姓名：张彦  职称：高级实验师

联系方式：

办公室地址：重庆南路280号1#407  

办公室电话：021-63846590转776428

邮箱：yan_zhang@shsmu.edu.cn

教育经历（从本科开始）

2001年-2006年 济宁医学院 临床医学 学士

2006年-2009年 上海交通大学 病理学 硕士

工作经历

2009.7-2020.9 上海交通大学医学院 基础医学院

2020.10-今 上海交通大学医学院 全球健康学院

社会/学术任职和活动

上海市食品学会乳酸菌专委会秘书

上海微生物学会会员

上海寄生虫学会会员

科研方向/主要研究内容

全健康科学/人兽共患病、耐药控制

从事全健康科学人兽共患病方向和细菌耐药控制研究，对钩端螺旋体病进行了机制探究（Emerging microbes & infections, 2017; BMC infectious diseases, 2012;）开发的诊断试剂等相关技术已经转化并产业化；曾主持省部级课题3项，发表研究论文30余篇。主讲五年制、八年制临床医学专业课程《病原生物学实验》，年均72学时。承担研究生入学安全教育和上海交通大学医学院成人教育学院的《实验室生物安全》课程，年均8学时。

搭建全健康公共技术与数据研究平台，为全健康科学研究提供硬件和软件支持。

科研项目

发表论文（格式：国标GB／T7714-2015）

1. Nan Zhou, Zile Cheng, Xiaoxi Zhang, Chao Lv, Chaoyi Guo, Haodong Liu, Ke Dong, Yan Zhang, Chang Liu, Yung-Fu Chang, Sheng Chen, Xiaokui Guo*, Xiao-Nong Zhou*, Min Li*,  Zhu YZ *(corresponding author). Global antimicrobial resistance: a system-wide comprehensive investigation using the Global One Health Index. Infect Dis Poverty 2022，23;11(1):92.

2. Mufeng Cai, Bingchun Pu, Yue Wang, Lin Lv, Chunyu Jiang, Xiaomei Fu, Yan Zhang, Wei Zhao, Ke Dong, Yi Yang, Yangming Liu, Yalu Wei, Zhengyue Zhang, Jianhui Li, Xiaokui Guo, Chang Liu, Jinhong Qin*. A Plasmid With Conserved Phage Genes Helps Klebsiella pneumoniae Defend Against the Invasion of Transferable DNA Elements at the Cost of Reduced Virulence. Front Microbiol 2022, 13:827545.  

3. Xiaomei Fu, Lin Lyu, Yue Wang, Yan Zhang, Xiaokui Guo, Qian Chen, Chang Liu*. Safety assessment and probiotic characteristics of Enterococcus lactis JDM1. Microbial Pathogenesis 2022,163:105380.

Feng T, Leptihn S, Dong K, Loh B,  Zhang Y, Stefan M, Li M, Guo X* and CuiZ*: JD419, a Staphylococcus aureus Phage With a Unique Morphology and Broad Host Range. Frontiers in microbiology 2021, 12:602902.

4. Li T, Lyu L, Zhang Y, Dong K, Li Q*, Guo X*, Zhu Y*: A newly isolated E. thailandicus strain d5B with exclusively antimicrobial activity against C. difficile might be a novel therapy for controlling CDI. Genomics 2021, 113:475-83.

5. Li T, Zhang Y, Dong K, Kuo CJ, Li C, Zhu YQ, Qin J, Li QT, Chang YF*, Guo X*, Zhu Y*: Isolation and Characterization of the Novel Phage JD032 and Global Transcriptomic Response during JD032 Infection of Clostridioides difficile Ribotype 078. mSystems 2020, 5.

6. Chen Q^#, Ma X^#, Li C, Shen Y, Zhu W, Zhang Y, Guo X, Zhou J*, Liu C*: Enteric Phageome Alterations in Patients With Type 2 Diabetes. Frontiers in cellular and infection microbiology 2020, 10:575084.

7. Ding B, Li Q, Guo M, Dong K, Zhang Y, Guo X, Liu Q, Li L*, Cui Z*: Prevention of Dermal Abscess Formation Caused by Staphylococcus aureus Using Phage JD007 in Nude Mice. Frontiers in microbiology 2018, 9:1553.

8. Zeng L^#, Wang D^#, Hu N, Zhu Q, Chen K, Dong K, Zhang Y, Yao Y*, Guo X*, Chang YF*, Zhu Y*: A Novel Pan-Genome Reverse Vaccinology Approach Employing a Negative-Selection Strategy for Screening Surface-Exposed Antigens against leptospirosis. Frontiers in microbiology 2017, 8:396.

9. Xia B^#, Sun L^#, Fan X, Xiao H, Zhu Y, Qin J, Cai C, Zhao W, Chang YF, Zhang Y*, Guo X*, He P*: A new model of self-resolving leptospirosis in mice infected with a strain of Leptospira interrogans serovar Autumnalis harboring LPS signaling only through TLR4. Emerging microbes & infections 2017, 6:e36.

10. Guo M, Feng C, Ren J, Zhuang X, Zhang Y, Zhu Y, Dong K, He P, Guo X*, Qin J*: A Novel Antimicrobial Endolysin, LysPA26, against Pseudomonas aeruginosa. Frontiers in microbiology 2017, 8:293.

11. Cui Z, Guo X, Dong K, Zhang Y, Li Q, Zhu Y, Zeng L, Tang R, Li L*: Safety assessment of Staphylococcus phages of the family Myoviridae based on complete genome sequences. Scientific reports 2017, 7:41259.

12. Cui Z*^#, Feng T^#, Gu F, Li Q, Dong K, Zhang Y, Zhu Y, Han L, Qin J, Guo X*: Characterization and complete genome of the virulent Myoviridae phage JD007 active against a variety of Staphylococcus aureus isolates from different hospitals in Shanghai, China. Virology journal 2017, 14:26.

13. Chen Q, Ren Y, Lu J, Bartlett M, Chen L, Zhang Y, Guo X, Liu C*: A Novel Prebiotic Blend Product Prevents Irritable Bowel Syndrome in Mice by Improving Gut Microbiota and Modulating Immune Response. Nutrients 2017, 9.

14. Zhang Q, Wan H, Huang S, Zhang Y, Wang Y, Guo X, He P*, Zhou M: Critical role of RIG-I-like receptors in inflammation in chronic obstructive pulmonary disease. The clinical respiratory journal 2016, 10:22-31.

15. Wang Y, Ding X, Chen Y, Guo M, Zhang Y, Guo X*, Gu H*: Antibiotic-loaded, silver core-embedded mesoporous silica nanovehicles as a synergistic antibacterial agent for the treatment of drug-resistant infections. Biomaterials 2016, 101:207-16.

16. Zhu W, Wang J, Zhu Y, Tang B, Zhang Y, He P, Zhang Y, Liu B, Guo X*, Zhao G*, Qin J*: Identification of three extra-chromosomal replicons in Leptospira pathogenic strain and development of new shuttle vectors. BMC genomics 2015, 16:90.

17. Zeng LB^#, Zhuang XR^#, Huang LL, Zhang YY, Chen CY, Dong K, Zhang Y, Cui ZL, Ding XL, Chang YF*, Guo XK*, Zhu YZ*: Comparative subproteome analysis of three representative Leptospira interrogans vaccine strains reveals cross-reactive antigens and novel virulence determinants. Journal of proteomics 2015, 112:27-37.

18. Wang Y, Zhuang X, Zhong Y, Zhang C, Zhang Y, Zeng L, Zhu Y, He P, Dong K, Pal U*, Guo X*, Qin J*: Distribution of Plasmids in Distinct Leptospira Pathogenic Species. PLoS neglected tropical diseases 2015, 9:e0004220.

19. Liu B*, Wang Y*, Guo X*, Zhu W*, Zhang Y*, He P*: Carboxyfluorescein diacetate succinimidyl ester labeling method to study the interaction between Leptospira and macrophages. Journal of microbiological methods 2014, 107:205-13.

20. He P, Deng C, Liu B, Zeng L, Zhao W, Zhang Y, Jiang X, Guo X, Qin J*: Characterization of a bifunctional enzyme with (p)ppGpp-hydrolase/synthase activity in Leptospira interrogans. FEMS microbiology letters 2013, 348:133-42.

21. Zhang Y^#, Lou XL^#, Yang HL, Guo XK, Zhang XY, He P*, Jiang XC*: Establishment of a leptospirosis model in guinea pigs using an epicutaneous inoculations route. BMC infectious diseases 2012, 12:20.

22. Cui Z, Zhou Y, Li H, Zhang Y, Zhang S, Tang S*, Guo X*: Complex sputum microbial composition in patients with pulmonary tuberculosis. BMC microbiology 2012, 12:276.

23. Zhong Y*, Chang X*, Cao XJ*, Zhang Y, Zheng H, Zhu Y, Cai C, Cui Z, Zhang Y, Li YY, Jiang XG, Zhao GP, Wang S*, Li Y*, Zeng R*, Li X*, Guo XK*: Comparative proteogenomic analysis of the Leptospira interrogans virulence-attenuated strain IPAV against the pathogenic strain 56601. Cell research 2011, 21:1210-29.

英文：

Name：Yan Zhang

Degree：M.D.

Title：Senior Experimentalist

Email Address: yan_zhang@shsmu.edu.cn

Office Address: 280 S. Chongqing Rd, Shanghai, China 200025

Office Tel: 021-63846590-77712

Education：

2001/09－2006/06 Jining college of Shangdong Province

2006/09－2009/06 Shanghai Jiao Tong University School of Medicine

Appointments：

2009/07－2020/09 Basic Medical College, Shanghai Jiao Tong University School of Medicine

2020/10－present School of Global Health, Chinese Centre for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine

Academic Participation and Activities：

Lactobacillus Professional Committee, Shanghai Society of Food Science, Secretary

Shanghai Society for Microbiology, member

Shanghai Society for parasitology, member

ResearchInterest：

Zoonosis; AMR control;