研究组长介绍
孙序序,博士，研究员，博士生导师。
2010年获得上海交通大学医学院细胞生物学博士。2010年至2012年曾在上海东方肝胆外科医院及香港中文大学中药研究所从事肝癌分子病理诊断及脂肪肝方面研究。2013年至2018年在美国德克萨斯大学西南医学中心从事表观遗传调控肝再生与肝癌方面博士后研究工作。现兼任中华医学会医学细胞生物学分会第六届青年委员会委员、中国细胞生物学会会员等。相关研究成果发表在Cell Stem Cell, Cancer Cell, EMBO J, Elife, Hepatology, Cell Reports等期刊上。
研究方向与进展
染色质重塑复合物是一类改变染色质结构调控基因表达的复合物，这类复合物基因在肿瘤中存在广泛突变，提示其抑癌基因作用。课题组运用基因编辑小鼠体内模型，分子细胞生物学以及生物信息学等方法研究染色质重塑复合物表观遗传调控在肿瘤以及其他疾病中改变染色质结构及细胞行为的作用及分子机制，解析相关发病机理。具体为:
（1）SWI/SNF染色质重塑复合物在肝癌中的分子机制研究。
（2）SWI/SNF染色质重塑复合物突变对细胞分化重编程的作用研究。
（3）针对SWI/SNF复合物突变肝癌的靶向药物研究。
科研项目
31970587，国家自然科学基金面上项目，染色质重塑因子ARID1A四种热点突变在肝癌中的功能及分子机制研究，2020.1-2023.12，60万元，主持人：孙序序
31771522，国家自然科学基金面上项目，SUMO2/3修饰和SENP3调控肝细胞自噬对代谢和在体肝脏应激应答的影响，2018.1-2021.12，59万，主持人：杨洁
81802773，国家自然科学基金青年科学基金项目，巨噬细胞SENP3调控胃炎免疫微环境促进胃癌发生的作用机制研究，2019.1-2021.12，21万，主持人：劳一敏
32000520，国家自然科学基金青年科学基金项目，ATG7的SUMO化修饰在自噬中的调控作用及分子机制的研究，2021.01-2023.12，24万，主持人：郭楚
代表性论文、专著与专利
1. Zixi Wang, Kenian Chen, Yuemeng Jia, Jen-Chieh Chuang, Xuxu Sun, Yu-Hsuan Lin, Cemre Celen, Lin Li, Fang Huang, Xin Liu, Diego H. Castrillon, Tao Wang, Hao Zhu. Dual ARID1A/ARID1B loss leads to rapid carcinogenesis and disruptive redistribution of BAF complexes. Nature Cancer 2020 September, 1, 909–922.
2. Yongxing Zhang, Kai Yang, Jie Yang, Yimin Lao, Lianfu Deng, Guoying Deng, Jing Yi, Xuxu Sun (co-corresponding author), Qiugen Wang. SENP3 Suppresses Osteoclastogenesis by De-conjugating SUMO2/3 from IRF8 in Bone Marrow-Derived Monocytes. Cell Reports 2020 February 11; 30, 1951–1963. e4
3. Xuxu Sun,* Sam C. Wang,* Yonglong Wei, Xin Luo, Yuemeng Jia, Lin Li, Purva Gopal, Min Zhu, Ibrahim Nassour, Jen-Chieh Chuang, Thomas Maples, Cemre Celen, Liem H. Nguyen, Linwei Wu, Shunjun Fu, Weiping Li, Lijian Hui, Feng Tian, Yuan Ji, Shuyuan Zhang, Mahsa Sorouri, Tae Hyun Hwang, Lynda Letzig, Laura James, Zixi Wang, Adam C. Yopp, Amit G. Singal, Hao Zhu. Arid1a has context-dependent oncogenic and tumor suppressor functions in liver cancer. Cancer Cell 2017, Nov 13; 32 (5), p574–589. e6.
4. Xuxu Sun, Jen-Chieh Chuang, Mohammed Kanchwala, Linwei Wu, Cemre Celen, Lin Li, Hanquan Liang, Shuyuan Zhang, Thomas Maples, Liem H. Nguyen, Sam C. Wang, Robert A.J. Signer, Mahsa Sorouri, Ibrahim Nassour, Xin Liu, Jian Xu, Meng Wu, Yong Zhao, Yi-Chun Kuo, Zhong Wang, Chao Xing, Hao Zhu. Suppression of the SWI/SNF component Arid1a promotes mammalian regeneration. Cell Stem Cell 2016 Apr 7; 18(4):456-466.
5. Shan Yan*, Xuxu Sun*, Binggang Xiang, Hui Cang, Xunlei Kang, Yuying Chen, Hui Li, Guiying Shi, Edward T H Yeh, Beilei Wang, Xiangrui Wang, Jing Yi. Redox regulation of the stability of the SUMO protease SENP3 via interactions with CHIP and Hsp90. EMBO J 2010 Nov17; 29(22):3773-86. (*Co-first author)
6. Sam C Wang, Ibrahim Nassour, Shu Xiao, Shuyuan Zhang, Xin Luo, Jeon Lee, Lin Li, Xuxu Sun, Liem H Nguyen, Jen-Chieh Chuang, Lan Peng, Scott Daigle, Jeanne Shen, Hao Zhu. SWI/SNF component ARID1A restrains pancreatic neoplasia formation. Gut 2019 Jul;68(7):1259-1270.
7. Austin Moore,Linwei Wu, Jen-Chieh Chuang, Xuxu Sun, Xin Luo, Purva Gopal, Lin Li, Cemre Celen, Michael Zimmer, Hao Zhu. Arid1a loss drives non-alcoholic steatohepatitis in mice via epigenetic dysregulation of hepatic lipogenesis and fatty acid oxidation. Hepatology 2019 May; 69(5):1931-1945
8. Cemre Celen, Jen-Chieh Chuang, Xin Luo, Nadine Nijem, Angela K Walker, Fei Chen, Shuyuan Zhang, Andrew S Chung, Liem H Nguyen, Ibrahim Nassour, Albert Budhipramono, Xuxu Sun, Levinus A Bok, Meriel McEntagart, Evelien F Gevers, Shari G Birnbaum, Amelia J Eisch, Craig M Powell, Woo-Ping Ge, Gijs WE Santen, Maria Chahrour, and Hao Zhu. Arid1b haploinsufficient mice reveal neuropsychiatric phenotypes and reversible causes of growth impairment. ELife 2017 Jul 11; 6. pii: e25730.
9. Kai Yang, Ming Wang, Yuzheng Zhao, Xuxu Sun, Yi Yang, Xie Li, Aiwu Zhou, Huilin Chu, Hu Zhou, Jianrong Xu, Mian Wu, Jie Yang,a, and Jing Yi. A redox mechanism underlying nucleolar stress sensing by nucleophosmin. Nat Communication. 2016 Nov 25; 7:13599.
10. Chi-Man Koon, Chun-Hay Ko, Xu-Xu Sun, Sandy Wan-Heng Hoi, Jacqueline Chor-Wing Tam, David Wing-Shing Cheung, King-Fai Cheng, Suet-Yee Pang, Wing-Man Lo, Ping Chook, Clara Bik-San Lau, Wai-Yee Chan, Ping-Chung Leung, Timothy Chi-Yui Kwok, Kwok-Pui Fung. Gene Expression Profiling on the Molecular Action of Danshen-Gegen Formula in a Randomized Placebo-Controlled Trial of Postmenopausal Women with Hypercholesterolemia. Evid Based Complement Alternat Med 2013, (2013) 703705
11. Wenming Cong, Hui Dong, Lu Tan, Xuxu Sun, Mengchao Wu. Surgicopathological classification of hepatic space-occupying lesions: a single-center experience with literature review. World J Gastroenterology 2011, 17(19):2372-8. Review Article.
12. Yan Han, Chao Huang, Xuxu Sun, Binggang Xiang, Edward T H Yeh, Yuying Chen, Hui Li, Guiying Shi, Hui Cang, Yueping Sun, Jian Wang, Wei Wang, Fei Gao, Jing Yi. SENP3-mediated de-conjugation of SUMO2/3 from promyelocytic leukemia is correlated with accelerated cell proliferation under mild oxidative stress. J Biol Chem 2010 Apr23; 285(17): 12906-15.
13. Chao Huang, Yan Han, Yumei Wang, Xuxu Sun, Shan Yan, Edward T H Yeh, Yuying Chen, Hui Cang, Hui Li, Guiying Shi, Jinke Cheng, Xueming Tang, Jing Yi. SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation. EMBO J 2009 Sep 16; 28(18): 2748-62.
14. Yong Zuo, Binggang Xiang, Jie Yang, Xuxu Sun, Hui Cang, Ying Wang, Jing Yi. Oxidative modification of caspase-9 facilitates its activation via disulfide-mediated interaction with Apaf-1. Cell Res 2009 Apr; 19(4): 449-57.
团队介绍
目前研究组共有9人，包括
孙序序，PI，研究员 xuxu.sun@outlook.com
杨洁，Co-PI，教授 yangjieyj@shsmu.edu.cn
王英，助研，wangying@shsmu.edu.cn
朱慧琴，实验师，zhuhuiqin21@yeah.net
崔智强，研究助理，zqcui65@163.com
郭楚，博后，guochu@shsmu.edu.cn
刘芳，博士生，fangliulucky@163.com
边琦，硕士生，563698002@qq.com
焉鸿宇，硕士生，2041420339@qq.com
