Cai Shiqing, Senior Researcher and doctoral supervisor
Email: sqcai@shsmu.edu.cn
Research directions: Aging of the nervous system and regulation of ion channel functions

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Tu C., Qian C., Li S., Lin DY., Liu ZY., Ouyang WG., Kang XL., Chen F., Song S., Cai,S*. (2025) Targeting the chromatin remodeler BAZ2B mitigates hepatic senescence and MASH fibrosis. Nat Aging. 5:1063-1078
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Ye, S., Song, S., Liu, X., Luo, Y., Cai,S.* (2025) A small-molecule screen identifies novel aging modulators by targeting 5-HT/DA signaling pathway. Aging Cell. 24: e14411.
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Yao, L., Ruan, M., Ye, S., Cai,S.* (2023) DNA topoisomerase 2-associated proteins PATL1 and PATL2 regulate the biogenesis of hERG K+ channels. PNAS. 120: e2206146120
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Yuan, J., Chang, S., Yin,S., Liu, Z., Cheng, X., Liu, X., Jiang, Q., Gao, G., Lin, D., Kang, X., Ye, S., Chen, Z., Yin, J., Hao, P., Jiang, L.* & Cai,S.* (2020) Two conserved epigenetic regulators prevent healthy ageing. Nature. 10: 1038
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Bai,X., Li,K., Yao,L., Kang,X., Cai,S.* (2018) A forward genetic screen identifies chaperone CNX-1 as a conserved biogenesis regulator of ERG K+ channels. J gen physiol. 150: 1189-1201
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Jiang,Q., Li,K., Lu,W., Li,S., Chen, X., Liu,X., Yuan,J.,Ding, Q.,Lan,F.,* ,Cai,S.,* (2018) Identification of small-molecule ion channel modulators in C. elegans channelopathy models. Nat commun. 9: 3941
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Yin,J., Gao,G., Liu,X., Hao,Z., Li,K., Kang,X., Li,H., Shan,Y., Hu,W., Li,H., Cai,S.* (2018) Genetic variation in glia-neuron signalling modulates ageing rate. Nature. 551: 198-203
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Li,K., Jiang,Q., Bai,X., Yang,Y., Ruan,M., Cai,S.* (2017) Tetrameric Assembly of K+ Channels Requires ER-Located Chaperone Proteins. Mol cell. 65: 52-65
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Chen,X., Ruan,M., Cai,S.* (2015) KChIP-like auxiliary subunits of Kv4 channels regulate excitability of muscle cells and control male turning behavior during mating in Caenorhabditis elegans. J neurosci. 35: 1880-1891
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Yin,J., Liu,X., Yuan,J., Jiang,J., and Cai,S.* (2014) Longevity manipulations differentially affect serotonin/dopamine level and behavioral deterioration in aging Caenorhabditis elegans. J Neurosci. 34: 3947-3958
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Sesti,F., Liu,S., Cai,S. (2010) Oxidation of potassium channels by ROS: a general mechanism of aging and neurodegeneration? Trends cell biol. 20: 45-51
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Cai,S.*, Wang,Y*., Ki Ho Park*., Tong,X., Pan,Z.,and Sesti ,F. (2009) Auto-phosphorylation of a voltage-gated K + channel controls non-associative learning. Embo. J. 28: 1601-1610
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Tutak,W., Ki-Ho, Park., Fanchini,G.,Vasilov, A., Cai,S., Partridge,N., Sesti,F., Chhowalla, M. (2009) Toxicity induced enhanced extracellular matrix production in osteoblastic cells cultured on single walled carbon nanotube networks. Nanotechnology, 20: 25101
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Cai,S., Sesti ,F.* (2009) Oxidation of a K+ Channel causes progressive decline in sensory function during ageing. Nat.neurosci. 12: 611-617
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Cai,S., Sesti ,F.* (2007) A new mode of regulation of N-type inactivation in a Caenorhabditis elegans voltage-gated potassium channel. J biol chem. 282: 18597-18601
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Cai,S., Li,W., Sesti ,F.* (2007) Multiple modes of A-type Potassium current regulation. Invited review Curr pharm frdign. 13: 3178-3184
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Hernandez,L., K.H.Park., Cai,S., Qin, L. Partridge,N., Sesti,F. (2007) The antiproliferative role of ERG K+ channels in rat osteoblastic cells. Cell biochem biophys. 47: 199-208
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Cai,S., Hernandez L., Wang Y., Ki Ho Park., Sesti F. (2005) MPS-1 is a K+channel b-subunit and a serine/threonine kinase. Nat.neurosci. 8: 1503-1509