王贤丽，副研究员
个人简介：2009年毕业于中国海洋大学细胞生物学专业，2009-2011在中国水产科学研究院从事博士后研究工作；2011-2015年在同济大学医学院从事师资博士后工作；2016-2019年在中国科学院神经科学研究所工作，并聘任副研究员；2019年进入上海交通大学医学院工作，聘为副研究员。多年来一直从事成体神经干细胞基因组稳定性对衰老的调控作用；以及发育过程中神经干细胞基因组稳定性对神经多样性的调控的研究。先后主持包括国家自然科学基金青年项目在内的9项省部级课题，共发表SCI收录论文20余篇，其中以第一作者发表12篇，参与编写论著一部，授权发明专利2项。
研究方向：
1. 干细胞应对营养应答参与肥胖、糖尿病等慢性疾病的调控作用；
2. 干细胞对毒理造成的DNA损伤应答的作用
3. 干细胞在肿瘤发生发展中的作用
课题及奖励：
国家自然科学基金青年项目（2016.01-2018.12）
第51批中国博士后科学基金面上二等资助 (2012.06-2013.09)
上海市博士后科研资助计划 (2012.09-2013.09)
上海市卫生系统优秀青年人才培养计划（2014.01-2016.12）
同济大学优秀人才培养计划（2011.12-2013.09）
第48批中国博士后科学基金面上二等资助（2010.03-2011.08）
山东省博士后创新项目专项资金一等资助（2011.03-2013.03）
山东省优秀中青年科学家科研奖励基金（2011.02-2013.12）
代表性成果（#共同第一作者）：
1. XL Wang, CX Sun, L Zhu, LX Sun, RJ Ma, ZG Wang, B Lu, X Chen, J Xu. Quantitative proteomic analysis revealed changes in protein synthesis and mitochondrial functions after acute DNA damage in mouse neural stem cells. Neuro Lett,653:355- 361,2017.
2. XL Wang, CM Dong, lX sun, L Zhu, CX Sun, RJ Ma, k Ning, JF Zhang, B Lu, J Xu. Quantitative proteomic analysis of age-related subventricular zone proteins associated with neurodegenerative disease. Sci Rep,2016,6,37443;doi:10.1038/srep 37443.
3. CM Dong #, XL Wang #, GM Wang, WJ Zhang, L Zhu, S Gao, DJ Yang, Y Qin, QJ Liang, YL Chen, HT Deng, K Ning, AB Liang, ZL Gao, J Xu. A stress induced cellular aging model with postnatal neural stem cells. Cell Death Dis,2014 Mar 13;5:e1116.doi: 10.1038/cddis.2014.82.
4. DJ Yang #, XL Wang #, A Ismail, CJ Ashman, CF Valori, GM Wang, SE Gao, A Higginbottom, PG Ince, M Azzouz, J Xu, PJ Shaw, K Ning. PTEN regulates AMPA receptor-mediated cell viability in iPS-derived motor neurons. Cell Death Dis,2014 Feb 27;5:e1096. doi:10.1038/cddis.2014.55.
5. N Wang #, XL Wang #, CG Yang, XJ Zhao, YX Zhang, TZ Wang, SL Chen. Molecular cloning and multifunctional characterization of GRIM-19 homologue from turbot. Dev Comp Immunol,43(1):96-105,2014.
6. CG Yang #, XL Wang #, J Tian, W Liu, F Wu, M Jiang, H Wen. Evaluation of reference genes for quantitative real-time RT-PCR analysis of gene expression in Nile tilapia . Gene,527:183-192,2013.
7. N Wang #, XL Wang #, CG Yang, SL Chen. Molecular cloning, subcelluar location and expression profile of signal transducer and activator of transcription 2 (STAT2) from turbot. Fish Shellfish Immun,35:1200-1208,2013.
8. XL Wang, YX Zhang, CG Yang, SL Chen. Cloning, characterization and expression analysis of Y-Box family members YB-1 in turbot. Fish Shellfish Immun,33(5):1215- 1221, 2012.
9. B Zhang #, XL Wang #, SL Chen. Establishment and characterization of a testicular cell line from half smooth tongue sole. Int J Bio Sci,7(4):452 -459,2011.
10. XL Wang, N Wang, ZX Sha, SL Chen. Establishment, characterization of a new cell line from heart of half smooth tongue sole. Fish Physiol Biochem, 36: 1181-1189,2010.
11. N Wang #, XL Wang #, ZX Sha, YS Tian, SL Chen. Development and characterization of a new marine fish cell line from turbot. Fish Physiol Biochem,36(4):1227-1234,2010.
12. XL Wang, N Wang, ZX Sha, SL Chen. Establishment, characterization, and virus susceptibility of a new marine cell line from spotted halibut. J Ocean U China,9(2):162-168,2010.
13. ZX Sha #, GC Ren #, XL Wang #, N Wang, SL Chen. Development and characterization of a cell line from the embryos of half smooth tongue sole. Acta Oceanol Sin,29(2):81-87,2010.
14. SE Gao, P Zhao, C Lin, YX Sun, YL Wang, ZC Zhou, DJ Yang, XL Wang, HZ Xu, F Zhou, LM Cao, W Zhou, K Ning, X Chen, J Xu. Differentiation of human adipose-derived stem cells into neuron-like cells which are compatible with photocurable three- dimensional scaffolds. Tissue Eng:Part A,2014,DOI: 10.1089/ten.tea.2012.0773.
15. YP Jin, JY Wang, HC Li, SE Gao, RF Shi, DJ Yang, XL Wang, L Zhu, XJ Wang, CW Chen, K Ning, QC Fu, J Xu, ZL Gao. Extracellular vesicles secreted by human adipose-derived stem cells hASCs improve survival rate of rats with acute liver failure by releasing lncRNA H19. EBioMedicine,34:231-242,2018.
16. CG Yang, XL Wang, L Wang, B Zhang, SL Chen. A new Akirin1 gene in turbot: Molecular cloning, characterization and expression analysis in response to bacterial and viral immunological challenge. Fish Shellfish Immun,30: 1031-1041,2011.
17. CG Yang, SS Liu, Bing Sun, XL Wang, N Wang, SL Chen. Iron-metabolic function and potential antibacterial role of Hepcidin and its correlated genes (Ferroportin 1 and Transferrin Receptor) in turbot. Fish Shellfish Immun,34:744-755,2013.
18. N Wang, CG Yang, ZZ Sun, XL Wang, SL Chen. Signal transducer and activator of transcription 3 (STAT3) homologue in turbot: molecular characterization and expression analysis. Fish Shellfish Immun,30(1):255-262,2011.
