姓名：朱泳璋

职称：病原微生物学副教授 / 微生物检验技术副主任技师

毕业院校：清华大学北京协和医学院博士、上海交通大学医学院病原生物学博士后、康奈尔大学兽医学院人畜共患病实验室访问学者      

籍贯：湖南岳阳   

联系电话：021-63846590转776974

工作单位：上海交通大学医学院全球健康学院

邮箱：yzhzhu@sjtu.edu.cn

教育经历

1998.09-2002.07  云南大学生命科学学院 国家生物学基地班  微生物学 学士

2002.09-2007.07  清华大学-北京协和医学院 医学生物学研究所 硕博连读 遗传学双博士

2007.09-2009.09  病原生物学教研室 上海交通大学医学院  病原生物学博士后

工作经历

2011.03-2017.07  病原生物学教研室 上海交通大学医学院   病原微生物学副教授

2014.11-2015.11  动物医学院人畜共患病实验室  康奈尔大学  访问学者

2017.08-2019.03  抗生素研究所 复旦大学附属华山医院 副教授

2020.06-2020.11  卫生检疫所P3实验室 广州海关技术中心 检验副主任技师

2020.12-至今    全球健康学院 上海交通大学医学院国家热带病研究中心  病原微生物学副教授

教学工作

• 主要承担上交医以下课程教学工作：“病原生物学”、“病原基因组”、“医学微生物学研究进展”、 “全球健康与全健康”；作为编委参加“医学微生物学”和“病原生物学”多本国家级医学教材编写；

• 荣获上海交通大学医学院基础医学院2016年度青年教师授课比赛一等奖；获2023、2024年上交医PBL案例大赛优胜奖；

社会学术任职

1. 中国微生物学会人兽共患病病原学专委会委员      

2. 中国生物工程学会噬菌体专委会委员

3. 中国微生物学会医学微生物学与免疫学专委会青年学组委员

4. 全国公共卫生与预防医学名词编写委员会热带医学名词编写分委员会委员

5. 教育部基础医学“101计划”核心教材-《基础医学核心实践与创新研究》编委

6. 上海预防医学会微生态学专委会委员            

7. 上海微生物学会微生物组专委会委员

8. 《中华地方病学杂志》和《中国人兽共患病学报》编辑委员会编委

主持科研项目

1. 国家重点研发计划-中英政府间旗舰挑战计划项目“基于全健康的中英细菌耐药动态变化规律及驱动因素研究”子课题“多重耐药病原菌在全健康系统的耐药动态变化规律”负责人（2024YFE0199000）：

2. 国家自然科学基金：钩端螺旋体黄疸出血群有毒株和无毒株毒力进化机制探索（30900051）

3. 省自然科学基金：基于基因组学和蛋白质组学方法筛选百日咳疫苗新抗原（BK2010158）

4. 国家博士后基金：钩端螺旋体秋季血清群强毒株和弱毒株全基因组测序及比较基因组学研究（20080430655）

主要研究方向

重要耐药菌和耐药基因在人-动物-环境多界面流行传播模式和相互作用机制

具体研究内容

崇明岛全健康系统AMR监测范式，以及上海重要伴侣动物犬猫病原谱和高风险耐药质粒跨界面流行传播规律研究等。以项目负责人主持国家重点研发计划子课题（中英政府间旗舰挑战计划项目）、国家自然科学青年基金、省自然科学基金和国家博士后基金等多项省部级课题，2018年以来以第一作者或通讯作者发表包括9篇中科院一区文章在内的SCI论文19篇，影响因子超过10分以上有8篇，累计影响因子超过150，包括Journal of Hazardous Materials、Enviroment International、 Emerging Microbes & infections、Sci Total Environ、Infectious Disease of Poverty、mSystems、Communications Biology和One Health等。

代表性论著

1. Yiwen Chen, Min Li, Bingqing Sun, Luming Xia, Yifei Zhang, Jun Feng, Min Chen, Zile Cheng, Chao Lv, Weiye Chen, Jiewen Huang, Qingtian Li, Yu Zhang, Jun Shang, Ying Cao, Tianyu Wang, Yanqi Liu, Mengmeng Wang, Bin Zhang, Xiaokui Guo*, Shixin Huang*, Zhu YZ*(corresponding author). Companion Animals as Sources of Hazardous Critically Important Antimicrobial-Resistant Escherichia coli : Genomic Surveillance in Shanghai.  Journal of Hazardous Materials (newly accepted).

2. Zile Cheng, Yiwen Chen, Min Li, Chao Lv, Nan Zhou, Weiye Chen, JieWen Huang, QingTian Li, Zijing Gao, Xuesong Feng, Li Shi, YuFeng Yao*, Xiaokui Guo*, Zhu YZ*(corresponding author). An Unusual 'Gift' from Humans: Third-Generation Cephalosporin-Resistant Enterobacterales in migratory birds along the East Asian-Australasian Flyway. Environment International. 2025 Feb 12:197:109320. doi: 10.1016/j.envint.2025.109320.

3. Dongling Long, Min Li, Lingchao Ma, Jiewen Huang, Chao Lv, Yiwen Chen, Zile Cheng, Chang Liu, Huitao Huang, Xiaokui Guo, Chao Yang*, Zhu YZ*(corresponding author). Epidemiological and genetic charateristics of Vibrio vulnificus from diverse sources in China during 2012-2023. Commun Biol. 2025 Jan 4;8(1):9.doi: 10.1038/s42003-024-07426-5.

4. Chao Lv, Jun Leng d, Minjian Qian, Bingqing Sun, HuiPing Ye, Min Li, Nan Zhou, Zile Cheng, Yiwen Chen, Xiaokui Guo, Jun Shang, Li Zhang*, Zhu YZ *(corresponding author). Antimicrobial resistance in Escherichia coli and Staphylococcus aureus at human-animal interfaces on Chongming Island, Shanghai: A One Health perspective. One Health Volume 19, December 2024, 100910.

5. Huang J, Zhou N, Cheng Z, Chen Y, Li M, Lv C, Guo X, Li Q, Yao Y*, Dong K*, Zhu YZ *(corresponding author). Chromosomally located bla_CMH in Enterobacter cloacae complex across human-bird-environment interfaces: A one-health perspective. Sci Total Environ 2024 Sep 23:954:176486.

6. Chen W, Chen Y, Cheng Z, Chen Y, Lv C, Ma L, Zhou N, Qian J, Liu C, Li M*, Guo X*, Zhu YZ *(corresponding author). Global patterns of syphilis, gonococcal infection, typhoid fever, paratyphoid fever, diphtheria, pertussis, tetanus, and leprosy from 1990 to 2021: findings from the Global Burden of Disease Study 2021. Infect Dis Poverty 2024 Sep 13;13(1):66.

7. Jiewen Huang, Chao Lv , Min Li , Tanvir Rahman , Yung-Fu Chang , Xiaokui Guo , Zhen Song , Yanan Zhao , Qingtian Li*, Peihua Ni* , Zhu YZ *(corresponding author). Carbapenem-resistant Escherichia coli exhibit diverse spatiotemporal epidemiological characteristics across the globe.  Communications Biology 7: 51 (2024).

8. Min Li, Haoran Zhang, Wengang Zhang, Ying Cao, Bingqing Sun, et al, Xiaokui Guo, Jun Shang*, Shixin Huang*, Zhu YZ *(corresponding author). One global disseminated 193 kb high-risk hybrid plasmid harboring tet(X4), mcr or blaNDM threatening public health.  Sci Total Environ 2023 Mar 14;876:162807.

9. Chang C, Guo W, Yu X, Guo C, Zhou N, Guo X, Huang RL*, Li Q*, Zhu Y*(corresponding author). Engineered M13 phage as a novel therapeutic bionanomaterial for clinical applications: From tissue regeneration to cancer therapy. Mater Today Bio 2023 Mar 24;20:100612.

10. Chao Lv, Jun Shang, Wengang Zhang, Bingqing Sun, Min Li, Chaoyi Guo, Nan Zhou, Xiaokui Guo*, Shixin Huang*, Zhu YZ *(corresponding author). Dynamic antimicrobial resistant patterns of Escherichia coli from healthy poultry and swine over 10 years in Chongming Island, Shanghai. Infect Dis Poverty 2022 Sep 16;11(1):98.

11. Nan Zhou, Zile Cheng, Xiaoxi Zhang, Chao Lv, Chaoyi Guo, Haodong Liu, Ke Dong, Yan Zhang, Chang Liu, Yung-Fu Chang, Sheng Chen, Xiaokui Guo*, Xiao-Nong Zhou*, Min Li*,  Zhu YZ* (corresponding author). Global antimicrobial resistance: a system-wide comprehensive investigation using the Global One Health Index. Infect Dis Poverty 2022 Aug 23;11(1):92.

12. Zhu Y (the first author), Shi L, Zeng Y, Piao D, Xie Y, Du J, Gao M, Gao W, Tian J, Yue J, Li M, Guo X, Yao Y*, Kang Y*. Key immunity characteristics of diverse stages of brucellosis in rural population from Inner Mongolia, China. Infect Dis Poverty 2022 Jun 4;11(1):63.

13. Hongye Wang, Dongshan Yan, Ya Li, Yanfei Gong, Yulin Mai, Bingxiang Li, Xiaoyong Zhu, Xinrui Wan, Liyun Xie, HuaKe Jiang, Min Zhang, Ming Sun*, Yufeng Yao*, Zhu YZ *(corresponding author). Clinical and antibody characteristics reveal diverse signatures of severe and non-severe SARS-CoV-2 patients. Infect Dis Poverty. 2022 Feb 2;11(1):15.

14. Tinghua Li, Yan Zhang, Ke Dong, Chih-Jung Kuo, Chong Li, Yong-Qiang Zhu, Jinhong Qin, Qing-Tian Li, Yung-Fu Chang*, Xiaokui Guo*, Zhu YZ *(corresponding author). Isolation and Characterization of the Novel Phage JD032 and Global Transcriptomic Response during JD032 Infection of Clostridioides difficile Ribotype 078.  mSystems 2020 May 5;5(3):e00017-20.

15. Cuicai Zhang, Jianmin Xu, Tinglan Zhang, Haiyan Qiu, Zhenpeng Li, Enmin Zhang, Shijun Li, Yung-Fu Chang, Xiaokui Guo*, Xiugao Jiang*, Zhu YZ *(corresponding author). Genetic Characteristics of Pathogenic Leptospira in wild small animals and livestock in Jiangxi Province, China, 2002-2015.  PLOS Neglected Tropical Diseases. June 24, 2019  10.1371/journal.pntd.0007513

16. Xu-ming Li, Yao-xia Kang1, Liang Lin, En-Hou Jia, Dong-Ri Piao, Hai Jiang, Cui-Cai Zhang, Jin He*, Yung-Fu Chang*, Xiao-Kui Guo*, Zhu YZ *(corresponding author). Genomic Characterization Provides New Insights for Detailed Phage- Resistant Mechanism for Brucella abortus. Front Microbiol. 03 May 2019.

17. Jiayu Wang, Zheng Teng, Wei Chu, Fanghao Fang, Xiaoqing Cui, Xiaokui Guo, Xi Zhang*, Bruce Thorley*, Zhu YZ *(corresponding author). The Emergence and Spread of One Coxsackievirus A16 Genogroup D Novel Recombinant Strain Causing a Clustering HFMD Outbreak in Shanghai, China, 2016.  Emerg Microbes Infect. 2018 Jul 18;7(1):131.

18. Jiayu Wang, Zheng Teng, Xiaoqing Cui, Chongshan Li, Hao Pan, Yaxu Zheng, Shenghua Mao, Yuying Yang, Limeng Wu, Xiaokui Guo*, Xi Zhang*, Zhu YZ *(corresponding author).  Epidemiological and Serological Surveillance of Hand-Foot-and-Mouth Disease in Shanghai, China, 2012- 2016.  Emerg Microbes Infect. 2018 Jan 24;7(1):8.