单细胞组学与疾病研究中心

何牮/ 职称:副研究员

学历学位:博士 研究生

Email: hejianwan@hotmail.com

何牮,博士,上海交通大学医学院副研究员、硕士生导师,单细胞组学与疾病研究中心基因组学平台主任。

个人简介

于吉林大学/美国加州大学圣迭戈分校(University of California,  San Diego)博士联合培养毕业。先后于美国洛斯阿拉莫斯国家实验室(Los Alamos National Laboratory)、中国科学院、上海交通大学等单位工作。

2019年加入上海交大医学院单细胞组学与疾病研究中心任基因组学平台主任。长期从事单细胞多组学分析技术的研发及肿瘤基因组学研究,运用新技术新策略在单细胞层面探究肿瘤等重大疾病的发病机制和在营养及药物干预下肿瘤微环境中肿瘤细胞与免疫细胞间的相互作用;筛选发现肿瘤防控新靶标,探讨诊疗肿瘤的新方法。

截止20219月,发表SCI收录的论文50余篇,其中35篇为近五年发表,总引用1100余次,H指数(h-index17,其中第一或通讯作者20篇。主持多项国家级、省部级及校级项目,参与多项国家级、科技部、医工交叉及横向课题。申请专利十余项(已授权两项),受邀撰写综述文章并推荐为封面文章,并多次于国内外重要学术会议进行报告并获奖。担任人卫出版社教材《基础医学概论》编委,多家学术期刊编委、审稿人及ISBRA会议program committee,美国癌症研究学会、中国生物化学与分子生物学会、中国抗癌协会、中国生物医学工程学会等多家学会会员,上海市决策咨询类科技专家,上海市中医药科技评审咨询专家,上海市卫生健康委员会医学科技评审专家等。

E-mail: jih003@sjtu.edu.cn

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近五年第一或通讯作者文章

1.    Jian He#et al. Int J Environ Res Public Health. 2021 Accepted.

2.    Jian He#et al. Construction of a human cell landscape of COVID-19 Infection at single-cell level. Clin Cancer Res 2021;27(6_Suppl): P42. DOI: https://doi.org/10.1158/1557-3265.COVID-19-21-P42.

3.    Jian He#, et al. A Novel Prognostic Biomarker LPAR6 in Hepatocellular Carcinoma via Associating with Immune Infiltrates. J Clin Transl Hepatol. Published online: Sep 17, 2021. DOI: 10.14218/JCTH.2021.00047

4.    Jian He, et al. Aging and disease. 2021, 12, 5;

5.    Jian He#, et al. MedComm. 2021;1-13.

6.    Jian He, et al. Chem Biodivers. 2019 Sep;16(9):e1900176.

7.    Jian He, et al. Single-Cell RNA-Seq Reveals Naïve B cells Associated with Better Prognosis of HCC. Preprint BioRxiv. doi: https://doi.org/10.1101/ 731935

8.    Jian He, et al. EBioMedicine. 2016 Oct;12:4-5.

9.    Jian He. Current organic chemistry. 2017, 21(19): 1-22.

10.  Jian He, et al. Recurrent somatic mutations of PRKAR1A in isolated cardiac myxoma. Oncotarget. 2017 Nov 28; 8(61): 103968–103974.

11.  Jian He. Scientific Reports, 2017 Aug 21;7(1):8867.

12.  Xinyu Hu, Yidi Qu, Qiubo Chu, Wenshu Li, Jian He#. Molecular Medicine Reports, 2018,17: 3599-3606.

13.  Jian He, et al. Organic Process Research & Development. 2016, 20 (6), pp 1093–1096.

14.  Jian He, et al. BioTechniques. 2016; 60 (3):129-135.

 

Jian He, Ph.D., Associate Professor

Director of Single-cell Genomics Core

The Center for Single-Cell Omics (CSCOmics) , School of Public Health,

Shanghai Jiao Tong University School of Medicine

Address: 227 South Chongqing Road, Shanghai, China

Email: jih003@sjtu.edu.cn

 

Dr. He obtained her Ph.D. degree from a joint Ph.D. program in Jilin University and University of California, San Diego, which was supported by China Scholarship Council. Dr. He then worked in Los Alamos National Laboratory in the United States, Chinese Academy of Sciences and Shanghai Jiao Tong University in China.

 

In 2019, Dr. He joined the Center for Single-Cell Omics in Shanghai Jiao Tong University School of Medicine as the core director of the genomics core.

 

Dr. He research focused on developing more sophisticated protocols of single-cell multiple-omics, and studying major diseases, especially oncology using single-cell omics strategies. As of Sept. 2021, Dr. He has authored 56 high-quality scholarly articles including twenty first-authored and correspondence author papers, which has been extensively cited. Also, Dr. He has filed 11 patents (2 issued). Also, she has been awarded research grants and awards from National Natural Science Foundation, China Postdoctoral Science Special Foundation, and so on. Dr. He was invited to contribute review articles by high influential research journals in her field and give oral presentations at national and international conferences. Dr. He also serves as an article reviewer of numerous notable international journals.

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Recent 5 years selected publications:

15.  Jian He#et al. Int J Environ Res Public Health. 2021 Accepted.

16.  Jian He#et al. Construction of a human cell landscape of COVID-19 Infection at single-cell level. Clin Cancer Res 2021;27(6_Suppl): P42. DOI: https://doi.org/10.1158/1557-3265.COVID-19-21-P42.

17.  Jian He#, et al. A Novel Prognostic Biomarker LPAR6 in Hepatocellular Carcinoma via Associating with Immune Infiltrates. J Clin Transl Hepatol. Published online: Sep 17, 2021. DOI: 10.14218/JCTH.2021.00047

18.  Jian He, et al. Aging and disease. 2021, 12, 5;

19.  Jian He#, et al. MedComm. 2021;1-13.

20.  Jian He, et al. Chem Biodivers. 2019 Sep;16(9):e1900176.

21.  Jian He, et al. Single-Cell RNA-Seq Reveals Naïve B cells Associated with Better Prognosis of HCC. Preprint BioRxiv. doi: https://doi.org/10.1101/ 731935

22.  Jian He, et al. EBioMedicine. 2016 Oct;12:4-5.

23.  Jian He. Current organic chemistry. 2017, 21(19): 1-22.

24.  Jian He, et al. Recurrent somatic mutations of PRKAR1A in isolated cardiac myxoma. Oncotarget. 2017 Nov 28; 8(61): 103968–103974.

25.  Jian He. Scientific Reports, 2017 Aug 21;7(1):8867.

26.  Xinyu Hu, Yidi Qu, Qiubo Chu, Wenshu Li, Jian He#. Molecular Medicine Reports, 2018,17: 3599-3606.

27.  Jian He, et al. Organic Process Research & Development. 2016, 20 (6), pp 1093–1096.

28.  Jian He, et al. BioTechniques. 2016; 60 (3):129-135.