研究方向
从事线粒体和衰老的分子机制研究，利用蛋白质组学的方法研究线粒体蛋白动态变化及其与衰老及相关疾病的关系。主要关注衰老和相关疾病中线粒体蛋白水平修饰（包括乙酰化、琥珀酰化和氧化等）对线粒体功能的调节和反向信号传导的影响，以及在衰老相关疾病中的作用。
奖励
2015: Charles A. King Trust Postdoctoral Research Fellowship
2017: Harvard Chinese life Science YongJin Distinguished Research Award
2017: 第十四批国家高层次人才计划
2022: 教学比赛三等奖
重要文献和书籍
1. Wang Jiahui, Yu Xiang, Zhong Youhuan, Ma Xiaomin, Gao Yuanzhu, Zhou Dejian, Wang Jie, Fu Yinkun, Shi fan, Su Juncheng, Huang Masha, Haigis Marcia, Wang Peiyi, Xu Yingjie*,Yang Wen*. The mitochondrial DNAJC co-chaperone TCAIM reduces α-ketoglutarate dehydrogenase protein levels to regulate metabolism.Mol Cell. 2025 Feb 6;85(3):638-651.e9.
2. Jiahui Wang, Ziyi Cao, Qun Zhang, Xiang Yu, Zhida Lan, Leiwen Zhao, Jie Wang, Wenjing Wang, Yu Zhang Zikan Zhong, Yutong Hou, Xiang He, Zhiyin An, Hang Yu, Yingjie Xu*,Wen Yang*. mRNA-encoded fluorescent proteins enable superior organelle labeling for live cell imaging.FASEB J. 2024 Dec 15;38(23):e70244.
3. Xiang He, Jiahui Zhang, Masha Huang, Jie Wang, Simin Yang, Xiang Yu*, Yingjie Xu*,Wen Yang*. Serum apolipoprotein H determines ferroptosis resistance by modulating cellular lipid composition.Cell Death Dis. 2024 Oct 1;15(10):718.
4. Wei Li, Masha Huang, Zhaoping Wu, Yu Zhang, Ying Cai, Juncheng Su, Jia Xia, Fan Yang, Desheng Xiao, Wen Yang*, Yingjie Xu*, Zhaoqian Liu*, mRNA-Lipid Nanoparticle-Mediated Restoration of PTPN14 Exhibits Antitumor Effects by Overcoming Anoikis Resistance in Triple-Negative Breast Cancer,Adv. Sci, 2024; 2309988.
5. Ying Cai, Yun Li, Yingjie Xu,Wen Yang*, Masha Huang*, TCEB3 initiates ovarian cancer apoptosis by mediating ubiquitination and degradation of MCL-1,FASEB J, 2024; 38(8) e23625. doi: 10.1096/fj.202400249RR.
6. Han Sun, Yu Zhang, Jiahui Wang, Juncheng Su, Dejian Zhou, Xiang Yu*, Yingjie Xu*,Wen Yang*, Application of Lung-Targeted Lipid Nanoparticle-delivered mRNA of soluble PD-L1 via SORT Technology in Acute Respiratory Distress Syndrome,Theranostics, 2023; 13(14):4974-4992.
7. Luo, X., Zhang, Z. H., Wang, J., Wang, X. L., Zhang, Y. N., Chen, J. Q., Ge, G. B.,Yang, W.*, Qian, X. H.*, Tian, Y.* and Yang, Y. J.*；Acyl-caged rhodamines: photo-controlled and self-calibrated generation of acetyl radicals for neural function recovery in early AD mice,Chemical Science, 2023; DOI: 10.1039/d3sc03035
8. Yutong Hou, Sihao Lin, Jia Xia, Yu Zhang, Yanan Yin, Masha Huang, Yingjie Xu*,Wen Yang*, Yingjian Zhu*; Alleviation of ischemia–reperfusion induced renal injury by chemically modified SOD2 mRNA delivered via lipid nanoparticles,Molecular Therapy Nucleic Acids,2023 Oct 26:34:102067.
9. Ran Yan, Wenjing Wang,Wen Yang*, Masha Huang* and Wei Xua*; Mitochondria-Related Candidate Genes and Diagnostic Model to Predict Late-Onset Alzheimer’s Disease and Mild Cognitive Impairment;Journal of Alzheimer’s Disease, 2023; DOI: 10.3233/JAD-230314
10. Yun Li, Jingjing Zhang, Ying Cai, Hua Liu,Wen Yang*, Yingjie Xu*, Masha Huang*; VSTM2L contributes to anoikis resistance and acts as a novel biomarker for metastasis and clinical outcome in ovarian cancer,BBRC, Apr 2023; DOI: 10.1016/j.bbrc.2023.03.073
11. Xiang Yu, Zheng Yang, Yu Zhang, Jia Xia, Jiahui Zhang, Qi Han, Hang Yu, Chengbiao Wu, Yingjie Xu, Wei* Xu*,Wen Yang*, Lipid Nanoparticle Delivery of Chemically Modified NGFR100W mRNA Alleviates Peripheral Neuropathy,Advanced Health Care Materials, 2023 Jan;12(3):e2202127.
12. Youhuan Zhong， Yuanzhu Gao， Dejian Zhou, Xiaomin Ma, Huan Chen, Yingjie Xu,Wen Yang*, Xiang* Yu, Structural basis for the activity and regulation of human α-ketoglutarate dehydrogenase revealed by Cryo-EM,Biochemical and Biophysical Research Communications, 2022, 602:120-126
13. Jingjing Zhang, Yun Li, Hua Liu, Jiahui Zhang, Jie Wang, Jia Xia, Yu Zhang, Xiang Yu, Jinyan Ma, Masha Huang, Jiahui Wang, Liangzhe Wang, Qian Li, Rutao Cui,Wen Yang*, Yingjie Xu* and Weiwei Feng*, Genome‑wide CRISPR/Cas9 library screen identifies PCMT1 as a critical driver of ovarian cancer metastasis,Journal of Experimental &Clinical Cancer Research, 2022, 41:24
14. Jia Xia, Jiahui Zhang, Liangzhe Wang, Hailong Liu, Jie Wang, Junyan Liu, Zhaoqian Liu, Yingjian Zhu, Yingjie Xu*,Wen Yang* and Yongjiang Yu*， Non-apoptotic function of caspase-8 confers prostate cancer enzalutamide resistance via NF-κB activation,Cell death and diseases, 2021, 12:833
15. Jing Xu, Jiahui Wang, Xiaoli Wang, Ruoming Tan, Xiaoling Qi, Zhaojun Liu, Hongping Qu, Tingting Pan, Qingyuan Zhan, Yong Zuo*,Wen Yang*, Jialin Liu*, Soluble PD-L1 improved direct ARDS by reducing monocyte-derived macrophages,Cell death and diseases, 2020, 11: 934
16. Kai Xin, Xinxing Li, Yinghua Guo, Youhuan Zhong, Jungang Wang, Haotian Yang, Jie Zhao, Chunlei Guo, Yunxia Huang, Zuhai Lei, Yi-Lun Ying, Xiao Luo, Haolu Wang, Xuhong Qian,Wen Yang*, Xiaowen Liang* & Youjun Yang*, A Monochromophoric Approach to Succinct Ratiometric Fluorescent Probes Without Probe-Product Crosstalk,CCS Chemistry, 2020, 2, 2307–2315
17. Wen Yang et al. Mitochondrial Sirtuins Coordinating Stress Responses Through Regulation of Mitochondrial Enzyme Networks, Introductory Review on Sirtuins in Biology, Aging, and Disease,2018, Pages 95-115
18. Wen Yang, Koji Nagasawa, Christian Münch, Yingjie Xu, Kyle Satterstrom, Seungmin Jeong, Sebastian D Hayes, Mark P. Jedrychowski, F. Sejal Kamlesh Vyas; Elma Zaganjor, Virginia Guarani, Alison Ringle, Steven P Gygi, J. Wade Harper, and Marcia C Haigis: Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-dependent Deacetylation in Response to Membrane Depolarization.Cell,2016,167(4): 985–1000.e21.
19. Xu Y,Yang W, Shi J, Zetter BR, Shi J.: Prohibitin 1 regulates tumor cell apoptosis via interaction with X-linked Inhibitor of Apoptosis Protein. J Mol Cell Biol,2016, 8 (3): 282-285.
20. Callista Yee,Wen Yang, and Siegfried Hekimi.: The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS inC. elegans.Cell, 2014, 157(4):897-909
21. Inuzuka,H., Gao,D., Finley,L.W.,Yang,W., Wan,L., Fukushima,H., Chin,Y.R., Zhai,B., Shaik,S., Lau,A.W., Wang,Z., Gygi,S.P., Nakayama,K., Teruya-Feldstein,J., Toker,A., Haigis,M.C., Pandolfi,P.P., and Wei,W.: Acetylation-dependent regulation of Skp2 function.Cell, 2012,150:179-193.
书籍
专利
徐颖洁，于翔，徐玮，杨文，杨峥，张宇。“神经生长因子突变体重组蛋白及应用”， 专利号：CN202210147754.4
美国/日本申请号：PCT/CN2022/114516; 欧洲专利申请号：EP22860539.0
杨文，徐颖洁，孙涵，张宇。肺靶向可溶性PD-L1 mRNA脂质纳米颗粒及其应用。 专利申请号：2023110858249
杨文,徐颖洁,王佳惠,俞航。细胞器荧光标记 mRNA 及其应用。专利申请号：2023116322023
研究经费
项目批准号：91954120; 项目名称：解析线粒体参与细胞器互作的蛋白网络及分子机制; 重大研究计划
项目批准号：31871430; 项目名称：神经细胞中C3orf23调控酮戊二酸脱氢酶的作用与机制研究; 面上项目
项目批准号：2019YFA0508601; 项目名称：蛋白质机器与生命过程调控重点专项
