Location:
Tian-Le Xu, Ph.D., Principal Investigator
E-mail：xu-happiness@shsmu.edu.cn
Work Phone：63846590-778022
Interpretation of Brain Cognitive Principles
Educational Experience
1993.08-1996.07, The Fourth Military Medical University, Ph.D. degree
1990.08-1993.07, The Fourth Military Medical University, Master degree
1982.08-1987.07, The Fourth Military Medical University, B.S. degree
Professional Experience
2022.08-present, Songjiang Institute and Songjiang Hospital, Shanghai Jiao Tong University School of Medicine, Executive Director
2020.05-present, Center for Children’s Brain Science, National Children's Medical Center (Shanghai), Director
2011.06-present, Department of Anatomy and physiology, Shanghai Jiao Tong University School of Medicine, Dean/Professor
2003.01-2011.05, Institute of Neuroscience, Chinese Academy of Sciences, Principal Investigator
1999.01-2003.01, College of Life Science, University of Science and Technology of China, Dean/Professor
1997.07-1999.01, Kyushu University, Postdoctoral Fellow
1996.08-1997.07, Department of Human Anatomy, The Fourth Military Medical University, Instructor
1987.08-1990.07, Department of Histology and Embryology, The Fourth Military Medical University, Teaching Assistant
Tian-Le Xu
Tian-Le Xu’s lab is dedicated to investigate the working mechanism of ion channels in sensation, memory and emotion. Focusing on the working model, abnormal mechanism, and novel intervention of acid-sensing ion channel ASIC3 and ASIC1a, Xu Lab has achieved a series of innovative findings. At the microscopic scale, Prof. Xu and his team aim to elucidate the signal transduction mechanisms of neuronal cells and their physiological relevance, and to investigate the role of the novel ion channel ASIC in synaptic plasticity and learning memory. In addition, Prof. Xu and his team are also interested in the potential role of ASICs in stroke, chronic pain and its associated emotional disorders. At the mesoscopic scale, Prof. Xu and his lab explore the long-range and local circuit mechanisms of "emotion (e.g., fear, happiness)-mood-empathy" and their interactions with memory, attention and social behavior from the perspective of "memory engram" to inspire new techniques of precise neuromodulation. Prof. Xu has published more than 50 impactful research articles as corresponding author in Neuron, Nat Commun, Natl Sci Rev, Mol Psychiatry, Sci Adv, Brain, eLife, Cell Rep, J Neurosci, etc., with more than 5000 citations. Under the great cultivation of Prof. Xu, 17 graduates from his lab have become independent PIs in famous universities and research institutions worldwide.
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Wang Q#, Zhu JJ#, Wang L, Kan YP, Liu YM, Wu YJ, Gu X, Yi X, Lin ZJ, Wang Q, Lu JF, Jiang Q, Li Y, Liu MG, Xu NJ, Zhu MX, Wang LY, Zhang S*, Li WG*, Xu TL*. Insular cortical circuits as an executive gateway to decipher threat or extinction memory via distinct subcortical pathways. Nat Commun, 2022, 13(1): 5540.
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Gu X#, Wu YJ#, Zhang Z, Zhu JJ, Wu XR, Wang Q, Yi X, Lin ZJ, Jiao ZH, Xu M, Jiang Q, Li Y, Xu NJ, Zhu MX, Wang LY, Jiang F*, Xu TL*, Li WG*. Dynamic tripartite construct of interregional engram circuits underlies forgetting of extinction memory. Mol Psychiatry, 2022, doi: 10.1038/s41380-022-01684-7.
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Li WG#, Wu YJ#, Gu X#, Fan HR, Wang Q, Zhu JJ, Yi X, Wang Q, Jiang Q, Li Y, Yuan TF, Xu H, Lu J, Xu NJ, Zhu MX, Xu TL*. Input associativity underlies fear memory renewal. Natl Sci Rev, 2021, 8(9): nwab004.
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Wang JJ#, Liu F#, Yang F, Wang YZ, Qi X, Li Y, Hu Q*, Zhu MX*, Xu TL*. Disruption of auto-inhibition underlies conformational signaling of ASIC1a to induce neuronal necroptosis. Nat Commun, 2020, 11(1): 475.
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Su XY#, Chen M#, Yuan Y, Li Y, Guo SS, Luo HQ, Huang C, Sun W, Li Y, Zhu MX, Liu MG*, Hu J*, Xu TL*. Central processing of itch in the midbrain reward center. Neuron, 2019, 102(4): 858-72.
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Wang Q#, Wang Q#, Song XL, Jiang Q, Wu YJ, Li Y, Yuan TF, Zhang S, Xu NJ, Zhu MX, Li WG*, Xu TL*. Fear extinction requires ASIC1a-dependent regulation of hippocampal-prefrontal correlates. Sci Adv, 2018, 4(10): eaau3075.
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Li WG#, Liu MG#, Deng S#, Liu YM, Shang L, Ding J, Hsu TT, Jiang Q, Li Y, Li F*, Zhu MX*, Xu TL*. ASIC1a regulates insular long-term depression and is required for the extinction of conditioned taste aversion. Nat Commun, 2016, 7: 13770.
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Wang YZ#, Wang JJ#, Huang Y, Liu F, Zeng WZ, Li Y, Xiong ZG, Zhu MX, Xu TL*. Tissue acidosis induces neuronal necroptosis via ASIC1a channel independent of its ionic conduction. eLife, 2015, 4: e05682.
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Yu Y#, Chen Z#, Li WG#, Cao H, Feng EG, Yu F, Liu H, Jiang H*, Xu TL*. A nonproton ligand sensor in the acid-sensing ion channel. Neuron, 2010, 68: 61-72.
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Gao J, Duan B, Wang DG, Deng XH, Zhang GY, Xu L, Xu TL*. Coupling between NMDA receptor and acid-sensing ion channel contributes to ischemic neuronal death. Neuron, 2005, 48: 635-46.
Address：Room 206, building 18,746 Zhongshan Zhong Road, Songjiang District, Shanghai
Postcode：201699
Telephone/Fax：63846590-778022
Email：xu-happiness@shsmu.edu.cn