个人简介 |

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姓名:沈玉娟 性别: 女 出生年月:1969.10 学位/学历:硕士 职称:研究员、硕士生导师 现任职务:药物室副主任(主持工作) 电子邮件:shenyj@nipd.chinacdc.cn; amyshyj12@163.com 办公地址:上海市瑞金二路207号 办公电话:电话:13564694660,021-64723472 传真:021-64376308 |
教育经历 |
1988.09-1992.07 上海交通大学农业与生物学院,兽医专业,学士学位 2004.09-2007.12苏州大学,病原生物学,硕士学位 |
工作经历 |
1992年7月至今 中国疾病预防控制中心寄生虫病预防控制所(国家热带病研究中心),研究员,硕士研究生导师 2014年9月至2015年8月 美国克瑞顿大学,访问学者 2015年4月至2021年3月 中国疾病预防控制中心寄生虫病预防控制所寄生虫病原与媒介生物学重点实验室副主任 2021年3月-至今 中国疾病预防控制中心寄生虫病预防控制所(国家热带病研究中心)药物室副主任(主持工作) |
社会/学术任职和活动 |
中国女医师协会公共卫生专业委员会委员 中华预防医学会旅行卫生分会委员会委员 中国微生物学会人兽共患病分会委员兼病原学专业委员会原虫学科组副组长 上海市免疫学会理事 上海市免疫学会感染与免疫专委会委员 上海市实验动物生物安全委员会委员 《中国人兽共患病学报》编委。 |
研究方向/主要研究内容 |
1. 寄生虫感染免疫及包虫病免疫致病机制 2. 新发肠道原虫病原学、分子流行病学、高通量检测技术、溯源和风险评估 |
科研/教学研究项目 |
1. 2021.1-2023.12,原头节外泌体miR-4989促细粒棘球蚴寄生部位血管生成作用及其机制研究,82072307,国家自然科学基金面上项目 2. 2018.1-2021.12,原头节外泌体lncRNAs对细粒棘球蚴感染小鼠MDSCs免疫下调作用及其机制研究,81772224,国家自然科学基金面上项目 3. 2014.1-2017.12,细粒棘球蚴感染小鼠Mo-MDSC源免疫抑制相关分子的研究,81371842,国家自然科学基金面上项目 4. 2008.1-2010.12,日本血吸虫雌雄合抱相关分子的研究,30771880,国家自然科学基金面上项目 5. 2018.1-2021.6自然疫源性传染病症候群寄生虫病原谱构成及流行规律研究,2018ZX10713001-004,国家科技重大专项(子课题) 6. 2008.11-2011.12,我国介水传播隐孢子虫病病源溯源及对策研究,200802012,国家公益性卫生行业科研专项 7. 2013.6-2015.6,饮水安全检测、监测、风险评估和预警预测关键技术研究,201302004,国家公益性卫生行业科研专项(子课题) 8. 2012.1-2013.12,新发肠道原虫病病原检测及风险评估,GWDTR201214,上海市公共卫生优秀学科带头人培养项目 9. 2008.10-2011.6重要寄生虫病原标本显微图像计算机实时自动鉴定系统的研究传染病病原体诊断和组合检测技术研究,2008ZX10004-002,国家科技重大专项(子课题) |
主要学术成果 |
专利 1. 沈玉娟,曹建平,刘华,袁忠英,姜岩岩,尹建海,王燕娟. 多重PCR检测肠道新发原虫试剂盒及检测方法,ZL 201510093500.9, 2017.2 2. 沈玉娟,陈盛霞,金红,李峰,潘雨青,孙启艳,吴亮,曹建平. 基于图像的寄生虫虫卵形状识别方法,ZL 201110022426.3,2012.10 已转化 3. 尹建海,曹建平,刘丛珊,张皓冰,沈玉娟. 熊果酸在制备抗包虫药物中的应用,ZL 2016 1 0517861.6,2019.4 4. 曹建平、Ugwu Chidiebere Emmanuel、沈玉娟、姜岩岩、段李平、袁忠英. 银杏酸在抗隐孢子虫中的应用, ZL 201310539693.7,2016.3 5. 曹建平,蔡辉霞,沈玉娟,韩秀敏,胡媛,王虎,卢潍媛,徐馀信,官亚宜. 诊断细粒棘球蚴病的重组抗原蛋白、其制备方法和用途,ZL 201010284913.2,2012.8 |
荣誉及奖项 |
1. 我国重要新发肠道原虫病原和分子检测关键技术研究及应用,上海市科技进步奖二等奖(2019)、中华医学科技奖二等奖(2019)、华夏医学科技奖三等奖(2019),排名第2 2. 我国隐孢子虫核酸检测和基因分型技术的研究及应用,中华预防医学科技奖三等奖(2015),排名第2 3. P2017-2018年度上海市卫生健康系统三八红旗集体(团队负责人) |
开设课程 |
《实验室生物安全实践》、《PCR实验》 |
Profile |
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Name:Yujuan Shen Gender: Female Date of birth: 10/1969 Degree:Master Title:Professor、postgraduate tutor Present Position:Vice director of Dept. of Pharmacology Email:shenyj@nipd.chinacdc.cn; amyshyj12@163.com Address:207 No.2 RuiJin Road, Shanghai Office Tel:86-21-64723472 |
Education |
9/1988-7/1992,Shanghai Jiaotong University School of Agricultural and Biological,Veterinary, Bachelor 9/2004-12/2007,Soochow University,Pathogen Biology,Master |
Appointments |
7/1992-present National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research),Professor, postgraduate tutor 9/2014-8/2015 Creighton University, USA, Visting Scholar 4/2015-3/2021 Key Laboratory of Parasite and Vector Biology, MOH, National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention,Vice director 3/2021-present Dept. of Pharmacology, National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research),Vice director |
Academic Participation and Activities |
Member of Public Health Branch of China Medical Women's Association Member of Travel Health Branch of Chinese Preventive Medicial Association Member of Zoonosis Branch of Chinese Society for Microbiology Member of Shanghai Immunology Society Member of Infection and Immunology Branch of Shanghai Immunology Society Member of Biosafety of Shanghai laboratory animal Society Editoral Board Member of Chinese Journal of Zoonoses |
Research interest |
1. Immunity and pathogenic mechanism of echinococcosis 2. Emerging intestinal protozoa pathogen , molecular epidemiology, high-throughput detection techniques, source track, and risk assessment |
Projects |
1. 1/2021-12/2023,Study on the role and mechanism of exosome-derived miR-4989 from Echinococcus granulosus protoscoleces in promoting angiogenesis at the parasitic sites, 82072307,National Natural Science Foundation 2. 1/2018-12/2021,Study on the mechanism ofimmune down-regulation on MDSCs in infected mice oflncRNAs from Echinococcus granulosus protoscolices-derived exosomes, 81772224,National Natural Science Foundation 3. 1/2014-12/2017,Study on the molecules associated with immunosuppression in Mo-MDSC derived from mice infected by Echinococcus granulosus,81371842,National Natural Science Foundation 4. 1/2008-12/2010, Study on the molecules of male-femal worm pairing of Schistosoma japonicum,30771880,National Natural Science Foundation 5. 1/2018-12/2021, Study on the parasitic pathogen spectrum composition and regularty of epidemic of natural focus infectiou diseases,2018ZX10713001-004,National Science and Technology Major Program of China (sub subject) 6. 11/2008-12/2011,Study on strategy and source track of waterborne cryptosporidiosis in China,200802012,Chinese Special Program for Scientific Research of Public Health 7. 6/2013-6/2015, Study on the key technologies of detection, surveillance, risk assessment, and forecasting and early warning on the safety of drinking water,201302004, Chinese Special Program for Scientific Research of Public Health (sub subject) 8. 1/2012-12/2013, Study on risk assessment and pathogen detection of the emerging intestinal protozoa,GWDTR201214, Shanghai Public Health Outstanding Academic Leader 9. 10/2008-6/2011, Real-time computer automatic identification system for microscopic images of key parasite,2008ZX10004-002,National Science and Technology Major Program of China (sub subject) |
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Patents |
1. Yujuan Shen, Jianping Cao, Hua Liu, Yanyan Jiang, Jianhai Yin, Yanjuan Wang. Multiplex PCR kit and detection method for detecting intestinal protozoa. ZL 201510093500.9,2/2017 2. Yujuan Shen, Shengxia Chen, Hong Jin, Feng Li, Yuqing Pan, Qiyan Sun, Liang Wu, Jiangping Cao. Identification method for parasite egg via image. ZL 201110022426.3,10/2012 (transformed) 3. Jianhai Yin, Jianping Cao, Congshan Liu, Haobing Zhang, Yujuan Shen. Application of ursolic acid in preparing anti-hydatid drugs. ZL 2016 1 0517861.6,4/2019 4. Jianping Cao, Ugwu Chidiebere Emmanuel,Yujuan Shen, Yanyan Jiang, Liping Duan, Zhongying Yuan. Function of Ginkgolic Acids for against Cryptosporidium. ZL 201310539693.7, 3/2016 5. Jianping Cao, Huixia Cai, Yujuan Shen, Xiumin Han, Yuan Hu, Hu Wang, Weiyuan Lu, Yuxin Xu, Yayi Guan. Recombinant antigen for diagnosis of Echinococcus granulosus, which application and preparation method. ZL 201010284913.2,8/2012 |
Honors and Awards |
1. Application and research on pathogen and molecular identification of key emerging intestinal protozoa in China. Shanghai Science and Technology Progress Award, the second prize, 2019; Chinese Medical Science and Technology Award, the second prize, 2019; Huaxia Medical Science and Technology Award, the third prize, 2019 2. Application and research on nucleic acid detection and molecular identification of Cryptosporidium in China. Chinese Preventive Medical Science and Technology Award, the third prize, 2015 3. Shanghai health systm, three, eight red flag group, 2017-2018(PI) |
Lectures |
Laboratory biosafety practices, PCR test |