1. Chen H#, Zhou Y#, Wang Q#, Zhou L, Wang Y, Xia B, Li Y, Feng Y, Lei D*, Wang Y*,Cheng W*. Detection of time-dependent uptake of microplastics by joint utilization of hepatic organoids and 3D-printed carrier. ACS Appl Mater Interfaces. 2026, 18 (36): 49808–49818. (IF=7.8, Q1)
2. Zhou Y, Chen H, Feng Y, Cheng W*, Wang Y*. Cardio-Vessel Organoids (CVO) generated from pluripotent stem cell for modelling the cardiovascular system in vitro and revealing the cardiovascular toxicity of drugs. Environ Toxicol Pharmacol. 2026, 124: 10502. (IF=4.2, Q1)
3. Chen H, Zhou Y, You Y, Feng Y, Wang Y*, Cheng W*. Aged microplastics disrupted copper homeostasis to induce vascular toxicity:in vivoand human vascular organoids-basedin vitrostudy. Environ Int. 2025, 206:109940. (IF=10.3, Q1)
4. Cheng W, Chen H, Zhou Y, You Y, Feng Y, Wang Y*. Low dose of micro-/nanoplastics mixture induced cardiac hypertrophy and reductive stress: the liver-heart crosstalk andhepatic-cardiac organoids-on-a-chip. J Hazard Mater. 2025, 490:137686. (IF=12.2, Q1)
5. Cheng W#, You Y#, Chen H, Zhou Y, Feng Y, Wang Y*. Integrated transcriptomics and metabolomics to explore the varied hepatic toxicity induced by aged- and pristine-microplastics: in vivo and human -originated liver organoids based in vitro study. Environ Res. 2025, 280: 121820. (IF=7.8, Q1)
6. Cheng W*, ChenH, Zhou Y, You Y, Lei D, Li Y, Feng Y, Wang Y*. Aged fragmented-polypropylene microplastics induced ageing statues-dependent bioenergetic imbalance and reductive stress:in vivo and liver organoids-based in vitro study. Environ Int. 2024, 191:108949.(IF=10.3, Q1)
7. ZhouY, Wu Q, Li Y, Feng Y, Wang Y*, Cheng W*. Low-dose of polystyrene microplastics induce cardiotoxicity in mice and human-originated cardiac organoids. Environ Int. 2023, 179:108171. (IF=11.8, Q1)
8. Xie Y, Li Y, Feng Y, Cheng W*, Wang Y*. Inhalable microplastics prevails in air: exploring the size detection limit. Environ Int. 2022,162:107151. (IF=13.352, Q1)
9. Cheng W#, Li X#, Yang S, Wang H, Li Y, Feng Y, Wang Y*. Low doses of BPF-induced hypertrophy in cardiomyocytes derived from human embryonic stem cells via disrupting the mitochondrial fission upon the interaction between ERβ and calcineurin A-DRP1 signaling pathway. Cell Biol Toxicol. 2022, 38:409-426. (IF=6.819, Q1)
10. Cheng W, Yang S, Li X, Liang F, Zhou R, Wang H, Feng Y, Wang Y*. Low doses of BPA induced abnormal mitochondrial fission and hypertrophy in human embryonic stem cell-derived cardiomyocytes via the calcineurin-DRP1 signaling pathway: A comparison between XX and XY cardiomyocytes. Toxicol Appl Pharmacol. 2020, 388:114850.(IF=4.460, Q2，editor推荐正刊与专刊同时收录)
Wei Cheng
Associate Researcher
Email:wcheng@shsmu.edu.cnmishua_@hotmail.com
Research interests
CSOT, Experiences in toxicology investigations (both academic and industrial), patents (20+ pended/granted items), and group standards.
1. Organoids- and Organ-on-chip based toxicity screening and toxic mechanism investigation of new pollutants
2. Hazard identification and risk assessment of microplastics
3. AI-assisted predictive toxicology
Professional experience
2020.07-present
Associate Researcher/Assistant researcher, Shanghai Jiao Tong University, School of Public Health
2017.10-2020.06
Shanghai Jiao Tong University, PhD in Public health and preventive medicine
Research projects
2024-2027 National key R&D program, sub-project PI
2023-2025 National Natural Science Foundation of China, PI
2022-2025 Foundation of Shanghai Science and Technology Committee (Specific Program for animal welfare and alternative testing), PI
Other professional activities
Member of the Organoids and Organs-on-Chips Committee, Chinese Society of Toxicology
Young Member of the Translational and Alternative Toxicology Committee, Chinese Society of Toxicology
Reviewers for Environment International、Journal of Hazardous Materials、Environmental Science & Technology、Redox biology、Environmental Pollution ect.,.
