赵旭贇 研究员

电话：021-63846590-776538

邮箱：xuyunzhao@shsmu.edu.cn

实验室人员组成：

PI：赵旭赟

助理研究员：宋红勇

技术员：理文琰

研究生：付寅坤、龙吟、彭欣、刘一帆、陈鼎

课题组研究方向：

主要研究RNA结合蛋白，膜转运蛋白等调控细胞代谢物和氧化还原状态影响。

1)棕色和米色脂肪产热功能以及能量代谢在肥胖和糖尿病中的作用；

2)肝细胞功能在非酒精性脂肪肝和肝炎发病过程中的作用。

课题组长学习及工作经历：

上海交通大学医学院医学检验专业，学士

上海交通大学医学院生物化学与分子生物学专业，博士

美国密歇根大学，博士后

美国密歇根大学生命科学研究所，研究助理

代表论文：

1. Zhao XY#, Zhou L, Chen Z, Ji Y, Peng X, Qi L, Li S, Lin JD#. The obesity-induced adipokine sST2 exacerbates adipose Treg and ILC2 depletion and promotes insulin resistance. Sci Adv. 2020 May 13;6(20):eaay6191 (#Co-corresponding author)

2. Liu T, Mi L, Xiong J, Orchard P, Yu Q, Yu L, Zhao XY, Meng Z, Parker S, Lin JD, Li S. BAF60a deficiency uncouples chromatin accessibility and cold sensitivity from white fat browning. Nat Commun. 2020 May 13;11(1):2379.

3. Xiong X, Kuang H, Ansari S, Liu T, Gong J, Wang S, Zhao XY et al. Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis. Mol Cell. 2019 Aug 8;75(3):644-660.e5

4. Zhao XY, Xiong X, Liu T, Mi L, Peng X, Rui C, Guo L, Li S, Lin JD. Long noncoding RNA licensing of obesity-linked hepatic lipogenesis and NAFLD pathogenesis. Nat Commun. 2018 Jul 30;9(1):2986. doi: 10.1038/s41467-018-05383-2.

5. Zhao XY, Li S, DelProposto JL, Liu T, Mi L, Porsche C, Peng X, Lumeng CN, Lin JD. The long noncoding RNA Blnc1 orchestrates homeostatic adipose tissue remodeling to preserve metabolic health. Mol Metab. 2018 Jun 8. pii: S2212-8778(18)30490-3

6. Li S, Mi L, Yu L, Yu Q, Liu T, Wang GX, Zhao XY, Wu J, Lin JD. Zbtb7b engages the long noncoding RNA Blnc1 to drive brown and beige fat development and thermogenesis. Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):E7111-E7120.

7. Chen Z, Wang GX, Ma SL, Jung DY, Ha H, Altamimi T, Zhao XY, Guo L, Zhang P, Hu CR, Cheng JX, Lopaschuk GD, Kim JK, Lin JD. Nrg4 promotes fuel oxidation and a healthy adipokine profile to ameliorate diet-induced metabolic disorders. Mol Metab. 2017 Jun 21;6(8):863-872.

8. Mi L, Zhao XY, Li S, Yang G, Lin JD. Conserved function of the long noncoding RNA Blnc1 in brown adipocyte differentiation. Mol Metab. 2016 Nov;6(1):101-110.

9. Shen SM, Guo M, Xiong Z, Yu Y, Zhao XY, Zhang FF, Chen GQ. AIF inhibits tumor metastasis by protecting PTEN from oxidation. EMBO Rep. 2015 Nov;16(11):1563-80.

10. Zhao XY, Lin JD. Long Noncoding RNAs: A New Regulatory Code in Metabolic Control. Trends Biochem Sci. 2015 Oct;40:586-596.

11. Wang GX, Zhao XY, Lin JD. The brown fat secretome: metabolic functions beyond thermogenesis. Trends Endocrinol Metab. 2015 May;26(5):231-237.

12. Wang GX*, Zhao XY*, Meng ZX, Kern Matthias, Dietrich Arne, Chen ZM, et al. The brown fat-enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuating hepatic lipogenesis. Nat Med. 2014 Dec;20(12):1436-43.

13. Zhao XY, Li S, Wang GX, Yu Q, Lin JD. A long noncoding RNA transcriptional regulatory circuit drives thermogenic adipocyte differentiation. Mol Cell. 2014 Aug 7;55(3):372-82.

14. Liu W, Shen SM, Zhao XY, Chen GQ. Targeted genes and interacting proteins of hypoxia inducible factor-1. Int J Biochem Mol Biol. 2012 May 31;3(2):165-78

15. Zhao XY*, Zhao KW*, Jiang Y, Zhao M, Chen GQ. Synergistic induction of galectin-1 by CCAAT/enhancer binding protein-a and hypoxia inducible factor-1a and its role in differentiation of acute myeloid leukemic cells. J Biol Chem. 2011 Oct 21;286(42):36808-19

16. Huang Y, Hou JK, Chen TT, Zhao XY, Yan ZW, Zhang J, Yang J, Kogan SC, Chen GQ. PML-RARα enhances constitutive autophagic activity through inhibiting the Akt/mTOR pathway. Autophagy. 2011 Oct 1;7(10):1132-44

17. Zhao XY*, Chen TT*, Xia L, Guo M, Xu Y, Yue F, Jiang Y, Chen GQ, Zhao KW. Hypoxia inducible factor-1 mediates expression of galectin-1: the potential role in migration/invasion of colorectal cancer cells. Carcinogenesis 2010 Aug; 31(8): 1367-75

18. Liao SH*, Zhao XY*, Han YH, Zhang J, Wang LS, Xia L, Zhao KW, Zheng Y, Guo M, Chen GQ. Proteomics-based identification of two novel direct targets of hypoxia-inducible factor-1 and their potential roles in migration/invasion of cancer cells. Proteomics 2009 Aug15;9(15):3901-12

19. Zhao M, Duan XF, Zhao XY, Zhang B, Lu Y, Liu W, Cheng JK, Chen GQ. Protein kinase Cdelta stimulates proteasome-dependent degradation of C/EBPalpha during apoptosis induction of leukemic cells. PloS One 2009 Aug 7;4(8):e6552