主题：Structural Biology of RNA-mediated Gene Regulation　　

　　主讲嘉宾：Dr. Dinshaw J. Patel

　　　　　　　Member and Abby Rockefeller Mauzé Chair in Experimental Therapeutics,

　　　　　　　Structural Biology Program，Memorial Sloan-Kettering Cancer Center

　　　　　　　Member, National Academy of Sciences, 2009

　　　　　　　Member, American Academy of Arts and Sciences, 2014             

　　报告摘要：

　　The role of RNA in information transfer and catalysis highlights its dual functionalities. Much of our effort in this area has focused on metabolite-sensing riboswitches and nucleolytic self-cleaving ribozymes on the one hand, and on CRISP-Cas systems on the other. The lecture will provide a few examples of principles underlying metabolite recognition by riboswitches, our studies on catalytic mechanisms adopted by nucleolytic ribozymes and recent x-ray and cryoEM studies on ternary complexes of Cas nucleases and multisubunit Cascades with bound crRNA and target DNA, and the impact of anti-CRISPR proteins in suppressing the CRISPR-Cas host defense pathway.

　　时间：4月17日（周二）11:15-12:30

　　地点：图书馆一楼演讲厅

　　主持人：雷鸣 教授