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沈玉娟

作者:   发布时间 :2020年10月28日

个人简介

readme.jpg

姓名:沈玉娟     

性别:         

出生年月:1969.10

学位/学历:硕士      

职称:研究员、硕士生导师

现任职务:药物室副主任(主持工作)

电子邮件:shenyj@nipd.chinacdc.cn; amyshyj12@163.com

办公地址:上海市瑞金二路207

办公电话:电话:13564694660021-64723472   传真:021-64376308

 

教育经历

1988.09-1992.07 上海交通大学农业与生物学院,兽医专业,学士学位

2004.09-2007.12苏州大学,病原生物学,硕士学位

 

工作经历

19927月至今    中国疾病预防控制中心寄生虫病预防控制所(国家热带病研究中心),研究员,硕士研究生导师

20149月至20158  美国克瑞顿大学,访问学者

20154月至20213 中国疾病预防控制中心寄生虫病预防控制所寄生虫病原与媒介生物学重点实验室副主任

20213-至今  中国疾病预防控制中心寄生虫病预防控制所(国家热带病研究中心)药物室副主任(主持工作)

 

社会/学术任职和活动

中国女医师协会公共卫生专业委员会委员

中华预防医学会旅行卫生分会委员会委员

中国微生物学会人兽共患病分会委员兼病原学专业委员会原虫学科组副组长

上海市免疫学会理事

上海市免疫学会感染与免疫专委会委员

上海市实验动物生物安全委员会委员

《中国人兽共患病学报》编委。

 

研究方向/主要研究内容

1.   寄生虫感染免疫及包虫病免疫致病机制

2.   新发肠道原虫病原学、分子流行病学、高通量检测技术、溯源和风险评估

 

科研/教学研究项目

1.       2021.1-2023.12,原头节外泌体miR-4989促细粒棘球蚴寄生部位血管生成作用及其机制研究,82072307,国家自然科学基金面上项目

2.       2018.1-2021.12,原头节外泌体lncRNAs对细粒棘球蚴感染小鼠MDSCs免疫下调作用及其机制研究,81772224,国家自然科学基金面上项目

3.       2014.1-2017.12,细粒棘球蚴感染小鼠Mo-MDSC源免疫抑制相关分子的研究,81371842,国家自然科学基金面上项目

4.       2008.1-2010.12,日本血吸虫雌雄合抱相关分子的研究,30771880,国家自然科学基金面上项目

5.       2018.1-2021.6自然疫源性传染病症候群寄生虫病原谱构成及流行规律研究,2018ZX10713001-004,国家科技重大专项(子课题)

6.       2008.11-2011.12,我国介水传播隐孢子虫病病源溯源及对策研究,200802012,国家公益性卫生行业科研专项

7.       2013.6-2015.6,饮水安全检测、监测、风险评估和预警预测关键技术研究,201302004,国家公益性卫生行业科研专项(子课题)

8.       2012.1-2013.12,新发肠道原虫病病原检测及风险评估,GWDTR201214,上海市公共卫生优秀学科带头人培养项目

9.       2008.10-2011.6重要寄生虫病原标本显微图像计算机实时自动鉴定系统的研究传染病病原体诊断和组合检测技术研究,2008ZX10004-002,国家科技重大专项(子课题)

 

主要学术成果


专利

1.        沈玉娟,曹建平,刘华,袁忠英,姜岩岩,尹建海,王燕娟. 多重PCR检测肠道新发原虫试剂盒及检测方法,ZL   201510093500.9 2017.2

2.      沈玉娟,陈盛霞,金红,李峰,潘雨青,孙启艳,吴亮,曹建平.   基于图像的寄生虫虫卵形状识别方法,ZL   201110022426.32012.10   已转化

3.      尹建海,曹建平,刘丛珊,张皓冰,沈玉娟.   熊果酸在制备抗包虫药物中的应用,ZL   2016 1 0517861.62019.4

4.      曹建平、Ugwu   Chidiebere Emmanuel、沈玉娟、姜岩岩、段李平、袁忠英. 银杏酸在抗隐孢子虫中的应用,

ZL   201310539693.72016.3

5.      曹建平,蔡辉霞,沈玉娟,韩秀敏,胡媛,王虎,卢潍媛,徐馀信,官亚宜.   诊断细粒棘球蚴病的重组抗原蛋白、其制备方法和用途,ZL   201010284913.22012.8

 

 

荣誉及奖项

1.      我国重要新发肠道原虫病原和分子检测关键技术研究及应用,上海市科技进步奖二等奖(2019)、中华医学科技奖二等奖(2019)、华夏医学科技奖三等奖(2019),排名第2

2.      我国隐孢子虫核酸检测和基因分型技术的研究及应用,中华预防医学科技奖三等奖(2015),排名第2

3.      P2017-2018年度上海市卫生健康系统三八红旗集体(团队负责人)

 

开设课程

《实验室生物安全实践》、《PCR实验》

 

Profile

 

       

 

NameYujuan Shen     

Gender:   Female         

Date   of birth 10/1969

DegreeMaster         

TitleProfessorpostgraduate tutor

Present   PositionVice director of Dept. of Pharmacology

Emailshenyj@nipd.chinacdc.cn; amyshyj12@163.com

Address207   No.2 RuiJin Road, Shanghai   

Office   Tel86-21-64723472

Education

9/1988-7/1992Shanghai Jiaotong University School of Agricultural   and BiologicalVeterinary   Bachelor

9/2004-12/2007Soochow   UniversityPathogen BiologyMaster

 

 

Appointments

7/1992-present    National   Institute of Parasitic Diseases, Chinese Center for Disease Control and   Prevention(Chinese Center for Tropical Diseases Research)Professor postgraduate tutor

9/2014-8/2015    Creighton University, USA   Visting Scholar

4/2015-3/2021    Key   Laboratory of Parasite and Vector Biology, MOH, National Institute of   Parasitic Diseases, Chinese Center for Disease Control and PreventionVice  director

3/2021-present    Dept. of Pharmacology, National   Institute of Parasitic Diseases, Chinese Center for Disease Control and   Prevention(Chinese Center for Tropical Diseases Research)Vice  director

 

Academic Participation and Activities

Member   of Public Health Branch of China Medical Women's   Association

Member of Travel Health Branch of Chinese Preventive   Medicial Association

Member of Zoonosis Branch of Chinese Society for   Microbiology

Member of Shanghai Immunology Society

Member of Infection and Immunology Branch of    Shanghai Immunology Society

Member of Biosafety of Shanghai laboratory animal   Society

Editoral Board Member of Chinese Journal of Zoonoses

 

Research   interest

1.   Immunity and pathogenic mechanism of echinococcosis

2. Emerging intestinal protozoa pathogen   , molecular epidemiology, high-throughput detection techniques, source track,   and risk assessment

 

Projects

1.     1/2021-12/2023Study   on the role and mechanism of exosome-derived miR-4989 from Echinococcus   granulosus protoscoleces in promoting angiogenesis at the parasitic   sites, 82072307National Natural Science Foundation

2.       1/2018-12/2021Study   on the mechanism ofimmune down-regulation on MDSCs in infected mice oflncRNAs   from Echinococcus granulosus protoscolices-derived exosomes, 81772224National   Natural Science Foundation

3.       1/2014-12/2017Study   on the molecules associated with immunosuppression in Mo-MDSC derived from   mice infected by Echinococcus granulosus81371842National   Natural Science Foundation

4.       1/2008-12/2010 Study on   the molecules of male-femal worm pairing of Schistosoma japonicum30771880National   Natural Science Foundation

5.       1/2018-12/2021   Study on the parasitic pathogen spectrum composition   and regularty of epidemic of natural focus infectiou diseases2018ZX10713001-004National   Science and Technology Major Program of China (sub subject   

6.       11/2008-12/2011Study   on strategy and source track of waterborne cryptosporidiosis in China200802012Chinese   Special Program for Scientific Research of Public Health

7.       6/2013-6/2015 Study on   the key technologies of detection, surveillance, risk assessment, and   forecasting and early warning on the safety of drinking water201302004   Chinese Special Program for Scientific Research of Public Health (sub subject

8.       1/2012-12/2013   Study on risk assessment and pathogen detection of the   emerging intestinal protozoaGWDTR201214 Shanghai   Public Health Outstanding Academic Leader

9.       10/2008-6/2011,     Real-time   computer automatic identification system for microscopic images of key   parasite2008ZX10004-002National Science and   Technology Major Program of China   (sub subject

 



Patents

1. Yujuan Shen, Jianping   Cao, Hua Liu, Yanyan Jiang, Jianhai Yin, Yanjuan Wang.  Multiplex   PCR kit and detection method for detecting intestinal protozoa.  ZL   201510093500.92/2017

2. Yujuan Shen,   Shengxia Chen, Hong Jin, Feng Li, Yuqing Pan, Qiyan Sun, Liang Wu, Jiangping   Cao.  Identification method   for parasite egg via image.  ZL   201110022426.310/2012   (transformed)

3. Jianhai Yin,   Jianping Cao, Congshan Liu, Haobing Zhang, Yujuan Shen.  Application   of ursolic acid in preparing anti-hydatid   drugs.  ZL 2016 1 0517861.64/2019

4. Jianping Cao, Ugwu Chidiebere Emmanuel,Yujuan Shen,   Yanyan Jiang, Liping Duan, Zhongying Yuan. Function of Ginkgolic   Acids for against Cryptosporidium.    ZL 201310539693.7,  3/2016

5. Jianping Cao, Huixia   Cai, Yujuan Shen, Xiumin Han, Yuan Hu, Hu Wang, Weiyuan Lu, Yuxin Xu, Yayi   Guan. Recombinant antigen for diagnosis of Echinococcus   granulosus, which   application and preparation   method.  ZL 201010284913.28/2012

  

Honors   and Awards

1. Application   and   research on   pathogen and molecular identification of key emerging   intestinal   protozoa    in   China.    Shanghai   Science and Technology Progress Award, the second   prize, 2019;  Chinese Medical Science and Technology   Award,    the second prize, 2019; Huaxia Medical Science and Technology   Award,    the third prize, 2019

2. Application   and   research on nucleic   acid detection and molecular identification   of Cryptosporidium in ChinaChinese   Preventive Medical Science and Technology Award,  the   third prize, 2015

3.   Shanghai health systm, three, eight red flag group,  2017-2018(PI)

 

Lectures

Laboratory biosafety   practices PCR test

 

 

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