FBS

Electron Microscopy Laboratory

Electron Microscope (EM) is an instrument that uses electron beams and electromagnetic lenses instead of light beams and optical lenses to magnify the micros...

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Main Instruments

Service items

01Scanning electron microscopy (SEM)

It is commonly used to observe the surface morphology of solids, with the main applications being:1. Observing and analyzing the overall morphology, surface protrusions, and intercellular relationships of blood cells, bacteria, and cultured cells;2. Observing and analyzing the surface structure of hollow tissues such as the digestive tract, respiratory tract, and blood vessels;3. Observing and ...

02Transmission Electron Microscope (TEM)

It is commonly used for observing the ultrastructure of microscopic substances that cannot be resolved by optical microscopy, with the main application areas being:1. Ultrastructural observation and analysis of organelles and tissue organs;2. Ultrastructural observation and analysis of prokaryotic cells and viruses;3. Analysis of ultrastructural pathological changes (pathological diagnosis);4. ...

03Conventional transmission electron microscopy techniques (for ultrastructural observation of biological tissues and cells)

Conventional transmission electron microscopy technology (used for observing ultrastructure of biological tissues and cells)Negative staining technology (used for observing the shape, structure, size, and surface structure characteristics of samples such as bacteria, viruses, particulate matter, or macromolecular complexes)Immunoelectron microscopy technology (using immunogold labeling technolo...

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Applications Examples

Our Achievements

1.A fine-tuning mechanism underlying self-control for autophagy: deSUMOylation of BECN1 by SENP3. Autophagy . (2019)
2.Nuclear PTEN safeguards pre-mRNA splicing to link Golgi apparatus for its tumor suppressive role. Nat Commun. (2018)
3.ASAP3 regulates microvilli structure in parietal cells and presents intervention target for gastric acidity. Signal Transduct Target Ther. (2017)
4.Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis . Nat Commun. (2017)
5.Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis. J Clin Invest. (2016)
6.Tissue acidosis induces neuronal necroptosis via ASIC1a channel independent of its ionic conduction . eLife. (2015)


Teams

Service Guide

Department of Core Facility of Basic Medical Sciences, Shanghai Jiao Tong University School of Medicine

postcode 299925

Old Red Mansion, 280 Chongqing South Road, Shanghai, China

021-63846590x776946