Location:
Educational Background
2012-2018 Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Ph.D.
2007-2011 Shandong Agricultural University, Bachelor's Degree
Work Experience
2023-Present Songjiang Research Institute, School of Medicine, Shanghai Jiao Tong University, Independent PI (Young Researcher).
2019-2022 Huashan Hospital, Fudan University, Postdoctoral Researcher/Young Researcher
Zhengrun Gao
Our group focuses on investigating the mechanisms and strategies for neural circuit remodeling under conditions of brain disorders. We also conduct reverse translational research, bridging the gap between clinical discoveries and basic research, to decipher the neural mechanisms of brain function recovery with the assistance of neuromodulating methods of various physical aspects (sonic, optical, electrical and magnetic). These insights provide novel strategies for clinical treatment of brain functional disorders. Our lab employs a comprehensive approach, combining multi-scale calcium imaging with optogenetic stimulation techniques, electrophysiological recordings, pharmacogenetics, whole-brain specific neural circuit tracing, and precise behavioral quantitative analysis, to achieve various objectives: (1) revealing the pathological mechanisms underlying the abnormal integration of sensory-motor information under brain disorders such as brain injuries, autism, and Parkinson's disease; (2) identifying biomarkers and regulatory targets in the process of brain function remodeling induced by peripheral and central sensory stimulation; (3) developing closed-loop adaptive control strategies based on the mechanisms of neural circuit remodeling to promote brain function recovery in patients.
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Liu Y, Lin W, Bai Z, Ge Y, Xiao Y, Zhu F, Zhang J, Wang B, Li Q, Gao L, Li Y, Shan C, Nagai J, Wu Y, Xu TL, Gao Z. Lcn2 from neutrophil extracellular traps induces astrogliosis and post-stroke emotional disorders. Neuron. 2025 Oct. (最后通讯作者)
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Chu T, Xiao Y, Lai H, Shi L, Cheng Y, Sun J, Pang Z, Cheng S, Zhao K, Gao Z, Wang R. Highly Conductive, Adhesive and Biocompatible Hydrogel for Closed-Loop Neuromodulation in Nerve Regeneration. ACS Nano. 2025 May 20. (共同通讯作者)
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Lu R, Pang Z, Gao T, He Z, Hu Y, Zhuang J, Zhang Q, Gao Z. Multisensory BCI promotes motor recovery via high-order network-mediated interhemispheric integration in chronic stroke. BMC Med. 2025 Jul 1.(最后通讯作者)
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Qin Zhang, Zhen Pang, Rongrong Lu, Hua He, Ulf Ziemann, Zhengrun Gao. Targeted Sensory System Neuromodulation Improves Sensorimotor and Cognitive Deficits After Brain Injury: Bridging Mechanisms to Practice. Neural Plasticity.2025 June 20.(最后通讯作者)
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Gao L, Yang XN, Dong YX, Han YJ, Zhang XY, Zhou XL, Liu Y, Liu F, Fang JS, Ji JL, Gao ZR, Qin XM. The potential therapeutic strategy in combating neurodegenerative diseases: Focusing on natural products. Pharmacol Ther. 2024 Dec. (共同通讯作者)
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Gao Z, Pang Z, Lei G, Chen Y, Cai Z, Zhu S, Lin W, Qiu Z, Wang Y, Shen Y, Xu W. Crossing nerve transfer drives sensory input-dependent plasticity for motor recovery after brain injury. Sci Adv. 2022 Sep 2.(第一作者)
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Gao Z, Pang Z, Chen Y, Lei G, Zhu S, Li G, Shen Y, Xu W. Restoring After Central Nervous System Injuries: Neural Mechanisms and Translational Applications of Motor Recovery. Neurosci Bull. 2022 Dec.(第一作者)
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Gao Z, Lei G, Pang Z, Chen Y, Zhu S, Huang K, Lin W, Shen Y, Xu W. A Mouse Model of Direct Anastomosis via the Prespinal Route for Crossing Nerve Transfer Surgery. J Vis Exp. 2021 Oct 19.(第一作者)
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Gao ZR, Chen WZ, Liu MZ, Chen XJ, Wan L, Zhang XY, Yuan L, Lin JK, Wang M, Zhou L, Xu XH, Sun YG. Tac1-Expressing Neurons in the Periaqueductal Gray Facilitate the Itch-Scratching Cycle via Descending Regulation. Neuron. 2019 Jan 2.(第一作者)