李亚东，研究员，独立PI，博士生导师。国家级海外青年人才项目获得者。2018年博士毕业于复旦大学，2023年在美国北卡罗来纳大学教堂山分校完成博士后训练，入职上海交通大学医学院松江研究院。2025年兼聘为上海交通大学护理学院学科PI。

课题组长期从事调控睡眠觉醒和学习记忆的神经环路和分子机制研究，相关成果以第一/通讯作者发表在Cell Stem Cell, Nature Neuroscience, Neuron等期刊。先后获美国NARSAD青年科学家奖，主持国自然等多项基金。课题组形成由博士后、博士生和科研助理构成的科研团队，可进行基于EEG在线解析的闭环神经调控、在体双光子成像结合VR编码学习记忆检测/EEG/LFP同步记录、多通道电生理、Patch-seq、蛋白质组学、脑片膜片钳和多种行为学检测。课题组经费保障完善，人员构成合理。现诚招神经环路和行为方向博士后一名。

课题组主要研究方向：

睡眠觉醒和学习记忆原理都是脑科学基本科学问题，其调控机制是当今脑科学研究的重点和热点。本课题组在神经网络和分子水平关注：（1）睡眠觉醒的机制及对记忆的调控作用。重点研究睡眠觉醒调控海马依赖的的学习记忆和情感行为的神经环路和分子机制。（2）阿尔茨海默病早期全身麻醉术后睡眠觉醒障碍和认知情感损害的环路和分子机制。

代表性论著：

1.    Ya-Dong Li(李亚东); Yan-Jia Luo; Wei-Kun Su, Jing Ge, Andrew Crowther, Ze-Ka Chen, Lu Wang, Michael Lazarus, Zi-Long Liu, Wei-Min Qu, Zhi-Li Huang, Anterior cingulate cortex projections to the dorsal medial striatum underlie insomnia associated with chronic pain, Neuron, 2024.02.14 (first and leading corresponding author, IF = 18.688)

2.    Ya-Dong Li(李亚东); Yan-Jia Luo; Ling Xie; Dalton S Tart; Ryan N Sheehy; Libo Zhang; Leon G Coleman Jr; Xian Chen; Juan Song; Activation of hypothalamic-enhanced adult-born neurons is sufficient to restores cognitive and affective function in Alzheimer's disease, Cell Stem Cell, 2023,31 (first author, IF = 23.9)

3.    Ya-Dong Li(李亚东); Yan-Jia Luo; Juan Song; Optimizing memory performance and emotional states: multi-level enhancement of adult hippocampal neurogenesis, Current Opinion in Neurobiology, 2023, 79 (first author, IF = 7.07)

4.    Ya-Dong Li(李亚东); Yan-Jia Luo; Ze-Ka Chen; Luis Quintanilla; Yoan Cherasse; Libo Zhang; Michael Lazarus; Zhi-Li Huang; Juan Song; Hypothalamic modulation of adult hippocampal neurogenesis in mice confers activity-dependent regulation of memory and anxiety-like behavior, Nature Neuroscience, 2022, 25: 630-645 (first author, IF = 28.8)

5.    Ya-Dong Li(李亚东); Yan-Jia Luo; Wei Xu; Jin Ge; Yoan Cherasse; Yi-Qun Wang; Michael Lazarus; Wei-Min Qu; Zhi-Li Huang; Ventral pallidal GABAergic neurons control wakefulness associated with motivation through the ventral tegmental pathway, Molecular Psychiatry, 2020, Oct(14): 2912-2928 (first author, IF = 15.9)

6.    Yadong Li(李亚东); Hechen Bao; Yanjia Luo; Cherasse Yoan; Heather Anne Sullivan; Luis Quintanilla; Ian Wickersham; Michael Lazarus; Yen-Yu Ian Shin; Juan Song; Supramammillary nucleus synchronizes with dentate gyrus to regulate spatial memory retrieval through glutamate release, eLife, 2020, 9(e53129): 1-23 (first author, IF = 7.7)

7.    Ya-Dong Li(李亚东); Jing Ge; Yan-Jia Luo; Wei Xu; Juan Wang; Michael Lazarus; Zong-Yuan Hong; Wei-Min Qu; Zhi-Li Huang; High cortical delta power correlates with aggravated allodynia by activating anterior cingulate cortex GABAergic neurons in neuropathic pain mice, PAIN, 2019, 161:288-299 (first author, IF = 7.926)

8.    Yan-Jia Luo; Jing Ge; Ze-Ka Chen; Zi-Long Liu; Michael Lazarus; Wei-Min Qu; Zhi-Li Huang; Ya-Dong Li(李亚东); Ventral pallidal glutamatergic neurons regulate wakefulness and emotion through separated projections, iScience, 2023, 26 (8) (Last corresponding author, IF = 5.75)

9.    Connor M Wander, Ya-Dong Li(李亚东), Hechen Bao, Brent Asrican, Yan-Jia Luo, Heather A Sullivan, Tzu-Hao Harry Chao, Wei-Ting Zhang, Samantha L Chéry, Dalton S Tart, Ze-Ka Chen, Yen-Yu Ian Shih, Ian R Wickersham, Todd J Cohen, Juan Song; Compensatory remodeling of a septo-hippocampal GABAergic network in the triple transgenic Alzheimer’s mouse model, Journal of Translational Medicine, 2023, 21 (1), 258 (co-first and co-corresponding author, IF = 8.448)

10.    Yan-Jia Luo; Ya-Dong Li(李亚东); Lu Wang; Su-Rong Yang; Xiang-Shan Yuan; Juan Wang; Yoan Cherasse; Michael Lazarus; Jiang-Fan Chen; Wei-Min Qu; Zhi-Li Huang; Nucleus accumbens controls wakefulness by a subpopulation of neurons expressing dopamine D1 receptors, Nature Communications, 2018, 9(1): 1576 (co-first author, IF = 17.694)

11.    Yu-Er Wu; Ya-Dong Li(李亚东); Yan-Jia Luo; Tian-Xiao Wang; Hui-Jing Wang; Shuo-Nan Chen; Wei-Min Qu; Zhi-Li Huang; Gelsemine alleviates both neuropathic pain and sleep disturbance in partial sciatic nerve ligation mice, Acta Pharmacologica Sinica, 2015, 11(36): 1308-1317

12.    Ze-Ka Chen; Hui Dong; Cheng-Wei Liu; Wen-Ying Liu; Ya-Nan Zhao; Wei Xu; Xiao Sun; Yan-Yu Xiong; Yuan-Yuan Liu; Xiang-Shan Yuan; Bing Wang; Michael Lazarus; Yoan Chérasse; Ya-Dong Li(李亚东); Fang Han; Wei-Min Qu; Feng-Fei Ding; Zhi-Li Huang ; A cluster of mesopontine GABAergic neurons suppresses REM sleep and curbs cataplexy, Cell Discovery, 2022, 8(1)

13.    Brent Asrican; Josh Wooten; Ya-Dong Li(李亚东); Luis Quintanilla; Feiran Zhang; Connor Wander; Hechen Bao; Chia-Yu Yeh; Yan-Jia Luo; Reid Olsen; Szu-Aun Lim; Jessica Hu; Peng Jin; Juan Song; Neuropeptides modulate local astrocytes to regulate adult hippocampal neural stem cells, Neuron, 2020, 108(2): 349-366

14.    Tian-Xiao Wang; Dou Yin; Wei Guo; Yuan-Yuan Liu; Ya-Dong Li(李亚东); Wei-Min Qu; Wu-Jian Han; Zong-Yuan Hong; Zhi-Li Huang; Antinociceptive and hypnotic activities of pregabalin in a neuropathic pain-like model in mice, Pharmacology Biochemistry and Behavior, 2015, (135): 31-39

15.    Ze-Ka Chen Luis Quintanilla, Yijing Su, Ryan N Sheehy, Jeremy M Simon, Yan-Jia Luo, Ya-Dong Li(李亚东), Zhe Chen, Brent Asrican, Dalton S Tart, W Todd Farmer, Guo-Li Ming, Hongjun Song, Juan SongSepto-dentate gyrus cholinergic circuits modulate function and morphogenesis of adult neural stem cells through granule cell intermediaries, Proceedings of the National Academy of Sciences, 2024, e2405117121

16.    Yan-Jia Luo, Hechen Bao, Andrew Crowther, Ya-Dong Li(李亚东), Ze-Ka Chen, Dalton S Tart, Brent Asrican, Libo Zhang, Juan Song; Sex-specific expression of distinct serotonin receptors mediates stress vulnerability of adult hippocampal neural stem cells in mice, Cell Reports, 2024, (43) 5,114140.

岗位要求

近半年内或即将取得护理学、医学、神经生物学、药理学或相关专业博士学位，在国内外顶尖科研机构受过优秀的科研训练，并发表过（或即将发表）重要科研成果并励志在学术上有所建树；优先考虑具备丰富的神经环路和睡眠/学习记忆/麻醉研究工作经验，并具备以下三项技术之一者：①在体多通道电生理；②单细胞测序和多组学分析；③神经影像。

岗位职责：

1. 在课题组长的指导下开展科研工作；

2. 独立或协助申请科研项目。

岗位待遇

1.提供有竞争力的薪酬待遇（20-30万元/年），缴纳五险一金；

2.支持申报医学院博士后激励计划、上海市“超级博士后”激励计划、全国博士后创新人才支持计划等各级基金及人才计划。

3.根据相关政策落实办理上海户口，可申请上海市公租房或交大医学院博士后公寓；

4.出站时条件优秀者可优先推荐申请上海交通大学引进类教师或科研岗位。

申请材料及流程

1.个人简历（包括基本信息、教育经历、工作经历、研究背景、发表论文、获奖情况等）

2.本人工作业绩及研究兴趣概述。

3.满足条件且有意向者，请将应聘材料发至联系邮箱，邮件主题请注明“博士后应聘+姓名+意向导师+研究方向”。后续将与申请人进行电话沟通和邀请面谈。

联系方式

联系人：祝老师，电话: 021-63846590-776866

电子邮箱：hlxydzb@shsmu.edu.cn

联系地址：上海市黄浦区重庆南路227号（上海交通大学医学院）东1舍208