食品安全与毒理学系

冯艳/ 职称：副教授

学历学位：博士 研究生

Email: fy_575@sjtu.edu.cn

 

 

个人简介

 

受教育经历

1999.9-2004.7 四川大学华西医学中心病理生理学专业 硕-博士研究生

1990.9-1995.7 北京大学医学部预防医学专业 医学学士

研究工作经历

2006.7-至今   上海交通大学医学院     讲师/副教授

2009.5-2011.4 美国德州大学泰勒医学研究中心/呼吸道感染性疾病防治中心 博士后

2004.9-2006.7 上海交通大学医学院上海市免疫学研究所 博士后

1999.9-2004.7 四川大学华西基础医学院病理学与病理生理学 硕/博士研究生

1995.7-1999.8 广西北海市疾病预防控制中心流行病科 卫生医师

 

主要研究方向                                                   

环境污染物暴露健康危害及其机制研究

 

主要研究课题（近五年15项之内）                                       

1．“基于人胚胎干细胞的环境内分泌干扰物低剂量暴露胚胎毒性评价模型的研究”

2. “PM2.5及其组分的神经发育毒性及机制研究”

3. “十溴联苯醚(BDE-209)长期暴露的免疫毒性效应及其机制研究”

4. “环境内分泌干扰物暴露及环境基因交互作用与女性生殖功能的关联”

5. “结核分枝杆菌分泌蛋白HtdY诱导树突状细胞成熟的信号通路及Th1/Th2极化研究”

6. “CD200R对肺泡巨噬细胞凋亡的影响及其在流感病毒感染早期的作用研究”

7. “TIPE2-Rac信号通路在感染免疫中的作用与机理研究”

 

主要研究成果(论文论著等,近五年，限20篇之内)                       

  1. Wei H, Feng Y, Liang F, Cheng W, Wu X, Zhou R, Wang Y. Role of oxidative stress and DNA hydroxymethylation in the neurotoxicity of fine particulate matter. Toxicology, 2017.01.30, 380：94~103

  2. Wei, Hongying, Liang, Fan, Meng, Ge, Nie, Zhiqing, Zhou, Ren, Cheng, Wei, Wu, Xiaomeng, Feng, Yan*, Wang, Yan*. Redox/methylation mediated abnormal DNA methylation as regulators of ambient fine particulate matter-induced neurodevelopment related impairment in human neuronal cells. Sci Rep, 2016.9.14, 6: 33402~33402

  3. Feng, Yan#, Zeng, Weihong#, Wang, Ying Shen, Hao, Wang, Yan. Long-term exposure to high levels of decabrominated diphenyl ether inhibits CD4 T-cell functions in C57BL/6 mice. J Appl Toxicol, 2016.9.01, 36(9): 1112~1119

  4. Cheng, Wei, Zhou, Ren, Liang, Fan, Wei, Hongying, Feng, Yan, Wang, Yan. Application of Mouse Embryonic Stem Cell Test to Detect Gender-Specific Effect of Chemicals: A Supplementary Tool for Embryotoxicity Prediction. Chem Res Toxicol, 2016.9.19, 29(9): 1519~1533

  5. Cheng, Wei, Zhou, Ren, Feng, Yan*, Wang, Yan*. Mainstream smoke and sidestream smoke affect the cardiac differentiation of mouse embryonic stem cells discriminately. Toxicology. 2016.5.16, 357-358:1~10

  6. Meng, Ge, Nie, Zhiqing, Feng, Yan, Wu, Xiaomeng, Yin, Yong, Wang, Yan. Typical halogenated persistent organic pollutants in indoor dust and the associations with childhood asthma in Shanghai, China.，Environ Pollut，2016.4.01，211：389~398

  7. Meng, Ge, Feng, Yan, Nie, Zhiqing, Wu, Xiaomeng, Wei, Hongying, Wu, Shaowei, Yin, Yong, Wang, Yan. Internal exposure levels of typical POPs and their associations with childhood asthma in Shanghai, China. Environ Res, 2016.4.01，146: 125~135

  8. Feng, Yan#, Hu, Qingliang#, Meng, Ge, Wu, Xiaomeng，Zeng, Weihong, Zhang, Xing, Yu, Yingxin, Wang, Yan. Simulating long-term occupational exposure to decabrominated diphenyl ether using C57BL/6 mice: Biodistribution and pathology. Chemosphere, 2015.2.13，128C: 118~124

  9. Zeng W, Wang Y, Liu Z, Khanniche A, Hu Q, Yan Feng, Ye W, Yang J, Wang S, Zhou L, Shen H, Wang Y. Long-term exposure to decabrominated diphenyl ether impairs CD8 T-cell function in adult mice，Cell Mol Immunol, 2014.7.1, 11(4): 367~376

  10. Guo, Jianfei#, Feng, Yan#, Barnes, Peter, Huang, Fang-Fang, Idell, Steven，Su, Dong-Ming, Shams, Homayoun. Deletion of FoxN1 in the thymic medullary epithelium reduces peripheral T cell responses to infection and mimics changes of aging. PLos One, 2012.01.01, 7(4): e34681~e34681

  11. Feng, Yan#, Kong, Ying#, Barnes, Peter F, Huang, Fang-Fang, Klucar, Peter, Wang, Xisheng, Samten, Buka, Sengupta, Mayami, Machona, Bruce, Donis, Ruben Tvinnereim, Amy R, Shams, Homayoun. Exposure to cigarette smoke inhibits the pulmonary T-cell response to influenza virus and Mycobacterium tuberculosis. Infection and Immunity, 2011.1.01, 79(1): 229~237

  12. Huang, Fang-Fang, Barnes, Peter F, Feng, Yan, Donis, Ruben, Chroneos, Zissis C, Idell, Steven, Allen, Timothy, Perez, Daniel R, Whitsett, Jeffrey A, Dunussi-Joannopoulos, Kyri, Shams, Homayoun. GM-CSF in the lung protects against lethal influenza infection. Am J Respir Crit Care Med, 2011.7.15, 184(2): 259~268

  13. Wu, CY#, Feng, Y#, Qian, GC, Wu, JH, Luo, J, Wang, Y, Chen, GJ, Guo, XK, Wang, ZJ. alpha-Galactosylceramide protects mice from lethal Coxsackievirus B3 infection and subsequent myocarditis. Clin Exp Immunol，2010.10.01, 162(1): 178~187

  14. Shi, Yufeng, Feng, Yan, Kang, Jiuhong, Liu, Chang, Li, Zhenxin, Li, Dangsheng, Cao, Wei, Qiu, Ju, Guo, Zhengliang, Bi, Enguang, Zang, Lei, Lu, Chuanzhen, Zhang, Jingwu Z, Pei, Gang. Critical regulation of CD4+ T cell survival and autoimmunity by beta-arrestin 1. Nat Immunol, 2007.8.01, 8(8): 817~824

 

教学工作                                                     

1、“卫生微生物学”课程的教学

2、“预防医学”课程的教学

3、“环境与健康”课程的教学