1.Cheng W, Chen H, Zhou Y, You Y, Feng Y, Wang Y*.Low dose of micro-/nanoplastics mixture induced cardiac hypertrophy and reductive stress: the liver-heart crosstalk andhepatic-cardiac organoids-on-a-chip.J Hazard Mater. 2025, 490:137686. (IF=12.2, Q1)
2.Cheng W*,ChenH,Zhou Y,You Y, Lei D, Li Y, Feng Y, Wang Y*.Aged fragmented-polypropylene microplastics induced ageing statues-dependent bioenergetic imbalance and reductive stress:in vivo and liver organoids-based in vitro study.Environ Int. 2024, 191:108949.(IF=10.3, Q1)
3.Cheng W*, Zhou Y, ChenH,Wu Q, Li Y, Wang H, Feng Y, Wang Y*. The iron matters: Aged microplastics disrupted the iron homeostasis in the liver organoids.Sci Total Environ.2024, 906:167529. (IF=8.2, Q1)
4.ZhouY, Wu Q, Li Y, Feng Y, Wang Y*,Cheng W*. Low-dose of polystyrene microplastics induce cardiotoxicity in mice and human-originated cardiac organoids.Environ Int. 2023, 179:108171. (IF=11.8, Q1)
5.Cheng W*, Zhou Y, Xie Y,Li Y, Zhou R, Wang H, Feng Y, Wang Y*. Combined effect of polystyrene microplastics and bisphenol A on the human embryonic stem cells-derived liver organoids: the hepatotoxicity and lipid accumulation.Sci Total Environ,2023, 854:158585. (IF=10.753, Q1)
6.Xie Y, Li Y, Feng Y,Cheng W*, Wang Y*. Inhalable microplastics prevails in air: exploring the size detection limit.Environ Int, 2022,162:107151. (IF=13.352,Q1)
7.Cheng W*, Li X, Zhou Y, Yu H, Xie Y, Wang H, Li Y, Feng Y, Wang Y*. Polystyrene microplastics induce hepatotoxicity and disrupt lipid metabolism in the liver organoids.Sci Total Environ,2022, 806 (Pt 1): 150328. (IF=10.753, Q1)
8.Cheng W#, Li X#, Yang S, Wang H, Li Y, Feng Y, Wang Y*. Low doses of BPF-induced hypertrophy in cardiomyocytes derived from human embryonic stem cells via disrupting the mitochondrial fission upon the interaction between ERβ and calcineurin A-DRP1 signaling pathway.Cell Biol Toxicol, 2022, 38:409-426. (IF=6.819, Q2)
9.Cheng W, Yang S, Li X, Liang F, Zhou R, Wang H, Feng Y, Wang Y*. Low doses of BPA induced abnormal mitochondrial fission and hypertrophy in human embryonic stem cell-derived cardiomyocytes via the calcineurin-DRP1 signaling pathway: A comparison between XX and XY cardiomyocytes.Toxicol Appl Pharmacol.2020, 388:114850.(IF=4.460, Q2，editor推荐正刊与专刊同时收录)
10.Cheng W, Yang S, Liang F, Zhou R, Li Y, Feng Y, Wang Y*. Low-dose exposure to triclosan disrupted osteogenic differentiation of mouse embryonic stem cells via BMP/ERK/Smad/Runx-2 signalling pathway.Food Chem Toxicol.2019, 127:1-10. (IF=5.572, Q1)
Wei Cheng
Associate Researcher
Email: wcheng@shsmu.edu.cn mishua_@hotmail.com
Research interests
Experiences in toxicology investigations (both academic and industrial), patents (20 pended/granted items), and group standards.
1. Organoids- and Organ-on-chip based toxicity screening and toxic mechanism investigation of new pollutants
2. Hazard identification and risk assessment of microplastics
3. AI-assisted predictive toxicology
Educational background
2014.09-2017.06
Shanghai Jiao Tong University, PhD in Public health and preventive medicine
Professional experience
2020.07-present
Associate Researcher/Assistant researcher, Shanghai Jiao Tong University, School of Public Health
2017.10-2020.06
Shanghai Jiao Tong University, PhD in Public health and preventive medicine
Research projects
2024-2027 National key R&D program, sub-project PI
2023-2025 National Natural Science Foundation of China, PI
2022-2025 Foundation of Shanghai Science and Technology Committee (Specific Program for animal welfare and alternative testing), PI
Other professional activities
Member of the Organoids and Organs-on-Chips Committee, Chinese Society of Toxicology
Young Member of the Translational and Alternative Toxicology Committee, Chinese Society of Toxicology
Reviewers for Environment International, Theranostics, Journal of Hazardous Materials, Ecotoxicology and Environmental Safety ect.,.
Selected Publications
1. Cheng W, Chen H, Zhou Y, You Y, Feng Y, Wang Y*. Low dose of micro-/nanoplastics mixture induced cardiac hypertrophy and reductive stress: the liver-heart crosstalk and hepatic-cardiac organoids-on-a-chip. J Hazard Mater. 2025, 490:137686.
2. Cheng W*, Chen H, Zhou Y, You Y, Lei D, Li Y, Feng Y, Wang Y*. Aged fragmented-polypropylene microplastics induced ageing statues-dependent bioenergetic imbalance and reductive stress: in vivo and liver organoids-based in vitro study. Environ Int. 2024, 191:108949.
3. Cheng W*, Zhou Y, Chen H, Wu Q, Li Y, Wang H, Feng Y, Wang Y*. The iron matters: Aged microplastics disrupted the iron homeostasis in the liver organoids. Sci Total Environ. 2024, 906:167529.
4. Zhou Y, Wu Q, Li Y, Feng Y, Wang Y*, Cheng W*. Low-dose of polystyrene microplastics induce cardiotoxicity in mice and human-originated cardiac organoids. Environ Int. 2023, 179:108171.
5. Cheng W*, Zhou Y, Xie Y, Li Y, Zhou R, Wang H, Feng Y, Wang Y*. Combined effect of polystyrene microplastics and bisphenol A on the human embryonic stem cells-derived liver organoids: the hepatotoxicity and lipid accumulation. Sci Total Environ, 2023, 854:158585.
6. Xie Y, Li Y, Feng Y, Cheng W*, Wang Y*. Inhalable microplastics prevails in air: exploring the size detection limit. Environ Int, 2022, 162:107151.
7. Cheng W*, Li X, Zhou Y, Yu H, Xie Y, Wang H, Li Y, Feng Y, Wang Y*. Polystyrene microplastics induce hepatotoxicity and disrupt lipid metabolism in the liver organoids. Sci Total Environ, 2022, 806 (Pt 1): 150328.
8. Cheng W#, Li X#, Yang S, Wang H, Li Y, Feng Y, Wang Y*. Low doses of BPF-induced hypertrophy in cardiomyocytes derived from human embryonic stem cells via disrupting the mitochondrial fission upon the interaction between ERβ and calcineurin A-DRP1 signaling pathway. Cell Biol Toxicol, 2022, 38:409-426.
9. Cheng W, Yang S, Li X, Liang F, Zhou R, Wang H, Feng Y, Wang Y*. Low doses of BPA induced abnormal mitochondrial fission and hypertrophy in human embryonic stem cell-derived cardiomyocytes via the calcineurin-DRP1 signaling pathway: A comparison between XX and XY cardiomyocytes. Toxicol Appl Pharmacol.2020, 388:114850.
10. Cheng W, Yang S, Liang F, Zhou R, Li Y, Feng Y, Wang Y*. Low-dose exposure to triclosan disrupted osteogenic differentiation of mouse embryonic stem cells via BMP/ERK/Smad/Runx-2 signalling pathway. Food Chem Toxicol. 2019, 127:1-10.
