1996年于南京大学获生物化学学士学位，1999年于南京大学获生物化学和分子生物学硕士学位，2005年于加州大学洛杉矶分校获生物化学和分子生物学博士学位。2005-2010年于瑞士苏黎世大学分子生物学研究所从事博士后研究。

2010年受聘于中科院上海生命科学研究院系统生物学重点实验室，任研究员、研究组长；2013-2018年任中科院上海生命科学研究院营养科学研究所研究员、研究组长；2018年起任上海交通大学医学院公共卫生学院研究员、研究组长。2010年入选中科院“百人计划”并获择优支持；2013年入选国家高层次青年人才。主持国家自然科学基金项目6项、上海市教委科研创新计划重大项目1项。

多年从事肿瘤与代谢疾病研究。主要研究外因（如饮食、环境等）和内因（基因功能异常）诱导的信号通路的失调与营养健康的失衡及疾病发生的内在联系。通过研究从外界进入的纳米结构/载体和细胞内的调控因子对营养代谢和稳态维持信号通路的调控和干涉，阐明营养健康失衡及疾病发生的分子机理，为癌症、糖尿病、神经退行性疾病等重大疾病的预防与治疗提供应对手段或潜在靶点。作为通讯作者发表SCI论文39篇（其中21篇影响因子大于10；11篇影响因子大于20；平均影响因子15.1），以主编、副主编、副主译、编者身份出版专著4部。

1、纳米技术的生物、医学应用：通过纳米载体增进肿瘤和代谢性疾病药物的靶向性和疗效（2025, Adv Mater, IF=29.4; 2025, Nat Commun, IF=15.7;2024, Adv Mater, IF=29.4;2023, Adv Mater, IF=29.4; 2021, Adv Mater, IF=29.4; 2021, Nano Today, IF=17.4; 2018, Mater Horiz, IF=13.3; 2017, ACS AMI, IF=9.5）；借助细胞间纳米结构塑造新型3D干细胞培养模型（2018, Adv Mater, IF=32.1）。

2、纳米结构与纳米载体的生物学效应：揭示食品用和医用纳米材料在代谢平衡、衰老和慢性疾病等生理和病理过程中的长期作用（2020, Adv Mater, IF=29.4; 2019, Mater Horiz, IF=13.3; 2016, Adv Mater, IF=29.4; 2014, Small, IF=13.3; 2016, Theranostics, IF=12.4; etc）。

3、营养代谢和稳态维持信号通路的分子机理：Wnt、Hippo、JNK和AMPK信号通路控制着包括胚胎和器官发育、代谢和稳态平衡、干细胞维持等重要生理和病变过程。这些信号通路的失调与多种重大疾病如糖尿病和癌症密切相关。我们致力于寻找这些信号通路中未知的调控基因和调节机制（2013, Dev Cell, IF=11.8; 2018, Cell Rep, IF=8.8; etc）。

（*：通讯作者；IF：影响因子）

1. Ma S#, Zhu W#, Ji X, Liu C, Chen N, Guo D*, Song H*. Multiplex Methionine Modulating Hydrogel for Cancer Metabolic Therapy. Adv Mater. 2025 May 16:e2420445. (IF=29.4)

2. Shen Y#, Wang H#, Guo D, Liu J, Sun J, Chen N, Song H*, Ji X*. Dual asparagine-depriving nanoparticles against solid tumors. Nat Commun. 2025 Jul 1;16(1):5675. (IF=15.7)

3. Yu Q#, Jiang K#, Ma S, Zheng Q, Tondi S, Reina C, Šabanović B, Wen C, Shen B, Aicher A, Song H*, Ma Y*, Heeschen C*. Elesclomol-copper combination synergistically targets mitochondrial metabolism in cancer stem cells to overcome chemoresistance in PDAC. Mol Ther. 2025 Sep 10:S1525-0016(25)00732-4. (IF=12.1)

4. Long M#, Zhou Y#, Guo D, Zhu Q, Liang H, Ji X, Chen N*, Song H*. Unzippable Siamese Nanoparticles for Programmed Two-Stage Cancer Immunotherapy. Adv Mater. 2024 May 29; 2402456. (IF=29.4)

5. Liang H#, Xu C#, Guo D#, Peng F, Chen N*, Song H*, Ji X*. Dismantlable Coronated Nanoparticles for Coupling the Induction and Perception of Immunogenic Cell Death. Adv Mater. 2024 Apr 21; 2313097. (IF=29.4)

6. Liu C#, Zhou Y#*, Guo D#, Huang Y, Ji X, Li Q, Chen N*, Fan C*, Song H*. Reshaping Intratumoral Mononuclear Phagocytes with Antibody-Opsonized Immunometabolic Nanoparticles. Adv Sci. 2023 Dec 6; 10(34):2303298. (IF=15.1)

7. Guo D#, Ji X#*, Xie H, Ma J, Xu C, Zhou Y, Chen N, Wang H*, Fan C*, Song H*. Targeted Reprogramming of Vitamin B₃ Metabolism as a Nanotherapeutic Strategy towards Chemoresistant Cancers. Adv Mater. 2023 Sep 7; 35(36):2301257. (IF=29.4)

8. Xu C#, Ji X#*, Zhou Y, Cheng Y, Guo D, Li Q, Chen N*, Fan C*, Song H*. Slimming and Reinvigorating Tumor-Associated Dendritic Cells with Hierarchical Lipid Rewiring Nanoparticles. Adv Mater. 2023 Jul 27; 35(30):2211415. (IF=29.4)

9. Ma J#, Guo D#, Ji X#, Zhou Y, Liu C, Li Q, Zhang J*, Fan C*, Song H*. Composite Hydrogel for Spatiotemporal Lipid Intervention of Tumor Milieu. Adv Mater. 2023 Apr 6; 35(14):2211579. (IF=29.4)

10. Ji X, Li Q, Song H*, Fan C*. Protein-Mimicking Nanoparticles in Biosystems. Adv Mater. 2022 Sep 15; 34(37):2201562. (IF=29.4)

11. Liu C#, Zhou Y#, Ji X, Xie H, Hu X, Yin M, Chen N*, Fan C*, Song H*. Nanobooster-Encapsulated Hybrid RNA as Anti-Tumor Viral Mimicry. Nano Today. 2021 June; 38:101211. (IF=17.4)

12. Ji X#, Guo D#, Ma J, Yin M, Yu Y, Liu C, Zhou Y, Sun J, Li Q, Chen N*, Fan C*, Song H*. Epigenetic Remodeling Hydrogel Patches for Multidrug-Resistant Triple-Negative Breast Cancer. Adv Mater. 2021 May 6; 33(18):2100949. (IF=29.4)

13. Zhou Y#, Liu C#, Yu Y#, Yin M, Sun J, Huang J, Chen N, Wang H*, Fan C*, Song H*. An Organelle-Specific Nanozyme for Diabetes Care in Genetically or Diet-Induced Models. Adv Mater. 2020 Nov 10; 32(45):2003708. (IF=29.4)

14. Liu C#, Hu X#, Li X#, Zhou Y, Wang H, Fan C*, Song H*. Reprogramming of Cancer Invasiveness and Macrophage Education via a Nanostructured Antagonist of the TGFß Receptor. Mater Horiz. 2019 Oct 1; 6(8):1675-1681. (IF=13.3)

15. Li X#, Xie X#, Ma Z#, Li Q, Liu L, Hu X, Liu C, Li B, Wang H, Chen N*, Fan C*, Song H*. Programming Niche Accessibility and In Vitro Stemness with Intercellular DNA Reactions. Adv Mater. 2018 Nov 15; 30(46):1804861. (IF=29.4)

16. Chen N#, Han Y#, Luo Y#, Zhou Y, Hu X, Yu Y, Xie X, Yin M, Sun J, Zhong W, Zhao Y, Song H*, Fan C*. Nanodiamonds-based non-canonical autophagy inhibitor synergistically induces cell death in oxygen-deprived tumors. Mater Horiz. 2018 Nov 1; 5(6):1204-1210. (IF=13.3)

17. Zhang Y#, Wang Z#, Li X, Wang L, Yin M, Wang L, Chen N*, Fan C*, Song H*. Dietary iron oxide nanoparticles delay aging and ameliorate neurodegeneration in Drosophila. Adv Mater. 2016 Feb 17; 28(7):1387-93. (IF=29.4)

18. Chen N, Wang H, Huang Q, Li J, Yan J, He D, Fan C*, Song H*. Long-Term Effects of Nanoparticles on Nutrition and Metabolism. Small. 2014; 10(18):3603-11. (IF=13.3)

19. Zhong W, Lü M, Liu L, Sun J, Zhong Z, Zhao Y, Song H*. Autophagy as new emerging cellular effect of nanomaterials. Sci Bull. 2013 Nov 25; 58(33):4031-8. (IF=18.9)

20. Schertel C#, Huang D#, Björklund M, Bischof J, Yin D, Li R, Wu Y, Zeng R, Wu J, Taipale J, Song H*, Basler K*. Systematic Screening of a Drosophila ORF Library In Vivo Uncovers Wnt/Wg Pathway Components. Dev Cell. 2013 Apr 29; 25(2):207-19. (IF=11.8)