Location:
Fangyuan Li
Email: lfy@shsmu.edu.cn
Intelligent biomaterials and brain science research
Education:
Ph.D. 2015 Seoul National University
Master 2011 The Catholic University of Korea
B.S. 2008 Wannan Medical College
Working experience:
2024-Now Assistant Professor, Songjiang Institute, Shanghai Jiao Tong University School of Medicine
2015-2024 Associate Professor/Lecturer, College of Pharmaceutical Sciences, Zhejiang University
Prof. Li is mainly engaged in research on the field of biomaterials. In recent years, she designed a series of high-performance disease microenvironment-responsive nanomaterials for highly sensitive and specific biomedical imaging as well as efficient therapy for diseases. The effect and mechanism of functional activation or amplification for certain molecules/ions in disease microenvironment of the responsive nanomaterials have been investigated. Overall, new strategies were developed for the controlled synthesis of biomaterials and their medical diagnosis and therapy of diseases. Based on the research, she has published papers in international academic journals, such as Nature Nanotechnology, Nature Communications, Advanced Materials, Journal of the American Chemical Society, Angewandte Chemie International Edition, National Science Review, Nano Today, Nano-Micro Letters, ACS Nano, ACS Central Science, Advanced Science, Advanced Drug Delivery Reviews, Nano Letters, Science Bulletin, etc. She has led projects funded by the National Key Research and Development Program of China, the National Natural Science Foundation of China, and the Natural Science Foundation of Zhejiang Province.
Fangyuan Li
Molecular events (including ion disturbances) in the disease microenvironment play an important role in the process of disease occurrence and development, which can be used as important markers to guide disease diagnosis and treatment. Our research group focuses on the design and synthesis of intelligent biomaterials that have high specificity and high sensitivity to the target molecules/ions of the disease microenvironment, to accurately monitor and regulate the target molecules/ions at the living level, achieving early diagnosis and effective treatment of diseases.
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Peihua Lin#, Bo Zhang#, Hongli Yang, Shengfei Yang, Pengpeng Xue, Ying Chen, Shiyi Yu, Jichao Zhang, Yixiao Zhang, Liwei Chen, Chunhai Fan, Fangyuan Li*, Daishun Ling*，An artificial protein modulator reprogramming neuronal protein functions，Nature Communications，2024, 15, 2039.
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Zeyu Liang#, Lin Xiao#, Qiyue Wang#, Bo Zhang, Wenkui Mo, Shangzhi Xie, Xun Liu, Ying Chen, Shengfei Yang, Pengzhan Wang, Fangyuan Li*, Daishun Ling*, Ligand-mediated magnetism-conversion nanoprobes for activatable ultra-high field magnetic resonance imaging, Angewandte Chemie International Edition, 2024, e202318948.
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Ying Chen#, Zeyu Liang#, Qiyue Wang, Lin Xiao, Shangzhi Xie, Shengfei Yang, Xun Liu, Daishun Ling*, Fangyuan Li*, Alpha-synuclein oligomers driven T1-T2 switchable nanoprobes for early and accurate diagnosis of Parkinson’s disease, Advanced Materials, 2023, e2310404.
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Qiyue Wang#, Tao Wang#, Shengfei Yang#, Hui Du, Bo Zhang, Sirui Cui, Daishun Ling*, Fangyuan Li*, Highly sensitive diagnosis of extracellular calcium ions associated brain diseases using Ca2+-dependent T2-T1 switchable magnetic nanosensors, Advanced Functional Materials, 2023, 202313286.
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Haibin Wu#, Fan Xia#, Lingxiao Zhang#, Chunyan Fang, Jiyoung Lee, Linji Gong, Jianqing Gao*, Daishun Ling*, Fangyuan Li*, A ROS-Sensitive Nanozyme-Augmented Photoacoustic Nanoprobe for Early Diagnosis and Therapy of Acute Liver Failure, Advanced Materials, 2022, 34(7): 2108348.