个人简介：
上海交通大学公共卫生学院副研究员，硕士生导师，入选上海市浦江人才计划。2017年毕业于复旦大学并获得生物信息学博士学位，曾在硕博连读期间联合培养于美国德克萨斯大学生物统计系；2017年进入上海交通大学医学院公共卫生学院工作；2019-2020年于乔治亚大学生物信息中心开展访问研究工作。
主要从事营养基因组学、遗传流行病学、基因组学及人工智能赋能精准健康研究。围绕“基因-环境-营养互作与复杂疾病发生机制”这一核心科学问题，综合运用大规模人群队列、多组学整合分析、因果推断及人工智能方法，系统研究营养因素、遗传变异与代谢性疾病、神经退行性疾病等复杂疾病的关联机制及健康效应。近年来，在Environmental Science & Technology、Genomics, Proteomics & Bioinformatic、Brain, Behavior, and Immunity等国际一流杂志以第一/通讯(含共同)作者发表论文20余篇，授权发明专利2项，软件著作权2项。担任Genomics, Proteomics & Bioinformatic、 Briefing in Bioinformatics等多家SCI杂志审稿人。主持及参与国家自然科学基金、国家重点研发计划、上海市科委、上海市教委等10余项科研项目，致力于推动人工智能、多组学技术与精准健康研究的交叉融合。
研究领域：
1.营养基因组学与精准营养
研究膳食、营养素与遗传背景的互作机制，解析营养因素对健康衰老及慢性疾病的影响规律，发展个体化营养评估与精准干预策略。
2.遗传流行病学与多组学系统生物学
整合遗传学、大规模人群队列及多组学数据，解析复杂疾病的病因机制与生物标志物。
3.人工智能驱动的精准医学与数字健康
开发人工智能和生物医学大数据分析方法，构建疾病风险预测、精准营养评估和健康管理模型。
教学工作：
主要承担本科及研究生授课任务，包括《医学信息学》《R语言医学数据分析》《营养大数据》《营养与食品卫生》《转化毒理学》等
近年主要研究成果：
Shi, S., Y. Dong, Z. Hu, et al. Zhou, J. Phenome- and Genome-Wide Insights Into Dietary Patterns: Health Consequences and Genetic Basis. eFood 7: e70159. https://doi.org/10.1002/efd2.70159.
Zhou, J.; Jiang, S.; Liu, D.; Li, X.; Zhou, Z.; Wang, Z.; Wang, H. Bidirectional Mendelian Randomization Analysis of Genetic Proxies of Plasma Fatty Acids and Pre-Eclampsia Risk. Nutrients 2024, 16, 3748. https://doi.org/10.3390/nu16213748
Fu Y, Wang Y, Chai ZT, Zhang C, Fang Y, Zhou J, Gu X, Zhang Z. Characterization of Cancer Hallmark Enhancer RNA Uncovers Novel Strategies for Precision Oncology. Genomics Proteomics Bioinformatics. 2026 15:qzag037.
Chen Y, Xu X, Pan Y, Wang S, Zhao W, Zhou B, Zhou J, Zheng Y, Zhou Z, Gu X. DIVERGE v4: A Platform for Large-Scale Analysis of Functional Divergence Across Multi-Gene Families. Mol Biol Evol. 2025 Oct 29;42(11)
Zhou J, Liu A, He F, Zhang Y, Shen L, Yu J, Zhang X. Draft Genome of White-blotched River Stingray Provides Novel Clues for Niche Adaptation and Skeleton Formation. Genomics Proteomics Bioinformatics. 2023 Jun;21(3):501-514.
Ba Q, Zhou J#, Li J, Cheng S, Zhang X, Wang H. Mutagenic Characteristics of Six Heavy Metals in Escherichia coli: The Commonality and Specificity. Environ Sci Technol. 2022 Oct 4;56(19):13867-13877. doi: 10.1021/acs.est.2c04785.
Shen Y, Zhou J, Nie K, et al. Oncogenic role of the SOX9-DHCR24-cholesterol biosynthesis axis in IGH-BCL2 + diffuse large B-cell lymphomas. Blood. 2022. Jan,139(1), 73-86
Zhang H, Shang R, Kim K, Zheng W, Johnson CJ, Sun L, Niu X, et al. Zhou J, Liu L, Eggenschwiler JT, Menke DB, Bronner ME, Grishin NV, Li W, Ye K, Zhang Y, Stolfi A, Bi P. Evolution of a chordate-specific mechanism for myoblast fusion. Sci Adv. 2022 Sep 2;8(35):eadd2696.
Zhou J, Liu C, Sun Y, Francis M, Ryu MS, Grider A, Ye K. Genetically predicted circulating levels of copper and zinc are associated with osteoarthritis but not with rheumatoid arthritis. Osteoarthritis Cartilage. 2021 Jul;29(7):1029-1035.
Zhou J, Sun Y, Huang W, Ye K. 2021, Altered blood cell traits underlie a major genetic locus of severe COVID-19. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES，76(8) E147-E154 glab035, https://doi.org/10.1093/gerona/glab035
Wang, Z., Zhou, J., Marshall, B., Rekaya, R., Ye, K. and Liu, H.X., 2020. SARS-CoV-2 receptor ACE2 is enriched in a subpopulation of mouse tongue epithelial cells in nongustatory papillae but not in taste buds or embryonic oral epithelium. ACS pharmacology & translational science, 3(4), pp.749-758.c
Zhou, J., Liu, C., Sun, Y., Huang, W. and Ye, K., 2021. Cognitive disorders associated with hospitalization of COVID-19: Results from an observational cohort study. Brain, Behavior, and Immunity. 91,383-392 doi: 10.1016/j.bbi.2020.10.019
Zhou J, Liu C, Francis M, Sun Y, Ryu MS, Grider A, Ye K. The Causal Effects of Blood Iron and Copper on Lipid Metabolism Diseases: Evidence from Phenome-Wide Mendelian Randomization Study. Nutrients. 2020 Oct 17;12(10):3174.
Li L, Liu D, Liu A, Li J, Wang H, Zhou J*. Genomic Survey of Tyrosine Kinases Repertoire in Electrophorus electricus With an Emphasis on Evolutionary Conservation and Diversification. Evol Bioinform. 2020 May 25;16:1176934320922519.
Liu A, He F, Shen L, Liu R, Wang Z, Zhou J. Convergent degeneration of olfactory receptor gene repertoires in marine mammals. BMC Genomics, 2019, 20(1), 977.
Zhou J, Liu D, Sa Z, Huang W, Zou Y, Gu X*. Effective estimation of the minimum number of amino acid residues required for functional divergence between duplicate genes. Molecular Phylogenetics and Evolution. 2017,113:126-138.
Sa Z#, Zhou J#, Zou Y, Su Z, Gu X*, Paralog-divergent Features May Help Reduce Off-target Effects of Drugs: Hints from Glucagon Subfamily Analysis, Genomics, Proteomics & Bioinformatics, 2017,15(4):246-254
