食品安全与毒理学系

李莎/ 职称:助理研究员

学历学位:博士 研究生

Email: lishaha@shsmu.edu.cn



个人简介

2018年博士毕业于香港大学,后继续在香港大学开展博士后研究工作,于2021年1月加入上海交通大学公共卫生学院。主要研究领域包括药食两用植物对肿瘤、肥胖、糖尿病、酒精性与非酒精性脂肪肝等代谢性疾病的干预作用及机制探讨,特别是免疫及肠道菌群在代谢性疾病的调控。以第一作者(含共一)或共同通讯作者在 Clinical and Translational Medicine,  Comprehensive Reviews in Food Science and Food Safety, Frontiers in Immunology,  Oxidative Medicine and Cellular Longevity, Food & Function 等学术期刊发表SCI论文19篇,其中2篇入选ESI前1%高被引论文。论文总引用次数超过3200,个人H指数31。


承担教学工作介绍

《营养与食品卫生学》等营养与食品安全相关课程

主要研究方向

1. 酒精性脂肪肝及非酒精性脂肪肝、肥胖、糖尿病等代谢性疾病的炎症、免疫调节病理生理机制研究;

2. 天然产物、中草药、药食两用植物等对代谢性疾病的改善及作用机理研究;

3. 膳食模式与代谢性疾病的防治



主要研究成果

1. Li Sha, Wang Ning, Tan Hor-Yue, Chueng Fan, Zhang Zhang-jin, Yuen Man-Fung, Feng Yibin*. Modulation of Gut Microbiota Mediates Berberine-Induced Expansion of Immuno-suppressive Cells to Against Alcoholic Liver Disease. Clinical And Translational Medicine, 2020:08-13.

2. Li Sha, So Tsz-him, Tang Guoyi, Tan Hor-Yue, Wang Ning, Ng Bacon Fung Leung, Chan Chris Kam Wa, Yu Edwin Chau-Leung*, Feng Yibin*. Chinese Herbal Medicine for Reducing Chemotherapy-Associated Side-Effects in Breast Cancer Patients: A Systematic Review and Meta-Analysis. Frontiers in Oncology, 2020. Volume: 10, Article Number: 599073.

3. Li Sha, Cheng Chien-Shan, Zhang Cheng, Tang Guo-Yi, Tan Hor-Yue, Chen Hai-Yong, Wang Ning, Lai Agnes Yuen-Kwan, Feng Yibin. Edible and Herbal Plants for the Prevention and Management of COVID-19. Frontiers in Pharmacology, 2021. Volume: 12, Article Number: 656103.

4.Li Sha, Wang Ning, Tan Hor-Yue, Hong Ming, Yuen Man-Fung, Li Huabin, Feng Yibin*. Expansion of Granulocytic, Myeloid-Derived Suppressor Cells in Response to Ethanol-Induced Acute Liver Damage. Frontiers in Immunology, 2018. Volume 9, Article Number: 1524.

5. Meng Xiao, Li Ya, Li Sha*, Gan Ren-You, Li Hua-Bin*. Natural Products for Prevention and Treatment of Chemical-Induced Liver Injuries. Comprehensive Reviews in Food Science and Food Safety, 2018. Volume: 17, Issue: 2, Pages: 472-495.

6.Li Sha, Tan Hor-Yue, Wang Ning, Feng Yigang, Wang Xuanbin, Feng Yibin*. Recent Insights into the Role of Immune Cells in Alcoholic Liver Disease. Frontiers in Immunology, 2019. Volume: 10, Article Number: 1328.

7. Wang Ning, Tan Hor-Yue, Li Sha, Wang Di, Xu Yu, Zhang Cheng, Xia Wen, Che Chi Ming, Feng Yibin*. Sbp2 Deficiency in Adipose Tissue Macrophages Drives Insulin Resistance in Obesity. Science Advances, 2019. Volume: 5, Issue: 8, Article Number: eaav019

8. Li Sha, Tan Hor Yue, Wang Ning, Cheung Fan, Hong Ming, Feng Yibin*. The Potential and Action Mechanism of Polyphenols in the Treatment of Liver Diseases. Oxidative Medicine and Cellular Longevity, 2018. Volume: 2018, Article Number: 8394818.

9. Lu Yuanjun, Chan Yau-Tuen, Tan Hor-Yue, Li Sha, Wang Ning, Feng Yibin*. Epigenetic Regulation in Human Cancer: The Potential Role of Epi-Drug in Cancer Therapy. Molecular Cancer, 2020. Volume: 19, Issue: 1, Article Number: 79.

10.Li Sha, Hong Ming, Tan Hor-Yue, Wang Ning, Feng Yibin*. Insights into the Role and Interdependence of Oxidative Stress and Inflammation in Liver Diseases. Oxidative Medicine and Cellular Longevity, 2016. Volume: 2016, Article Number: 4234061.

11. Li Sha, Tan Hor-Yue, Wang Ning, Zhang Zhang-Jin, Lao Lixing, Wong Chi-Woon, Feng Yibin*. The Role of Oxidative Stress and Antioxidants in Liver Diseases. International Journal of Molecular Sciences, 2015. Volume: 16, Issue: 11, Pages: 26087-26124.

12. Li Sha, Gan Li-Qin, Li Shu-Ke, Zheng Jie-Cong, Xu Dong-Ping, Li Hua-Bin*. Effects of Herbal Infusions, Tea and Carbonated Beverages on Alcohol Dehydrogenase and Aldehyde Dehydrogenase Activity. Food & Function, 2014. Volume: 5, Issue: 1, Pages: 42-49.

13. Li Sha, Li Shu-Ke, Gan Ren-You, Song Feng-Lin, Kuang Lei, Li Hua-Bin*. Antioxidant Capacities and Total Phenolic Contents of Infusions from 223 Medicinal Plants. Industrial Crops and Products, Volume: 51, Pages: 289-298.

14. Li Sha, Wang Ning, Hong Ming, Tan Hor-Yue, Pan Guofeng, Feng Yibin*. Hepatoprotective Effects of a Functional Formula of Three Chinese Medicinal Herbs: Experimental Evidence and Network Pharmacology-Based Identification of Mechanism of Action and Potential Bioactive Components. Molecules, 2018. Volume: 23, Issue: 2, Article Number: 352.

15. Li Sha, Xu Yu, Guo Wei, Chen Feiyu, Zhang Cheng, Tan Hor-Yue, Wang Ning, Feng Yibin*. The Impacts of Herbal Medicines and Natural Products on Regulating the Hepatic Lipid Metabolism. Frontiers in Pharmacology, 2020 Volume: 11, Article Number: 351.


获得荣誉称号

入选2020年度“上海市海外高层次人才计划-千人计划”。