regulation of interleukin-1 receptor and toll like receptor (TLR) signaling by MEKK3. Nature Immunology,2004,5:95-103.   [Link]

16.  Yang J, Lin Y, Guo Z, Borem M, Huang H, Liao, Chen Z, Liu ZG, and Su B. (Corresponding author).Essential role of MEKK3 in TNF-induced NF-kB activation.Nature Immunology ,2001,2:620-624.   [Link]

17.  Su B.(First author), Jacinto, E., Hibi, M., Kallunki, T., Karin, M., and Ben-Neriah, Y. .JNK mediates signal integration during costimulation of T lymphocytes. Cell .,1994, 77:727-736,.   [Link]



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Qijun Wang,Ph.D.

Associate Professor

E-mail:qijun_wang@sjtu.edu.cn


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Xiaodong_Yang,Ph.D.

Associate Professor

E-mail:xdyang@shsmu.edu.cn


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Zhengfeng_Yang,Ph.D.

Associate Professor

E-mail:yangzf@shsmu.edu.cn


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Chun_Ruan,Ph.D.

Associate Professor

E-mail:chunruan@sjtu.edu.cn


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Yongxiao_Liu,M.S


E-mail:liuyongxiao@shsmu.edu.cn


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Liyuan_Jiang,M.S


E-mail: jiangliyuan@shsmu.edu.cn


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Xiaoli_Jiang,M.S


E-mail:jiangxiaoli@shsmu.edu.cn


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Yu_Shi,M.S


E-mail:pijiuhua86@126.com


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Dingqiang_Fang

Postdoctor

E-mail:fangdingqiang@shsmu.edu.cn


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Ningbo _Wu

Postdoctor

E-mail:wuningbo1989@163.com


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Hongzhi Liu

Ph.D. Candidate (Class 2013)

E-mail:lhz1206@sjtu.edu.cn


1465288461.jpg

Hongxiang Sun

Ph.D. Candidate (Class 2014)

E-mail:sun758426@sjtu.edu.cn


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Yuheng_Han

Ph.D Candidate (Class2016)

E-mail:yuhenghan@sjtu.edu.cn


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Song Li

Ph.D. Candidate (Class 2015)

E-mail:lisifnil@163.com


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Jingsi Jin

Ph.D. Candidate (Class 2016)

E-mail:Jingsi_Jin@sjtu.edu.cn


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Xiaoyun_Zhao

Ph.D Candidate (Class2016)

E-mail:xiaoyun630rf@sjtu.edu.cn


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Jianmei_Tan

Ph.D Candidate (Class2017)

E-mail:tanjianmei@sjtu.edu.cn


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Jinngjing_Qi

Ph.D Candidate (Class2017)

E-mail:qijingjing100@sjtu.edu.cn


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Dandan_Wu


E-mail:DandanWu1994@sjtu.edu.cn


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Hongqian_Chen

Ph.D Candidate (Class2018)

E-mail:disannychen@sjtu.edu.cn


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Liang_Li

Ph.D Candidate (Class2019)

E-mail:waire16@sjtu.edu.cn


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Xinyu_Wang

Ph.D Candidate (Class2018)

E-mail:381250842@qq.com



Lab Location:Room 1111, No.5 Bldg., West Compus, 280 South Chongqing Rd.,Shanghai

Tel:86-021-63846590-776564


                 

Copyright 2016. Shanghai Institute of Immunology,Shanghai Jiao Tong University School of Medicine.All Rights Reserved.