Location:
Dong Guo
Email: dguo@zju.edu.cn
Research Interests: Cellular Metabolism and Diseases
Education
2011–2016 Ph.D., School of Life Sciences / School of Medicine, Xiamen University
2006–2010 B.Sc., School of Life Sciences, Shandong University of Technology
Professional Experience
2026–present Principal investigator, Songjiang Research Institute, Shanghai Jiao Tong University School of Medicine
2022–2026 Principal investigator, The First Affiliated Hospital, Zhejiang University School of Medicine
2019–2022 Postdoctoral Fellow, Zhejiang University School of Medicine
2017–2019 Assistant investigator, The First People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Guo Dong
Dr. Dong Guo’s lab is dedicated to investigating the roles and mechanisms of glucose metabolic homeostasis in the development and progression of tumors, metabolic diseases, and neurodegenerative disorders. He has published papers in journals such as Cell Metabolism, Immunity, Molecular Cell (2021, 2025), Nature Metabolism, and Nature Reviews Cancer. His work has received over 3,000 citations, with an H‑index of 25.
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Dong Guo#*, Ying Meng#, Shudi Luo#, Xiaoming Jiang#, Yanhua Zheng#, Lihui Wu, Qingqing Yang, Suyao Li, Hongfei Jiang, Shan Li, Zheng Wang, Min Li, Qingang Wu, Liwei Xiao, Rongxuan Zhu, Xuxiao He, Yanyan Hu, Hong Zhao, Xianglai Ye, Yingying Tong, Jing Fang, Daqian Xu, Jun Xu, and Zhimin Lu*. Lactate binds and inhibits STING to promote tumor immune evasion. Immunity. 2026 Jul 14;59(7):1811-1824.e7.
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Dong Guo#; Ying Meng#; Gaoxiang Zhao#; Qingang Wu; Zhimin Lu*; Moonlighting functions of glucose metabolic enzymes and metabolites in cancer. Nature Reviews Cancer. 2025 Jun;25(6):426-446.
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Dong Guo#; Qiujing Yu#; Yingying Tong#; Xu Qian#; Ying Meng; Fei Ye; Xiaoming Jiang; Lihui Wu; Qingqing Yang; Suyao Li; Min Li; Qingang Wu; Liwei Xiao; Xuxiao He; Rongxuan Zhu; Guijun Liu; Dou Nie; Shudi Luo; Leina Ma; Ren-An Jin; Zhihua Liu; Xiao Liang*; Dong Yan*; Zhimin Lu*. OXCT1 succinylation and activation by SUCLA2 promotes ketolysis and liver tumor growth. Molecular Cell. 2025 Feb 20;85(4):843-856.e6.
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Ying Meng#, Dong Guo#, Liming Lin#, Hong Zhao, Shudi Luo, Xiaoming Jiang, and Zhimin Lu*. Glycolytic enzyme PFKL governs lipolysis by promoting lipid droplet-mitochondria tethering to enhance β-oxidation and tumor cell proliferation. Nature Metabolism. 2024;6(6):1092-1107.
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Dong Guo#, Ying Meng#, Xiaoming Jiang#, Zhimin Lu*. Hexokinases in cancer and other pathologies. Cell Insight. 2023 Jan 3;2(1):100077.
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Dong Guo#, Haiyan He#, Ying Meng, Shudi Luo, and Zhimin Lu*. Determiners of cell fates: the TCA cycle versus the citrate-malate shuttle. Protein & Cell. 2023 Apr 13;14(3):162-164.
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Dong Guo#, Yingying Tong#, Xiaoming Jiang, Ying Meng, Hongfei Jiang, Linyong Du, Qingang Wu, Shudi Luo, Min Li, Shan Li, Liwei Xiao, Haiyan He, Xuxiao He, Qiujing Yu, Jing Fang, and Zhimin Lu*. Aerobic glycolysis promotes tumor immune evasion by Hexokinase 2-mediated phosphorylation of IκBα. Cell Metabolism. 2022 Sep 6;34(9):1312-1324.e6. (Highlighted in Cancer Discovery).
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Wenting Xie#, Dong Guo#, Jieyin Li#, Lei Yue, Qi Kang, Guimiao Chen, Tingwen Zhou, Han Wang, Kai Zhuang, Lige Leng, Huifang Li, Zhenyi Chen, Weiwei Gao*, Jie Zhang*. CEND1 deficiency induces mitochondrial dysfunction and cognitive impairment in Alzheimer's disease. Cell Death and Differentiation. 2022 Dec;29(12):2417-2428.
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Yiyuan Yuan#, Huimin Li#, Wang Pu#, Leilei Chen#, Dong Guo#, Hongfei Jiang#, Bo He#, Siyuan Qin#, Kui Wang#, Na Li#, Jingwei Feng#, Jing Wen#, Shipeng Cheng#, Yaguang Zhang#, Weiwei Yang*, Dan Ye*, Zhimin Lu*, Canhua Huang*, Jun Mei*, Hua-Feng Zhang*, Ping Gao*, Peng Jiang*, Shicheng Su*, Bing Sun*, and Shi-Min Zhao*. Cancer Metabolism and Tumor Microenvironment: Fostering Each Other? Science China Life Sciences. 2022 Feb;65(2):236-279.
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Yingying Tong#, Dong Guo#, Shu-Hai Lin#, Liangjia Zhen, Dianqiang Yang, Chunmin Ma, Fei Shao, Min Li, Qiujing Yu, Yuhui Jiang, Lei Li, Jing Fang, Rilei Yu*, Zhimin Lu*. SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells. Molecular Cell. 2021 Jun 3;81(11):2303-2316.e8.