个人简介
2011年毕业于中国科学院上海生命科学研究院，获博士学位；2016年进入上海交通大学医学院工作，2019至2020年在耶鲁大学医学院/癌症生物学研究所担任高级研究学者，现担任上海交通大学医学院公共卫生学院研究员和研究组长。获上海市浦江人才、上海市卫生系统优秀青年、上海市人才发展资金、上海交通大学晨星学者等资助，长期从事我国食药资源和成分的分子毒理药理学研究，作为负责人主持国家自然科学基金项目3项和上海市科研项目多项，作为主要骨干和完成人参与国家自然科学基金重点项目、科技部科技支撑计划等重大项目多项。申请国家发明专利8项（授权3项），获计算机软件著作权登记1项，参与编写国家食品安全风险评估中心安全性评价工作导则草案，开展上海市卫健委食品安全风险评估工作，出版食品安全和营养相关译著和专著各1部。担任J Hazard Mater、Environ Health Perspect、Genomics Proteomics Bioinformatics、Toxicol Appl Pharmacol、Environ Toxicol Pharmacol等十多个杂志审稿人。
学术任职
中华预防医学会卫生毒理分委会委员、中国环境诱变剂学会生物标志物专委会委员、中国毒理学会毒理学替代法与转化毒理学、食品毒理学等专委会青年委员、中国抗癌协会肿瘤病因学分委会青年委员、上海市毒理学会理事等。
研究领域：食药资源毒理与药理学研究
1）立足于我国食源性化学污染物、新材料、新食品原料等成分，从鉴定毒性效应、阐释作用机制、建立评估策略等层面，系统探讨环境中食源性危害因素长期低剂量暴露的潜在健康风险和有害结局路径（AOP），开展“以体外人源细胞为模型、以毒性通路为核心、以作用方式为重点”的转化毒理学评价研究。
2）聚焦我国特色食药资源及其活性物质，探究其在慢病发生发展过程中（肿瘤、代谢、衰老等）的靶向干预策略和保护效果，从效应靶细胞和机体环境两个层面发现预防和治疗新靶标，鉴定具有靶向效应的食药资源和活性成分，开发靶向干预和防治新策略，体现精准预防干预的新思路。
代表性成果（第一/通讯作者论文）
（#第一作者；*通讯作者；IF：影响因子）
1) Ma X#, Hou M, Liu C, Li J, Ba Q*, Wang H*. Cadmium accelerates bacterial oleic acid production to promote fat accumulation in Caenorhabditis elegans. J Hazard Mater 2022, 421:126723. (*corresponding author) (IF: 10.588)
2) Chen F#, Li J*, Wang H*, Ba Q*. Anti-tumor effects of Chinese medicine compounds by regulating immune cells in microenvironment. Front Oncol 2021, 11:746917. (*corresponding author) (IF: 6.244)
3) Wang Z#, Sun Y#, Yao W*, Ba Q*, Wang H*. Effects of cadmium exposure on the immune system and immunoregulation. Front Immunol 2021, 12:695484. (*corresponding author) (IF: 7.561)
4) Chen P#, Wang Y#, Li J, Bo X, Wang J, Nan L, Wang C, Ba Q*, Liu H*, Wang H*. Diversity and intratumoral heterogeneity in human gallbladder cancer progression revealed by single-cell RNA sequencing. Clin Transl Med 2021, 11:e462. (*corresponding author) (IF: 11.492)
5) Sun M#, Gu P#, Yang Y#, Yu L#, Jiang Z, Li J, Chen Y*, Ba Q*, Wang H*. Mesoporous silica nanoparticles inflame tumors to overcome anti-PD-1 resistance through TLR4-NFκB axis. J Immunother Cancer 2021, 9(6):e002508. (*corresponding author) (IF: 13.751)
6) Yang Y#, Sun M#, Li W#, Liu C, Jiang Z, Gu P, Li J, Wang W, You R, Ba Q*, Li X*, Wang H*. Rebalancing TGF-β/Smad7 signaling via Compound kushen injection in hepatic stellate cells protects against liver fibrosis and hepatocarcinogenesis. Clin Transl Med 2021, 11:e410. (*corresponding author) (IF: 11.492)
7) Xu Y#, Mu W#, Li J, Ba Q*, Wang H*. Chronic cadmium exposure at environmental-relevant level accelerates the development of hepatotoxicity to hepatocarcinogenesis. Sci Total Environ 2021, 783:146958. (*corresponding author) (IF: 7.963)
8) Wu C#, Ba Q#, Lu D, Li W, Salovska B, Hou P, Mueller T, Rosenberger G, Gao E, Di Y, Zhou H, Fornasiero EF, Liu Y*. Global and Site-Specific Effect of Phosphorylation on Protein Turnover. Developmental Cell 2021, 56(1):111-24. (#co-first author) (IF: 12.27)
9) Jiang Z#, Mu W, Yang Y, Sun M, Liu Y, Gao Z, Li J, Gu P, Wang H, Lu Y, Ba Q*, Wang H*. Cadmium exacerbates dextran sulfate sodium-induced chronic colitis and impairs intestinal barrier. Sci Total Environ 2020, 744:140844. (*corresponding author) (IF: 7.963)
10) Yang Y#, Sun M, Yao W, Wang F, Li X, Wang W, Li J, Gao Z, Qiu L, You R, Yang C*, Ba Q*, Wang H*. Compound kushen injection relieves tumor-associated macrophage-mediated immunosuppression through TNFR1 and sensitizes hepatocellular carcinoma to sorafenib. J Immunother Cancer 2020, 8(1):e000317. (*corresponding author) (IF: 13.751)
11) Chen P#, Duan X#, Li X, Li J, Ba Q*, Wang H*. HIPK2 suppresses tumor growth and progression of hepatocellular carcinoma through promoting the degradation of HIF-1α. Oncogene 2020, 39(14):2863-76. (*corresponding author) (IF: 9.867)
12) Mu W#, Wang Y#, Huang C, Fu Y, Li J, Wang H, Jia X*, Ba Q*. Effect of long-term intake of dietary titanium dioxide nanoparticles on intestine inflammation in mice. J Agric Food Chem 2019, 67(33):9382-9. (*corresponding author) (IF: 4.192)
13) Li J, Li M, Chen P*, Ba Q*. High expression of PALB2 predicts poor prognosis in patients with advanced breast cancer. FEBS OPEN Bio 2018, 8: 56–63. (*corresponding author) (IF: 1.959)
14) Huang C#, Sun M, Yang Y, Wang F, Ma X, Li J, Y Wang, Ding Q, Ying H, Song H, Wu Y, Y Jiang, Jia X, Ba Q*, Wang H*. Titanium dioxide nanoparticles prime a specific activation state of macrophages. Nanotoxicology 2017, 11(6):737-50. (*corresponding author) (IF: 5.811)
15) Ba Q#, Li X, Huang C, Li J, Fu Y, Chen P, Duan J, Hao M, Zhang Y, Li J, Sun C, Ying H, Song H, Zhang R, Shen Z, Wang H*. BCCIPβ modulates the ribosomal and extraribosomal function of S7 through a direct interaction. J Mol Cell Biol 2017, 9(3):209-19. (IF: 5.595)
16) Ba Q#, Li M#, Chen P, Huang C, Duan X, Lu L, Li J, Chu R, Xie D, Song H, Wu Y, Ying H, Jia X*, Wang H*. Sex-dependent effects of cadmium exposure in early life on gut microbiota and fat accumulation in mice. Environ Health Perspect 2017, 125(3):437-44. (IF: 8.44)
17) Chen P#, Duan X#, Li M, Huang C, Li J, Chu R, Ying H, Song H, Jia X, Ba Q*, Wang H*. Topological, functional, and dynamic properties of the protein interaction networks rewired by benzo(a)pyrene. Toxicol Appl Pharmacol 2016, 310:150-8. (*corresponding author) (IF: 3.791)
18) Ba Q#, Huang C#, Fu Y, Li J, Chu R, Jia X*, Wang H*. Cumulative metabolic effects of low-dose benzo(a)pyrene exposure on human cells. Toxicol Res 2016, 5:107-15. (IF: 1.969)
19) Ba Q#, Li J, Huang C, Qiu H, Li J, Chu R, Zhang W, Xie D, Wu Y*, Wang H*. Effects of benzo[a]pyrene exposure on human hepatocellular carcinoma cell angiogenesis, metastasis, and NF-κB signaling. Environ Health Perspect 2015, 123(3):246–54. (IF: 8.443)
20) Zhang X#, Ba Q#, Gu Z*, Guo D, Zhou Y, Xu Y, Wang H*, Ye D*, Liu H*. Fluorescent coumarin-artemisinin conjugates as mitochondria-targeting theranostic probes for enhanced anticancer activities. Chem Eur J 2015, 21(48):17415-21. (#co-first author) (IF: 5.771)
21) Ba Q#, Li J#, Huang C, Li J, Chu R, Wu Y*, Wang H*. Topological, functional, and dynamic properties of the protein interaction networks rewired by benzo(a)pyrene. Toxicol Appl Pharmacol 2015, 283(2):83–91. (IF: 3.847)
22) Huang C#, Ba Q#, Yue Q, Li J, Li J, Chu R, Wang H*. Artemisinin rewires the protein interaction network in cancer cells: network analysis, pathway identification, and target prediction. Mol Biosyst 2013, 9(12):3091-100. (*co-first author) (IF: 3.183)
23) Li J#, Ba Q#, Yin J#, Wu S, Zhuan F, Xu S, Li J, Salazar JK, Zhang W, Wang H*. Surface display of recombinant drosophila melanogaster acetylcholinesterase for detection of organic phosphorus and carbamate pesticides. PLoS One 2013, 8(9):e72986. (*co-first author) (IF: 3.534)
24) Ba Q#, Duan J#, Tian J#, Wang Z, Chen T, Li X, Chen P, Wu S, Xiang L, Li J, Chu R, Wang H*. Dihydroartemisinin promotes angiogenesis during the early embryonic development of zebrafish. Acta Pharmacol Sin 2013, 34(8):1101-7. (IF: 2.496)
25) Ba Q#, Zhou N, Duan J, Chen T, Hao M, Yang X, Li J, Yin J, Chu R, Wang H*. Dihydroartemisinin exerts its anticancer activity through depleting cellular iron via transferrin receptor-1. PLoS One 2012, 7(8):e42703. (IF: 3.73)
26) Ba Q#, Hao M#, Huang H#, Hou J, Ge S, Zhang Z, Yin J, Chu R, Jiang H, Wang F, Chen K, Liu H*, Wang H*. Iron deprivation suppresses hepatocellular carcinoma growth in experimental studies. Clin Cancer Res 2011, 17(24):7625-33. (IF: 7.742)
27) Hao M#, Ba Q#, Yin J, Li J, Zhao Y, Wang H*. Deglycosylated ginsenosides are more potent inducers of CYP1Al, CYP1A2 and CYP3A4 expression in HepG2 cells than glycosylated ginsenosides. Drug Metab Pharmacokinet 2011, 26(2):201-5. (*co-first author) (IF: 2.321)
