李亚东Ph.D.

研究员，课题组长

Songjiang Research Institute, Shanghai Jiao Tong University School of Medicine

上海交通大学医学院松江研究院

个人信息:

出生年月: 1990-10

地 址: 上海市松江区中山中路746号18号楼203

手 机: 021-67722409, (86)15711616541

邮 箱: yadlee@126.com,

网 站: https://www.x-mol.com/groups/yadleelab?lang=zh

教育经历:

2015.09–2018.06： 复旦大学，博士，药理学，导师：黄志力/曲卫敏

2012.09–2015.06： 皖南医学院/复旦大学，硕士，药理学，导师：黄志力/洪宗元

2008.09–2012.06： 皖南医学院，本科

工作经历:

2023.03–至今 上海交通大学医学院松江研究院，研究员，课题组长

2018.10–2023.02 北卡罗来纳大学教堂山分校，博士后，合作导师: Juan Song

研究兴趣:

李亚东博士主要研究方向为睡眠觉醒发生机制及对学习记忆和情感的调控作用，重点关注：1）睡眠觉醒调控记忆和情感的神经环路和分子机制；2）阿尔兹海默病中认知和情感损害的环路和分子机制，开创性的提出通过干预觉醒水平改善认知和情感功能的新策略；3）慢性痛和麻醉相关睡眠障碍和认知损害的病理机制及干预策略。

学术成绩:

1）在生理性睡眠觉醒发生机制方面，发现了腹侧基底神经节中伏隔核和腹侧苍白球调控动机相关觉醒的关键作用；2）在睡眠障碍发生机制方面，揭示了前扣带回皮层-纹状体环路调控慢性痛失眠的关键机制，为睡眠障碍的干预提供了新靶点；3）在睡眠觉醒调控学习记忆机制方面，阐明了觉醒核团调控成体海马神经发生进而改善记忆的新机制，为改善阿尔兹海默病记忆障碍提供了新策略。以上研究成果为解析睡眠觉醒发生机制及对记忆调控作用提供了关键的理论基础。李亚东以第一或通讯作者身份在Nat Neurosci、Cell Stem Cell和Neuron等期刊发表论文11篇，获国自然海外优青项目（国家级）和上海市青年领军人才（省部级）项目的资助。主持国自然面上项目等各类项目5项。

学术兼职:

中国睡眠研究会理事

中国神经科学会国际交流委员会委员

中国神经科学会学习记忆基础与临床分会委员

中国神经科学会神经发育委员会委员

上海市情感脑功能解析与障碍干预重点实验室主任助理

学术期刊:

Sleep Research编委

《中国临床药理学与药物治疗学》（北大核心）编委

个人荣誉:

发表文章:

1. Ya-Dong Li(李亚东); Yan-Jia Luo; Wei-Kun Su, Jing Ge, Andrew Crowther, Ze-Ka Chen, Lu Wang, Michael Lazarus, Zi-Long Liu, Wei-Min Qu, Zhi-Li Huang, Anterior cingulate cortex projections to the dorsal medial striatum underlie insomnia associated with chronic pain,Neuron, 2024.02.14(first and leading corresponding author, IF = 18.688)

2. Ya-Dong Li(李亚东); Yan-Jia Luo; Ling Xie; Dalton S Tart; Ryan N Sheehy; Libo Zhang; Leon G Coleman Jr; Xian Chen; Juan Song; Activation of hypothalamic-enhanced adult-born neurons is sufficient to restores cognitive and affective function in Alzheimer's disease,Cell Stem Cell, 2023,31 (first author, IF = 23.9)

3. Ya-Dong Li(李亚东); Yan-Jia Luo; Juan Song; Optimizing memory performance and emotional states: multi-level enhancement of adult hippocampal neurogenesis,Current Opinion in Neurobiology, 2023, 79 (first author, IF = 7.07)

4. Ya-Dong Li(李亚东); Yan-Jia Luo; Ze-Ka Chen; Luis Quintanilla; Yoan Cherasse; Libo Zhang; Michael Lazarus; Zhi-Li Huang; Juan Song; Hypothalamic modulation of adult hippocampal neurogenesis in mice confers activity-dependent regulation of memory and anxiety-like behavior,Nature Neuroscience, 2022, 25: 630-645 (first author, IF = 28.8)

5. Ya-Dong Li(李亚东); Yan-Jia Luo; Wei Xu; Jin Ge; Yoan Cherasse; Yi-Qun Wang; Michael Lazarus; Wei-Min Qu; Zhi-Li Huang; Ventral pallidal GABAergic neurons control wakefulness associated with motivation through the ventral tegmental pathway,Molecular Psychiatry, 2020, Oct(14): 2912-2928 (first author, IF = 15.9)

6. Yadong Li(李亚东); Hechen Bao; Yanjia Luo; Cherasse Yoan; Heather Anne Sullivan; Luis Quintanilla; Ian Wickersham; Michael Lazarus; Yen-Yu Ian Shin; Juan Song; Supramammillary nucleus synchronizes with dentate gyrus to regulate spatial memory retrieval through glutamate release,eLife, 2020, 9(e53129): 1-23 (first author, IF = 7.7)

7. Ya-Dong Li(李亚东); Jing Ge; Yan-Jia Luo; Wei Xu; Juan Wang; Michael Lazarus; Zong-Yuan Hong; Wei-Min Qu; Zhi-Li Huang; High cortical delta power correlates with aggravated allodynia by activating anterior cingulate cortex GABAergic neurons in neuropathic pain mice,PAIN, 2019, 161:288-299 (first author, IF = 7.926)

8. Yan-Jia Luo; Jing Ge; Ze-Ka Chen; Zi-Long Liu; Michael Lazarus; Wei-Min Qu; Zhi-Li Huang;Ya-Dong Li(李亚东); Ventral pallidal glutamatergic neurons regulate wakefulness and emotion through separated projections, iScience,2023, 26 (8) (Last corresponding author, IF = 5.75)

9. Connor M Wander,Ya-Dong Li(李亚东), Hechen Bao, Brent Asrican, Yan-Jia Luo, Heather A Sullivan, Tzu-Hao Harry Chao, Wei-Ting Zhang, Samantha L Chéry, Dalton S Tart, Ze-Ka Chen, Yen-Yu Ian Shih, Ian R Wickersham, Todd J Cohen, Juan Song; Compensatory remodeling of a septo-hippocampal GABAergic network in the triple transgenic Alzheimer’s mouse model,Journal of Translational Medicine, 2023, 21 (1), 258 (co-first and co-corresponding author, IF = 8.448)

10. Yan-Jia Luo;Ya-Dong Li(李亚东); Lu Wang; Su-Rong Yang; Xiang-Shan Yuan; Juan Wang; Yoan Cherasse; Michael Lazarus; Jiang-Fan Chen; Wei-Min Qu; Zhi-Li Huang; Nucleus accumbens controls wakefulness by a subpopulation of neurons expressing dopamine D1 receptors,Nature Communications, 2018, 9(1): 1576 (co-first author, IF = 17.694)

11. Yu-Er Wu;Ya-Dong Li(李亚东); Yan-Jia Luo; Tian-Xiao Wang; Hui-Jing Wang; Shuo-Nan Chen; Wei-Min Qu; Zhi-Li Huang; Gelsemine alleviates both neuropathic pain and sleep disturbance in partial sciatic nerve ligation mice,Acta Pharmacologica Sinica, 2015, 11(36): 1308-1317

12. Ze-Ka Chen; Hui Dong; Cheng-Wei Liu; Wen-Ying Liu; Ya-Nan Zhao; Wei Xu; Xiao Sun; Yan-Yu Xiong; Yuan-Yuan Liu; Xiang-Shan Yuan; Bing Wang; Michael Lazarus; Yoan Chérasse;Ya-Dong Li(李亚东); Fang Han; Wei-Min Qu; Feng-Fei Ding; Zhi-Li Huang ; A cluster of mesopontine GABAergic neurons suppresses REM sleep and curbs cataplexy,Cell Discovery, 2022, 8(1)

13. Brent Asrican; Josh Wooten;Ya-Dong Li(李亚东); Luis Quintanilla; Feiran Zhang; Connor Wander; Hechen Bao; Chia-Yu Yeh; Yan-Jia Luo; Reid Olsen; Szu-Aun Lim; Jessica Hu; Peng Jin; Juan Song; Neuropeptides modulate local astrocytes to regulate adult hippocampal neural stem cells,Neuron, 2020, 108(2): 349-366

14. Tian-Xiao Wang; Dou Yin; Wei Guo; Yuan-Yuan Liu;Ya-Dong Li(李亚东); Wei-Min Qu; Wu-Jian Han; Zong-Yuan Hong; Zhi-Li Huang; Antinociceptive and hypnotic activities of pregabalin in a neuropathic pain-like model in mice,Pharmacology Biochemistry and Behavior, 2015, (135): 31-39

15. Ze-Ka Chen; Luis Quintanilla; Yijing Su; Ryan N. Sheehy; Jeremy M. Simon; Yan-Jia Luo;Ya-Dong Li(李亚东); Zhe Chen; Brent Asrican; Dalton S. Tart; W. Todd Farmer; Guo-Li Ming; Hongjun Song; Juan Song; Septo-dentate gyrus cholinergic circuits modulate function and morphogenesis of adult neural stem cells through granule cell intermediaries,Proceedings of the National Academy of Sciences, 2024, 121(40)

16. Yan-Jia Luo; Hechen Bao; Andrew Crowther;Ya-Dong Li(李亚东); Ze-Ka Chen; Dalton S. Tart; Brent Asrican; Libo Zhang; Juan Song; Sex-specific expression of distinct serotonin receptors mediates stress vulnerability of adult hippocampal neural stem cells in mice,Cell Reports, 2024, 43(5): 114140

科研项目：

2024-2027，国家自然科学基金面上项目, 32371028

2024-2026，上海市科委启明星A类项目，24QA2704800

2023-2026，上海市卫计委面上项目, 202340046

2023-2024，上海交通大学“交大2030”计划C类项目

2021-2023，BBRF Young Investigators, 29600（结题）

人才项目：

2022上海市青年领军人才（海外）

2023国家自然科学基金海外优青