实验室人员组成：

PI：杨文

助理研究员：郑媛

技术员：王洁

博士后：何翔

研究生：李沄，杨峥，侯雨彤，蔡颖

联合培养：李薇，闫冉

本科生：苏俊澄，孙涵

课题组长主要学习工作经历：

上海复旦大学，学士学位

加拿大麦吉尔大学，获博士学位

美国哈佛医学院，博士后

研究方向与进展：

从事线粒体和衰老的分子机制研究，利用蛋白质组学的方法研究线粒体蛋白动态变化及其与衰老及相关疾病的关系。主要关注衰老和相关疾病中线粒体蛋白水平修饰（包括乙酰化、琥珀酰化和氧化等）对线粒体功能的调节和反向信号传导的影响。现阶段主要包括以下几个课题方向：

1. 线粒体过氧化物介导的反向信号传导与衰老和细胞死亡

2. 酮戊二酸脱氢酶特异性伴侣素蛋白的功能及其与疾病的关系

3. 线粒体-细胞器互作的蛋白网络

4. 线粒体代谢与癌症耐药

代表论文：

1. Zhang J, Li Y, Liu H, Zhang J,Wang J, Xia J, Zhang Y, Yu X, Ma J, Huang M, Wang J, Wang L, Li Q, Cui R, Yang W*, Xu Y*，Feng W*. Genome-wide CRISPR/Cas9 library screen identifies PCMT1 as a critical driver of ovarian cancer metastasis. J Exp Clin Cancer Res. 2022; 41:24. doi: 10.1186/s13046-022-02242-3(* Co-correspoding author)

2. Xia, J., Zhang, J., Wang, L., Xu, Y., Yang, W., Yu, Y.(2021). Non-apoptotic function of caspase-8 confers prostate cancer enzalutamide resistance via NF-κB activation. Cell Death Disease 12,833.

3. Zhang, JH; Yin, YN; Wang, JH; Zhang, JJ; Liu, H; Feng, WW; Yang, W; Bruce Zetter;Xu, YJ.(2021).Prohibitin regulates mTOR pathway via the interaction with FKBP8. Frontiers of Medicine 15,448-459

4. Mao,C., Xu, Y.,Yang, W., Liu, Z.(2021).Genome-wide analysis identify novel germline genetic variations in ADCY1 influencing platinum-based chemotherapy response in non-small cell lung cancer. Acta Pharmaceutica Sinica B. Oct

5. Jing Xu, Jiahui Wang, Xiaoli Wang, Ruoming Tan, Xiaoling Qi, Zhaojun Liu, Hongping Qu, Tingting Pan, Qingyuan Zhan, Yong Zuo* ,Wen Yang* , Jialin Liu*, Soluble PD-L1 improved direct ARDS by reducing monocyte-derived macrophages, Cell death and diseases, 2020 Oct 30;11(10):934. doi: 10.1038/s41419-020-03139-9.

6.Wen Yang et al. Mitochondrial Sirtuins Coordinating Stress Responses Through Regulation of Mitochondrial Enzyme Networks, Introductory Review on Sirtuins in Biology, Aging, and Disease, 2018, Pages 95-115

7.Wen Yang et al. Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-dependent Deacetylation in Response to Membrane Depolarization. Cell， 2016 Nov 3

8.Callista Yee, Wen Yang, and Siegfried Hekimi.:  The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. elegans. Cell, 2014 May 8;157(4):897-909

9.Hekimi S, Lapointe J, Yang W,:  Taking a “good” look at free radicals in the aging process. Trends in Cell Biology, 2011, Jan;67(1):1-8.

10.Yang W and Hekimi S: A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans. PLOS biology. 2010 Dec; 8(12):e1000556

11.Yang W and Hekimi S: Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans. Aging Cell. 2010 Jun;9(3):433-47.