个人简介

尹胜菊，副研究员，硕士生导师。2013年获得北京大学医学博士学位，2018年至2021年在北京大学公共卫生学院和基础医学院从事博士后研究工作。主持国自然基金等5项，作为课题骨干参与国家十四五重点研发计划等。以通讯/第一作者在Journal of Hazardous Materials、Environmental International、Human Reproduction等期刊发表论文30余篇。

社会任职/学术头衔

中国毒理学会发育毒理与发育源性疾病防控专业委员会委员

中国环境诱变剂学会环境与发育源性疾病专委会委员

中国妇幼保健协会出生缺陷防治与分子遗传分会委员

上海市残疾人康复协会残疾预防专委会委员兼妇女与儿少健康学组副组长

主要研究方向

生命早期环境暴露与妇幼健康，聚焦以出生队列为基础的女性生殖健康及子代神经发育的环境致病风险因素及作用机制研究。

代表性科研项目

1. 国家自然科学基金青年项目，有机氯农药对叶酸/同型半胱氨酸代谢的干扰作用研究，2021.01-2023.12，主持。

2. 科技部重点研发计划项目课题，建立中国育龄期女性生殖内分泌激素临床适用标准，2024.01-2026.12，课题骨干。

3. 上海市科学技术委员会，科技创新行动计划面上项目，孕期多时点有机磷系阻燃剂混合暴露在子代神经行为发育中的作用机制及风险评估策略，2023.04-2026.03，主持。

4. 上海市卫生健康委员会，临床研究专项面上项目，孕期有机磷系阻燃剂暴露及甲状腺激素水平改变对子代神经发育的影响，2023.01-2025.12，主持。

5. 北京市自然科学基金委，青年基金，镉暴露致胎儿唇腭裂作用及DNA甲基化机制研究，2021.01-2022.12，主持。

近五年代表性研究成果（#共同第一作者，*通讯作者）

[1]. Wang, L.; Wang, Q.; Sun, J.; Huang, Y.; Zhang, Q.; Wei, L.; Yin, S.*; Lai, D*. Elevated plasma molybdenum level increases the risk of premature ovarian insufficiency through vascular endothelial injury. Hum Reprod 2025.

[2]. Wang, H.; Fu, D.; Liu, X.; Chang, X.; Guo, S.; Cheng, X.; Tian, Y.; Ran, J.; Zhang, J.*; Yin, S*. Prenatal exposure to a mixture of organophosphate ester and organophosphorus pesticides in relation to child neurodevelopment in the Shanghai Birth Cohort. Ecotoxicol Environ Saf 2025, 290, 117618.

[3]. Yuan, Y.; Dong, X.; Yin, S.*; Zhang, G.; Zhou, H.; Li, G.; Tang, Y.; Wei, X.; Zhang, H. Focal adhesions Kindlin-1 and Kindlin-2 affected by epigenetic modifying in hepatocarcinogenesis. Clin Transl Med 2024, 14, (1), e1517.

[4]. Wei, J.; Fu, D.; Guo, S.; Tian, T.; Huang, Y.; Li, Z.; Wang, L.; Jin, L.; Ye, W.; Ren, A.; Yin, S*. Elementomics of 32 elements in cord serum depicts the risk of orofacial clefts: A case-control study in Shanxi, China. Environ Pollut 2024, 362, 125037.

[5]. Qiu, W.; Yin, S.#; Abulaiti, K.; Li, X.; Lu, Y.; Zhang, Q.; Zhan, M.; Zhang, J. Preconception exposure to bisphenol A and its alternatives: Effects on female fecundity mediated by oxidative stress and ovarian reserve. Sci Total Environ 2024, 957, 177558.

[6]. Cheng, X.; Lu, Q.; Lin, N.; Mao, D.; Yin, S.*; Gao, Y.*; Tian, Y*. Prenatal exposure to a mixture of organophosphate flame retardants and infant neurodevelopment: A prospective cohort study in Shandong, China. Int J Hyg Environ Health 2024, 258, 114336.

[7]. Du, Z.; Yin, S.#; Liu, B.; Zhang, W.; Sun, J.; Fang, M.; Xu, Y.; Hua, K.; Tu, P.; Zhang, G.; Ma, Y.; Lu, Y. Metabolomics and network analysis uncovered profound inflammation-associated alterations in hepatitis B virus-related cirrhosis patients with early hepatocellular carcinoma. Heliyon 2023, 9, (5), e16083.

[8]. Yin, S.; Wei, J.; Wang, C.; Jin, L.; Wang, L.; Li, Z.; Zhang, Y.; Yin, C.; Ren, A. Alkali and alkaline earth elements in maternal serum and occurrence of orofacial clefts in offspring. Reprod Toxicol 2022, 110, 97-104.

[9]. Yin, S.; Tian, T.; Wang, C.; Wang, D.; Pi, X.; Liu, M.; Jin, L.; Liu, J.; Wang, L.; Li, Z.; Ren, A.; Yin, C. Prenatal uranium exposure and risk for fetal neural tube defects: A case-control study in women living in a rural area of northern China. J Hazard Mater 2022, 424, (Pt B), 127466.

[10]. Tian, T.; Yin, S.#; Chen, Y.; Wang, C.; Liu, M.; Jin, L.; Li, Z.; Liu, J.; Zhang, Y.; Wang, L.; Ren, A. Elevated concentrations of chromium in maternal serum, umbilical cord serum, and cord tissue are associated with an increased risk for orofacial clefts. Environ Res 2022, 214, (Pt 1), 113799.

[11]. Yin, S.; Sun, Y.; Yu, J.; Su, Z.; Tong, M.; Zhang, Y.; Liu, J.; Wang, L.; Li, Z.; Ren, A.; Jin, L. Prenatal exposure to organochlorine pesticides is associated with increased risk for neural tube defects. Sci Total Environ 2021, 770, 145284.

[12]. Tian, T.; Yin, S.#; Jin, L.; Liu, J.; Wang, C.; Wei, J.; Liu, M.; Li, Z.; Wang, L.; Yin, C.; Ren, A. Single and mixed effects of metallic elements in maternal serum during pregnancy on risk for fetal neural tube defects: A Bayesian kernel regression approach. Environ Pollut 2021, 285, 117203.

[13]. Yin, S.; Wei, J.; Wei, Y.; Jin, L.; Wang, L.; Zhang, X.; Jia, X.; Ren, A. Organochlorine pesticides exposure may disturb homocysteine metabolism in pregnant women. Sci Total Environ 2020, 708, 135146.

[14]. Yin, S.; Wang, C.; Wei, J.; Wang, D.; Jin, L.; Liu, J.; Wang, L.; Li, Z.; Ren, A.; Yin, C. Essential trace elements in placental tissue and risk for fetal neural tube defects. Environ Int 2020, 139, 105688.

[15]. Yin, S.; Wang, C.; Wei, J.; Jin, L.; Liu, J.; Wang, L.; Li, Z.; Yin, C.; Ren, A. Selected essential trace elements in maternal serum and risk for fetal orofacial clefts. Sci Total Environ 2020, 712, 136542.