研究方向：
1. 干细胞参与肥胖、糖尿病等的调控作用；
2. 表观遗传调控干细胞再生的作用；
3. 干细胞在肿瘤发生发展中的作用；
4. 营养元素对衰老的干预。
课题及奖励：
1. 校企合作横向项目（2025-2029）
2. 国家自然科学基金面上项目（2022-2026）
3. 国家自然科学基金青年项目（2016-2018）
4. 第51批中国博士后科学基金面上二等资助（2012-2013）
5. 上海市博士后科研资助计划（2012-2013）
6. 上海市卫生系统优秀青年人才培养计划（2014-2016）
7. 同济大学优秀人才培养计划（2011-2013）
8. 第48批中国博士后科学基金面上二等资助（2010-2011）
9. 山东省博士后创新项目专项资金一等资助（2011-2013）
10. 山东省优秀中青年科学家科研奖励基金（2011-2013）
代表性成果：
1. XL Wang, WC Zhang, SZ Yang, CD Zheng, ZN Wang, GT Yang, CX Huang, HY Yao, KN Huang, YY Yan, SL Jiang, JG Sun, QG Xie, YJ Zhang, XG Li, H Wang. Transcriptomic comparison of human intestinal organoids and Caco-2 cells in modeling nutrient absorption: insights from infant formula and breast milk. npj Science of Food,2026,DOI: 10.1038 /s4153 8-025-00672-9.
2. XL Wang, WC Zhang, CD Zheng, CX Huang, HY Yao, ZN Wang, KN Huang, YY Yan, SL Jiang, JG Sun, QG Xie, YJ Zhang，XG Li, H Wang. Multistage metabolomic analyses reveal the differential effects of infant iormula and breast milk on the growth and development of human small intestinal organoids. Mol Nutr Food Res,2025,DOI: 10.1002/mnfr.70068.
3. SY Ge, YT Xiang, XY Hua, ZN Wang, QF Hu, YJ Guo, JQ Huang, CP Zhao, JJ Wu, XLWang*, CY Sun*. The characteristics of brain function alterations in patients with chronic prostatitis/chronic pelvic pain syndrome across varying symptom severities evaluated by NIH-CPSI. Front Neurosci,2025Feb26:19:1511654.doi:10.3389/fnins.2025.1511654. eCol le ction 2025.
4. XL Wang, YX Jing, CD Zheng, CX Huang, HY Yao, ZN Wang, KN Huang, YY Yan, SL Jiang, JG Sun, QG Xie, YJ Zhang, XG Li, H Wang. Using transcriptomics to investigate the effects of infant formulae on the growth and development of small intestinal organoids and Caco2 cells. Journal of Functional Foods, 2025, 131:106951.
5. WC Zhang, CX Huang, HY Yao, SZ Yang, Z Jiapaer, J Song, XL Wang. Retrotransposon: an insight into neurological disorders from perspectives of neurodevelopment and aging. Transl Neurodegener, 2025, DOI: 10.1186/s40035-025-00471-y.
6. XL Wang, SSZh Yang, CD Zheng, CX Huang, HY Yao, ZM Guo, YL Wu, Zn Wang, ZY Wu, RH Ge, W Cheng, YY Yan, SR Jiang, JG Sun, JQ Li, QG Xie, XG Li, H Wang. Multi-omics profiles of small intestine organoids in reaction to breast milk and different infant formula preparations. Nutrients,2024, 16, 2951.
7. XL Wang, YM Zhong, CD Zheng, CX Huang, HY Yao, ZM Guo, YL Wu, ZN Wang, ZY Wu, RH Ge, W Cheng, YY Yan, SR Jiang, JG Sun, JQ Li, QG Xie, XG Li, H Wang. Transcriptome and metabolome analyses reveal the effects of formula and breast milk on the growth and development of human small intestinal organoids. Food Res int,2024 Aug23. doi:org/10.1016/j.foodres.2024.114999.
8. XL Wang, YX Jing, CD Zheng, CX Huang, HY Yao, ZM Guo, YL Wu, Zn Wang, ZY Wu, RH Ge, W Cheng, YY Yan, SR Jiang, JG Sun, JQ Li, QG Xie, XG Li, H Wang. Using integrated transcriptomics and metabolomics to explore the effects of infant formula on the growth and development of small intestinal organoids. Food Funct, Food Funct., 2024, 15, 9191–9209. doi: 10.1039 /d4fo01723d.
9. HX Cheng, LY Hua, HL Tang, ZY Bao, XP Xu, HG Zhu, SY Wang, ZD Jiapaer, R Bhatia , Ian F. Dunn, JJ Deng, DJ Wang, XL Wang*, Y Gong*. CBX7 reprograms metabolic flux to protect against meningioma progression by modulating the USP44 /c-MY C/LDHA axis. J Mol Cell Biol,2023 Oct 3:mjad057. doi: 10.1093/jmcb/mjad057.
10. J Ren#, XL Wang#, CM Dong#, GM Wang#, WJ Zhang, CH Cai, MQ Qian, DJ Yang, B Ling, K Ning, ZY Mao, BH Liu, TH Wang, LL Xiong, WY Wang, AB Liang, ZL Gao, J Xu. Sirt1 protects subventricular zone-derived neural stem cells from DNA double-strand breaks and contributes to olfactory function maintenance in aging mice. Stem Cells,2022, doi: 10.1093/stmcls/sxac008.
11. CM Dong#, XL Wang#, GM Wang#, LX Sun#, L Zhu, DJ Yang, S Gao, WJ hang, B Ling, AB Liang, ZL Gao, J Xu. ATM modulates subventricular zone neural stem cell maintenance and senescence through Notch signaling pathway. Stem Cell Res,58 (2022)102618, https://doi.org /10. 1016/j.scr.2021.102618.
12. YP Jin, JY Wang, HC Li, SE Gao, RF Shi, DJ Yang, XL Wang, L Zhu, XJ Wang, CW Chen, K Ning, QC Fu, J Xu, ZL Gao. Extracellular vesicles secreted by human adipose-derived stem cells hASCs improve survival rate of rats with acute liver failure by releasing lncRNA H19. EBioMedicine,34:231-242,2018.
13. XL Wang, CX Sun, L Zhu, LX Sun, RJ Ma, ZG Wang, B Lu, X Chen, J Xu. Quantitative proteomic analysis revealed changes in protein synthesis and mitochondrial functions after acute DNA damage in mouse neural stem cells. Neuro Lett,2017, 653: 355-361.
14. XL Wang, CM Dong, lX sun, L Zhu, CX Sun, RJ Ma, k Ning, JF Zhang, B Lu, J Xu. Quantitative proteomic analysis of age-related subventricular zone proteins associated with neurodegenerative disease. Sci Rep,2016,6,37443;doi:10.1038/ srep37443.
15. SE Gao, P Zhao, C Lin, YX Sun, YL Wang, ZC Zhou, DJ Yang, XL Wang, HZ Xu, F Zhou, LM Cao, W Zhou, K Ning, X Chen, J Xu. Differentiation of human adipose-derived stem cells into neuron-like cells which are compatible with photocurable three- dimensional scaffolds. Tissue Eng:Part A,2014,DOI: 10.1089/ten.tea.2012.0773.
16. CM Dong#, XL Wang#, GM Wang, WJ Zhang, L Zhu, S Gao, DJ Yang, Y Qin, QJ Liang, YL Chen, HT Deng, K Ning, AB Liang, ZL Gao, J Xu. A stress induced cellular aging model with postnatal neural stem cells. Cell Death Dis,2014 Mar13;5: e1116. doi: 10.1038/cddis. 2014.82.12.
17. DJ Yang#, XL Wang#, A Ismail, CJ Ashman, CF Valori, GM Wang, SE Gao, A Higginbottom, PG Ince, M Azzouz, J Xu, PJ Shaw, K Ning. PTEN regulates AMPA receptor- mediated cell viability in iPS-derived motor neurons. Cell Death Dis,2014 Feb 27;5:e1096. doi:10.1038/cddis.2014.55.
