Lab Leader: Yujie Tang

Lab Name: Laboratory of Oncogenic Mechanisms & Targeted Diagnostics and Therapeutics of Pediatric Solid Tumors

Lab Info：Our lab performs basic medical research of pediatric solid tumors, focusing on epigenetic mechanisms of oncogenesis and targeted diagnostic and therapeutic strategies. We are collaborating with clinicians from pediatric solid tumor related clinical departments of many affiliated hospitals, to study various types of pediatric solid tumor including DIPG, medulloblastoma, neuroblastoma, hepatoblastoma, Ewing sarcoma, osteosarcoma, and chondroblastoma. We are building tumor tissue bank and patient-derived primary tumor model bank, performing multi-omics profiling together with functional genomic screening and small molecule screening, to systematically dissect and illustrate novel oncogenic mechanisms and targeted diagnostic and therapeutic strategies. Our research has been published on various prestigious journals including Cancer Cell, PNAS, Cancer Research, Oncogene, Cell Death & Disease and Journal of Experimental & Clinical Cancer Research. We have also obtained many fundings and supports including The Recruitment Program of Global Experts of China (National 1000-Youth Talents Program), The Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning, Shanghai Rising-Star Program, the general program of National Natural Science Foundation of China.

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Lab Leader: Qiong Wang

Lab Name: Laboratory of Stem Cell and Regenerative Medicine

Lab Info：Stem cell research will not only reveal unique insights into basic developmental and disease mechanisms, but also provide the foundation for future therapies. Elucidating the regulatory network of stem cell pluripotency and differentiation is a prerequisite for understanding their physiological functions and pathological mechanisms. Currently, by using human and mouse stem cells, organoids as well as animal models, her lab applies functional genomics, epigenetics and bioinformatics to understand the regulatory mechanism of stem cell differentiation under physiological and pathological conditions, which will help speed the clinical applications of stem cell therapy. Her primary research interests focus on: 1.) Study the early fate-determination mechanism of embryonic stem cell towards mesendoderm; 2.) Identify key development regulators of mesendoderm organs, such as pancreas and kidney, and study the clinical applications of adult stem cells or progenitors.

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Lab Leader: Mingliang Zhang

Lab Name: Laboratory of Stem Cells & Neuroregeneration

Lab Info：Diseases that affect the brain or other parts of the central nervous system raise fascinating questions in neuroscience. Among the most disabling and complex conditions is the interaction of neurons with glial cells, particularly oligodendrocytes, the myelin-producing cells, as well as their functions on the brain. Our group maintains a strong focus on myelin development and dedicates to developing the chemical/genetic tools for remyelination. By combining the cutting-edge technologies of stem cells and chemical biology, we are developing the small-molecule chemicals promoting myelination, deciphering the codes for remyelination, exploring the contribution of myelin-neuron interaction to the neurodevelopment and regeneration, and clarifying the potential roles of myelin formation on improving the dysfunction of cognition and brain aging. We devote ourselves to providing reparative strategies for stimulating endogenous regeneration and ultimately reconstructing brain functions. Supported by the National Key R & D Program of China, the National Natural Science Foundation of China, the Basic Research Program of Shanghai Science and Technology Committee, and the Project of the Shanghai Municipal Education Commission currently, our representative works have been published in journals, including Cell Stem Cell, Cell Rep., and J. Mol. Cell Biol. We are now seeking highly motivated research associates and postdoc fellows with backgrounds in stem cells, neuron biology, and chemical biology, and to work on the projects of myelination biology. Applicants could send a single PDF file with the updated CV and publications to mingliang.zhang@shsmu.edu.cn. Your participation is highly desired.

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Lab Leader: Lingjie Li

Lab Name: Laboratory of Epigenetic Regulation of Stem Cell Differentiation, Development and Disease

Lab Info：Our lab is interested in understanding the mechanism of cell fate determination. By using multidimensional epigenomic technology in our established stem cell differentiation and development model system, we aim to decipher the regulatory mechanism of lineage commitment, tissues homeostasis, and related diseases in epithelial tissues, especially with the skin as a major focus. On this basis, we devote our effort to developing new stem cell and genomic technologies in skin regenerative medicine and complex disease diagnosis and treatment. Our current research mainly includes the following aspects: 1. Epigenetic regulation of epithelial tissue development; 2. Regulatory mechanism of early ectodermal differentiation and development; 3. Skin tissue homeostasis and related disease; 4. Stem cell-based skin regenerative medicine.

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Lab Leader: Huang Lei

Lab Name: Laboratory of Genes and Signal Pathways Related to Tumor Initiation

Lab Info：Much of our effort focuses on understanding the mechanism of cancer initiation and uncovering targets for cancer therapy. The goals of our research are: (1) understanding the role of the oncoprotein MUC1 in tumorigenesis and therapy, particularly in breast cancer, lung cancer and esophagus squamous cell carcinoma (ESCC); (2) exploring the mechanism of how MUC1 is activated and degraded; (3) developing MUC1 as a prognostic and predictive marker to guide the application of tumor therapeutic.

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Lab Leader: Ying Jin

Lab Name: Laboratory of Pluripotent Stem Cell & Developmental Biology

Lab Info：Over the years, Jin lab has focused on the self-renewal and differentiation regulatory mechanism of pluripotent stem cells, especially human embryonic stem cells, and is committed to revealing signaling pathways, transcription factors and epigenetic regulatory factors that ensures the infinite self-renewal of embryonic stem cells, aiming to optimize the in vitro culture system of human embryonic stem cells and lay the foundation for obtaining functional cells essential for clinical treatment.

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Lab Leader: Fanyi Zeng

Lab Name: Laboratory of Developmental Biology

Lab Info：The Laboratory of Developmental Biology (LDB) is under Professor Fanyi Zeng's leadership, and the group's main interests include broad aspects of human genetics and developmental biology, particularly diagnosis and treatment of common genetic diseases, stem cell biology, and research on preimplantation development.

Over the years, the laboratory has received major funding from National Basic Research Program of China (as Chief Scientist), National Natural Science Foundation of China, National Science Fund for Distinguished Young Scholars, National Key R&D Program, and more, totaling more than 30 million RMB.

The LDB currently has four staff members, including two senior and two intermediate staff members, as well as one Ph.D. student.

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