研究组长介绍
赵旭贇，男，1983年3月出生，上海交通大学基础医学院生物化学与细胞分子生物学系研究员。
2011年博士毕业于上海交通大学医学院，随后在美国密歇根大学分别担任博士后和研究助理。2019年正式入职上海交通大学基础医学院生物化学与细胞分子生物学系担任课题组长，并获得国家高层次人才计划青年项目资助。主要研究长链非编码RNA和脂肪分泌蛋白在调控棕色脂肪分化、脂肪组织炎症反应以及肝脏脂质代谢在肥胖和相关代谢性疾病发生发展过程中的作用。迄今已在NATURE MEDICINE、MOLECULAR CELL、NATURE COMMUNICATIONS、SCIENCE ADVANCES和MOLECULAR METABOLISM等学术期刊上发表论文19篇。工作受到国家自然科学基金委面上项目基金支持。
研究方向与进展：
目前，课题组主要研究RNA结合蛋白，膜转运蛋白等调控
1)棕色和米色脂肪产热功能以及能量代谢在肥胖和糖尿病中的作用；
2)肝细胞功能在非酒精性脂肪肝和肝炎发病过程中的作用。
科研项目：
1. 82070894，国家自然科学基金面上项目， Zbtb7b调控脂肪细胞和免疫细胞通讯维持肥胖和糖尿病进展过程中胰岛素敏感性和代谢稳态的作用，2021.01-2024.12，在研，主持。
代表性论文、专著与专利：
1. Zhao XY（通讯作者）, Zhou L, Chen Z, Ji Y, Peng X, Qi L, Li S, Lin JD. The obesity-induced adipokine sST2 exacerbates adipose Treg and ILC2 depletion and promotes insulin resistance. Sci Adv. 2020 May 13;6(20):eaay6191. doi: 10.1126/sciadv.aay6191. PMID: 32426492; PMCID: PMC7220368.
2. Liu T, Mi L, Xiong J, Orchard P, Yu Q, Yu L, Zhao XY, Meng ZX, Parker SCJ, Lin JD, Li S. BAF60a deficiency uncouples chromatin accessibility and cold sensitivity from white fat browning. Nat Commun. 2020 May 13;11(1):2379. doi: 10.1038/s41467-020-16148-1. PMID: 32404872; PMCID: PMC7221096.
3. Xiong X, Kuang H, Ansari S, Liu T, Gong J, Wang S, Zhao XY, Ji Y, Li C, Guo L, Zhou L, Chen Z, Leon-Mimila P, Chung MT, Kurabayashi K, Opp J, Campos-Pérez F, Villamil-Ramírez H, Canizales-Quinteros S, Lyons R, Lumeng CN, Zhou B, Qi L, Huertas-Vazquez A, Lusis AJ, Xu XZS, Li S, Yu Y, Li JZ, Lin JD. Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis. Mol Cell. 2019 Aug 8;75(3):644-660.e5. doi: 10.1016/j.molcel.2019.07.028. PMID: 31398325; PMCID: PMC7262680.
4. Zhao XY, Li S, DelProposto JL, Liu T, Mi L, Porsche C, Peng X, Lumeng CN, Lin JD. The long noncoding RNA Blnc1 orchestrates homeostatic adipose tissue remodeling to preserve metabolic health. Mol Metab. 2018 Aug;14:60-70. doi: 10.1016/j.molmet.2018.06.005. Epub 2018 Jun 8. PMID: 29934059; PMCID: PMC6034069.
5. Zhao XY, Xiong X, Liu T, Mi L, Peng X, Rui C, Guo L, Li S, Li X, Lin JD. Long noncoding RNA licensing of obesity-linked hepatic lipogenesis and NAFLD pathogenesis. Nat Commun. 2018 Jul 30;9(1):2986. doi: 10.1038/s41467-018-05383-2. PMID: 30061575; PMCID: PMC6065308.
6. Chen Z, Wang GX, Ma SL, Jung DY, Ha H, Altamimi T, Zhao XY, Guo L, Zhang P, Hu CR, Cheng JX, Lopaschuk GD, Kim JK, Lin JD. Nrg4 promotes fuel oxidation and a healthy adipokine profile to ameliorate diet-induced metabolic disorders. Mol Metab. 2017 Jun 21;6(8):863-872. doi: 10.1016/j.molmet.2017.03.016. PMID: 28752050; PMCID: PMC5518721.
7. Li S, Mi L, Yu L, Yu Q, Liu T, Wang GX, Zhao XY, Wu J, Lin JD. Zbtb7b engages the long noncoding RNA Blnc1 to drive brown and beige fat development and thermogenesis. Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):E7111-E7120. doi: 10.1073/pnas.1703494114. Epub 2017 Aug 7. PMID: 28784777; PMCID: PMC5576792.
8. Mi L, Zhao XY, Li S, Yang G, Lin JD. Conserved function of the long noncoding RNA Blnc1 in brown adipocyte differentiation. Mol Metab. 2016 Nov 3;6(1):101-110. doi: 10.1016/j.molmet.2016.10.010. PMID: 28123941; PMCID: PMC5220282.
9. Wang GX, Zhao XY, Lin JD. The brown fat secretome: metabolic functions beyond thermogenesis. Trends Endocrinol Metab. 2015 May;26(5):231-7. doi: 10.1016/j.tem.2015.03.002. Epub 2015 Apr 2. PMID: 25843910; PMCID: PMC4417028.
10. Shen SM, Guo M, Xiong Z, Yu Y, Zhao XY, Zhang FF, Chen GQ. AIF inhibits tumor metastasis by protecting PTEN from oxidation. EMBO Rep. 2015 Nov;16(11):1563-80. doi: 10.15252/embr.201540536. Epub 2015 Sep 28. PMID: 26415504; PMCID: PMC4641507.
11. Zhao XY, Lin JD. Long Noncoding RNAs: A New Regulatory Code in Metabolic Control. Trends Biochem Sci. 2015 Oct;40(10):586-596. doi: 10.1016/j.tibs.2015.08.002. PMID: 26410599; PMCID: PMC4584418.
12. Wang GX, Zhao XY（共同第一作者）, Meng ZX, Kern M, Dietrich A, Chen Z, Cozacov Z, Zhou D, Okunade AL, Su X, Li S, Blüher M, Lin JD. The brown fat-enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis. Nat Med. 2014 Dec;20(12):1436-1443. doi: 10.1038/nm.3713. Epub 2014 Nov 17. PMID: 25401691; PMCID: PMC4257907.
13. Zhao XY, Li S, Wang GX, Yu Q, Lin JD. A long noncoding RNA transcriptional regulatory circuit drives thermogenic adipocyte differentiation. Mol Cell. 2014 Aug 7;55(3):372-82. doi: 10.1016/j.molcel.2014.06.004. Epub 2014 Jul 4. PMID: 25002143; PMCID: PMC4127104.
14. Liu W, Shen SM, Zhao XY, Chen GQ. Targeted genes and interacting proteins of hypoxia inducible factor-1. Int J Biochem Mol Biol. 2012;3(2):165-78. Epub 2012 May 31. PMID: 22773957; PMCID: PMC3388736.
15. Huang Y, Hou JK, Chen TT, Zhao XY, Yan ZW, Zhang J, Yang J, Kogan SC, Chen GQ. PML-RARα enhances constitutive autophagic activity through inhibiting the Akt/mTOR pathway. Autophagy. 2011 Oct;7(10):1132-44. doi: 10.4161/auto.7.10.16636. Epub 2011 Oct 1. PMID: 21673516; PMCID: PMC3210306.
16. Zhao XY（共同第一作者）, Zhao KW, Jiang Y, Zhao M, Chen GQ. Synergistic induction of galectin-1 by CCAAT/enhancer binding protein alpha and hypoxia-inducible factor 1alpha and its role in differentiation of acute myeloid leukemic cells. J Biol Chem. 2011 Oct 21;286(42):36808-19. doi: 10.1074/jbc.M111.247262. Epub 2011 Aug 31. PMID: 21880716; PMCID: PMC3196150.
17. Zhao XY（共同第一作者）, Chen TT, Xia L, Guo M, Xu Y, Yue F, Jiang Y, Chen GQ, Zhao KW. Hypoxia inducible factor-1 mediates expression of galectin-1: the potential role in migration/invasion of colorectal cancer cells. Carcinogenesis. 2010 Aug;31(8):1367-75. doi: 10.1093/carcin/bgq116. Epub 2010 Jun 4. PMID: 20525878.
18. Zhao M, Duan XF, Zhao XY, Zhang B, Lu Y, Liu W, Cheng JK, Chen GQ. Protein kinase Cdelta stimulates proteasome-dependent degradation of C/EBPalpha during apoptosis induction of leukemic cells. PLoS One. 2009 Aug 7;4(8):e6552. doi: 10.1371/journal.pone.0006552. PMID: 19662097; PMCID: PMC2719015.
19. Liao SH, Zhao XY（共同第一作者）, Han YH, Zhang J, Wang LS, Xia L, Zhao KW, Zheng Y, Guo M, Chen GQ. Proteomics-based identification of two novel direct targets of hypoxia-inducible factor-1 and their potential roles in migration/invasion of cancer cells. Proteomics. 2009 Aug;9(15):3901-12. doi: 10.1002/pmic.200800922. PMID: 19637235.
团队介绍：
赵旭贇，博士，PI/研究员，xuyunzhao@shsmu.edu.cn
宋红勇，博士，助理研究员，hysong2003@126.com
理文琰，博士，技术员，greater1234@126.com
付寅坤，博士在读，yinkunfu@shsmu.edu.cn
龙吟，博士在读，longyin8864@163.com
彭欣，硕士在读，pengxin1997@sjtu.edu.cn
薛傑元，博士在读（联合培养），JieyuanXue@outlook.com
刘喆麒，博士在读（联合培养），734672500@qq.com
周文凯，硕士在读（联合培养），302724428@qq.com
