食品安全与毒理学系

周婧琪/ 职称:助理研究员

学历学位:博士 研究生

Email: jingqizhou@sjtu.edu.cn

个人简介:

2017年毕业于复旦大学并获得生物信息学博士学位曾在硕博连读期间联合培养于美国德克萨斯大学生物统计系2017年进入上海交通大学医学院公共卫生学院工作;2019-2020年于乔治亚大学生物信息中心开展访问研究工作。主要从事精准医学与公共健康相关研究。基于人类遗传学、基因组学及临床表型数据,深入研究复杂疾病发生发展过程中的遗传因素与环境因素的交互作用,构建广泛应用的健康指数标准体系并建立健康标准数据库,系统性地探讨和发展用于复杂疾病预防的新技术和新方法。以第一承担人获得国家自然科学基金一项,校级课题两项,参与国家级和省部级多项课题研究。研究成果发表在Molecular Biology and Evolution, Genomics Proteomics and Bioinformatics, Brain Behaviour and Immunity等国际一流杂志,累积发表SCI论文20余篇。学术兼职为国际MAQC学会(组学大数据质量控制学会)会员、美国人类遗传学会会员(ASHG)、分子生物与进化学协会(SMBE)和中国生物工程学会暨全国计算生物学和生物信息学学会会员。担任Briefing in Bioinformatics、Genome Biology and Evolution、Current Drug Metabolism等多家SCI杂志审稿人。


研究方向:

基因组学与精准公共卫生:利用基因组学和其他大数据和人工智能来预测疾病风险和与结果,用于改善群体健康;

基于多组学数据整合的复杂疾病靶标预测研究;


主要科研项目:

国家自然科学基金青年项目,31801049,课题负责人

上海交通大学医工交叉基金,YG2017QN69,课题负责人

上海交通大学青年师资科研能力海外培训项目,KJ3-0221-18-4403,课题负责人

上海交通大学新进青年教师启动计划,课题负责人


近五年代表性成果:

Zhou, J., Liu, C., Sun, Y., Huang, W. and Ye, K., 2020. Cognitive disorders associated with hospitalization of COVID-19: Results from an observational cohort study. Brain, Behavior, and Immunity. Jan; 91:383-392.

Zhou J, Sun Y, Huang W, Ye K. 2021, Altered blood cell traits underlie a major genetic locus of severe COVID-19. The Journals of Gerontology: Series A, glab035

Zhou, J., Liu, C., Francis, M., Sun, Y., Ryu, M.S., Grider, A. and Ye, K., 2020. The Causal Effects of Blood Iron and Copper on Lipid Metabolism Diseases: Evidence from Phenome-Wide Mendelian Randomization Study. Nutrients, 12(10), p.3174.

Zhou, J., Liu, C., Sun, Y., Francis, M., Ryu, M.S., Grider, A. and Ye, K., Genetically predicted circulating levels of copper and zinc are associated with osteoarthritis but not with rheumatoid arthritis. Osteoarthritis and Cartilage. 2021 Feb 25;S1063-4584(21)00620-8.

Sun Y, Zhou J, Ye K. White Blood Cells and Severe COVID-19: A Mendelian Randomization Study. J Pers Med. 2021 Mar 12;11(3):195.

Zhou J, Liu C, Francis M, Sun Y, Ryu M, Grider A, Ye K. Shared and Unique Clinical Effects of Five Circulating Minerals: A Comparative Phenome-Wide Mendelian Randomization Study. Current Developments in Nutrition, 01 Jun 2021, 5(Suppl2):1112-1112

Francis M, Li C, Sun Y, Zhou J, Li X, Brenna JT, Ye K. Genome-wide association study of fish oil supplementation on lipid traits in 81,246 individuals reveals new gene-diet interaction loci. PLoS Genet. 2021 Mar 24;17(3):e1009431.

Wang, Z., Zhou, J., Marshall, B., Rekaya, R., Ye, K. and Liu, H.X., 2020. SARS-CoV-2 receptor ACE2 is enriched in a subpopulation of mouse tongue epithelial cells in nongustatory papillae but not in taste buds or embryonic oral epithelium. ACS pharmacology & translational science, 3(4), pp.749-758.

Li L, Liu D, Liu A, Li J, Wang H*, Zhou J*. 2020, Genomic survey of tyrosine kinases repertoire in Electrophorus electricus with an emphasis on evolutionary conservation and diversification. Evolutionary Bioinformatics. DOI: 10.1177/1176934320922519

Liu A, He F, Shen L, Liu R, Wang Z, Zhou J*. Convergent degeneration of olfactory receptor gene repertoires in marine mammals. BMC Genomics, 2019, 20(1), 977.

Zhang Y, Song J, Shi Q, Song X, Shen L, Zhou J*, Shao J*. The prognostic signature of the somatic mutations in Ewing sarcoma: from a network view. Japanese Journal of Clinical Oncology. 2019, 49(7):604-13.

Zhou J, Liu D, Sa Z, Huang W, Zou Y*, Gu X*. Effective estimation of the minimum number of amino acid residues required for functional divergence between duplicate genes. Molecular Phylogenetics and Evolution. 2017,113:126-138.

Sa Z#, Zhou J#, Zou Y, Su Z, Gu X*, Paralog-divergent Features May Help Reduce Off-target Effects of Drugs: Hints from Glucagon Subfamily Analysis, Genomics, Proteomics & Bioinformatics, 2017,15(4):246-254

Zhou Z, Zou Y, Zhou J, Zhao S, Su Z, Gu X*. Mutation-profile-based methods for understanding selection forces in cancer somatic mutations: a comparative analysis. Oncotarget, 2017,8(35):58835-58846