杨文 研究员
线粒体代谢与衰老研究组
电话：63846590-776492
邮箱：yangwen@shsmu.edu.cn
研究方向
从事线粒体和衰老的分子机制研究，利用蛋白质组学的方法研究线粒体蛋白动态变化及其与衰老及相关疾病的关系。主要关注衰老和相关疾病中线粒体蛋白水平修饰（包括乙酰化、琥珀酰化和氧化等）对线粒体功能的调节和反向信号传导的影响。现阶段主要包括以下几个课题方向：
1. 线粒体过氧化物介导的反向信号传导与衰老和细胞死亡
2. 酮戊二酸脱氢酶特异性伴侣素蛋白的功能及其与疾病的关系
3. 线粒体-细胞器互作的蛋白网络
4. 线粒体代谢与癌症耐药
个人简历
杨文，博士，博士生导师。2010年获得加拿大麦吉尔大学博士学位，2011-2017年于美国哈佛大学医学院从事博士后研究。2017年加入生化与分子细胞生物学系，担任研究员。课题组聚焦线粒体代谢与衰老相关研究。近年来以第一作者在国际重要学术刊物(如Cell, PLOS Biology等)上发表SCI论文，他引超过700次。曾获Charles A. King fellowship Award。
科研项目
项目批准号：91954120
项目名称：解析线粒体参与细胞器互作的蛋白网络及分子机制
项目类别：重大研究计划
项目批准号：31871430
项目名称：神经细胞中C3orf23调控酮戊二酸脱氢酶的作用与机制研究
项目类别：面上项目
项目批准号：2019YFA0508601;
项目名称：蛋白质机器与生命过程调控
项目类别：重点专项
论文与专著
1. Zhang J, Li Y, Liu H, Zhang J, Wang J, Xia J, Zhang Y, Yu X, Ma J, Huang M, Wang L, Li Q, Cui R, Yang W*, Xu Y*, Feng W*. Genome-wide CRISPR/Cas 9 library screen identifies PCMT1 as a critical driver of ovarian cancer metastasis. J Exp Clin Cancer Res. 2022;41:24. doi:10.1186/s13046-022-02242-3(*Co-corresponding author)
2. Xia, J., Zhang, J., Wang, L., Xu, Y., Yang, W., Yu, Y.(2021). Non-apoptotic function of caspase-8 confers prostate cancer enzalutamide resistance via NF-κB activation. Cell Death Disease 12,833.
3. Zhang, JH; Yin, YN; Wang, JH; Zhang, JJ; Liu, H; Feng, WW; Yang, W; Bruce Zetter;Xu, YJ.(2021).Prohibitin regulates mTOR pathway via the interaction with FKBP8. Frontiers of Medicine 15,448-459
4. Mao,C., Xu, Y.,Yang, W., Liu, Z.(2021).Genome-wide analysis identify novel germline genetic variations in ADCY1 influencing platinum-based chemotherapy response in non-small cell lung cancer. Acta Pharmaceutica Sinica B. Oct
5. Jing Xu, Jiahui Wang, Xiaoli Wang, Ruoming Tan, Xiaoling Qi, Zhaojun Liu, Hongping Qu, Tingting Pan, Qingyuan Zhan, Yong Zuo* ,Wen Yang* , Jialin Liu*, Soluble PD-L1 improved direct ARDS by reducing monocyte-derived macrophages, Cell death and diseases, 2020 Oct 30;11(10):934. doi: 10.1038/s41419-020-03139-9.3.
6.Kai Xin, Xinxing Li, Yinghua Guo, Youhuan Zhong, Jungang Wang, Haotian Yang, Jie Zhao, Chunlei Guo, Yunxia Huang, Zuhai Lei, Yi-Lun Ying, Xiao Luo, Haolu Wang, Xuhong Qian, Wen Yang*, Xiaowen Liang* &Youjun Yang*, A Monochromophoric Approach to Succinct Ratiometric Fluorescent Probes Without Probe-Product Crosstalk, CCS Chemistry, 2020, In Press
7. Wen Yang et al. Mitochondrial Sirtuins Coordinating Stress Responses Through Regulation of Mitochondrial Enzyme Networks, Introductory Review on Sirtuins in Biology, Aging, and Disease, 2018, Pages 95-115
8. Wen Yang, Koji Nagasawa, Christian Münch, Yingjie Xu, Kyle Satterstrom, SeungminJeong, Sebastian D Hayes, Mark P. Jedrychowski, F. Sejal Kamlesh Vyas; Elma Zaganjor, Virginia Guarani, Alison Ringle, Steven P Gygi, J. Wade Harper, and Marcia C Haigis: Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-dependent Deacetylation in Response to Membrane Depolarization. Cell, 2016, 167(4): 985–1000.e21.
9. Xu Y, Yang W, Shi J, Zetter BR, Shi J.: Prohibitin 1 regulates tumor cell apoptosis via interaction with X-linked Inhibitor of Apoptosis Protein. J Mol Cell Biol, 2016, 8 (3): 282-285.
10. Callista Yee, Wen Yang, and Siegfried Hekimi.: The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. elegans. Cell, 2014, 157(4):897-909
11. Inuzuka,H., Gao,D., Finley,L.W., Yang,W., Wan,L., Fukushima,H., Chin,Y.R., Zhai,B., Shaik,S., Lau,A.W., Wang,Z., Gygi,S.P., Nakayama,K., Teruya-Feldstein,J., Toker,A., Haigis,M.C., Pandolfi,P.P., and Wei,W.: Acetylation-dependent regulation of Skp2 function. Cell, 2012,150:179-193.
12. Hekimi S, Lapointe J, Yang W,: Taking a “good” look at free radicals in the aging process. Trends in Cell Biology, 2011, 67(1):1-8.
13. Yang W and Hekimi S: A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans. PLOS biology. 2010, 8(12):e1000556
14. Van Raamsdonk JM, Meng Y, Camp D, Yang W, Jia X, Bénard C, and Hekimi S: Decreased Energy Metabolism Extends Lifespan in Caenorhabditis elegans Without Reducing Oxidative Damage. Genetics. 2010, 185(2):559-71.
15. Yang W and Hekimi S: Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans. Aging Cell. 2010, 9(3):433-47.
16. Yang W*, Li J*, Hekimi S: A Measurable increase in oxidative damage due to reduction in superoxide detoxification fails to shorten the life span of long-lived mitochondrial mutants of Caenorhabditis elegans. Genetics. 2007, 177(4):2063-74.
