王兆军 教授 博士生导师

上海交通大学 致远荣誉教师

上海交通大学医学院全球健康学院 副院长

上海市免疫学研究所 PI

联系方式：

办公室地址：上海市重庆南路280号5号楼1207室

办公室电话：021-63846590-776349

邮箱：zjwang@sjtu.edu.cn

教育经历（从本科开始）

1991年-1996年 上海第二医科大学 学士

1999年-2002年 上海第二医科大学 硕士

2003年-2006年 上海交通大学 博士

工作经历

1996年-至今 上海第二医科大学/上海交通大学医学院 教师

2008年-2012年 美国宾夕法尼亚大学医学院 博士后

2017年-至今 上海交通大学医学院党委教师工作部 副部长

2021年-至今 上海市免疫学研究所 PI

2023年-至今 上海交通大学医学院全球健康学院副院长

社会/学术任职和活动

第一届国家疾病预防控制标准委员会寄生虫病标准专业委员会委员

中国预防医学会医学寄生虫分会委员

上海市医学会医学教育专科分会委员会教师教学发展学组副组长

上海市医师协会整合医学分会委员

《中国寄生虫学与寄生虫病杂志》《热带医学杂志》《中国血吸虫病防治杂志》编委

《Frontiers in Immunology》Review Editor

科研方向/主要研究内容

科研项目

项目编号	项目类型	项目名称	起止年月	备注
82272362	国家自然科学基金面上项目	PRL2在中性粒细胞胞外诱捕网形成及重症疟疾中的作用机制研究	2023.1-2026.12	项目负责人
81971486	国家自然科学基金面上项目	PRL2调控固有免疫细胞活化及其在抗菌感染免疫中的作用机制	2020.1-2023.12	项目负责人
81471971	国家自然科学基金面上项目	血吸虫虫卵16kD钙结合蛋白诱导巨噬细胞极化调控宿主免疫病理反应的机制研究	2015.1-2018.12	项目负责人
81172808	国家自然科学基金面上项目	TIPE2-Rac信号通路在感染免疫中的作用与机理研究	2012.1-2015.12	项目负责人
30600517	国家自然科学基金青年科学基金项目	日本血吸虫特异抗原调节自身免疫病的机理研究	2007.1-2009.12	项目负责人

发表论文（格式：国标GB／T7714-2015）

[1] DU X, REN B, LI C, et al. PRL2 regulates neutrophil extracellular trap formation which contributes to severe malaria and acute lung injury [J]. Nature communications, 2024, 15(1).

[2] LEI Y, GUO X, LUO Y, et al. Synovial microenvironment-influenced mast cells promote the progression of rheumatoid arthritis [J]. Nature communications, 2024, 15(1).

[3] SUN Z-S, WAN E-Y, AGBANA Y L, et al. Global One Health index for zoonoses: A performance assessment in 160 countries and territories [J]. iScience, 2024.

[4] LI Q, YUE T, DU X, et al. HSC70 mediated autophagic degradation of oxidized PRL2 is responsible for osteoclastogenesis and inflammatory bone destruction [J]. Cell Death & Differentiation, 2023, 30(3): 647-59.

[5] ZHANG X-X, LI X-C, ZHANG Q-Y, et al. Tackling global health security by building an academic community for One Health action [J]. Infectious Diseases of Poverty, 2023, 12(1).

[6] LI Q, LI X, KAN S, et al. Clonorchis sinensis calcium-binding protein Cs16 causes acute hepatic injury possibly by reprogramming the metabolic pathway of bone marrow-derived monocytes [J]. Frontiers in Cellular and Infection Microbiology, 2023, 13.

[7] KAN S, LI Q, LI H-M, et al. Clonorchis sinensis infection modulates key cytokines for essential immune response impacted by sex [J]. PLoS neglected tropical diseases, 2022, 16(9).

[8] WU C, DU X, TANG L, et al. Schistosoma japonicum SjE16.7 Protein Promotes Tumor Development via the Receptor for Advanced Glycation End Products (RAGE) [J]. Frontiers in immunology, 2020, 11.

[9] DU X, ZHANG Y, LI X, et al. PRL2 serves as a negative regulator in cell adaptation to oxidative stress [J]. Cell & bioscience, 2019, 9(1).

[10] YIN C, WU C, DU X, et al. PRL2 Controls Phagocyte Bactericidal Activity by Sensing and Regulating ROS [J]. Frontiers in immunology, 2018, 9.

[11] FAYNGERTS S A, WANG Z, ZAMANI A, et al. Direction of leukocyte polarization and migration by the phosphoinositide-transfer protein TIPE2 [J]. Nature immunology, 2017, 18(12): 1353-60.

[12] FANG Y, WU C, CHEN Q, et al. SjE16.7 activates macrophages and promotes Schistosoma japonicum egg-induced granuloma development [J]. Acta tropica, 2015, 149: 49-58.

[13] WANG Z, FAYNGERTS S, WANG P, et al. TIPE2 protein serves as a negative regulator of phagocytosis and oxidative burst during infection [J]. Proceedings of the National Academy of Sciences, 2012, 109(38): 15413-8.

[14] WANG Z, QIU J, GUO T B, et al. Anti-Inflammatory Properties and Regulatory Mechanism of a Novel Derivative of Artemisinin in Experimental Autoimmune Encephalomyelitis [J]. The Journal of Immunology, 2007, 179(9): 5958-65.

[15] HU W, YAN Q, SHEN D-K, et al. Evolutionary and biomedical implications of a Schistosoma japonicum complementary DNA resource [J]. Nature genetics, 2003, 35(2): 139-47.

英文：

Name：Zhaojun Wang

Degree：PhD                  

Title：  Professor, Vice-Dean of School of Global Health

Email Address: zjwang@sjtu.edu.cn

Office Address: 280 South Chongqing Road, Room 1207

Office Tel: 021-63846590-776349

Education：

Ph.D in Immunology, Shanghai Jiao Tong University, China

Master in Microbiology and Parasitology, Shanghai Second Medical University, China

Bachelor in Medical laboratory science, Shanghai Second Medical University, China

Appointments：

1996 - 2005 Shanghai Second Medical University, Teaching Assistant, Lecturer and Associate Professor

2005 - Present Shanghai Jiao Tong University School of Medicine, Associate and Full Professor

2008 - 2012 University of Pennsylvania School of Medicine, Postdoctoral Researcher

2017 - Present Faculty development department, Shanghai Jiao Tong University School of Medicine, Vice director

2021 - Present Shanghai Institute of Immunology, Principal Investigator

2023 - Present School of Global Health, School of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Vice dean

Academic Participation and Activities：

[1] DU X, REN B, LI C, et al. PRL2 regulates neutrophil extracellular trap formation which contributes to severe malaria and acute lung injury [J]. Nature communications, 2024, 15(1).

[2] LEI Y, GUO X, LUO Y, et al. Synovial microenvironment-influenced mast cells promote the progression of rheumatoid arthritis [J]. Nature communications, 2024, 15(1).

[3] SUN Z-S, WAN E-Y, AGBANA Y L, et al. Global One Health index for zoonoses: A performance assessment in 160 countries and territories [J]. iScience, 2024.

[4] LI Q, YUE T, DU X, et al. HSC70 mediated autophagic degradation of oxidized PRL2 is responsible for osteoclastogenesis and inflammatory bone destruction [J]. Cell Death & Differentiation, 2023, 30(3): 647-59.

[5] ZHANG X-X, LI X-C, ZHANG Q-Y, et al. Tackling global health security by building an academic community for One Health action [J]. Infectious Diseases of Poverty, 2023, 12(1).

[6] LI Q, LI X, KAN S, et al. Clonorchis sinensis calcium-binding protein Cs16 causes acute hepatic injury possibly by reprogramming the metabolic pathway of bone marrow-derived monocytes [J]. Frontiers in Cellular and Infection Microbiology, 2023, 13.

[7] KAN S, LI Q, LI H-M, et al. Clonorchis sinensis infection modulates key cytokines for essential immune response impacted by sex [J]. PLoS neglected tropical diseases, 2022, 16(9).

[8] WU C, DU X, TANG L, et al. Schistosoma japonicum SjE16.7 Protein Promotes Tumor Development via the Receptor for Advanced Glycation End Products (RAGE) [J]. Frontiers in immunology, 2020, 11.

[9] DU X, ZHANG Y, LI X, et al. PRL2 serves as a negative regulator in cell adaptation to oxidative stress [J]. Cell & bioscience, 2019, 9(1).

[10] YIN C, WU C, DU X, et al. PRL2 Controls Phagocyte Bactericidal Activity by Sensing and Regulating ROS [J]. Frontiers in immunology, 2018, 9.

[11] FAYNGERTS S A, WANG Z, ZAMANI A, et al. Direction of leukocyte polarization and migration by the phosphoinositide-transfer protein TIPE2 [J]. Nature immunology, 2017, 18(12): 1353-60.

[12] FANG Y, WU C, CHEN Q, et al. SjE16.7 activates macrophages and promotes Schistosoma japonicum egg-induced granuloma development [J]. Acta tropica, 2015, 149: 49-58.

[13] WANG Z, FAYNGERTS S, WANG P, et al. TIPE2 protein serves as a negative regulator of phagocytosis and oxidative burst during infection [J]. Proceedings of the National Academy of Sciences, 2012, 109(38): 15413-8.

[14] WANG Z, QIU J, GUO T B, et al. Anti-Inflammatory Properties and Regulatory Mechanism of a Novel Derivative of Artemisinin in Experimental Autoimmune Encephalomyelitis [J]. The Journal of Immunology, 2007, 179(9): 5958-65.

[15] HU W, YAN Q, SHEN D-K, et al. Evolutionary and biomedical implications of a Schistosoma japonicum complementary DNA resource [J]. Nature genetics, 2003, 35(2): 139-47.

Research Interest：Infection and Immunity

Innate host immunity is the first line of defense against pathogen infection, playing a critical role in host resistance to pathogenic microorganisms. Prof Wang’s lab focuses on how leukocytes adapt to infectious or inflammatory environments and regulate their functions in response to diverse pathogens, such as protozoa and helminths.